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Chemical compound
Lanosterol is a tetracyclic triterpenoid from which all animal and fungal steroids are derived. By contrast, plant steroids are produced via cycloartenol
Lanosterol
Mammalian protein found in Homo sapiens
cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by
Lanosterol_synthase
Polycyclic organic compound having sterane as a core structure
steroids are manufactured in cells from a sterol: cholesterol (animals), lanosterol (opisthokonts), or cycloartenol (plants). All three of these molecules
Steroid
Protein-coding gene in the species Homo sapiens
Lanosterol 14α-demethylase (CYP51A1) is the animal version of a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4,4-dimethylcholesta-8(9)
Lanosterol 14 alpha-demethylase
Lanosterol_14_alpha-demethylase
Antifungal medication
the conversion of squalene to lanosterol. In fungi, lanosterol is then converted to ergosterol; in humans, lanosterol becomes cholesterol. However, as
Terbinafine
Antifungal medication
binding, while still allowing binding of the enzyme's natural substrate, lanosterol. Development of resistance to one azole in this way will confer resistance
Fluconazole
Pharmaceutical fungicide or fungistatic used to treat and prevent mycosis
Rimocidin Azole antifungals inhibit the conversion of lanosterol to ergosterol by inhibiting lanosterol 14α-demethylase. These compounds have a five-membered
Antifungal
Chemical compound
intermediate in the synthesis of the cell membrane sterol precursors lanosterol and cycloartenol, as well as saponins. It is formed when squalene is oxidized
2,3-Oxidosqualene
Terpene hydrocarbon
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Limonene
Chemical compound
component of the fungal cell membrane, by inhibiting the P450 enzyme lanosterol 14-alpha demethylase. Clotrimazole may slow fungal growth or result in
Clotrimazole
Drug class
from lanosterol. Ergosterol is absent in animals but is an essential component of the cell membranes of many fungi and protozoa, and so lanosterol 14α-demethylase
Steroidogenesis_inhibitor
Species of plant
along with the known phytoconstituents lauric acid, β-sitosterol and lanosterol. Marshmallows are used in gardening as ornamental plants. The leaves,
Althaea_officinalis
Bio-organic compound that serves as the building unit of terpenes
(vitamin E), dolichols, and squalene. Heme A has an isoprenoid tail, and lanosterol, the sterol precursor in animals, is derived from squalene and hence from
Isoprene
cycloartenol Lanosterol synthase (LAS), found in all animals and fungi, and occasionally in plants, which produces primarily lanosterol Sterols and triterpenes
Oxidosqualene_cyclase
Class of chemical compounds
cucurbitane core, although in practice they are biosynthesised from either lanosterol (animals and fungi) or cycloartenol (plants) via the cyclization of squalene
Triterpene
Class of oily organic compounds found in plants
pyrophosphate. Squalene is then processed biosynthetically to generate either lanosterol or cycloartenol, the structural precursors to all the steroids. Sesquarterpenes
Terpene
American chemist and Nobel Laureate (born 1941)
Barry (1968). Studies of the mechanism of action of 2,3-oxidosqualene-lanosterol cyclase: featuring enzymic cyclization of modified squalene oxides (Ph
Karl_Barry_Sharpless
Sterol biosynthesized by all animal cells
steps. This is followed by 19 additional steps to convert the resulting lanosterol into cholesterol. A human male weighing 68 kg (150 lb) normally synthesizes
Cholesterol
Class of enzymes
the sterol biosynthesis, responsible for removing a methyl group from lanosterol (in animals and fungi) or obtusifoliol (in plants). It catalyzes a chemical
Sterol_14-demethylase
Chemical compound
Similarly to other azole fungicides, prochloraz is an inhibitor of the enzyme lanosterol 14α-demethylase (CYP51A1), which is necessary for the production of ergosterol
Prochloraz
Class of enzymes
synthase 1), and CYP51A1, lanosterol 14-α-demethylase, sometimes unofficially abbreviated to LDM according to its substrate (lanosterol) and activity (demethylation)
Cytochrome_P450
Chemical compound
the steroids of fungi and animals, which are, instead, produced from lanosterol. The biosynthesis of cycloartenol starts from the triterpenoid squalene
Cycloartenol
Protein family
metabolism. Lanosterol synthase (EC 5.4.99.7) (oxidosqualene-lanosterol cyclase) catalyzes the cyclization of (S)-2,3-epoxysqualene to lanosterol, the initial
Prenyltransferase
Chemical compound
Isavuconazole works by inhibition of lanosterol 14α-demethylase, the enzyme responsible for converting lanosterol to ergosterol via a demethylation reaction
Isavuconazonium
Chemical compound
synthesis of ergosterol from lanosterol by interfering with 14α-demethylase. Ergosterol is a smaller molecule than lanosterol; it is synthesized by combining
Ergosterol
Chinese-American ophthalmologist
subsequently moved to China and continues his research, which includes work on lanosterol. stem cell research (particularly limbal stem cells), gene editing, and
Kang_Zhang
Chemical compound
tetrazole containing orally bioavailable and selective inhibitor of fungal lanosterol 14α-demethylase (CYP51), has shown promising efficacy in the treatment
Oteseconazole
Recessive genetic condition
step towards cholesterol biosynthesis. Squalene leads to the creation of lanosterol, from which there are multiple pathways that lead to cholesterol biosynthesis
Smith–Lemli–Opitz_syndrome
Organic compound
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Ethanol
Medication for treating fungal infections
other antifungals. Azole antifungals inhibit the enzyme that converts lanosterol into ergosterol. Common examples of azole antifungals include clotrimazole
Topical_antifungal
Chemical compound
acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies
Ganoderic_acid
Chemical compound
3-oxidosqualene. It then undergoes an enzyme-catalysed cyclisation to produce lanosterol, which can be elaborated into other steroids such as cholesterol and ergosterol
Squalene
Labdane-type diterpenoid resin acid found in conifers
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Communic_acid
Chemical compound
the cytochrome P450 enzyme lanosterol of fungi, also known as CYP3A4. The gene ERG11 controls lanosterol creation. Lanosterol is found within the yeast
Terconazole
Class of plant-derived organic compounds with soap-like properties
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Saponin
Substance of biological origin that is soluble in nonpolar solvents
squalene and then folded up and formed into a set of rings to make lanosterol. Lanosterol can then be converted into other steroids such as cholesterol and
Lipid
Class of enzymes
"Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase". Biochem
Delta24-sterol_reductase
Chemical compound
of lanosterol to cholesterol, a critical metabolic pathway in animals, fungi, and some protozoa. Zymostenol is produced from 14-demethyl lanosterol via
Zymostenol
Species of fungus
Cultivated chaga developed a reduced number of phytosterols, particularly lanosterol, an intermediate in the synthesis of ergosterol and lanostane-type triterpenes
Inonotus_obliquus
Medication used to treat fungal infections
inhibits the fungal-mediated synthesis of ergosterol, via inhibition of lanosterol 14α-demethylase. Because of its ability to inhibit cytochrome P450 3A4
Itraconazole
Chemical compound
Disregarding some intermediate compounds (e.g. 4-4-dimethylzymosterol), lanosterol can be considered a precursor of zymosterol in the cholesterol synthesis
Zymosterol
Chemical compound
The synthesis of dinosterol begins with the cyclization of squalene to lanosterol, but then diverges from cholesterol biosynthesis. The biosynthesis of
Dinosterol
Polymer harvested from certain trees
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Natural_rubber
Chemical compound
inhibition of CYP51, a crucial component in the demethylation process of lanosterol or 24-methyl dihydroano-sterol at position 14. Disruption of this process
Prothioconazole
Chemical compound
building-blocks of squalene, the immediate precursor to sterols, which cyclizes to lanosterol (a methylated sterol) and further metabolized to cholesterol. A number
Lovastatin
Unsaturated hydrocarbon
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Monoterpene
Species of flowering plant
acid, and nicotinic acid. From the flowers, diosgenin, β-sitosterol, and lanosterol have been isolated. Goji Gouqi jiu List of culinary fruits List of dried
Lycium_barbarum
Chemical compound
used to produce vegan D3. 7-DHC is used for vitamin D3 synthesis via lanosterol in land animals, via cycloartenol in plants, and in algae together with
7-Dehydrocholesterol
List of Cytochrome P450 enzymes
CYP46A1 CYP46A4P CYP51 cholesterol biosynthesis 1 subfamily, 1 gene, 3 pseudogenes CYP51A1 (lanosterol 14-alpha demethylase) CYP51P1, CYP51P2, CYP51P3
Cytochrome P450 (individual enzymes)
Cytochrome_P450_(individual_enzymes)
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Madecassoside
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Sandaracopimaric_acid
Dammarendiol, Dammarenediol‑II, & Ocotillol‑type aglycones. Lanostane-type, e.g. Lanosterol, Cycloartenol, Parkeol, Schiglauzic acid, Ganoderic acids (from Ganoderma)
Sapogenin
Carotenoid pigment
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Lycopene
Set of chemical reactions in organisms
squalene and then folded up and formed into a set of rings to make lanosterol. Lanosterol can then be converted into other sterols such as cholesterol and
Metabolism
Class of chemical compounds
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Iridoid
Croatian-Swiss chemist (1887–1976)
career. In 1952, Oskar Jeger and he supervised a team which isolated lanosterol and established the link between terpenes and steroids. Ružička retired
Leopold_Ružička
Simplest secondary alcohol
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Isopropyl_alcohol
Class of chemical compounds
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Polyphenol
Class of chemical compounds; yellow, orange or red plant pigments
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Carotenoid
Chemical compound
also been reported to inhibit mammalian sterol biosynthesis by affecting lanosterol demethylation. Although used in agriculture for pest management purposes
Fenpropimorph
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Abietic_acid
Chemical compound
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Sorbitol
Type of membrane protein that is permanently attached to the biological membrane
determined:[citation needed] prostaglandin H2 syntheses 1 and 2 (cyclooxygenases) lanosterol synthase and squalene-hopene cyclase microsomal prostaglandin E synthase
Integral_membrane_protein
Pungent chemical compound in chili peppers
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Capsaicin
Antifungal chemical compound
enzyme participates in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. Lower doses of fluconazole and itraconazole are required
Ketoconazole
Vitamin D3, a chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Cholecalciferol
Aromatic alcohol
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Benzyl_alcohol
Chemical compound
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Glycerol
Chemical compound
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Mannitol
Sugar alcohol that is used as a sweetener
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Erythritol
Chemical compound
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
1-Octen-3-ol
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Juniperol
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Pulegone
Class of enzymes
Gaylor JL (1985). "Microsomal enzymes of cholesterol biosynthesis from lanosterol. Purification and characterization of delta 7-sterol 5-desaturase of rat
C-5_sterol_desaturase
Class of aromatic organic chemicals found in plants
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Terpenoid
Chemical compound
"Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase". Biochem
Lathosterol
Chemical compound
molecule is known as a "cholestadiene". Examples include fusidic acid, lanosterol, and stigmasterol. Cholestene is a widely available chemical, used and
Cholestene
Portion of plant-derived food that cannot be completely digested
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Dietary_fiber
Chemical compound
Sulconazole (trade name Exelderm) is an antifungal medication of the imidazole class. It is available as a cream or solution to treat skin infections such
Sulconazole
with the CYP Symbol CYP51F1. ERG11 catalyzes the C14-demethylation of lanosterol to 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first
ERG11
Index of chemical compounds with the same molecular formula
pentacyclic triterpenoid Euphol Friedelin, a triterpene Isoarborinol Lanosterol, a tetracyclic triterpenoid Lupeol Obtusifoliol 2,3-Oxidosqualene Parkeol
C30H50O
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Zizyberenalic_acid
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Dehydroabietic_acid
Organic compound used as flavouring and analgesic
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Menthol
Addition of a hydrogen-boron bond to C=C, C=N, C=O, or C≡C bonds
Ochlschlager, A. C. (1992). "Synthesis of inhibitors of 2,3-oxidosqualene-lanosterol cyclase: conjugate addition of organocuprates to N-(carbobenzyloxy)-3-carbomethoxy-5
Hydroboration
Red-orange pigment of the terpenoids class
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Β-Carotene
Organic compound ethane-1,2-diol
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Ethylene_glycol
Mammalian protein found in Homo sapiens
diepoxysqualene (DOS). DOS is converted to 24(S),25-epoxylanosterol by lanosterol synthase. Antifungal drug#Allylamines GRCh38: Ensembl release 89: ENSG00000104549
Squalene_monooxygenase
Chemical compound
products of lanosterol, dihydrolanosterol can be demethylated by mammal or yeast cytochrome P450 sterol 14alpha-demethylase. Lanosterol Obtusifoliol
Dihydrolanosterol
Chemical compound
to carbon number 3 in the 5α isomer with a hydroxyl group results in lanosterol, the biogenetic precursor of the steroids in animals. Voser, W.; Montavon
Lanostane
Active region of an enzyme
biosynthesis by inhibiting the Lanosterol 14 alpha-demethylase, so no new ergosterol is produced and harmful 14α-lanosterol is accumulated within the cell
Active_site
CH3OH; simplest possible alcohol
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Methanol
Species of fungus
corticosteroid cortexolone and by phenanthrene. C. elegans also possesses a lanosterol 14-alpha demethylase, another enzyme in the cytochrome P450 family. Cunninghamella
Cunninghamella_elegans
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Madecassic_acid
Family of sugars with a six-carbon ring
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Cyclohexane-1,2,3,4,5,6-hexol
Chemical compounds produced by plants
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Phytochemical
Chemical compound
inhibit CYP11A1 (cholesterol side-chain cleavage enzyme) and CYP51A1 (lanosterol-14α-demethylase), similarly but more potently relative to ketoconazole
Levoketoconazole
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Geranylfarnesol
Chemical compound
Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Euphol Lanosterol Madecassoside Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic
Palustric_acid
Organic compound with at least one hydroxyl (–OH) group
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol
Alcohol_(chemistry)
LANOSTEROL
LANOSTEROL
LANOSTEROL
LANOSTEROL
Boy/Male
Hindu, Indian, Traditional
Lord of Gopi's
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Given by Water; Cloud
Girl/Female
Indian
Part of Lord Shiva
Girl/Female
Muslim/Islamic
Morning breeze dew
Girl/Female
Polish
Lucky.
Boy/Male
Indian, Punjabi, Sikh
Most Excellent
Female
Norse
Old Norse name composed of the elements gunnr "war" and varr "cautious, vigilant," hence "war-vigilant."
Boy/Male
Arabic, Muslim
Another Name of Madina City
Surname or Lastname
English (Yorkshire)
English (Yorkshire) : habitational name from a place in West Yorkshire called Lofthouse (see Loftus).Americanized form of the Norwegian cognate Lofthus.
Boy/Male
Indian
Pertaining to mecca
LANOSTEROL
LANOSTEROL
LANOSTEROL
LANOSTEROL
LANOSTEROL