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RAPGEF2

RAPGEF2

Protein-coding gene in the species Homo sapiens

exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene. RAPGEF2 is a cyclic AMP binding protein. Members of the RAS subfamily of

RAPGEF2

Cyclic adenosine monophosphate

Cellular second messenger

channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2. cAMP is associated with kinases function in several biochemical processes

Cyclic adenosine monophosphate

Cyclic_adenosine_monophosphate

Stereocilia (inner ear)

Mechanosensing organelles of hair cells

Hwajin (2012). "DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth". International Journal of Epidemiology

Stereocilia (inner ear)

Stereocilia_(inner_ear)

RasGEF domain

Protein domain

activity of these proteins. KNDC1; PLCE1; RALGDS; RALGPS1; RALGPS2; RAPGEF1; RAPGEF2; RAPGEF3; RAPGEF4; RAPGEF5; RAPGEF6; RAPGEFL1; RASGEF1A; RASGEF1B; RASGEF1C;

RasGEF domain

RasGEF_domain

RAP1A

Protein-coding gene in the species Homo sapiens

gene. RAP1A has been shown to interact with: C-Raf, MLLT4, PDE6D, RALGDS, RAPGEF2, and TSC2. GRCh38: Ensembl release 89: ENSG00000116473 – Ensembl, May 2017

RAP1A

PDZ domain

Protein family

PDZRN3 PDZRN4 PICK1 PPP1R9A PPP1R9B PREX1 PRX PSCDBP PTPN13 PTPN3 PTPN4 RAPGEF2 RGS12 RGS3 RHPN1 RIL RIMS1 RIMS2 SCN5A SCRIB SDCBP SDCBP2 SHANK1 SHANK2

PDZ domain

PDZ_domain

List of human protein-coding genes 6

P61225 13415 RAP2C HGNC:21165; Q9Y3L5 13416 RAPGEF1 HGNC:4568; Q13905 13417 RAPGEF2 HGNC:16854; Q9Y4G8 13418 RAPGEF3 HGNC:16629; O95398 13419 RAPGEF4 HGNC:16626;

List of human protein-coding genes 6

List_of_human_protein-coding_genes_6

Cyclic nucleotide-binding domain

Protein domain

KCNH8; PNPLA6; PNPLA7; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKG1; PRKG2; RAPGEF2; RAPGEF3; RAPGEF4; RAPGEF6; RCNC2; SLC9A10; SLC9A11; Schultz SC, Shields

Cyclic nucleotide-binding domain

Cyclic_nucleotide-binding_domain

RAPGEF3

Protein-coding gene in humans

Rap/Ras-specific GEF proteins that also include C3G (RAPGEF1), PDZ-GEF1 (RAPGEF2), PDZ-GEF2 (RAPGEF6), Repac (RAPGEF5), CalDAG-GEF1 (ARHGEF1), CalDAG-GEF3

RAPGEF3

RALGDS

Protein-coding gene in the species Homo sapiens

with: Arrestin beta 1, Arrestin beta 2, HRAS, KRAS, MRAS, RAP1A, RAP2A, RAPGEF2, and RRAS. GRCh38: Ensembl release 89: ENSG00000160271 – Ensembl, May 2017

RALGDS