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MAP4K1

MAP4K1

Protein-coding gene in the species Homo sapiens

the MAP4K1 gene. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation. MAP4K1 has

MAP4K1

MAP kinase kinase kinase kinase

Family of proteins

migration, and apoptosis. There are currently seven identified MAP4Ks. MAP4K1 (aka HPK1) MAP4K2 (aka GCK) MAP4K3 (aka GLK) - plays a role in TCR mediated

MAP kinase kinase kinase kinase

MAP_kinase_kinase_kinase_kinase

Hippo signaling pathway

Signaling pathway that controls organ size

becomes active. Misshapen (Msn, MAP4K4/6/7 in mammals) and Happyhour (Hppy, MAP4K1/2/3/5 in mammals) act in parallel to Hpo to activate Wts. Wts is a nuclear

Hippo signaling pathway

Hippo_signaling_pathway

List of human protein-coding genes 5

Q9NYL2 9214 MAP3K21 HGNC:29798; Q5TCX8 9215 MAP4 HGNC:6862; P27816 9216 MAP4K1 HGNC:6863; Q92918 9217 MAP4K2 HGNC:6864; Q12851 9218 MAP4K3 HGNC:6865; Q8IVH8

List of human protein-coding genes 5

List_of_human_protein-coding_genes_5

B-cell linker

Mammalian protein found in Homo sapiens

family, and Nck. BLNK has also been shown to interact with SH3KBP1 and MAP4K1. A more recent mass spectrometry study of BLNK in DT40 cells found that

B-cell linker

B-cell_linker

Protein kinase domain

Protein domain

MAP3K21 ; MAP3K3 ; MAP3K4 ; MAP3K5 ; MAP3K6 ; MAP3K7 ; MAP3K8 ; MAP3K9 ; MAP4K1 ; MAP4K2 ; MAP4K3 ; MAP4K4 ; MAP4K5 ; MAPK1 ; MAPK10 ; MAPK11 ; MAPK12 ;

Protein kinase domain

Protein_kinase_domain

Linker for activation of T cells

Human protein and gene for T-cell signaling

Activation of T cells has been shown to interact with: GRAP2, GRAP, Grb2, ITK, MAP4K1 PIK3R1, PLCG1, SHB, VAV1, and ZAP-70. GRCh38: Ensembl release 89: ENSG00000213658

Linker for activation of T cells

Linker_for_activation_of_T_cells

GRB2

Protein-coding gene in the species Homo sapiens

Linker of activated T cells, Lymphocyte cytosolic protein 2, MAP2, MAP3K1 MAP4K1, MED28, MST1R, MUC1, Mitogen-activated protein kinase 9, NCKIPSD, NEU3,

GRB2

Adapter molecule crk

Protein found in humans

Cbl gene, Dock180, EPS15, Epidermal growth factor receptor, Grb2, IRS4, MAP4K1, MAPK8, NEDD9, PDGFRA, PDGFRB, PTK2, Paxillin RAPGEF1, RICS, SH3KBP1, and

Adapter molecule crk

Adapter_molecule_crk

NCK1

Protein-coding gene in the species Homo sapiens

interact with: ABL1, CBL, DNM1, DAG1, EIF2B2, EPHB1, EGFR, KHDRBS1, LCP2, MAP4K1, MAP4K4, MINK1, NCKIPSD, NEDD9, PAK1, PDGFRB, PKN2, PTK2, RASA1, RICS, RRAS

NCK1

CRKL

Protein-coding gene in the species Homo sapiens

BCR gene, CBLB, CD117, CD34, Cbl gene, Dock2, EPOR, GAB1, GAB2, INPP5D, MAP4K1, MAP4K5, NEDD9, PIK3R2, Paxillin RAPGEF1, RICS, STAT5A, Syk, and WAS. Crk

CRKL

GRAP2

Protein-coding gene in the species Homo sapiens

CCNDBP1, CD28, Linker of activated T cells, Lymphocyte cytosolic protein 2 MAP4K1, and STAMBP. GRCh38: Ensembl release 89: ENSG00000100351 – Ensembl, May

GRAP2

Drebrin-like

Protein-coding gene in the species Homo sapiens

Drebrin-like has been shown to interact with Cyclin-dependent kinase 4, MAP4K1 and ZAP-70. GRCh38: Ensembl release 89: ENSG00000136279 – Ensembl, May 2017

Drebrin-like