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Protein-coding gene in the species Homo sapiens
member 2 (PLEKHG2) is a protein that in humans is encoded by the PLEKHG2 gene. It is sometimes written as ARHGEF42, FLJ00018. The PLEKHG2 protein is
PLEKHG2
Protein family
shown to activate a Rho guanine nucleotide exchange factor (RhoGef) gene PLEKHG2 which is upregulated in a number of leukemia cell lines and mouse models
G_beta-gamma_complex
Proteins which remove GDP from GTPases
activation of Ran to allow nuclear export of proteins. Ras-GRF1 Kalirin PLEKHG2 Ephexin5 is a RhoA GEF involved in neuronal synapse development. G proteins
Guanine nucleotide exchange factor
Guanine_nucleotide_exchange_factor
Protein-coding gene in the species Homo sapiens
pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections". HIV Med. 16 (2): 114–21
Ubiquitin-fold modifier conjugating enzyme 1
Ubiquitin-fold_modifier_conjugating_enzyme_1
Protein domain
ITSN2/Intersectin 2; KALRN/Kalirin; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG4B; PLEKHG5; PLEKHG6; PREX1; PREX2; RASGRF1; RASGRF2;
RhoGEF_domain
Clinical Significance
PLEKHA7, PLEKHA8, PLEKHB1, PLEKHB2, PLEKHC1, PLEKHF1, PLEKHF2, PLEKHG1, PLEKHG2, PLEKHG3, PLEKHG4, PLEKHG5, PLEKHG6, PLEKHH1, PLEKHH2, PLEKHH3, PLEKHJ1
Pleckstrin_homology_domain
12318 PLEKHF2 HGNC:20757; Q9H8W4 12319 PLEKHG1 HGNC:20884; Q9ULL1 12320 PLEKHG2 HGNC:29515; Q9H7P9 12321 PLEKHG3 HGNC:20364; A1L390 12322 PLEKHG4 HGNC:24501;
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
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