AI & ChatGPT searches , social queriess for LIGAND EFFICIENCY
Search references for LIGAND EFFICIENCY. Phrases containing LIGAND EFFICIENCY
See searches and references containing LIGAND EFFICIENCY!
Search references for LIGAND EFFICIENCY. Phrases containing LIGAND EFFICIENCY
See searches and references containing LIGAND EFFICIENCY!LIGAND EFFICIENCY
Measure of a ligand's binding energy per atom
Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme. Ligand efficiency
Ligand_efficiency
Parameter used in drug design
Lipophilic efficiency (LiPE), sometimes referred to as ligand-lipophilicity efficiency (LLE) is a parameter used in drug design and drug discovery to
Lipophilic_efficiency
Topics referred to by the same term
number, a dimensionless number ratio in physics Ligand efficiency, a measure of the binding energy of a ligand to its binding partner Linear Executable, an
LE
Pharmaceutical discovery procedure
enzymatic clearance etc. Some descriptors such as ligand efficiency (LE) and lipophilic efficiency (LiPE) combine such parameters to assess druglikeness
Drug_discovery
Radioactive biochemical substance used for diagnosis or for study of receptor systems
therapeutic radioactive isotope and the cell-targeting compound — the ligand. The ligand is the target binding site; it may be on the surface of the targeted
Radioligand
Concept in drug design
which lowers the risk of idiosyncratic drug reactions. Ligand efficiency and lipophilic efficiency. Molecular weight: The great majority of drugs on the
Druglikeness
Stage of drug discovery
lipophilicity can be linked in single parameter such as ligand efficiency and lipophilic efficiency. low to moderate binding to human serum albumin low interference
Hit_to_lead
Method used in drug discovery
hydrophilic ligand increases the chances that the final optimized ligand will not be too hydrophobic (log P < 5). Higher ligand efficiency so that the
Fragment-based_lead_discovery
Any chemical that inhibits the function of CDKs
inhibitor of CDK2 without off-target binding (CDK1 and CDK9) based on ligand efficiency and binding affinity. Cyclin-dependent kinase § Medical significance
CDK_inhibitor
Ligand-targeted liposomes for use in medical applications
A ligand-targeted liposome (LTL) is a nanocarrier with specific ligands attached to its surface to enhance localization for targeted drug delivery. The
Ligand-targeted_liposome
Mammalian protein found in humans
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by
PD-L1
Protein found in humans
inhibitor of CDK2 without off-target binding (CDK1 and CDK9) based on ligand efficiency and binding affinity. Known CDK inhibitors are p21Cip1 (CDKN1A) and
Cyclin-dependent_kinase_2
Invention of new medications based on knowledge of a biological target
therapeutics have also been developed. The phrase "drug design" is similar to ligand design (i.e., design of a molecule that will bind tightly to its target)
Drug_design
Prediction method in molecular modeling
which predicts the preferred orientation of one molecule to a second when a ligand and a target are bound to each other to form a stable complex. Knowledge
Docking_(molecular)
Alternative to silicon-based photovoltaics
to become a high-efficiency option for applications where maximizing power per unit area is critical. Utilizing organic chiral ligands shows promise for
Perovskite_solar_cell
Chemical compound
as a pentadentate ligand. The material is of interest because it is a product of the degradation of metal-edta complexes. The ligand can be modified at
Ethylenediaminetriacetic_acid
Chemical reaction
the metal but rather interacts with its ligands, which is often a metal hydride and a protic hydrogen on a ligand. As such, in most cases dihydrogen is
Asymmetric_hydrogenation
Type of flow battery technology
stationary applications. The IRFB can achieve up to 70% round trip energy efficiency. In comparison, other long duration storage technologies such as pumped
Iron_redox_flow_battery
Regulation of enzyme activity
directly to an enzyme's active site or the binding site of the endogenous ligand of a receptor are called orthosteric regulators or modulators. The site
Allosteric_regulation
Cascade of intracellular and molecular events for transmission/amplification of signals
although in some cases the term sensor is used. The changes elicited by ligand binding (or signal sensing) in a receptor give rise to a biochemical cascade
Signal_transduction
Class of chemical substance
coordinated to organic ligands to form one-, two-, or three-dimensional structures that are usually porous. The organic ligands included are sometimes
Metal–organic_framework
Ionotropic receptor and ligand-gated ion channel
GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory
GABAA_receptor
Chemical reaction(s) which favor one chiral isomer over another
dominated by the development of new classes of ligands. Certain ligands, often referred to as "privileged ligands", are effective in a wide range of reactions;
Enantioselective_synthesis
Seventh letter in the Greek alphabet
to kinetic energy. Chemistry, the hapticity, or the number of atoms of a ligand attached to one coordination site of the metal in a coordination compound
Eta
Technique in analytical chemistry
straight chain alkyl ligands, such as C3, C4, C8, C18. The number counts the carbon atoms in a ligand. For example, a C3 ligand is a propyl. The longer
High-performance liquid chromatography
High-performance_liquid_chromatography
Type of inhibitor
proximity-induced reaction. Covalent bonding can lead to potencies and ligand efficiencies that are either exceptionally high or, for irreversible covalent
Targeted_covalent_inhibitors
Science of drugs and medications and their effects
allowed analysis of drugs' effects on tissues. The development of the ligand binding assay in 1945 allowed quantification of the binding affinity of
Pharmacology
Chemical compound
Originally six of the eight faces were thought to be capped by hydride ligands. This structural assignment was revised in 2014; the hydrides are now best
Stryker's_reagent
Photoluminescent particles
reveals the dominant role of ligand in non-radiative relaxation process. There are several ways to increase the efficiencies of upconverting nanoparticles
Upconverting_nanoparticles
towards TBP ligand, thus needing further advanced separation processes and different extracting agents such as nitrogen-bearing ligands, also known as
Advanced reprocessing of spent nuclear fuel
Advanced_reprocessing_of_spent_nuclear_fuel
Mammalian protein found in humans
DBD with the LBD; along with the DBD, contains a ligand dependent nuclear localization signal E) – Ligand binding domain (LBD) containing activation function
Androgen_receptor
Technique used in mass spectroscopy
determination of high-affinity protein-ligand complexes by electrospray ionization mass spectrometry and ligand competition". J Mass Spectrom. 43 (5):
Electrospray_ionization
Vitamin used in animal cell metabolism
of cobalt, which occupies the center of a corrin ligand and is further bound to a benzimidazole ligand and adenosyl group. Several related species behave
Vitamin_B12
Type of solar cell based on quantum dot devices
iodide as a ligand that does not bond to oxygen was introduced. This maintains stable n- and p-type layers, boosting the absorption efficiency, which produced
Quantum_dot_solar_cell
to sample the search space with optimal efficiency. Most docking programs in use account for a flexible ligand, and several attempt to model a flexible
Searching the conformational space for docking
Searching_the_conformational_space_for_docking
Nano-scale semiconductor particles
functionalization. However, because of the detrimental effect organic ligands have on PL efficiency, further studies have been conducted to obtain all-inorganic
Quantum_dot
Sub-discipline of analytical chemistry
chromatography Electrophoresis Preparative native polyacrylamide gel electrophoresis Ligand binding assays Dual polarisation interferometry ELISA (Enzyme-linked immunosorbent
Bioanalysis
Class of immune system proteins
proliferation, and survival, while others lead to greater adaptive immunity. If the ligand is a bacterial factor, the pathogen might be phagocytosed and digested,
Toll-like_receptor
Excited state dynamic
the slowest forms of relaxation. Once a metal complex undergoes metal-to-ligand charge transfer, the system can undergo intersystem crossing, which, in
Intersystem_crossing
Chemical compound
type of ligand bound to the dot. The CdSe ligand shell may contain both X type ligands which form covalent bonds with the metal and L type ligands that form
Cadmium_selenide
Elements with atomic numbers 57-70
Complexes of a New Heptadentate Tripodal Ligand: A Route to Gadolinium Complexes with an Improved Relaxation Efficiency". Inorganic Chemistry. 40 (26): 6737–6745
Lanthanide
Photochemical energy transfer mechanism
is dependent on ligand binding, this FRET technique is applicable to fluorescent indicators for the ligand detection. FRET efficiencies can also be inferred
Förster resonance energy transfer
Förster_resonance_energy_transfer
Non-invasive analytical tool
picrate, and salicylate complexes. The efficiency of the energy transfer from the ligand to the ion is determined ligand-metal bond. The energy transfer is
Lanthanide_probes
Partition method to study protein ligand association processes
is a partition method introduced by Carvalho and Melo to study protein ligand association processes. This method enables the stabilization energy decomposition
Semiempirical_Energy_Based
Cross-coupling reaction used in organic synthesis
effect; that is, the catalyst efficiency decreases as the dendrimer generation increases. A recyclable polymeric phosphine ligand is obtained from ring-opening
Sonogashira_coupling
Type of thin-film solar cell
Polytechnique Fédérale de Lausanne (EPFL) until the publication of the first high efficiency DSSC in 1991. Michael Grätzel has been awarded the 2010 Millennium Technology
Dye-sensitized_solar_cell
Chemical compound
through emodin dimerization, but despite confirming Hyp-1’s structure and ligand-binding capability, its catalytic role in hypericin biosynthesis remains
Hypericin
Chemical compound
degradation of the deoxyribonucleotide polymers. Adenosine acts the primary ligand which binds to the G protein-coupled receptor A2A leading to an increase
Polydeoxyribonucleotide
Class of antidepressant medication
reuptake inhibitors of serotonin, some SSRIs are also, coincidentally, ligands of the sigma receptors. Fluvoxamine is an agonist of the σ1 receptor, while
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Medical imaging technique
Leukocytes possess high adhesion efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system. One ligand:receptor pair (PSGL-1:selectin)
Contrast-enhanced_ultrasound
Biological signalling molecule
carrier plasma glycoproteins (e.g., thyroxine-binding globulin (TBG)) to form ligand-protein complexes. Some hormones, such as insulin and growth hormones, can
Hormone
Embryonic signaling pathway for proper cell differentiation
present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intracellular signaling molecule called Hedgehog (Hh) found in fruit
Hedgehog_signaling_pathway
Germanium production methods
catechol ligand is alpha to the oxygen. The second Grignard reagent substitutes the now uni-dentate catechol-grignard adduct, removing the ligand and resulting
Chlorine-free germanium processing
Chlorine-free_germanium_processing
American chemist
Sciences at Stanford University. The Tsuji–Trost reaction and the Trost ligand are named after him. He is prominent for advancing the concept of atom economy
Barry_Trost
Coupling reaction of aryl or alkyl groups
the year 2000, various bidentate ligands were found to improve the efficiency of the Ullmann reaction. Bidentate ligands allow for milder reaction conditions
Ullmann_reaction
Site-specific recombinase technology
after delivery of tamoxifen. This is done through the fusion of a mutated ligand binding domain of the estrogen receptor to the Cre recombinase, resulting
Cre-Lox_recombination
Integral membrane protein
flow.[citation needed] The nAChRs are ligand-gated ion channels, and, like other members of the "cys-loop" ligand-gated ion channel superfamily, are composed
Acetylcholine_receptor
Pluripotent stem cell generated directly from a somatic cell
for human cells, with efficiencies around 0.01–0.1%. However, considerable advances have been made in improving the efficiency and the time it takes to
Induced_pluripotent_stem_cell
Mammalian protein found in Homo sapiens
bound cells. P-selectin glycoprotein ligand-1 (PSGL-1) derived from human neutrophils is also a high-efficiency ligand for endothelium-expressed E-selectin
E-selectin
Class of chemical compounds
carbanion-like properties, lithiated ylides function as ligands. Thus Me2P(CH2)2Li is a potential bidentate ligand. (Chloromethylene)triphenylphosphorane
Wittig_reagents
Composite structure formed by phospholipids
compatible with lipid bilayer structure. A liposome design may employ surface ligands for attaching to desired cells or tissues. Based on vesicle structure,
Liposome
Ability of biomolecules to bind specific ligands
site of a macromolecule (such as a protein) to bind specific ligands. The fewer ligands a protein can bind, the greater its specificity. Specificity describes
Chemical_specificity
Measure of an acid's strength in solution
this reaction, in which the ligand loses a proton, the pKa of the protonated ligand must be known. In practice, the ligand may be polyprotic; for example
Acid_dissociation_constant
Central nervous system stimulant prodrug
information. Therapeutic doses of amphetamine also enhance cortical network efficiency, an effect which mediates improvements in working memory in all individuals
Lisdexamfetamine
Chemical reactions that convert carbon monoxide and hydrogen into liquid hydrocarbons
surface-bound metal carbonyls. The CO ligand is speculated to undergo dissociation, possibly into oxide and carbide ligands. Other potential intermediates are
Fischer–Tropsch_process
Class of depressant drugs derived from barbituric acid
relatively non-selective compounds that bind to an entire superfamily of ligand-gated ion channels, of which the GABAA receptor channel is only one of several
Barbiturate
Any of the fifteen lanthanides plus scandium and yttrium
fly ash has been developed using citrate and oxalate with strong organic ligands capable of precipitating REEs. A 2019 study suggests that "fulfillment
Rare-earth_element
Artificial process that uses sunlight energy to drive chemical synthesis
their efficient visible light absorption and long-lived consequent metal-to-ligand charge transfer excited state, which makes the complexes strong reducing
Artificial_photosynthesis
Type of chemical reaction
ruthenium catalyst, [CpRu(CH3CN)3]PF6, has a cyclopentadienyl ligand, three acetonitrile ligands and a phosphorus hexafluoride counterion; the acidic proton
Aldol_condensation
Behavior. 24 (6): 1513–9. doi:10.1016/0091-3057(86)90477-6. PMID 2942947. "Ligand: buspirone". IUPHAR/BPS Guide to Pharmacology. 36. Savitz J, Lucki I, Drevets
Buspirone
Biochemical methods of separation and characterization of proteins
content or ligand binding. Some variants of affinity immunoelectrophoresis are similar to affinity chromatography by use of immobilized ligands. Binding
Immunoelectrophoresis
Chemical compound
Thomas A.; Zhang, Li; Loftus, Joseph; Smith, Jeffrey W. (2000-07-21). "Ligand Binding to Integrins". Journal of Biological Chemistry. 275 (29): 21785–21788
Arginylglycylaspartic_acid
Chemical element with atomic number 26 (Fe)
higher positive charge and is more polarizing, lowering the energy of its ligand-to-metal charge transfer absorptions. Thus, all the above complexes are
Iron
Species of bacteria
Kuipers EJ, Doukas M, et al. (October 2022). "Constitutive programmed death ligand 1 expression protects gastric G-cells from Helicobacter pylori-induced inflammation"
Helicobacter_pylori
Gamma-aminobutyric acid analog
nerve damage (inflammatory or neuropathic conditions). Gabapentin is a ligand of the α2δ calcium channel subunit. The α2δ-1 protein is coded by the CACNA2D1
Gabapentin
Method of separating chemical or biological samples
(ACE), utilizes intermolecular binding interactions to understand protein-ligand interactions. Pharmaceutical companies use ACE for a multitude of reasons
Capillary_electrophoresis
Central nervous system stimulant
psychoactive derivatives. In organic chemistry, amphetamine is an excellent chiral ligand for the stereoselective synthesis of 1,1'-bi-2-naphthol. The substituted
Amphetamine
Antidepressant medication
and an antagonist of the α1- and α2-adrenergic receptors. It is also a ligand of the 5-HT2C receptor with lower affinity than for the 5-HT2A receptor
Trazodone
Peptide hormone
activation of phospholipase C resulting from the binding of an extracellular ligand (hormone or neurotransmitter) to a G protein-coupled membrane receptor.
Insulin
Type of chemical compound
schematic equation for these syntheses is shown, where M = metal ion and L = a ligand: H2porphyrin + [MLn]2+ → M(porphyrinate)Ln−4 + 4 L + 2 H+ Representative
Porphyrin
Infection caused by Bacillus anthracis bacteria
amounts of a nontoxic catalyst composed of iron and tetroamido macrocyclic ligands are combined with sodium carbonate and bicarbonate and converted into a
Anthrax
Collection of enantiomers
chiral pool are amino acids, sugars, and terpenes. Their use improves the efficiency of total synthesis. Not only does the chiral pool contribute a premade
Chiral_pool
Chemical element with atomic number 29 (Cu)
with ligands. In aqueous solution, copper(II) exists as [Cu(H 2O) 6]2+ . This complex exhibits the fastest water exchange rate (speed of water ligands attaching
Copper
Family of chemical compounds
Cyclic(alkyl)(amino) carbenes (CAACs) are a class of stable singlet carbene ligands that feature one amino and one sp3 alkyl group adjacent to the carbene
Cyclic_alkyl_amino_carbenes
Chemical compound
may also yield other gold(I) complexes, especially with organic ligands. Often the ligand serves as reducing agent as illustrated with thiourea, CS(NH2)2:
Chloroauric_acid
Human liver enzyme
dopamine in the brain and liver. Considerable variation exists in the efficiency and amount of CYP2D6 enzyme produced between individuals. Hence, for drugs
CYP2D6
Type of electrochemical cell
solutions. Metal-organic flow batteries use organic ligands to improve redox properties. The ligands can be chelates such as EDTA, and can enable the electrolyte
Flow_battery
Chemical compound
reacting system, ensuring high efficiency and selectivity. The labile THF ligand in W(CO)5(THF) makes it highly reactive in ligand substitution reactions, allowing
Pentacarbonyl(tetrahydrofuran)tungsten
Pentacarbonyl(tetrahydrofuran)tungsten
Pharmacodynamics and pharmacokinetics of ethanol
mechanisms remains an area of research, but ethanol has been shown to affect ligand-gated ion channels, particularly the GABAA receptor. After oral ingestion
Pharmacology_of_ethanol
Chemical element with atomic number 34 (Se)
structure of [ReOSe(2-Se-py)3]: A rhenium(V) complex with selenium(0) as a ligand". Inorganic Chemistry Communications. 45: 48–50. doi:10.1016/j.inoche.2014
Selenium
Protein-coding gene in the species Homo sapiens
molecule ligands. The majority of MR1 ligands are uracil analogues, but some non-uracil drug-like molecules also weakly bind to MR1. The ligands 5-OP-RU
Major histocompatibility complex, class I-related
Major_histocompatibility_complex,_class_I-related
Calcium titanium oxide mineral
through chiral ligands leads to the methods of direct synthesis using chiral ligands, post-synthetic chiral ligand exchange, chiral-ligand-assisted reprecipitation
Perovskite
Chemical element with atomic number 80 (Hg)
mercury(II) compounds (e.g. mercury(II) cyanide if cyanide is used as the ligand). Mercury(I) chloride, a colorless solid also known as calomel, is really
Mercury_(element)
Drug mixture used mainly to treat ADHD and narcolepsy
occur together and never occur alone. NMDA receptors are voltage-dependent ligand-gated ion channels that requires simultaneous binding of glutamate and a
Adderall
Chemical reaction which forms a cyclic molecule
beta-hydrogen elimination. Efficiency of the reaction varies substantially depending on the alkenes used, but rational ligand design may permit expansion
Cycloaddition
Technique of electroplating
An earlier view suggested, that an active Cr3+ species (perhaps, with a ligand rather than water) forms initially from electroreduced Cr6+. This active
Chrome_plating
Iron-carrying compounds
reduction to Fe2+ which has little affinity to these ligands. Siderophores are usually classified by the ligands used to chelate the ferric iron. The major groups
Siderophore
Molecule that carries genetic information
Lu XJ, Shakked Z, Olson WK (July 2000). "A-form conformational motifs in ligand-bound DNA structures". Journal of Molecular Biology. 300 (4): 819–40. doi:10
DNA
Blood vessel formation, when new vessels emerge from existing vessels
microvasculature. Delta-like ligand 4 (Dll4) is a protein with a negative regulatory effect on angiogenesis. Dll4 is a transmembrane ligand, for the notch family
Angiogenesis
Chemical element with atomic number 13 (Al)
formula R4Al2 which contain an Al–Al bond and where R is a large organic ligand. A variety of compounds of empirical formula AlR3 and AlR1.5Cl1.5 exist
Aluminium
LIGAND EFFICIENCY
LIGAND EFFICIENCY
Female
English
Short form of Latin Eliana, LIANA means "sun."Â
Girl/Female
Hindu
Art, Softness
Female
French
French form of Latin Eliana, ÉLIANE means "sun."
Female
English
Short form of French Éliane, LIANE means "sun."Â
Girl/Female
Hebrew Latin
White.
Surname or Lastname
English
English : habitational name from Lingart, Lancashire, or Lingards Wood in Marsden, West Yorkshire, both named from Old English līn ‘flax’ + garðr ‘enclosure’.
Female
English
Scottish surname transferred to unisex forename use, from the name of a place in Ayrshire, LOGAN means "hollow, lowland."Â
Surname or Lastname
English
English : variant of Lygon, name of an aristocratic English family said to be of Norman origin. The name is of unknown etymology. According to Morlet it is a variant of L’Higon, a patronymic from Higon, a southern French variant of Hugo. This seems rather doubtful.Polish (also Ligoń) : nickname from a derivative of Old Polish ligać ‘to lie’ or ‘to kick up a fuss’.The first known Ligon immigrant to North America, Col. Thomas Lygon or Ligon, came to VA from England in 1640.
Boy/Male
American, Anglo, Australian, British, Chinese, Christian, English, Irish
From the Meadow Land; Land Lying Fellow
Male
Scottish
Scottish surname transferred to unisex forename use, from the place name in Ayrshire, LOGAN means "hollow, lowland."Â
Male
Native American
Native American Miwok name LIWANU means "growl of a bear."
Boy/Male
German, Spanish
Famous Land
Girl/Female
Muslim
Art, Softness
Boy/Male
Native American
Growl of a bear.
Male
Irish
Irish name derived from the name of the Celtic god Lug, LUGAID means "oath." Many historical and legendary figures have borne this name.
Boy/Male
English American
From the meadow land 'Pasture ground.
Surname or Lastname
English (Yorkshire)
English (Yorkshire) : from a Norman female personal name, Legard, derived from the Germanic name Liutgard (borne by Charlemagne’s wife), composed of the elements liut ‘people’, ‘tribe’ + gard ‘enclosure’.French : metonymic occupational name for a gardener, or status name for someone who owned garden, from Old French gard ‘garden’ with the definite article le.
Girl/Female
Greek English
Liberator. Feminine of Lysander.
Surname or Lastname
English
English : variant of Ligon with excrescent patronymic -s.
Surname or Lastname
English
English : variant of Wiggin.German : variant of Weigand (see Wiegand).
LIGAND EFFICIENCY
LIGAND EFFICIENCY
Female
Celtic
, mirth.
Boy/Male
Hindu
Surname or Lastname
English and German
English and German : variant of Wick.
Boy/Male
Anglo, British, English
Supreme Power; Name of a King
Girl/Female
Australian, Hindu, Indian
Goddess Durga
Male
Russian
(Казимир) Russian form of Polish Kazimierz, KAZIMIR means "commands peace."
Girl/Female
Indian
Praiseworthy, Commendable
Surname or Lastname
English (of Norman origin)
English (of Norman origin) : habitational name from any of various places, for example in Aisne and Calvados, so called from Old French pierre ‘stone’ + pont ‘bridge’.All the New England Pierpont lines seem to be descended from James and his sons John and Robert, who came to America about 1640. James also may have had a brother Robert who was part of that group. The southern Pierpo(i)nt family are descended from Henry, who came to the VA–MD region in 1635.
Boy/Male
Australian, Hindu, Indian, Telugu
Sweet; Caring
Girl/Female
German, Swedish
Mighty with a Spear; Strength of the Spear
LIGAND EFFICIENCY
LIGAND EFFICIENCY
LIGAND EFFICIENCY
LIGAND EFFICIENCY
LIGAND EFFICIENCY
n.
Same as Ligan.
n.
A luxuriant woody plant, climbing high trees and having ropelike stems. The grapevine often has the habit of a liane. Lianes are abundant in the forests of the Amazon region.
n.
A broad, level, elevated area of land; a plateau.
n.
Ground, in respect to its nature or quality; soil; as, wet land; good or bad land.
n.
Any one of the numerous species of reptiles belonging to the order Lacertilia; sometimes, also applied to reptiles of other orders, as the Hatteria.
a.
Pecuniarily embarrassed through owning much unprofitable land.
n.
A kind of canvaslike cotton fabric, used to stiffen and protect the lower part of trousers and of the skirts of women's dresses, etc.; -- so called from Wigan, the name of a town in Lancashire, England.
n.
A piece of rope with thimble or block spliced into one or both of the ends.
v. t.
To catch and bring to shore; to capture; as, to land a fish.
n.
See Ribbon.
n.
A piece of timber with a forked end, used in dragging a heavy stone, a log, or the like, from a field.
n.
A solemn form of supplication in the public worship of various churches, in which the clergy and congregation join, the former leading and the latter responding in alternate sentences. It is usually of a penitential character.
n. pl.
A tribe of North American Indians, inhabiting the northern part of Mexico. They belong to the Tinneh stock, and are closely related to the Apaches.
n.
The solid part of the surface of the earth; -- opposed to water as constituting a part of such surface, especially to oceans and seas; as, to sight land after a long voyage.
n. & v.
See Ligan.
n.
Goods sunk in the sea, with a buoy attached in order that they may be found again. See Jetsam and Flotsam.
v. t.
To tell or narrate, as a legend.
n.
See Rib-band.
n.
Alt. of Liana