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Chemical compound
approved the compound on January 22, 2010. 4-AP has been used as treatment for KCNA2-related disorders with gene mutations that show a clear gain-of-function
4-Aminopyridine
Protein-coding gene in the species Homo sapiens
member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene. Potassium channels represent the most complex class of voltage-gated
KCNA2
Group of genetic disorders
KCNA2-related disorders are caused by mutations to the Kv1.2 channels encoded by the KCNA2 gene. These neurological disorders are associated with a spectrum
KCNA2-related_disorders
Family of small signalling G proteins
GTPase Effector RhoA Cit, Cnksr1, Diaph1, Diaph2, DgkQ, FlnA, KcnA2, Ktn1, Rtkn1, Rtkn2, Rhpn1, Rhpn2, Itpr1, PlcG1, PI-5-p5K, Pld1, Pkn1, Pkn2, Rock1
Rho_family_of_GTPases
Group of genetic disorders affecting motor neurons controlling the lower limbs
Lehesjoki AE, Helbig I, Lerche H, Lemke JR (2016) A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia. Ann Neurol
Hereditary_spastic_paraplegia
Ion channel that selectively passes K+
investigated for the treatment of conditions such as multiple sclerosis and KCNA2-related disorders. Off target drug effects can lead to drug induced Long
Potassium_channel
Family of ion channel proteins
CATSPER4 RYR1; RYR2; RYR3 Kvα1.x - Shaker-related: Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), Kv1.8 (KCNA10)
Cation_channel_superfamily
Protein-coding gene in the species Homo sapiens
activation. This gene appears to be intronless and is clustered together with KCNA2 and KCNA10 genes on chromosome 1. KCNA3 encodes the voltage-gated Kv1.3
KCNA3
toxin is a potent inhibitor of the Kv1.2 potassium channel, encoded by the KCNA2 gene and a less potent blocker of Kv1.3 channels, encoded by the KCNA3 gene
Pandinus imperator (Pi3) toxin
Pandinus_imperator_(Pi3)_toxin
Genetic form of epilepsy
with Jeavons syndrome, Lennox-Gastaut syndrome, and other epilepsies. - KCNA2: This gene encodes a delayed potassium channel that helps a neuron repolarize
Dravet_syndrome
C9JR72 7966 KCMF1 HGNC:20589; Q9P0J7 7967 KCNA1 HGNC:6218; Q09470 7968 KCNA2 HGNC:6220; P16389 7969 KCNA3 HGNC:6221; P22001 7970 KCNA4 HGNC:6222; P22459
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Class of transport proteins
inactivating or non-inactivating Kvα1.x - Shaker-related: Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), Kv1.8 (KCNA10)
Voltage-gated potassium channel
Voltage-gated_potassium_channel
to the α-KTx8 subfamily and targets the voltage-gated potassium channels KCNA2 (Kv1.2), and KCNA3 (Kv1.3). OSK3 is secreted from the venom gland of Orthochirus
OSK3
channels Kv1.2 and Kv1.3. These channels are coded respectively by the genes KCNA2 and KCNA3 and their inhibition is reversible. hKv1.2 is inhibited with a
Pi5
Medical condition
(2016). "Rett-like phenotypes: expanding the genetic heterogeneity to the KCNA2 gene and first familial case of CDKL5-related disease". Clinical Genetics
CDKL5_deficiency_disorder
Protein-coding gene in the species Homo sapiens
expression may be regulated by MITF. KCNAB2 has been shown to interact with KCNA2. Voltage-gated potassium channel GRCh38: Ensembl release 89: ENSG00000069424
KCNAB2
Protein-coding gene in the species Homo sapiens
channel in short-term plasticity. KCNA4 has been shown to interact with DLG4, KCNA2 and DLG1. Voltage-gated potassium channel Voltage-gated potassium-channel
KCNA4
Chemical compound
rectifier, slowly inactivating channels of the subfamily A member 2 (Kv1.2/KCNA2) [1] and they can reversibly block the shaker B potassium-channels (Kv1
Pandinotoxin
Protein and coding gene in humans
ARHGAP5, ARHGDIA, ARHGEF11, ARHGEF12, ARHGEF3, CIT DGKQ, DIAPH1, GEFT, ITPR1, KCNA2, KTN1, MAP3K1, PKN2, PLCG1, Phospholipase D1, Protein kinase N1, RAP1GDS1
Transforming_protein_RhoA
Protein domain
group of proteins that contain the BTB/POZ domain. BTBD10; KCNA1; KCNA10; KCNA2; KCNA3; KCNA4; KCNA5; KCNA6; KCNA7; KCNB1; KCNB2; KCNC1; KCNC2; KCNC3; KCNC4;
Potassium channel tetramerisation domain
Potassium_channel_tetramerisation_domain
Field of study
caused the downregulation of the voltage-gated potassium channels in subunit Kcna2 in the dorsal root ganglion (DRG). A knockout of G9a in the DRG neurons
Epigenetics_of_chronic_pain
Protein-coding gene in the species Homo sapiens
isoforms, have been reported. PTPRA has been shown to interact with Grb2 and KCNA2. GRCh38: Ensembl release 89: ENSG00000132670 – Ensembl, May 2017 GRCm38:
PTPRA
Mammalian protein found in Homo sapiens
ERBB4 EXOC4 FYN FZD7 GRIK1 GRIK2 GRIK5 GRIN2A GRIN2B GRIN2C HER2/neu HGS KCNA2 KCNA4 KCNA5 KCNJ12 Kir2.1 LGI1 LRP1 LRP2 NLGN1 NOS1 PTK2B SEMA4C and SHANK2
DLG4
Protein found in humans
tissues. Cortactin has been shown to interact with: ACTR3 ARPC2, CTNND1, FER, KCNA2, SHANK2, WASL, and WIPF1. actin gelsolin transferrin villin ENSG00000288401
Cortactin
Index of articles on biophysics
Hopfield John Kendrew Journal of Applied Biomechanics Julia Goodfellow KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2
Index_of_biophysics_articles
Protein-coding gene in the species Homo sapiens
Xiao J, et al. (November 2016). "G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons". Scientific Reports. 6 37704
EHMT2
protease trypsin (Kd=30 nM) and the voltage-gated potassium channels Kv1.2/KCNA2 (IC50=2800 nM). Kalicludines and dendrotoxins compete for binding to these
Kalicludine
toxin isolated from the same species’ venom, targeting the Kv1.2 channel (KCNA2). OdK2 is a relatively small peptide with 38 amino acids and a monoisotopic
OdK2
IR channels. The IC50 values for these channels are 172.59 nM for Kv1.2/KCNA2, 2245.93 nM for Kv1.6/KCNA6, 1006.48 nM for human Kv1.3/KCNA3, and 94.25
BscTx3
KCNA2
KCNA2
KCNA2
KCNA2
Girl/Female
Tamil
Hamsini | ஹமà¯à®¸à®¿à®¨à¯€
Who rides a swan, Saraswati
Boy/Male
Hindu
Medicine
Female
Hindi/Indian
(मोहना) Feminine form of Hindi Mohan, MOHANA means "attractive, bewitching."
Girl/Female
Hindu, Indian
From the Euxine; Black Sea
Girl/Female
Indian
The th Nakshathra, A bright star
Female
Greek
(ÎœÎγαιÏα) Greek name MEGAIRA means "grudge." In mythology, this is the name of one of the Furies (Erinyes). Virgil named two others: Alekto "unceasing" and Tisiphone "murder-retribution."
Girl/Female
Indian, Sanskrit
Woman
Male
Norse
 Old Norse equivalent of Old High German Siegfried, composed of the elements sigr "victory" and friør "love, peace," hence "victory-peace."
Boy/Male
Indian
The protector
Boy/Male
Hindu, Indian, Tamil, Traditional
Lord Rama; Pleasing; Charming
KCNA2
KCNA2
KCNA2
KCNA2
KCNA2