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Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN)
Retromer
Protein-coding gene in the species Homo sapiens
membrane (direct recycling). Two forms of retromer are known: the VPS26A retromer and the VPS26B retromer, the latter being dedicated to direct recycling
SORL1
Protein-coding gene in the species Homo sapiens
(PD) and Alzheimer's disease (AD). VPS35 is part of a complex called the retromer, which is responsible for transporting select cargo proteins between vesicular
VPS35
American biochemist and academic
work with Dr. Scott Small of Columbia University, which focuses on the retromer endosomal protein trafficking pathway and its role in Alzheimer's and Parkinson's
Gregory_Petsko
Vacuole to which materials ingested by endocytosis are delivered
the Golgi that carry molecules to endosomes. In the opposite direction, retromer generates vesicles at early endosomes that carry molecules back to the
Endosome
Protein-coding gene in the species Homo sapiens
encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to
VPS26A
Protein family
BLOC-1: DTNBP1 BLOC153 BLOC-2: HPS3 HPS5 HPS6 BLOC-3: HPS1 HPS4 Coats: Retromer TIP47 Small GTPase Dynamin DNM1 DNM2 DNM3 Other EHD protein family: EHD1
SNARE_protein
Protein-coding gene in the species Homo sapiens
intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi
SNX5
American neurologist and neuroscientist
testing of therapeutic interventions for three hippocampal-based conditions: retromer-enhancers for Alzheimer's disease; dietary flavanols for cognitive aging;
Scott_A._Small
trafficking complex have similar heterotetramers of the AP complexes. Retromer is not closely related, has been reviewed, and its proteins will not be
Vesicular transport adaptor protein
Vesicular_transport_adaptor_protein
Protein-coding gene in the species Homo sapiens, named for ketazocine
receptor (MOR) contains a C-terminal LENL recycling motif that engages retromer complexes for rapid plasma membrane recycling, and the δ-opioid receptor
Κ-opioid_receptor
Class of plant hormones
Glanc M, Friml J (April 2018). "Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane". Proceedings
Gibberellin
Mammalian protein found in humans
S, Cimermancic P, Krogan NJ, von Zastrow M (Jun 2011). "SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling
Beta-2_adrenergic_receptor
Uniporter protein
EC, Bell AJ, Heesom KJ, et al. (May 2013). "A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal
GLUT1
Protein found in humans
"Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer". J. Cell Biol. 165 (1): 111–22. doi:10.1083/jcb.200312034. PMC 2172078
Cation-dependent mannose-6-phosphate receptor
Cation-dependent_mannose-6-phosphate_receptor
Group of signal transduction pathways involved in embryonic development
as GPR177 (wntless) and evenness interrupted and complexes such as the retromer complex. Upon secretion, the ligand can be prevented from reaching its
Wnt_signaling_pathway
Protein-coding gene in the species Homo sapiens
encoded by the OXR1 gene. Loss of OXR1 function causes decline of the retromer complex. GRCh38: Ensembl release 89: ENSG00000164830 – Ensembl, May 2017
OXR1
Protein-coding gene in the species Homo sapiens
interacts with OSBPL1A and CLN3. Rab7A was also shown to interact with the Retromer Complex, most likely through the Vps35 subunit. RAB7 is a small GTPase
RAB7A
Protein-coding gene in the species Homo sapiens
proteins in Wnt-secreting cells. Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction. A homozygous
Protein_wntless_homolog
Office skyscraper in Manhattan, New York
Cornerstone Research (41st floor & entire 42nd, 43rd and 44th floors) Retromer Therapeutics (47th floor) List of tallest buildings in New York City "599
599_Lexington_Avenue
Human genetic disorder
Debanjan; Arendt, Kristin; Chen, Lu; Malenka, Robert (2017-04-05). "The Retromer Supports AMPA Receptor Trafficking During LTP". Neuron. 94 (1): 74–82.e5
Schaaf–Yang_syndrome
Protein-coding gene in the species Homo sapiens
Gleeson PA, Wicking C, Teasdale RD (November 2005). "A novel mammalian retromer component, Vps26B". Traffic. 6 (11): 991–1001. doi:10.1111/j.1600-0854
VPS26B
Protein-coding gene in the species Homo sapiens
coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex. The homologous protein (one that performs the same function) in
VPS29
Protein-coding gene in humans
WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35". The Biochemical Journal. 442 (1): 209–20. doi:10.1042/BJ20111761
CCDC22
Protein-coding gene in the species Homo sapiens
protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex. This gene encodes a member of the sorting nexin family. Members
SNX1
PMID 32502405. Wilson KA, Bar S, et al. (Jan 2024). "OXR1 maintains the retromer to delay brain aging under dietary restriction". Nature Communications
Drosophila Genetic Reference Panel
Drosophila_Genetic_Reference_Panel
Medical condition
"Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain". Cell Metabolism
Infantile neuroaxonal dystrophy
Infantile_neuroaxonal_dystrophy
protein belonging to the sorting nexin family that is a component of the retromer complex. The protein contains a coiled-coil domain at its C terminus and
SNX6
Inability to synthesize an organic compound required for growth
PMID 19301095. S2CID 1870305. "Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein
Auxotrophy
Factors causing Parkinson's disease
number of diseases that involve disruptions of normal mitochondrial and retromer activity, including PD. VPS35-related PD is extremely rare. The GBA gene
Causes_of_Parkinson's_disease
Protein-coding gene in the species Homo sapiens
component cytoplasm cytosol endosome early endosome membrane early phagosome retromer complex early endosome phagocytic vesicle extracellular exosome cytoplasmic
SNX3
American geneticist
David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ (2014). "The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor
Hugo_J._Bellen
KNOP1 gene
Burstein, E., … Cullen, P. J. (2017). Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nature Cell Biology, 19(10), 1214–1225
KNOP1
Protein-coding gene in the species Homo sapiens
TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking". Hum. Mol. Genet. 26 (4): 729–741. doi:10.1093/hmg/ddw413
TMEM230
Protein-coding gene in humans
"Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer". J. Cell Biol. 165 (1): 111–22. doi:10.1083/jcb.200312034. PMC 2172078
RAB9A
Protein
network in a retromer-mediated manner. SNX8 is therefore localized in early endosomes, as its colocalization with components of the retromer such as SNX1
SNX8
New Zealand physiology academic
Rasulov; Polly Tenci; Kirk L Hamilton; Fiona J McDonald (5 October 2020). "Retromer is involved in epithelial sodium channel trafficking". American Journal
Fiona_McDonald_(physiologist)
Protein-coding gene in humans
binding Cellular component cytoplasm endosome membrane basal part of cell retromer complex trans-Golgi network perinuclear region of cytoplasm nucleus late
Natural resistance-associated macrophage protein 2
Natural_resistance-associated_macrophage_protein_2
Protein found in humans
release their cargo. The IGF2Rs are recycled back to the Golgi by the retromer complex, again by way of interaction with GGAs and vesicles. The cargo
Insulin-like growth factor 2 receptor
Insulin-like_growth_factor_2_receptor
Protein-coding gene in the species Homo sapiens
KIAA0196 KIAA0196". Seaman MN, Gautreau A, Billadeau DD (November 2013). "Retromer-mediated endosomal protein sorting: all WASHed up!". Trends in Cell Biology
KIAA0196
Protein-coding gene in the species Homo sapiens
with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport". Journal of Cell Science. 118 (Pt 19):
SNX2
Protein-coding gene in the species Homo sapiens
Morishita W, Goswami D, Arendt K, Chen L, Malenka R (April 2017). "The Retromer Supports AMPA Receptor Trafficking During LTP". Neuron. 94 (1): 74–82.e5
MAGEL2
Protein-coding gene in the species Homo sapiens
binding retromer complex binding Cellular component early endosome membrane intracellular membrane-bounded organelle membrane plasma membrane retromer complex
WASHC2C
Protein-coding gene in the species Homo sapiens
binding Cellular component early endosome membrane membrane nucleoplasm retromer complex early endosome immunological synapse WASH complex cytoplasm endosome
SNX27
Protein-coding gene in the species Homo sapiens
component of plasma membrane intracellular anatomical structure nucleoplasm retromer complex early endosome nucleus fibrillar center nucleolus cytosol Biological
TRIM27
Hang; Rojas, Raul; Bonifacino, Juan S.; Hurley, James H. (June 2006). "The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal
Alpha_Arrestin
Protein-coding gene in humans
protein binding metal ion binding Cellular component cytoplasm macropinosome retromer complex lysosomal membrane early endosome endosome membrane extracellular
ANKFY1
Protein-coding gene in the species Homo sapiens
binding Cellular component cytoplasm centrosome membrane dynactin complex retromer complex cell leading edge dynein complex microtubule cytoskeleton kinetochore
DCTN1
RETROMER
RETROMER
RETROMER
RETROMER
Boy/Male
Hindu, Indian, Marathi
Calm; Tranquil; Steady; Quiet
Girl/Female
Hindu, Indian, Kannada, Malayalam, Marathi, Tamil, Telugu
One who has a Beautiful Body
Boy/Male
British, English
Town Meadow
Boy/Male
Native American
Nez perce word for an elm branch.
Male
Italian
Italian form of Roman Plinius, of unknown PLINIO means. In use by the Portuguese and Spanish.
Boy/Male
American, Anglo, British, English, German, Swedish, Teutonic
Man of Peace; Hero's Peace; Peaceful Strength
Girl/Female
Muslim
Bright, Masculine zealand
Male
Spanish
Spanish form of Roman Latin Amantius, AMANCIO means "loving."
Girl/Female
Tamil
Variant of katherine pure
Girl/Female
Arabic, Muslim, Pashtun
Prosperous
RETROMER
RETROMER
RETROMER
RETROMER
RETROMER