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LEFLUNOMIDE

  • Leflunomide
  • Chemical compound

    Leflunomide, sold under the brand name Arava among others, is an immunosuppressive conventional disease-modifying antirheumatic drug (DMARD), used in

    Leflunomide

    Leflunomide

    Leflunomide

  • Teriflunomide
  • Drug used in treatment of multiple sclerosis

    Teriflunomide, sold under the brand name Aubagio, is the active metabolite of leflunomide. Teriflunomide was investigated in the Phase III clinical trial TEMSO

    Teriflunomide

    Teriflunomide

    Teriflunomide

  • BK virus
  • Member of the polyomavirus family

    patients with BKVAN after switching MMF to leflunomide.[citation needed] There are no dosing guidelines for leflunomide in BKVAN. Patient to patient variability

    BK virus

    BK virus

    BK_virus

  • Rheumatoid arthritis
  • Type of autoimmune arthritis

    with other frequently used agents including sulfasalazine and leflunomide. Leflunomide is effective when used for 6–12 months, with similar effectiveness

    Rheumatoid arthritis

    Rheumatoid arthritis

    Rheumatoid_arthritis

  • Colestyramine
  • Pharmaceutical drug

    taking leflunomide or teriflunomide to aid drug elimination in the case of drug discontinuation due to severe side effects caused by leflunomide or teriflunomide

    Colestyramine

    Colestyramine

    Colestyramine

  • Biological half-life
  • Time taken for a drug to halve its concentration in blood plasma

    donepezil [46–51]. Fluoxetine Monograph. Accessed 15 April 2021. "Arava (leflunomide) dosing, indications, interactions, adverse effects, and more". Medscape

    Biological half-life

    Biological half-life

    Biological_half-life

  • Sarcoidosis
  • Abnormal formation of clumps of inflammatory cells (granulomata)

    steroid-sparing agents, such as azathioprine, methotrexate, mycophenolic acid, and leflunomide are often used as alternatives to corticosteroids. Of these, methotrexate

    Sarcoidosis

    Sarcoidosis

    Sarcoidosis

  • Disease-modifying antirheumatic drug
  • Category of drugs

    csDMARDs are the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs are drugs that were developed

    Disease-modifying antirheumatic drug

    Disease-modifying antirheumatic drug

    Disease-modifying_antirheumatic_drug

  • Prodrug
  • Compound that is metabolized into a pharmacologically active drug

    lung etc.) Carbamazepine, captopril, carisoprodol, heroin, molsidomine, leflunomide, paliperidone, phenacetin, primidone, psilocybin, sulindac, fursultiamine

    Prodrug

    Prodrug

  • TTC7A
  • Protein-coding gene in the species Homo sapiens

    ineffective in treating TTC7A Deficiency. Recent research shows that Leflunomide reduces intestinal tract narrowing, restores gut motility, and increases

    TTC7A

    TTC7A

    TTC7A

  • Leukopenia
  • Medical condition

    such as sirolimus, mycophenolate mofetil, tacrolimus, ciclosporin, leflunomide and TNF inhibitors, have leukopenia as a known complication. Interferons

    Leukopenia

    Leukopenia

    Leukopenia

  • Trifluoromethylation
  • Chemical compound

    compounds have a trifluoromethyl group incorporated: fluoxetine, mefloquine, leflunomide, nulitamide, dutasteride, bicalutamide, aprepitant, celecoxib, fipronil

    Trifluoromethylation

    Trifluoromethylation

  • Polyarteritis nodosa
  • Systemic necrotizing inflammation of medium-sized muscular arteries

    or leflunomide may be helpful. Some patients have entered a remission phase when a four-dose infusion of rituximab is used before the leflunomide treatment

    Polyarteritis nodosa

    Polyarteritis nodosa

    Polyarteritis_nodosa

  • Ankylosing spondylitis
  • Type of arthritis of the spine

    manageable with just a TNFi or other medication. Conventional DMARDs such as leflunomide are also considered to be part of this class. Concerns exist about a

    Ankylosing spondylitis

    Ankylosing spondylitis

    Ankylosing_spondylitis

  • SAPHO syndrome
  • Medical condition

    NSAIDs, corticosteroids, sulfasalazine, methotrexate, ciclosporin and leflunomide. Some patients have responded to antibiotics. The rationale for their

    SAPHO syndrome

    SAPHO_syndrome

  • Pyrimidine metabolism
  • Set of biological pathways

    in multiple sclerosis. Examples include Leflunomide and Teriflunomide (the active metabolite of leflunomide). In order to understand how life arose,

    Pyrimidine metabolism

    Pyrimidine_metabolism

  • Spondyloarthritis
  • Joint diseases of the vertebral column

    axial illness, conventional DMARDs such methotrexate, sulfasalazine, or leflunomide may be useful in treating peripheral spondyloarthritis. These drugs are

    Spondyloarthritis

    Spondyloarthritis

  • Felty's syndrome
  • Autoimmune disease

    improve neutropenia in severe disease. Use of rituximab, methotrexate and leflunomide have been successful in reducing disease severity. Use of gold therapy

    Felty's syndrome

    Felty's_syndrome

  • Dihydroorotate dehydrogenase
  • Class of enzymes

    opening of a tunnel leading to the active site. Leflunomide has been shown to bind in this tunnel. Leflunomide is being used for treatment of rheumatoid and

    Dihydroorotate dehydrogenase

    Dihydroorotate dehydrogenase

    Dihydroorotate_dehydrogenase

  • List of drugs by year of discovery
  • 1997 Mometasone furoate (Nasonex) 1997 1997 2017 1997 Eletriptan 1997 2002 2017 1998 Ropivacaine 1998 1998 1998 2008 1998 Leflunomide 1998 1998 2008

    List of drugs by year of discovery

    List_of_drugs_by_year_of_discovery

  • Ipilimumab
  • Pharmaceutical drug

    paralysis, and myasthenia gravis. The combination of ipilimumab with either leflunomide or vemurafenib may lead to increased hepatotoxicity. T lymphocytes can

    Ipilimumab

    Ipilimumab

    Ipilimumab

  • Granulomatosis with polyangiitis
  • Autoimmune disease with chronic blood vessel inflammation

    immunosuppressing medications such as rituximab, methotrexate, azathioprine, leflunomide, or mycophenolate mofetil are used. TNF inhibitors, such as etanercept

    Granulomatosis with polyangiitis

    Granulomatosis with polyangiitis

    Granulomatosis_with_polyangiitis

  • Sanofi
  • French multinational pharmaceutical and healthcare company

    Rhinathiol (Carbocisteine), for cough and mucus. – Rheumatology Arava (Leflunomide), for rheumatoid and psoriatic arthritis. Kevzara (Sarilumab), for blood

    Sanofi

    Sanofi

    Sanofi

  • Brazilian Controlled Drugs and Substances Act
  • Brazil's federal drug control statute

    (CAS: 60364-26-3 , CID 6377520 from PubChem) Lacosamide Lamotrigine Leflunomide Levetiracetam Levomepromazine Levomilnacipran Lisuride Lithium Loperamide

    Brazilian Controlled Drugs and Substances Act

    Brazilian_Controlled_Drugs_and_Substances_Act

  • Psoriatic arthritis
  • Long-term inflammatory arthritis

    include damage to the kidneys. Oral small molecules such as methotrexate, leflunomide, cyclosporin, azathioprine, and sulfasalazine are used in persistent

    Psoriatic arthritis

    Psoriatic arthritis

    Psoriatic_arthritis

  • Pregnancy category
  • Risk of fetal injury due to the use of a pharmaceutical

    B1 B Cefotaxime B1 B Diclofenac C D third trimester Isotretinoin X X Leflunomide X X Loperamide B3 C Nicotine D ? Paracetamol (acetaminophen) A C Paroxetine

    Pregnancy category

    Pregnancy_category

  • Antiplatelet drug
  • Class of pharmaceuticals

    Cytotoxic drugs or drugs associated with bone marrow suppression (e.g.: leflunomide, hydroxychloroquine, adalimumab, infliximab, etanercept, sulfasalazine

    Antiplatelet drug

    Antiplatelet_drug

  • Zebrafish
  • Species of fish

    that an inhibition of the DHODH protein (by a small molecule called leflunomide) prevented development of the neural crest stem cells which ultimately

    Zebrafish

    Zebrafish

    Zebrafish

  • List of drugs: Le
  • (INN) ledercillin vk ledismase (INN) ledoxantrone (INN) lefetamine (INN) leflunomide (INN) lefradafiban (INN) Legubeti leiopyrrole (INN) lemalesomab (INN)

    List of drugs: Le

    List_of_drugs:_Le

  • Decoy cells
  • Virally infected epithelial cells found in urine

    proposed to target polyomavirus BK, such as cidofovir, fluoroquinolones, leflunomide, and statins are far from established and the published results on their

    Decoy cells

    Decoy cells

    Decoy_cells

  • Corneal transplantation
  • Surgical procedure of repairing corneal tissue to treat corneal blindness

    including cyclosporine A, tacrolimus, mycophenolate mofetil, sirolimus, and leflunomide to prevent graft rejection is increasing but there is insufficient evidence

    Corneal transplantation

    Corneal transplantation

    Corneal_transplantation

  • Canine histiocytic diseases
  • Category of disease affecting dogs

    we have had success with immuno-suppressive doses of Cyclosporin A or Leflunomide. These drugs are potent inhibitors of T cell activation and their ability

    Canine histiocytic diseases

    Canine_histiocytic_diseases

  • Isoxazole
  • Chemical compound

    antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Leflunomide is an isoxazole-derivative drug. Examples of AAS containing the isoxazole

    Isoxazole

    Isoxazole

  • Antiarthritics
  • Drug class

    anti-arthritic medications. Common DMARDs include oral methotrexate, leflunomide, or sulfasalazine. Conventional DMARDs have a slow onset of action and

    Antiarthritics

    Antiarthritics

    Antiarthritics

  • Mucous membrane pemphigoid
  • Autoimmune blistering disease

    cyclophosphamide, methotrexate, thalidomide, mycophenolate mofetil, leflunomide, sulphasalazine, sulphapuridine, sulphamethoxypiridazine, tetracyclines

    Mucous membrane pemphigoid

    Mucous_membrane_pemphigoid

  • Severe cutaneous adverse reactions
  • Group of adverse drug reactions involving the skin and mucosa

    being the third most common cause of the disorder; Strontium ranelate, leflunomide, dapsone, and nonsteroidal anti-inflammatory drugs (diclofenac, celecoxib

    Severe cutaneous adverse reactions

    Severe_cutaneous_adverse_reactions

  • Rheumatoid nodule
  • Medical condition

    increased pulmonary nodule growth following treatments with methotrexate, leflunomide, and etanercept. Central nervous system nodules Like cardiac nodules

    Rheumatoid nodule

    Rheumatoid nodule

    Rheumatoid_nodule

  • Drug rash with eosinophilia and systemic symptoms
  • Rare reaction to certain medications

    medications include minocycline, sulfasalazine, strontium ranelate, leflunomide, dapsone, and nonsteroidal anti-inflammatory drugs (diclofenac, celecoxib

    Drug rash with eosinophilia and systemic symptoms

    Drug_rash_with_eosinophilia_and_systemic_symptoms

  • Arava
  • Topics referred to by the same term

    Israel Aircraft Industries Arava, a brand name for the antirheumatic drug leflunomide Arava Shahaf (born 1990), Israeli female footballer Aravah (Sukkot),

    Arava

    Arava

  • Phyllis Gardner (clinical pharmacologist)
  • American physician and academic (1950–2025)

    "Mechanism of the antiproliferative action of leflunomide – A77 1726, the active metabolite of leflunomide, does not block T-cell receptor-mediated signal

    Phyllis Gardner (clinical pharmacologist)

    Phyllis_Gardner_(clinical_pharmacologist)

  • Mixed connective tissue disease
  • Medical condition

    contraindicated, alternative disease-modifying medications for RA, such as leflunomide or azathioprine, may be used. High dosages of corticosteroids are typically

    Mixed connective tissue disease

    Mixed_connective_tissue_disease

  • ATC code L04
  • Pharmaceutical drug classification

    Iptacopan L04AJ09 Danicopan L04AJ10 Vilobelimab L04AJ11 Pozelimab L04AK01 Leflunomide L04AK02 Teriflunomide L04AL01 Efgartigimod alfa L04AL02 Rozanolixizumab

    ATC code L04

    ATC_code_L04

  • List of drugs: Aq–Ar
  • aranotin (INN) araprofen (INN) arasertaconazole (INN) Arava. Redirects to Leflunomide Arazil Arazlo arbaclofen placarbil (USAN, INN) arbaprostil (INN) arbekacin

    List of drugs: Aq–Ar

    List_of_drugs:_Aq–Ar

  • Brequinar
  • Chemical compound

    been shown to inhibit completely vaccinia virus in cell based assay. Leflunomide - Clinically used DHODH inhibitor Methotrexate - the most widely used

    Brequinar

    Brequinar

    Brequinar

  • C12H9F3N2O2
  • Index of chemical compounds with the same molecular formula

    mass: 270.21 g/mol, exact mass: 270.0616 u) may refer to: Teriflunomide Leflunomide This set index page lists chemical structure articles associated with

    C12H9F3N2O2

    C12H9F3N2O2

  • A77
  • Topics referred to by the same term

    camera made by Sony Teriflunomide (A77 1726), the active metabolite of leflunomide Benoni Defense in the Encyclopaedia of Chess Openings This disambiguation

    A77

    A77

  • Outline of immunology
  • Overview of and topical guide to immunology

    Azathioprine Mycophenolic acid dihydroorotate dehydrogenase inhibitors Leflunomide Teriflunomide antifolate Methotrexate Macrolides/ other IL-2 inhibitors

    Outline of immunology

    Outline_of_immunology

  • Transition state analog
  • Class of chemical compounds

    RL, Copeland RA (January 1996). "The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase". Biochemistry

    Transition state analog

    Transition_state_analog

  • Uveitic glaucoma
  • Glaucoma caused by uveitis or its treatments

    antimetabolites such as azathioprine, methotrexate, mycophenolate mofetil, and leflunomide; alkylating agents such as cyclophosphamides and chlorambucil; and biological

    Uveitic glaucoma

    Uveitic_glaucoma

  • Index of oncology articles
  • laryngectomy – laser surgery – laser therapy – LCIS – LDH – lectin – leflunomide – leiomyoma – leiomyosarcoma – lentinan – lepirudin – leptomeningeal

    Index of oncology articles

    Index_of_oncology_articles

  • Aleixo Muise
  • Canadian scientist and physician

    Thiagarajah, Jay R.; Muise, Aleixo M. (2020). "Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency"

    Aleixo Muise

    Aleixo Muise

    Aleixo_Muise

  • S416
  • Chemical compound

    influenza, Zika virus, Ebola virus and SARS-CoV-2. Brequinar Teriflunomide Leflunomide Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, et al. (October 2020)

    S416

    S416

    S416

  • Josef Smolen
  • Austrian rheumatologist and immunologist (born 1950)

    contributions to the understanding of other then new drugs, such as leflunomide. Most recently, he was involved in the development of an antibody against

    Josef Smolen

    Josef_Smolen

  • Management of multiple sclerosis
  • Approaches to managing the disease

    the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation

    Management of multiple sclerosis

    Management_of_multiple_sclerosis

  • Immune-mediated thrombocytopaenia
  • Immune related haematological animal disease

    be used in more severe cases such as: azathioprine, cyclophosphamide, leflunomide, danazol, mycophenolate, mofetil, and cyclosporine. Azathioprine is not

    Immune-mediated thrombocytopaenia

    Immune-mediated_thrombocytopaenia

  • Synergistic enhancer (antiretroviral)
  • doctors are still using it for various reasons.[citation needed] Leflunomide Leflunomide has the trade name Arava. It enhances AZT through depleting a dNTP

    Synergistic enhancer (antiretroviral)

    Synergistic_enhancer_(antiretroviral)

  • Anne Simmonds
  • Chemist

    Hawrylowicz; Richards DF; Kirschbaum B; Simmonds HA (1 August 1998). "Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes

    Anne Simmonds

    Anne_Simmonds

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Online names & meanings

  • Nirjala | நிர்ஜலா
  • Girl/Female

    Tamil

    Nirjala | நிர்ஜலா

    A type of fast without water

  • Manning
  • Surname or Lastname

    English

    Manning

    English : patronymic from Mann 1 and 2.Irish : adopted as an English equivalent of Gaelic Ó Mainnín ‘descendant of Mainnín’, probably an assimilated form of Mainchín, a diminutive of manach ‘monk’. This is the name of a chieftain family in Connacht. It is sometimes pronounced Ó Maingín and Anglicized as Mangan.Anstice Manning, widow of Richard Manning of Dartmouth, England, came to MA with her children in 1679. Her great-great-grandson Robert, born at Salem, MA, in 1784, was the uncle and protector of author Nathaniel Hawthorne. Another early bearer of the relatively common British name was Jeffrey Manning, one of the earliest settlers in Piscataway township, Middlesex Co., NJ. His great-grandson James Manning (1738–91) was a founder and the first president of Rhode Island College (Brown University).

  • Paveen
  • Boy/Male

    Indian, Tamil

    Paveen

    King

  • Navyata | நாவ்யதா 
  • Girl/Female

    Tamil

    Navyata | நாவ்யதா 

    New, Fresh

  • Gordhan
  • Boy/Male

    Gujarati, Indian

    Gordhan

    Lord Krishna

  • Rasmiya
  • Girl/Female

    Arabic, Muslim

    Rasmiya

    Ceremonious; Formal; Feminine of Rasmi

  • Aaqilah |
  • Girl/Female

    Muslim

    Aaqilah |

    Intelligent

  • Dhulika
  • Girl/Female

    Hindu, Indian

    Dhulika

    Pollen of Flowers

  • Awf
  • Boy/Male

    Muslim/Islamic

    Awf

    Guest fragrance, lion;

  • Immaculata
  • Girl/Female

    French, German, Latin

    Immaculata

    Without Stain; Immaculate

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