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Photoreceptor phosphodiesterase 6 (PDE6 or PDE-6) is a protein complex family, which is highly concentrated in the retina. cGMP PDE6A PDE6B PDE6C PDE6D
PDE6
Protein-coding gene in the species Homo sapiens
subunit beta is the beta subunit of the protein complex PDE6 that is encoded by the PDE6B gene. PDE6 is crucial in transmission and amplification of visual
PDE6B
Medication used to treat erectile dysfunction
treating pulmonary arterial hypertension. Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil. Some sildenafil users see
Tadalafil
Chemical compound
similar ocular side effects due to their similar selectivity overlap with PDE6, an enzyme found in the eye. Beyond its indications for erectile dysfunction
Vardenafil
Mammalian protein found in humans
mechanism of action of E4021 on both the nonactivated and activated forms of rod PDE6 because both states are relevant to understanding how PDE5-selective inhibitors
CGMP-specific phosphodiesterase type 5
CGMP-specific_phosphodiesterase_type_5
Vasodilating drug
influences their side effect profile. For example, sildenafil also inhibits PDE6 which is present in the retina of the eye; this reaction is thought to be
PDE5_inhibitor
Drug for erectile dysfunction and hypertension
because sildenafil, while selective for PDE5, does have some affinity for PDE6, which is the phosphodiesterase found in the retina. Patients thus taking
Sildenafil
Medical term for seeing everything tinted in blue
interfere with enzymes in the retina, particularly phosphodiesterase-6 (PDE6). This disruption affects how the retina processes light, leading to temporary
Cyanopsia
Chemical compound
market. It is a phosphodiesterase inhibitor, selective for the subtypes PDE5, PDE6, PDE9 and PDE11. IC50 values are 0.76, 0.15, 29.0, and 12.0 μM, respectively
Zaprinast
Chemical compound
used as a treatment for erectile dysfunction. However, the drug can inhibit PDE6 in retina (albeit with less affinity than PDE5). This has been shown to result
Cyclic guanosine monophosphate
Cyclic_guanosine_monophosphate
Protein domain
of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which
GAF_domain
Part of the eye
turn causes the Ga-subunit of the protein to activate a phosphodiesterase (PDE6), which degrades cGMP, resulting in the closing of Na+ cyclic nucleotide-gated
Retina
Process by which light activates retinal cells
The alpha subunit-GTP complex activates phosphodiesterase, also known as PDE6. It binds to one of two regulatory subunits of PDE (which itself is a tetramer)
Visual_phototransduction
Enzyme and protein-coding gene in humans
modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3". Cellular Signalling. 13 (10): 735–741. doi:10
PDE10A
Drug discovery
unintended effects of PDE5 inhibitors against other PDE isozymes, such as PDE1, PDE6 and PDE11. It is theorised that improved selectivity of PDE5 inhibitors may
Discovery and development of phosphodiesterase 5 inhibitors
Discovery_and_development_of_phosphodiesterase_5_inhibitors
Protein-coding gene in the species Homo sapiens
AR, Holder GE, Rana NA, Ripamonti C, Sharpe LT (2008). "The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low
RGS9BP
AR; Holder, GE; Rana, NA; Ripamonti, C; Sharpe, LT (2008). "The loss of PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low
Bradyopsia
PDE6
PDE6
PDE6
PDE6
Male
Basque
, Sunday child.
Boy/Male
Gaelic German
Female
Hawaiian
 Hawaiian name MALINA means "calming; soothing." Compare with other forms of Malina.
Boy/Male
Indian
Picture, Painting
Girl/Female
Hindu, Indian
The Earth
Girl/Female
Hindu, Indian, Kannada, Marathi, Telugu
Born in Sea; Goddess Lakshmi
Boy/Male
Hindu, Indian
Joyful
Biblical
my God the Father
Surname or Lastname
English
English : possibly a variant of Minns.Perhaps an Americanized spelling of Dutch Mijnes, which can be a nickname or occupational name from Middle Dutch minne ‘beloved’, ‘sweetheart’, or a metronymic from a short form of a female personal name such as Jacqueminne or Willeminne. Compare Min 2.Possibly a variant spelling of Mines.
Male
Arthurian
, stallion.
PDE6
PDE6
PDE6
PDE6
PDE6