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PNEUMOLYSIN

Pneumolysin

Pneumolysin is a virulence factor of the Gram-positive bacteria Streptococcus pneumoniae. It is a pore-forming toxin of 53 kDa composed of 471 amino acids

Pneumolysin

Streptococcus pneumoniae

Species of bacterium

typically when the host's immune system is suppressed. Invasins, such as pneumolysin, an antiphagocytic capsule, various adhesins, and immunogenic cell wall

Streptococcus pneumoniae

Streptococcus_pneumoniae

Exotoxin

Toxin from bacteria that destroys or disrupts cells

pneumolysin, which is released from the cytoplasm of Streptococcus pneumoniae when the bacteria lyse. The CDCs Streptococcus pneumoniae Pneumolysin,

Exotoxin

Pneumococcal pneumonia

Medical condition

Pro-inflammatory effects are exhibited by the single pneumococcal toxin, pneumolysin (Ply); use of anti-Ply antibodies result in decreased inflammation. Studies

Pneumococcal pneumonia

Pneumococcal_pneumonia

Pneumococcal infection

Medical condition

host immune cells by inhibiting C3b opsonization of the bacterial cells Pneumolysin (Ply)—a 53-kDa pore-forming protein that can cause lysis of host cells

Pneumococcal infection

Pneumococcal_infection

Fura-2-acetoxymethyl ester

Chemical compound

devoid of neurotoxicity". Mutepe, N. Daphney (2013). "Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin". v t e

Fura-2-acetoxymethyl ester

Fura-2-acetoxymethyl_ester

Pore-forming toxin

Protein-produced toxins that create pores in cell membrane

proliferation, phagocytosis, and proinflammatory cytokine release. CDCs, such as pneumolysin, from S. pneumoniae, form pores as large as 260 Å (26 nm), containing

Pore-forming toxin

Pore-forming_toxin

Cholesterol-dependent cytolysin

Family of toxins from bacteria

shared by all CDCs, which essentially corresponds to the sequence of pneumolysin, the shortest member of the family. CDCs with longer sequences usually

Cholesterol-dependent cytolysin

Cholesterol-dependent_cytolysin

MACPF

Large group of transport proteins

HR (2005). "Structural basis of pore formation by the bacterial toxin pneumolysin". Cell. 121 (2): 247–56. doi:10.1016/j.cell.2005.02.033. PMID 15851031

MACPF

Cytolysin

Substances toxic to individual cells

E. coli α-hemolysin, Aeromonas aerolysin) to 25–30 nm (streplysin O, pneumolysin). Depending on how the pores are formed, the pore forming cytolysins

Cytolysin

MAPK11

Protein-coding gene in the species Homo sapiens

Gerber J, Spreer A, Bähr M, Michel U, Nau R (2002). "Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends

MAPK11