Reference for NICASTRIN. Search for NICASTRIN

AI searches containing NICASTRIN

NICASTRIN

Nicastrin

Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene. Nicastrin (abbreviated NCT) is a protein that is part of the

Nicastrin

Gamma secretase

Type of protein

secretase complex consists of four individual proteins: PSEN1 (presenilin-1), nicastrin, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer

Gamma secretase

Gamma_secretase

Early-onset Alzheimer's disease

Alzheimer's disease developed before the age of 65

Presenilins 1 and 2 are the enzymatic centers of this complex along with nicastrin, Aph1, and PEN-2. Alpha-secretase cleavage of APP, which precludes the

Early-onset Alzheimer's disease

Early-onset_Alzheimer's_disease

PEN-2

Protein-coding gene in the species Homo sapiens

protein (APP). The gamma secretase complex consists of PEN-2, APH-1, nicastrin, and the catalytic subunit presenilin. PEN-2 is a 101-amino acid integral

PEN-2

APH-1

Protein gene product

Caenorhabditis elegans as a regulator of the cell-surface localization of nicastrin and an essential component in the Notch signaling pathway. APH-1 homologs

APH-1

Topics referred to by the same term

Dakota Nuclear Compton Telescope, a balloon-borne gamma-ray detector Nicastrin, a protein component of the gamma secretase enzyme complex Nocturnal clitoral

NCT

Presenilin-1

Protein-coding gene in the species Homo sapiens

mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes". J. Biol. Chem. 278 (9): 7374–80

Presenilin-1

Presenilin-2

Protein-coding gene in the species Homo sapiens

interact with: BCL2-like 1, CAPN1, CIB1, Calsenilin, FHL2, FLNB, KCNIP4, Nicastrin, and UBQLN1. GRCh38: Ensembl release 89: ENSG00000143801 – Ensembl, May

Presenilin-2

Amyloid-beta precursor protein secretase

Type of enzyme

domain. γ-secretase is actually a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. Presenilin is believed to harbor the protease domain

Amyloid-beta precursor protein secretase

Amyloid-beta_precursor_protein_secretase

Alzheimer's disease in the Hispanic/Latino population

complex imaged using cryo-electron microscopy. The structure contains nicastrin (red), presenilin-1 (orange), PEN-2 (blue), and APH-1 (green). This is

Alzheimer's disease in the Hispanic/Latino population

Alzheimer's_disease_in_the_Hispanic/Latino_population

Peter St George-Hyslop

British-Canadian neurologist and neuroscientist

disease. These include the discovery of the presenilins (PSEN1 and PSEN2), Nicastrin, TREM2, Apolipoprotein E and SORL1 genes. Presenilin mutations are the

Peter St George-Hyslop

Peter_St_George-Hyslop

UBQLN2

Protein-coding gene in the species Homo sapiens

presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin". Biochem. J. 391 (Pt 3): 513–25. doi:10.1042/BJ20050491. PMC 1276952

UBQLN2

Bruce Beutler

American immunologist and geneticist

Yu, Gang; Beutler, Bruce (March 3, 2020). "Essential requirement for nicastrin in marginal zone and B-1 B cell development". Proceedings of the National

Bruce Beutler

Bruce_Beutler

Marilyn Farquhar

American biologist (1928–2019)

Liao, F; Li, F; Wong, PC; Farquhar, MG; Thinakaran, G; Xu, H (2005). "Nicastrin is critical for stability and trafficking but not association of other

Marilyn Farquhar

Marilyn_Farquhar

Presenilin

Family of related multi class transmembrane proteins

intramembrane protease, a four-member protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2. It has a very broad range of substrates for its proteolytic

Presenilin