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Toxicity in the kidneys
in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with some medications predominantly excreted
Nephrotoxicity
Volatile anaesthesia medication
mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway". Anesthesiology
Methoxyflurane
Condition in which there are elevated levels of the fluoride ion in the body
(seronegative) rheumatoid arthritis or ankylosing spondylitis. Fluoride induced nephrotoxicity is kidney injury due to toxic levels of serum fluoride, commonly due
Fluoride_toxicity
Species of plant
properties towards kidneys (nephrotoxicity). This is likely due to the Caleicine in the plant being metabolised into the nephrotoxic compound Eugenol that can
Calea_ternifolia
Antibiotic medication
factor for upper-extremity deep-vein thrombosis. Damage to the kidneys (nephrotoxicity) and to the hearing (ototoxicity) were side effects of the early, impure
Vancomycin
Chemical compound
individuals. Other side effects include nephrotoxicity, neuromuscular toxicity, and hypersensitivity reactions. Nephrotoxicity can be particularly worrisome when
Tobramycin
enhancing the efficacy of certain medications or reducing drug-induced nephrotoxicity, and potential risks, including unwanted drug accumulation and altered
Renal tubular transport inhibitor
Renal_tubular_transport_inhibitor
Psychoactive drug, often called ecstasy
2017. Retrieved 31 August 2017. Luciano RL, Perazella MA (June 2014). "Nephrotoxic effects of designer drugs: synthetic is not better!". Nature Reviews
MDMA
Antibiotic medication
risk can be minimized by reducing the duration of use. Amikacin causes nephrotoxicity (damage to the kidneys), by acting on the proximal renal tubules. It
Amikacin
Pathological conditions of the kidney, impairing the organ's ability to filter blood
"Cisplatin nephrotoxicity". In: UpToDate, Palevsky PM (Ed), UpToDate, Waltham, MA, 2013. http://www.uptodate.com/contents/cisplatin-nephrotoxicity Robinson
Kidney_disease
Antibiotic medication
of the most nephrotoxic drugs of this class. Oftentimes, acute nephrotoxicity is reversible, but it may be fatal. The risk of nephrotoxicity can be affected
Gentamicin
Species of flowering plant in the buttercup family Ranunculaceae
Souad (September 2, 2015). "Damascenine induced hepatotoxicity and nephrotoxicity in mice and in vitro assessed human erythrocyte toxicity". Interdisciplinary
Nigella_damascena
Toxin found in animal feed
abortion Ochratoxin Aspergillus ochraceus, Penicillium verrucosum nephrotoxicity, mild liver damage, immune suppression Ergot alkaloid Claviceps purpurea
Mycotoxins_in_animal_feed
Loop diuretic medication
consistent with findings from earlier studies. Other precautions include nephrotoxicity, sulfonamide (sulfa) allergy, and increased free thyroid hormone effects
Furosemide
Stomach acid suppressing medication
infections (including Clostridioides difficile), and kidney damage (nephrotoxicity). A rare, though less understood, side effect of the PPI class is the
Rabeprazole
Chemical compound
the formula HCOOLi, and a molar mass of 51.95 g/mol. It is potentially nephrotoxic. Lithium formate crystalises in the orthorhombic crystal system, with
Lithium_formate
Antifungal medication
liposomal nystatin appears to cause fewer cases of and less severe nephrotoxicity than observed with amphotericin B. Bitter taste and nausea are more
Nystatin
Chemical compound and pharmaceutical drug
1984. Cisplatin has a number of side effects that can limit its use: Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major
Cisplatin
Inhalational anaesthetic
investigation into potential correlation of sevoflurane use and renal damage (nephrotoxicity). However, this should be subject to further investigation, as a recent
Sevoflurane
Chemical compound
auranthine has been reported. MacGeorge, K. M; Mantle, P. G (1990). "Nephrotoxicity of Penicillium aurantiogriseum and P. Commune from an endemic nephropathy
Auranthine
Medical imaging technique
approx. 0.03–0.1%. Of particular interest is the lower incidence of nephrotoxicity, compared with iodinated agents, when given at usual doses—this has
Magnetic_resonance_imaging
Antiviral drug used to treat or prevent HIV and hepatitis infections
use of tenofovir disoproxil is associated with nephrotoxicity and bone loss. Presentation of nephrotoxicity can appear as Fanconi syndrome, acute kidney
Tenofovir_disoproxil
Antiviral drug
prevent this nephrotoxicity. Hypersensitivity to cidofovir or probenecid (as probenecid needs to be given concurrently to avoid nephrotoxicity). It is known
Cidofovir
Death of the cells in the renal tubules
Investigation. 64 (4): 546–56. PMID 1673163. Tulkens, P.M. (March 1989). "Nephrotoxicity of aminoglycoside antibiotics". Toxicology Letters. 46 (1–3): 107–123
Acute_tubular_necrosis
Causation of harm by any medical activity
kidneys; these are prescribed only in severe infections where the risk of nephrotoxicity is preferable to the consequences of the infection. Adverse effects
Iatrogenesis
Anaerobic parasitic protist
should be used with caution in patients with colitis, as it is both nephrotoxic and ototoxic. Absorption through the damaged wall of the intestinal tract
Entamoeba_histolytica
Class of pharmaceutical drugs
candidiasis, pseudomembranous colitis, superinfection, eosinophilia, nephrotoxicity, neutropenia, thrombocytopenia, and fever.[citation needed] The commonly
Cephalosporin
Antibiotic
Escherichia coli The main toxicities described with intravenous treatment are nephrotoxicity (damage to the kidneys) and neurotoxicity (damage to the nerves), but
Colistin
Fungal infection of the lungs
patients who might be at risk of nephrotoxicity, although all preparations of amphotericin B have a risk of nephrotoxicity. Individuals on amphotericin B
Histoplasmosis
Species of flowering plant
Aihua (11 June 2019). "Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms". Frontiers in Pharmacology
Asarum_europaeum
NSAID analgesic and anti-inflammatory drug
inhibitor of COX-2 byproducts, particularly prostaglandins. It may be less nephrotoxic than indomethacin. There are two known polymorphs of the compound. Nabumetone
Nabumetone
Antifungal and antiparasitaric chemical compound
RT, Badaró R (June 2012). "Does lipid emulsion reduce amphotericin B nephrotoxicity? A systematic review and meta-analysis". Clinical Infectious Diseases
Amphotericin_B
Mass poisonings since the 1990s
alternative to glycerine for industrial applications. Diethylene glycol is nephrotoxic and can result in multiple organ dysfunction syndrome (MODS), especially
Toxic_cough_syrup
Immunosuppressive drug
hypertension, blurred vision, liver and kidney problems (tacrolimus nephrotoxicity), hyperkalemia, hypomagnesemia, hyperglycemia, diabetes mellitus, itching
Tacrolimus
Variety of grape
making Champagne. Along with grapes and raisins, Zante currants are nephrotoxic to dogs. This toxicity manifests as kidney failure and can be seen in
Zante_currant
Species of flowering plant
pigs in large amounts over several days. Such forage may cause fatal nephrotoxicity, presumably because of its high oxalate content. Other symptoms, such
Amaranthus_retroflexus
Citrus fruit
resulting in numerous adverse effects including bone marrow suppression, nephrotoxicity, abnormal heart rhythm, rhabdomyolysis, hypotension, gastrointestinal
Grapefruit
Genus of plants
36. doi:10.2460/javma.2002.220.49. PMID 12680447. Hall J (1992). "Nephrotoxicity of Easter Lily (Lilium longiflorum) when ingested by the cat". Proc
Lilium
Fungal infection
primary agent) is known to be associated with increased drug-induced nephrotoxicity impairing kidney function. Other formulations have been developed such
Coccidioidomycosis
Chemical compound
of toxicity that have been studied for citrinin are acute toxicity, nephrotoxicity, genotoxicity and its carcinogenicity. The acute toxicity of citrinin
Citrinin
Chemical compound
intravenously. Nephrotoxicity: Like cisplatin, nephrotoxicity, harm to the kidneys, is the primary dose-limiting factor. However, the nephrotoxicity of nedaplatin
Nedaplatin
Anticonvulsant
adverse reactions are possible, including Steven Johnson syndrome, nephrotoxicity, hepatitis, aplastic anemia, neutropenia, or agranulocytosis. More common
Trimethadione
Species of bacterium
strains can be treated by gentamicin and ampicillin antibiotics. A less nephrotoxic combination of ampicillin and ceftriaxone (even though E. faecalis is
Enterococcus_faecalis
Chemical element with atomic number 32 (Ge)
little oral toxicity. However, synthetic soluble germanium salts are nephrotoxic, and synthetic chemically reactive germanium compounds with halogens
Germanium
Functional unit of nephron
risk of further renal damage such as beginning medications with known nephrotoxicity. In 1666, Italian biologist and anatomist Marcello Malpighi first described
Glomerulus_(kidney)
Group of venomous snakes from Asia
individual. Clinical cardiotoxicity is not widely observed, nor is nephrotoxicity present among patients bitten by this species, presumably due to the
King_cobra
Treatment of cancer using drugs that inhibit cell division or kill cells
does not flow from the liver to the intestine) and liver fibrosis. Nephrotoxicity (kidney damage) can be caused by tumor lysis syndrome and also due direct
Chemotherapy
Tetracycline-class antibiotic
Minostad 50 mg-Kapseln. "Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals". Environmental health criteria
Doxycycline
Toxic effects on the nervous system
poisoning". Batrachotoxin Cytotoxicity Multiple chemical sensitivity Nephrotoxicity Ototoxicity Penitrem A Excitotoxicity Toxicity Cunha-Oliveira, Teresa;
Neurotoxicity
Any derivative of oxalic acid; chemical compound containing oxalate moiety
older platinum-based drugs, avoiding the dose-limiting side-effect of nephrotoxicity. Oxalic acid and oxalates can be oxidized by permanganate in an autocatalytic
Oxalate
Member of the polyomavirus family
cidofovir without apparent nephrotoxicity. Nephrotoxicity is a major concern for this drug. IVIG is expensive, nephrotoxic (due to osmosis) and requires
BK_virus
Combination medication
reduced ejection fraction. Potential side effects include angioedema, nephrotoxicity, and low blood pressure. It was approved for medical use in the United
Sacubitril/valsartan
Species of Asian elapid snake
Preeti; Chowdhuri, Soumeek; Mukhopadhyay, Partha Pratim (2018-01-29). "Nephrotoxicity in krait bite: a rare case series of three fatalities in consecutive
Banded_krait
Drug interactions with grapefruit juice
risk of harmful or even dangerous effects (gastrointestinal bleeding, nephrotoxicity), increased from 17 to 43. The interaction between citrus and medication
Grapefruit–drug_interactions
Pharmaceutical drug
an aminoglycoside, it can increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blockage, result in some hearing loss or can continue
Capreomycin
Inhalational anesthesia medication
and is rapidly eliminated from the lungs. It is not associated with nephrotoxicity and is resistant to defluorination. It is carried by albumin in the
Desflurane
NSAID analgesic veterinary drug
In horses, this includes gastric ulcers, right dorsal colitis, and nephrotoxicity. Flunixin is a prohibited substance under International Federation for
Flunixin
Disease where the kidneys fail to adequately filter waste products from the blood
action on the kidneys is not fully understood, but may be due in part to nephrotoxic metabolites of myoglobin.[citation needed] Chronic kidney failure has
Kidney_failure
Derivative of folic acid used in cancer treatment
However, no apparent effect is seen on pre-existing methotrexate-induced nephrotoxicity. While not specifically an antidote for methotrexate, folinic acid may
Folinic_acid
Pharmaceutical fungicide or fungistatic used to treat and prevent mycosis
cholesterol, increasing the risk of human toxicity. Amphotericin B is nephrotoxic when given intravenously. As a polyene's hydrophobic chain is shortened
Antifungal
Chemical compound
(English: /əˌrɪstəˈloʊkɪk/) are a family of carcinogenic, mutagenic, and nephrotoxic phytochemicals commonly found in the flowering plant family Aristolochiaceae
Aristolochic_acid
Chemical compound
catalysts to this reaction. While dichloroacetylene is nephrotoxic in rats, its nephrotoxicity in humans is not well-understood. Dichloroacetylene has
Dichloroacetylene
Broad-spectrum poisoning
"Does prolonged oral exposure to cyanide promote hepatotoxicity and nephrotoxicity?". Toxicology. 174 (2): 87–95. Bibcode:2002Toxgy.174...87S. doi:10
Cyanide_poisoning
Drugs used to achieve relief from pain
rheumatoid arthritis; Kawasaki's disease GI bleeds; ulcers; Reye syndrome; nephrotoxicity; blood dyscrasias (rarely); Stevens–Johnson syndrome (uncommon/rare)
Analgesic
Chemical element with atomic number 31 (Ga)
injected in large doses; precipitation of this hydroxide resulted in nephrotoxicity in animals. In lower doses, soluble gallium is tolerated well and does
Gallium
Species of vine
rotunda contains aristolochic acids which are carcinogenic, mutagenic, and nephrotoxic. Plants of Aristolochia rotunda Flower of Aristolochia rotunda The small
Aristolochia_rotunda
Species of tree
prior normal renal function, this can result in neurotoxic as well as nephrotoxic effects. In Malaysia, very acidic bilimbis are used to clean kris blades
Averrhoa_bilimbi
Class of highly effective antibiotic agents
hydrolyzed in the mammalian kidney by a dehydropeptidase enzyme to a nephrotoxic intermediate, and thus is co-formulated with the dehydropeptidase inhibitor
Carbapenem
Species of lily
36. doi:10.2460/javma.2002.220.49. PMID 12680447. Hall J (1992). "Nephrotoxicity of Easter Lily (Lilium longiflorum) when ingested by the cat". Proc
Lilium_longiflorum
Vitamin B9; nutrient essential for DNA synthesis
"Successful rescue in a patient with high dose methotrexate-induced nephrotoxicity and acute renal failure". Leukemia & Lymphoma. 29 (1–2): 205–9. doi:10
Folate
Medication
was an effective agent; it was associated, however, with unacceptable nephrotoxicity and agranulocytosis. The toxicity was proposed to arise from the thiourea
Cimetidine
Species of vine
oxidase activity and methylglyoxal levels in aristolochic acid-induced nephrotoxicity". Life Sciences. 114 (1): 4–11. doi:10.1016/j.lfs.2014.07.034. Nchinech
Aristolochia_longa
Dose dependant harmfulness of substances
toxic gases Material safety data sheet (MSDS) Mutagen Hepatotoxicity Nephrotoxicity Neurotoxicity Ototoxicity Paracelsus Physiologically-based pharmacokinetic
Toxicity
Infection of the heart's inner surface (endocardium)
gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic". Clinical Infectious Diseases. 48 (6): 713–21. doi:10.1086/597031. PMID 19207079
Infective_endocarditis
Six noble, precious metallic elements clustered together in the periodic table
of the side effects to these drugs include nausea, hearing loss, and nephrotoxicity. Handling of these drugs by medical personal also led to side effects
Platinum_group
Abnormal presence of albumin in the urine
Sjogren syndrome Dehydration / low blood volume Cardiovascular disease Nephrotoxic medications Infections Urinary tract obstruction In all cases, the result
Albuminuria
Chemical compound
panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity. Panipenem/betamipron Finch RG (2003). Antibiotic and chemotherapy:
Betamipron
Drug that produces a dream-like state of consciousness
Sprando RL (2016). "Evaluation of "Dream Herb," Calea zacatechichi, for Nephrotoxicity Using Human Kidney Proximal Tubule Cells". J Toxicol. 2016 9794570.
Oneirogen
Type of drug
Control. Retrieved 12 March 2014. Wolinsky, Hines (1962). "Neurotoxic and nephrotoxic effects of colistin in patients with renal disease". www.nejm.org. doi:10
Drug_of_last_resort
Class of medications
was an effective agent; however, it was associated with unacceptable nephrotoxicity and agranulocytosis. It was proposed that the toxicity arose from the
H2_receptor_antagonist
Chemical compound belonging to the class of triazine
another low-toxicity substance), it will form an insoluble and rather nephrotoxic complex, as evidenced in dogs and cats during the 2007 pet food contamination
Cyanuric_acid
Hardening of small arteries (arterioles)
in zero-time biopsy is a risk factor for tacrolimus-induced chronic nephrotoxicity". Nephrology (Carlton). 20 Suppl 2: 51–7. doi:10.1111/nep.12461. PMID 26031587
Arteriolosclerosis
Urinary system cancer that begins in the urinary bladder
side effects include changes in the menstrual cycle, neuropathy, and nephrotoxicity. Checkpoint inhibitor (immunotherapy) side effects commonly include
Bladder_cancer
Type of antibiotic
overgrowth. Neomycin is not administered via injection, as it is extremely nephrotoxic (damaging to kidney function) even when compared to other aminoglycosides
Neomycin
Class of antibiotic drugs
hydrophilic moiety attached to enhance tissue distribution and reduce nephrotoxicity. Vancomycin was isolated in 1953 and used clinically by 1958, while
Glycopeptide_antibiotic
Symptoms resulting from kidney damage
proteins in urine as a consequence of metal accumulation. Penicillin is nephrotoxic in people with kidney failure, and captopril can aggravate proteinuria
Nephrotic_syndrome
Antidote for certain metal poisonings
it by painful intramuscular injection Serious side effects include nephrotoxicity and hypertension. Dimercaprol has been found to form stable chelates
Dimercaprol
cisplatin derivative with broad antitumour activity and comparatively less nephrotoxicity. A second group with an NCI contract, led by John Montgomery at the
History of cancer chemotherapy
History_of_cancer_chemotherapy
Presence of myoglobin in the urine
of the urine, believed to reduce the breakdown of myoglobin into its nephrotoxic metabolites, thus preventing renal damage. Often, IV normal saline is
Myoglobinuria
Chemical compound
level of 1.1 mg/m2. Diarrhea was treatable with loperamide. Lack of nephrotoxicity and low urinary excretion supported use of drug without hydration. Tesoriero
Triplatin_tetranitrate
Antibacterial drug
many parts of the world. Still, the relatively frequent occurrence of nephrotoxicity and ototoxicity during aminoglycoside treatment makes physicians reluctant
Aminoglycoside
Medical condition
even among patients with comorbidities reported to predispose them to nephrotoxicity. Moreover, hydration, the most established prevention measure to prevent
Contrast-induced_nephropathy
Shock and kidney failure due to crushing of skeletal muscle
on the kidneys is not understood completely, but may be due partly to nephrotoxic metabolites of myoglobin. The most devastating effects upon the body
Crush_syndrome
Chemical element with atomic number 78 (Pt)
include nausea and vomiting, hair loss, tinnitus, hearing loss, and nephrotoxicity.) Organoplatinum compounds such as the above anti-tumor agents, as well
Platinum
American toxicologist, academic, and author
role in chemical toxicity susceptibility and identified biomarkers of nephrotoxicity from therapeutic drugs. Additionally, he applied computational toxicology
Bruce_A._Fowler
Class of therapeutic drug for relieving pain and inflammation
may also cause kidney impairment, especially in combination with other nephrotoxic agents. Kidney failure is especially a risk if the patient is also concomitantly
Nonsteroidal anti-inflammatory drug
Nonsteroidal_anti-inflammatory_drug
Contrast agent
Early generations of intravenous (IV) contrast carried considerable nephrotoxicity, necessitating continual assessment of renal function. IV and PO (per
Iopamidol
Medical antimicrobial drug
heart failure are quite frequent. Kidney: 25 percent develop signs of nephrotoxicity ranging from mild, asymptomatic azotemia (increased serum creatinine
Pentamidine
Chemotherapy and immunosuppressant medication
found to increase the plasma concentrations of methotrexate, as have nephrotoxic agents such as cisplatin, the GI drug colestyramine, and dantrolene.
Methotrexate
Poisoning caused by lead in the body
p. 267 Ekong EB, Jaar BG, Weaver VM (December 2006). "Lead-related nephrotoxicity: a review of the epidemiologic evidence". Kidney International. 70 (12):
Lead_poisoning
NEPHROTOXICITY
NEPHROTOXICITY
NEPHROTOXICITY
NEPHROTOXICITY
Boy/Male
Hindu, Indian, Tamil
Poet; Goddess Saraswati
Boy/Male
Hindu, Indian
Earth
Male
Egyptian
, a royal scribe.
Boy/Male
British, English
Harmful
Boy/Male
Tamil
One with boundless splendor, Incomparable, Glorious
Girl/Female
Tamil
Jayakirthi | ஜயாகீரà¯à®¤à¯€Â
Glory of victory
Boy/Male
Indian
Friend for Happiness; Crown
Boy/Male
Latin
Merciful.
Girl/Female
British, English, French, German
Nobility
Surname or Lastname
English
English : variant of Haycock.
NEPHROTOXICITY
NEPHROTOXICITY
NEPHROTOXICITY
NEPHROTOXICITY
NEPHROTOXICITY