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LIMK1

  • LIMK1
  • Protein-coding gene in the species Homo sapiens

    LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene. There are approximately 40 known eukaryotic LIM proteins, so named for the

    LIMK1

    LIMK1

    LIMK1

  • Lim kinase
  • Actin-binding kinases

    proteins. The LIM kinase family is made up of two proteins: LIM kinase-1 (LIMK1) and LIM kinase-2 (LIMK2) ADF/cofilin are the only substrates yet identified

    Lim kinase

    Lim_kinase

  • Williams syndrome
  • Genetic disorder

    BCL7B CLDN3 CLDN4 CLIP2 EIF4H ELN FZD9 FKBP6 GTF2I GTF2IRD1 HIP1 KCTD7 LAT2 LIMK1 MDH2 NCF1 NSUN5 POR RFC2 STX1A TBL2 TRIM50 TRIM73 TRIM74 WBSCR14 WBSCR18

    Williams syndrome

    Williams syndrome

    Williams_syndrome

  • Pyr1
  • Chemical compound

    able to interact in a few minutes or even seconds with molecules such as LIMK1. Its reversibility enables it to quickly activate and inhibit itself, making

    Pyr1

    Pyr1

    Pyr1

  • Spike-timing-dependent plasticity
  • Biological process that adjusts the strength of connections between neurons in the brain

    actin-binding proteins such as cofilin and profilin. During the transient phase, LIMK1 phosphorylates ADF/cofilin, inhibiting actin depolymerization, expanding

    Spike-timing-dependent plasticity

    Spike-timing-dependent_plasticity

  • Dendritic spine
  • Small protrusion on a dendrite that receives input from a single axon

    transient stage, the signaling cascade caused by synaptic activity results in LIMK1 phosphorylating ADF/cofilin via both the RhoA and Cdc42 pathways, which

    Dendritic spine

    Dendritic spine

    Dendritic_spine

  • Cofilin 1
  • Protein-coding gene in humans

    neuronal migration. Cofilin 1 has been shown to interact with HSPH1 and LIMK1. GRCh38: Ensembl release 89: ENSG00000172757 – Ensembl, May 2017 GRCm38:

    Cofilin 1

    Cofilin 1

    Cofilin_1

  • PDZ domain
  • Protein family

    GOPC GRASP GRIP1 GRIP2 HTRA1 HTRA2 HTRA3 HTRA4 IL16 INADL KIAA1849 LDB3 LIMK1 LIMK2 LIN7A LIN7B LIN7C LMO7 LNX1 LNX2 LRRC7 MAGI1 MAGI2 MAGI3 MAGIX MAST1

    PDZ domain

    PDZ domain

    PDZ_domain

  • SSH2
  • Protein-coding gene in the species Homo sapiens

    ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by

    SSH2

    SSH2

    SSH2

  • Actin remodeling of neurons
  • Process of remodeling actin filaments in neurons

    LTD. Actin binding proteins prove significant in actin remodeling, as the LIMK1/ADF/Cofilin Pathway facilitates the development of F-actin. Actin Depolymerizing

    Actin remodeling of neurons

    Actin remodeling of neurons

    Actin_remodeling_of_neurons

  • YWHAZ
  • Protein-coding gene in the species Homo sapiens

    NOXA, AKT1, BCAR1, BAX, BAD, C-Raf, CDC25B, GP1BA, GP1BB, HMGN1, IL9R, LIMK1, P53, PRKCE PRKCZ, TNFAIP3, TSC2, Tau protein, and VIM. 14-3-3 protein PEPITEM

    YWHAZ

    YWHAZ

    YWHAZ

  • Cyclin-dependent kinase inhibitor 1C
  • Protein-coding gene in the species Homo sapiens

    Cyclin-dependent kinase inhibitor 1C has been shown to interact with: LIMK1, MYBL2, MyoD, and PCNA. ENSG00000129757 GRCh38: Ensembl release 89: ENSG00000273707

    Cyclin-dependent kinase inhibitor 1C

    Cyclin-dependent kinase inhibitor 1C

    Cyclin-dependent_kinase_inhibitor_1C

  • PAK6
  • microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathway". Oncotarget. 6 (6): 3904–17. doi:10.18632/oncotarget

    PAK6

    PAK6

    PAK6

  • ROCK1
  • Protein

    motility. These functions are activated by phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Additionally, ROCK1 phosphorylates

    ROCK1

    ROCK1

    ROCK1

  • Dual-specificity phosphatase
  • Protein family

    In accordance with their proposed rule, proteins like ADF, cofilin and LIMK1 are slingshot substrates. Phosphatases of Regenerating Liver (PRLs): Three

    Dual-specificity phosphatase

    Dual-specificity_phosphatase

  • SSH1
  • Protein-coding gene in the species Homo sapiens

    ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by

    SSH1

    SSH1

    SSH1

  • Metaplasticity
  • Psychological term

    conducted. When the wit receptor is activated, a particular protein known as LIMK1 becomes active as well. Eaton and Davis also studied the synaptic footprints

    Metaplasticity

    Metaplasticity

  • Samantha Butler
  • American academic

    Keith D.; Riche, Soizic; Butler, Samantha J. (2019-11-20). "The Cofilin/Limk1 Pathway Controls the Growth Rate of Both Developing and Regenerating Motor

    Samantha Butler

    Samantha Butler

    Samantha_Butler

  • Kadmon Corporation
  • Biopharmeceutical company based in New York City

    Kloog, Y; Wolfson, HJ (2012). "Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton"

    Kadmon Corporation

    Kadmon_Corporation

  • LAT2
  • Protein-coding gene in the species Homo sapiens

    "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23". Mamm. Genome. 11 (10): 890–8. doi:10

    LAT2

    LAT2

    LAT2

  • SSH3
  • Protein-coding gene in the species Homo sapiens

    ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by

    SSH3

    SSH3

    SSH3

  • Protein kinase domain
  • Protein domain

    JAK1 ; JAK2 ; JAK3 ; KALRN ; KDR ; KIT ; KSR1 ; KSR2 ; LATS1 ; LATS2 ; LCK ; LIMK1 ; LIMK2 ; LMTK2 ; LMTK3 ; LRRK1 ; LRRK2 ; LTK ; LYN ; MAK ; MAP2K1 ; MAP2K2 ;

    Protein kinase domain

    Protein kinase domain

    Protein_kinase_domain

  • DNAJC30
  • Protein-coding gene in the species Homo sapiens

    (WS-βTRP), WBSCR14 (WS-bHLH), STX1A, CLDN3 (CPETR2, RVP1), CLDN4 (CPETR1), LIMK1, EIF4H (WBSCR1), WBSCR15 (WBSCR5), RFC2, CYLN2 (CLIP-115, WBSCR4, WBSCR3)

    DNAJC30

    DNAJC30

    DNAJC30

  • Neuregulin 1
  • Protein-coding gene in the species Homo sapiens

    activation of SERCA2. Neuregulin 1 has been shown to interact with ERBB3 and LIMK1. A schizophrenia associated- missense mutation in Neuregulin 1 has been

    Neuregulin 1

    Neuregulin 1

    Neuregulin_1

  • EIF4H
  • Protein-coding gene in the species Homo sapiens

    "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23". Mamm. Genome. 11 (10): 890–8. doi:10

    EIF4H

    EIF4H

    EIF4H

  • RFC2
  • Protein-coding gene in the species Homo sapiens

    "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23". Mammalian Genome. 11 (10): 890–8. doi:10

    RFC2

    RFC2

    RFC2

  • PAK4
  • Mammalian protein found in Homo sapiens

    are mediated though phosphorylation of its effector proteins, including, LIMK1-Thr508, integrin β5-Ser759/Ser762, p120-catenin-Ser288, superior cervical

    PAK4

    PAK4

    PAK4

  • List of human protein-coding genes 4
  • Q9UGP4 8730 LIMD2 HGNC:28142; Q9BT23 8731 LIME1 HGNC:26016; Q9H400 8732 LIMK1 HGNC:6613; P53667 8733 LIMK2 HGNC:6614; P53671 8734 LIMS1 HGNC:6616; P48059

    List of human protein-coding genes 4

    List_of_human_protein-coding_genes_4

  • MiR-134
  • Family of microRNA precursors

    indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA. In the human brain, SIRT1 is thought to mediate CREB protein through

    MiR-134

    MiR-134

    MiR-134

  • LATS1
  • Protein-coding gene in the species Homo sapiens

    et al. (2004). "LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1". Nat. Cell Biol. 6 (7): 609–17. doi:10.1038/ncb1140. PMID 15220930. S2CID 20493738

    LATS1

    LATS1

    LATS1

  • Cadherin–catenin complex in learning and memory
  • activate SRC leading to activation of Rac1 which results in phosphorylation of LIMK1 and LIMK2 to deactivate cofilin causing G-actin polymerization. Meanwhile

    Cadherin–catenin complex in learning and memory

    Cadherin–catenin_complex_in_learning_and_memory

  • PAK1
  • Mammalian protein found in Homo sapiens

    ARHGEF2, ARPC1B, BMX, C-Raf, CDC42, Cyclin-dependent kinase 5, DYNLL1, LIMK1, NCK1, PAK1IP1 and RAC1. GRCh38: Ensembl release 89: ENSG00000149269 – Ensembl

    PAK1

    PAK1

    PAK1

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Online names & meanings

  • Kareshma
  • Girl/Female

    Indian, Telugu

    Kareshma

    Miracle

  • Chitresh | சித்ரேஷ 
  • Boy/Male

    Tamil

    Chitresh | சித்ரேஷ 

    Moon, Wonderful Lord

  • Lloyd
  • Boy/Male

    Celtic American Welsh

    Lloyd

    Gray.

  • Zoha | زوہا
  • Girl/Female

    Muslim

    Zoha | زوہا

    Morning light 93rd Sura of Quran

  • Neeha
  • Girl/Female

    Arabic, Bengali, Hindu, Indian, Telugu

    Neeha

    Dew Drop; Affection; Diamond

  • Kingman
  • Surname or Lastname

    English

    Kingman

    English : status name denoting a servant of the king, a member of the king’s household.

  • Afroz
  • Girl/Female

    Arabic, Muslim, Parsi

    Afroz

    Illuminated

  • Anvith
  • Boy/Male

    Hindu

    Anvith

    One who bridgesth gap, Friend

  • Arno
  • Boy/Male

    German American

    Arno

    The eagle rules; strong as an eagle. Famous Bearer: Movie star and producer/directer Arnold...

  • Orup
  • Boy/Male

    Bengali, Danish, Indian, Russian

    Orup

    Handsome; Beautiful

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LIMK1

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