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Proteins involved in nucleocytoplasmic transport
Karyopherins are transport proteins involved in the nuclear transport of moving molecules between the cytoplasm and the nucleus of a eukaryotic cell. (The
Karyopherin
Protein family
Importin is a type of karyopherin involved in the nuclear transport of moving protein molecules from a cell's cytoplasm to the nucleus. It does so by
Importin
Type of amino acid sequence
allows the protein to bind to Importin β2 (also known as transportin or karyopherin β2), which then translocates the cargo protein into the nucleus. The
Nuclear_localization_sequence
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-4 also known as karyopherin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene. The transport of molecules
Importin_subunit_alpha-4
Class of adaptor proteins
Importin alpha, or karyopherin alpha refers to a class of adaptor proteins that are involved in the import of proteins into the cell nucleus. They are
Importin_α
Protein-coding gene in the species Homo sapiens
protein is a karyopherin which interacts with nuclear localization sequence to target nuclear proteins to the nucleus. The classical karyopherin receptor
Transportin_1
Protein-coding gene in the species Homo sapiens
importin alpha and beta subunits. Each of these subunits are part of the karyopherin family of proteins. Importin alpha binds the NLS-containing cargo in
KPNB1
Eukaryotic membrane-bounded organelle containing DNA
process mediated by a family of transport factors known as karyopherins. Those karyopherins that mediate movement into the nucleus are also called importins
Cell_nucleus
Protein-coding gene in the species Homo sapiens
1016/S0014-5793(97)01265-9. PMID 9395085. S2CID 84237136. "Entrez Gene: KPNA5 karyopherin alpha 5 (importin alpha 6)". Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear
Importin_subunit_alpha-6
Protein-coding gene in the species Homo sapiens
first step of nuclear import are members of the alpha importin family of karyopherins such as importin subunit alpha-1. These include the Xenopus protein importin
Importin_subunit_alpha-1
Protein-coding gene in the species Homo sapiens
"Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes"
Importin_subunit_alpha-5
Protein-coding gene in the species Homo sapiens
receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin
Importin_subunit_alpha-7
Protein-coding gene in the species Homo sapiens
Importin subunit alpha-3, also known as karyopherin subunit alpha-4, is a protein that in humans is encoded by the KPNA4 gene. The nuclear import of karyophilic
Importin_subunit_alpha-3
Openings in nuclear envelope of eukaryotic cells
hydrolase-dependent process. This family is further subdivided to the karyopherin-α and the karyopherin-β subfamilies. Other nuclear transport receptors include NTF2
Nuclear_pore_complex
Protein-coding gene in the species Homo sapiens
Blobel G, Radu A (September 1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153". Proc. Natl
NUP98
Protein-coding gene in the species Homo sapiens
salivary gland pleomorphic adenomas. PLAG1 has been shown to interact with Karyopherin alpha 2. GRCh38: Ensembl release 89: ENSG00000181690 – Ensembl, May 2017
PLAG1
Family of proteins that form the nuclear pore complex
transporter molecules karyopherins. Karyopherins will bind to their cargo, and reversibly interact with the FG repeats in nucleoporins. Karyopherins and their cargo
Nucleoporin
GTPase functioning in nuclear transport
transport of proteins across the nuclear envelope by interacting with karyopherins and changing their ability to bind or release cargo molecules. Cargo
Ran_(protein)
Mechanism of molecules moving across the nuclear membrane
association with transport factors known as nuclear transport receptors, like karyopherins called importins to enter the nucleus and exportins to exit. Proteins
Nuclear_transport
Singaporean nano- and biophysicist
phenomenon can be leveraged towards bio-inspired applications. He studies how karyopherin receptors facilitate this highly rapid and selective process through
Roderick_Lim
Small non-coding ribonucleic acid molecule
nucleocytoplasmic shuttler Exportin-5. This protein, a member of the karyopherin family, recognizes a two-nucleotide overhang left by the RNase III enzyme
MicroRNA
discovery of a large family of nuclear transport factors – broadly termed karyopherins (aka importins and exportins). Together with his colleagues, he introduced
John_D._Aitchison
Protein-coding gene in the species Homo sapiens
directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein
ZBTB33
Protein-coding gene in the species Homo sapiens
PMC 2132560. PMID 9298975. Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proceedings of
TNPO2
Protein-coding gene in the species Homo sapiens
binds NTF2 suggesting the formation of a higher order gating complex. Karyopherin beta2 (transportin), a riboprotein transporter also interacts with p62
Nuclear_pore_glycoprotein_p62
Protein-coding gene in the species Homo sapiens
anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role
Nucleoporin_153
Protein-coding gene in humans
autism spectrum disorder. UBR5 has been shown to interact with: CIB1, Karyopherin alpha 1, MAPK1, and TOPBP1. GRCh38: Ensembl release 89: ENSG00000104517
UBR5
Class of anticancer drugs
development of the SINE compounds. SINEs work by binding to CRM1, a karyopherin which performs nuclear transport of hundreds of proteins—including tumor
Selective inhibitor of nuclear export
Selective_inhibitor_of_nuclear_export
Cellular process
through the hydrophobic central channel of the nuclear pore complex. The karyopherin Crm1 is the receptor for both ribosomal subunits and mediates export
Ribosome_biogenesis
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List of MeSH codes (D12.776.660)
List_of_MeSH_codes_(D12.776.660)
Protein-coding gene in the species Homo sapiens
have been found for this gene. ARL4A has been shown to interact with Karyopherin alpha 2. GRCh38: Ensembl release 89: ENSG00000122644 – Ensembl, May 2017
ARL4A
Protein tandem repeat
Representative examples of HEAT repeat proteins include importin β (also known as karyopherin β) family, regulatory subunits of condensin and cohesin, separase, PIKKs
HEAT_repeat
necessary for the transport of proteins into and out of the nucleus by karyopherin proteins. In mammalian and plant cells, RanGAP is located at the nuclear
RanGAP
Protein found in humans
CIITA, NMD3, Nucleoporin 62, RANBP1, RANBP3, Ran, SMARCB1, and p53. Karyopherin Importin Nuclear transport Nuclear export signal GRCh38: Ensembl release
XPO1
Protein-coding gene in the species Homo sapiens
PMC 2674570. PMID 19436707. Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proceedings of
NXF1
Protein-coding gene in the species Homo sapiens
Yamazaki T, Hanada K, et al. (June 2007). "Differential regulation of karyopherin alpha 2 expression by TGF-beta1 and IFN-gamma in normal human epidermal
IRF1
transport between the nucleus and the cytoplasm. For example, the beta-karyopherin superfamily consists of alpha solenoid proteins formed from HEAT repeats;
Alpha_solenoid
Protein found in humans
Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. Bibcode:1997PNAS
60S_ribosomal_protein_L13
Chemical compound
export signal (NES) can be transported to the cytoplasm by binding to a karyopherin protein called chromosome region maintenance 1 (CRM1)/exportin 1. This
Callystatin_A
Importin alpha 1 Interferon, alpha 1 Interleukin 13 receptor, alpha 1 Karyopherin alpha 1 Laminin, alpha 1 Major histocompatibility complex, class II,
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Species of virus
associated with VP2 or VP3. Nuclear localization sequences consistent with karyopherin interactions have been identified in capsid protein sequences, facilitating
Murine_polyomavirus
Protein-coding gene in the species Homo sapiens
receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin
IPO5
Protein-coding gene in the species Homo sapiens
common and reversible modification that impairs the protein's binding of karyopherin beta (Transportin-1) resulting in nuclear localization of hnRNPA1. hnRNP A1
HNRNPA1
Protein-coding gene in the species Homo sapiens
facilitates the nuclear import of splicing factor TXNL4A through the karyopherin β2 receptor". The Journal of Biological Chemistry. 295 (13): 4093–4100
PQBP1
Anti-cancer drug
works by binding to exportin 1 (also known as XPO1 or CRM1). XPO1 is a karyopherin which performs nuclear transport of several proteins, including tumor
Selinexor
Protein family
new virions are assembled. This nuclear import process, mediated by karyopherins, acts on assembled VP1 pentamers in complex with VP2 or VP3; oligomerization
Major_capsid_protein_VP1
Indian cell biologist
Malhotra, Pawan; Chauhan, Virander S. (1 May 2005). "Identification of karyopherin β as an immunogenic antigen of the malaria parasite using immune mice
Asif_Mohmmed
Amino acid sequence causing a protein to be exported from the nucleus to the cytoplasm
(HIV-1) Rev protein and cAMP-dependent protein kinase inhibitor (PKI). The karyopherin receptor CRM1 has been identified as the export receptor for leucine-rich
Nuclear_export_signal
Protein-coding gene in the species Homo sapiens
An SRP1 is also found from the 23-399 amino acids. The SRP1 domain is Karyopherin(importin) alpha. This is involved in the exchange of molecules from the
TMCO6
Protein-coding gene in the species Homo sapiens
of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip". The Journal of Biological Chemistry. 275 (14): 10099–104
RCC1
Protein-coding gene in the species Homo sapiens
"Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13". Molecular and Cellular Biology. 24 (11): 4824–4834. doi:10.1128/MCB
IPO13
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Chain 1 KPNA1 Importin-ɑ5 Karyopherin Subunit Alpha 1 KPNA2 Importin-ɑ1 Karyopherin Subunit Alpha 2 KPNA3 Importin-ɑ4 Karyopherin Subunit Alpha 3 KPNA6 Importin-ɑ7
Stress_granule
Protein-coding gene in the species Homo sapiens
PMID 10400669. Brownawell AM, Macara IG (January 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". The
ILF3
Medicine. Brownawell AM, Macara IG (Jan 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". The
XPO5
One of the five main histone proteins
nucleus. Proteins responsible for nuclear import of H2A protein are karyopherin and importin. Recent studies also show that nucleosome assembly protein
Histone_H2A
Protein embedded in inner membrane of nuclear envelope
S2CID 31393050. King, Megan C.; Patrick Lusk, C.; Blobel, Günter (2006). "Karyopherin-mediated import of integral inner nuclear membrane proteins". Nature
Inner nuclear membrane protein
Inner_nuclear_membrane_protein
Protein-coding gene in the species Homo sapiens
Yaseen NR, Blobel G (Apr 1997). "Cloning and characterization of human karyopherin beta3". Proceedings of the National Academy of Sciences of the United
Nucleoporin_214
Protein-coding gene in the species Homo sapiens
localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)". International Immunology. 13 (10): 1265–1274. doi:10
ITK_(gene)
Protein-coding gene in the species Homo sapiens
Yaseen NR, Blobel G (Apr 1997). "Cloning and characterization of human karyopherin beta3". Proceedings of the National Academy of Sciences of the United
RANBP2
Matrix protein
Additionally, eVP24 inhibits interferon signaling by competitively binding to karyopherins which blocks phosphorylated STAT1 nuclear import. In 2014, it was found
Ebola_viral_protein_24
Protein-coding gene in the species Homo sapiens
have been described. RECQL has been shown to interact with KPNA4 and Karyopherin alpha 2. GRCh38: Ensembl release 89: ENSG00000004700 – Ensembl, May 2017
RECQL
Coronavirus gene encoding an accessory protein
binding of ORF6 protein to karyopherins. In SARS-CoV-2, the ORF6 protein reportedly interacts with RAE1 and NUP98, blocking karyopherin interactions. Ninot-Pedrosa
ORF6
Protein found in humans
Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin β3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. Bibcode:1997PNAS.
60S_ribosomal_protein_L23
Protein-coding gene in the species Homo sapiens
contain the NLS, the sequence in DUT-M is sequestered away from cognate karyopherins. The isoelectric points of DUT-N (6.0) and DUT-M (8.1) correspond to
DUT_(gene)
Protein family
capsid proteins can bind via its nuclear localisation signal (NLS) to karyopherins Kapbeta(2) and Kapbeta(3) and inhibit the Kapbeta(2) and Kapbeta(3) nuclear
Late_protein
Classification of membrane proteins including ion channels
PMP22-Claudin (Claudin2) Family 1.I.1 Nuclear pore complex family, including karyopherins 1.I.2 Plant plasmodesmata family 2.A.1 Major Facilitator superfamily
Transporter Classification Database
Transporter_Classification_Database
585.750.500 – karyopherins MeSH D12.776.543.585.750.500.100 – alpha karyopherins MeSH D12.776.543.585.750.500.249 – beta karyopherins MeSH D12.776.543
List of MeSH codes (D12.776.543)
List_of_MeSH_codes_(D12.776.543)
University. Diaz, Connor; G. Thankam, Finosh; K. Agrawal, Devendra (2023). "Karyopherins in the Remodeling of Extracellular Matrix: Implications in Tendon Injury"
C19orf38
530.750.500 – karyopherins MeSH D12.776.157.530.750.500.100 – alpha karyopherins MeSH D12.776.157.530.750.500.249 – beta karyopherins MeSH D12.776.157
List of MeSH codes (D12.776.157)
List_of_MeSH_codes_(D12.776.157)
KARYOPHERIN
KARYOPHERIN
KARYOPHERIN
KARYOPHERIN
Girl/Female
Hindu
Good minded
Boy/Male
Hindu
Praise of the glorious protector, Lord Krishna
Girl/Female
Spanish
Light; illumination.
Girl/Female
Spanish
Altar of heaven.
Male
Egyptian
, the deity of the setting sun.
Boy/Male
Hindu
One of the name of Lord Shiva
Boy/Male
Latin Teutonic
Majestic.
Girl/Female
British, English
Flower
Girl/Female
Biblical
Smoke.
Biblical
the plain; that makes equality
KARYOPHERIN
KARYOPHERIN
KARYOPHERIN
KARYOPHERIN
KARYOPHERIN