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Search references for NEDD4. Phrases containing NEDD4
See searches and references containing NEDD4!NEDD4
Protein-coding gene in the species Homo sapiens
ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 (whence "NEDD4") is an enzyme that is
NEDD4
Protein-coding gene in the species Homo sapiens
the NEDD4L gene. In mouse the protein is commonly known as NEDD4-2 and the gene Nedd4-2. NEDD4-2 has been shown to ubiquitinate and therefore down regulate
NEDD4L
Protein-coding gene in the species Homo sapiens
NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene. NDFIP2 has been shown to interact with NEDD4. Conversely
NDFIP2
Protein-coding gene in the species Homo sapiens
NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme
WWP2
Protein-coding gene in the species Homo sapiens
NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene. WW domain-containing proteins are found in all eukaryotes
WWP1
Protein-coding gene in the species Homo sapiens
Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene. The protein encoded by this gene belongs to a small group
NDFIP1
Tumor suppressor gene
org/CVCL_1406 PTEN has been shown to interact with: CSNK2A2, CSNK2A1, MAGI3 MVP, NEDD4, NR3C4, P53, and PTK2. Multiple hamartoma syndrome ENSG00000284792 GRCh38:
PTEN_(gene)
Set of three serine threonine-specific protein kinases
the resulting polyphosphorylated Akt is ubiquitinated partly by E3 ligase NEDD4. Most of the ubiquitinated-phosphorylated-Akt1 is degraded by the proteasome
Protein_kinase_B
Chemical compound
indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation". Molecular Cancer Research
Indole-3-carbinol
Cell receptor protein found in humans
with: ARHGEF12, C-src tyrosine kinase, Cbl gene, EHD1, GRB10, IRS1, Mdm2, NEDD4, PIK3R3, PTPN11, RAS p21 protein activator 1, SHC1 SOCS2, SOCS3, and YWHAE
Insulin-like growth factor 1 receptor
Insulin-like_growth_factor_1_receptor
Intracellular communication process
results in the removal of AMPA receptors from the membrane via the ligase NEDD4-1, weaking the overall synapse. Increased intracellular level of Ca2+ can
Calcium_signaling
Series of biochemical reactions
tumour necrosis factor α (TNFα), which in turn repress PTEN expression. NEDD4-1, an E3 ligase that recognises PTEN for degradation is up-regulated by
Akt/PKB_signaling_pathway
role in mitochondrial processes. Additionally, C15orf62 interacts with NEDD4, an E3 ubiquitin ligase, indicating its involvement in protein turnover
C15orf62
Human protein and coding gene
Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM (August 2008). "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation
Arrestin_beta_1
Medical condition
Specifically, the PY motif in the protein is deleted or altered so the E3 ligase (Nedd4) no longer recognizes the channel. This loss of ability to be degraded leads
Liddle's_syndrome
Human chromosome
protein Microtubule associated scaffold protein 2 NDFIP2: encoding protein NEDD4 family-interacting protein 2 NUPL1: encoding protein Nucleoporin p58/p45
Chromosome_13
Protein-coding gene in the species Homo sapiens
and verified through affinity capture-MS. C19orf18 protein interacts with Nedd4 family interacting protein 1 (NDFIP1) which promotes pancreatic beta cell
C19orf18
Protein-coding gene in the species Homo sapiens
as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394
LITAF
Protein-coding gene in the species Homo sapiens
humans is encoded by the PMEPA1 gene. TMEPAI has been shown to interact with NEDD4. GRCh38: Ensembl release 89: ENSG00000124225 – Ensembl, May 2017 GRCm38:
TMEPAI
Protein-coding gene in the species Homo sapiens
been shown to interact with: Baculoviral IAP repeat-containing protein 3, NEDD4, PJA1, PJA2, and UBE3A. GRCh38: Ensembl release 89: ENSG00000131508 – Ensembl
UBE2D2
Protein found in humans
Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM (August 2008). "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation
Arrestin_beta_2
French-American virologist
Xiang, Y.; Aiyar, A.; Carter, C.; Leis, J. (2001). "Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma
Fadila_Bouamr
Protein
HECTD4 HECW1, HECW2 HERC1, HERC2, HERC3, HERC4, HERC5, HERC6 HUWE1, ITCH NEDD4, NEDD4L PPIL2 PRPF19 PIAS1, PIAS2, PIAS3, PIAS4 RANBP2 RNF4, RNF167 RBX1
Ubiquitin_ligase
Protein-coding gene in the species Homo sapiens
with female infertility. SCNN1A has been shown to interact with: NEDD4L, NEDD4, and Ubiquitin C Epithelial sodium channel GRCh38: Ensembl release 89: ENSG00000111319
SCNN1A
Protein-coding gene in the species Homo sapiens
variants has not been determined. UBE2D3 has been shown to interact with NEDD4. GRCh38: Ensembl release 89: ENSG00000109332 – Ensembl, May 2017 GRCm38:
UBE2D3
Human gene
13 (1) 76. doi:10.1186/s40478-025-01994-1. PMC 12001695. PMID 40234994. "NEDD4 WW Domain-Binding Protein 5 (Human)", Encyclopedia of Signaling Molecules
ECOP
pathways. The team led by Reddy is credited with the identification of NEDD4-like E3 ubiquitin-protein ligase WWP2, an E3 ligase, as a regulator for
Maddika_Subba_Reddy
Protein-coding gene in the species Homo sapiens
"Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase". J. Biol. Chem. 277 (4): 2897–907. doi:10.1074/jbc.M110047200
UBQLN2
Protein-coding gene in the species Homo sapiens
PMID 16964243. S2CID 14294292. Malakhova OA, Zhang DE (April 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". The Journal
UBA1
Q9NQS3 10407 NECTIN4 HGNC:19688; Q96NY8 10408 NEDD1 HGNC:7723; Q8NHV4 10409 NEDD4 HGNC:7727; P46934 10410 NEDD4L HGNC:7728; Q96PU5 10411 NEDD8 HGNC:7732;
List of human protein-coding genes 5
List_of_human_protein-coding_genes_5
American geneticist (1949–2016)
Rochet JC, Buchwald SL, Lindquist S (2013). "Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons". Science. 342
Susan_Lindquist
Protein domain
serine-threonine kinases of the Hippo tumor suppressor pathway; Mus musculus (Mouse) NEDD4, involved in the embryonic development and differentiation of the central
WW_domain
Protein-coding gene in the species Homo sapiens
so-called WW domains in a special E3 ubiquitin-protein ligase named Nedd4-2. Nedd4-2 ligates ubiquitin to the C-terminus of the ENaC subunit which marks
SCNN1G
Protein-coding gene in the species Homo sapiens
found for this gene. UBE2E1 has been shown to interact with Ataxin 1 and NEDD4. GRCh38: Ensembl release 89: ENSG00000170142 – Ensembl, May 2017 GRCm38:
UBE2E1
Protein found in humans
for proteasome-mediated destruction by an "E3 ubiquitin ligase" called NEDD4-2. This mechanism may be a distinct way to control the survival of a neuron
Tropomyosin_receptor_kinase_A
Protein-coding gene in the species Homo sapiens
higher SGK1 mRNA levels". SGK has been shown to interact with: KPNA2, MAPK7, NEDD4, PDPK1, and SLC9A3R2. GRCh38: Ensembl release 89: ENSG00000118515 – Ensembl
SGK1
Protein-coding gene in humans
CDC25C has been shown to interact with MAPK14, CHEK1, PCNA, PIN1, PLK3 and NEDD4. Cdc25 GRCh38: Ensembl release 89: ENSG00000158402 – Ensembl, May 2017 GRCm38:
CDC25C
Protein-coding gene in the species Homo sapiens
as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394
WBP2
Protein-coding gene in humans
(27094594) UBE2L3 has been shown to interact with: ARIH1, ARIH2, CBL, CHEK1, NEDD4, PARK2, SMURF2, TNFAIP3, TNFSF4, TNIP1, TRAF6, UBE3A, UBE3A, and UBOX5.
UBE2L3
Protein-coding gene in the species Homo sapiens
Kumar S, Poronnik P, Hooper JD (August 2008). "The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family
Tweety_family_member_2
Mammalian protein found in Homo sapiens
Brown DL, Wylie FG, Stow JL, Kumar S (July 2004). "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and
SMURF1
Protein-coding gene in Homo sapiens
N, Miyamoto C, et al. (November 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating
UBE3A
Protein-coding gene in the species Homo sapiens
so-called WW domains in a special E3 ubiquitin-protein ligase named Nedd4-2. Nedd4-2 ligates ubiquitin to the C-terminus of the ENaC subunit which marks
SCNN1B
American microbiologist
Ashok; Carter, Carol; Leis, Jonathan (2001-09-18). "Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma
Carol_A._Carter
Gene profile for C10orf88 (aka PAAT)
Krahe, Ralf; Hackman, Peter; Udd, Bjarne (2014). "Abnormal Splicing of NEDD4 in Myotonic Dystrophy Type 2". The American Journal of Pathology. 184 (8):
PAAT_(protein)
Protein-coding gene in the species Homo sapiens
Neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) E3 ubiquitin-protein ligase Biogrid, InnateDB Nucleotide-binding oligomerization
PRR16
Protein-coding gene in humans
Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM (August 2008). "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation
Mdm2
proteins including the ubiquitin ligase Rsp5, which is a member of the NEDD4 ubiquitin ligase family. In yeast, these motifs are required for α-arrestin-mediated
Alpha_Arrestin
Post-translational carbohydrate modification of proteins
O-GlcNAc-modified Proteins Reveal Glycosylation of the Ubiquitin Ligase NEDD4-1". Proceedings of the National Academy of Sciences of the United States
O-GlcNAc
channel ENaC. These mutations abrogate the binding to the ubiquitin ligase NEDD4, thereby inhibiting channel degradation and prolonging the half-life of
Short_linear_motif
Protein-coding gene in the species Homo sapiens
PMID 18223681. Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium
HECW1
Protein-coding gene in the species Homo sapiens
as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394
WBP1
Virus matrix protein
matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4". J. Mol. Biol. 326 (2): 493–502. doi:10.1016/S0022-2836(02)01406-7. PMID 12559917
VP40
Protein-coding gene in humans
et al. (Nov 2004). "Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases". Kidney International
BSND
Protein-coding gene in the species Homo sapiens
Aqeilan RI, Rossi M, Salomoni P, Murillas R, et al. (July 2007). "The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch"
ITCH
Protein-coding gene in the species Homo sapiens
Verkade P, Simons K, Rotin D (Jun 2000). "Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb". The
Annexin_A13
Protein-coding gene in the species Homo sapiens
isoforms have been found for this gene. SCAMP3 has been shown to interact with NEDD4. ENSG00000116521 GRCh38: Ensembl release 89: ENSG00000263290, ENSG00000116521
SCAMP3
Protein-coding gene in humans
I, Huibregtse JM, McDonnell DP (2001). "Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates"
DAZAP2
Protein domain
FER1L5; HECW1; HECW2; ITCH; ITSN1; ITSN2; MAP3K20; MCTP1; MCTP2; MTAC2D1; NEDD4; NEDD4L; NEDL1; OTOF; PKN1; PKN2; PKN3; PCLO; PIK3C2A; PIK3C2B; PIK3C2G;
C2_domain
Enzyme found in humans
et al. (1998). "Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis". The Journal of Biological Chemistry. 273 (22): 13524–13530
Caspase_6
Protein-coding gene in the species Homo sapiens
Vecchione A, Marchese A, Henry P, Rotin D, Morrione A (May 2003). "The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like
GRB10
Protein-coding gene in the species Homo sapiens
affinity chromatography and two hybrid arrays, are MIER1, EMSY, CHPT1, HDLBP, NEDD4, WWOX, and TTHY3. There is strong evidence for a direct interaction between
TMEM171
Mammalian protein found in Homo sapiens
(KCTD2), Neural precursor cell expressed developmentally down-regulated 4 (NEDD4), SEC24 family member B (SEC24D), Ubiquitin associated and SH3 domain containing
Transmembrane_protein_255A
Protein-coding gene in humans
been shown to interact with: CRKL, Epidermal growth factor receptor, Grb2, NEDD4, PIK3R1, and SH3KBP1. GRCh38: Ensembl release 89: ENSG00000114423 – Ensembl
CBLB_(gene)
Protein-coding gene in the species Homo sapiens
this gene encoding the same protein. AP1G2 has been shown to interact with NEDD4. GRCh38: Ensembl release 89: ENSG00000213983 – Ensembl, May 2017 GRCm38:
AP1G2
Mammalian protein found in humans
1152/ajprenal.00001.2008. PMID 18632802. Raikwar NS, Thomas CP (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and
Ubiquitin_C
Protein-coding gene in the species Homo sapiens
Al-Khalili O, et al. (July 2013). "WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination". American Journal of Physiology. Renal Physiology
WNK4
Protein-coding gene in the species Homo sapiens
as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394
RNF11
NEDD4
NEDD4
NEDD4
NEDD4
Girl/Female
Tamil
Krishnaveni | கà¯à®°à®¿à®·à¯à®¨à®¾à®µà¯‡à®¨à¯€
River
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Sage
Girl/Female
American, Australian, Christian, Gaelic
Pure Beauty
Girl/Female
Assamese, Bengali, Gujarati, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Oriya, Punjabi, Sanskrit, Sikh, Tamil, Telugu, Traditional
Peace
Male
English
Variant spelling of English Reuben, REUBHEN means "behold a son!"
Boy/Male
Tamil
Girl/Female
Hindu, Indian, Traditional
Goddess Parvati
Boy/Male
Hindu, Indian
Worshipper
Boy/Male
Indian
Decision
Girl/Female
American, Australian, Chinese, Christian, Irish, Jamaican
Dark Feminine of Ciaran; Mountain Range
NEDD4
NEDD4
NEDD4
NEDD4
NEDD4