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Chemical compound
Isatin, also known as tribulin, is an organic compound derived from indole with formula C8H5NO2. The compound was first obtained by Otto Linné Erdman and
Isatin
Swiss chemical engineer (1854–1922)
of isatin. and several reactions have been named after him: Sandmeyer isonitrosoacetanilide isatin synthesis(1919) and Sandmeyer diphenylurea isatin synthesis(1903)
Traugott_Sandmeyer
Chemical reaction
(also known as the Pfitzinger-Borsche reaction) is the chemical reaction of isatin with base and a carbonyl compound to yield substituted quinoline-4-carboxylic
Pfitzinger_reaction
Chemical reaction
better catalyzed by catalyst with trifluoromethyl group chiral barriers. Isatin-derived ketimine commonly undergoes catalytic asymmetric Mannich reaction
Ketimine_Mannich_reaction
Chemical compound
such as in the hydrolysis of vinyl halides and the allylation of isatins and isatin ketoimines. Johansson, Georg; Sandström, Magnus; Mosbæk, H.; Søtofte
Mercury(II)_perchlorate
Chemical sedative and hypnotic drug
acid, which serves as the desiccant. Notably, it is used to synthesize isatin. In this synthesis, chloral hydrate reacts with aniline and hydroxylamine
Chloral_hydrate
Chemical compound
and sorbitol. Oxyphenisatin has cathartic properties. The ketone group of isatin (1) is nonenolizable and has interesting properties. In strong acid it becomes
Oxyphenisatine
Blue dye derived from indigo
Another use is as a dissolved ozone indicator through the conversion to isatin-5-sulfonic acid. This reaction has been shown not to be specific to ozone:
Indigo_carmine
Species of flowering plant
isatis-tinctoria CoL: 3Q3HY EoL: 583877 EPPO: ISATI EUNIS: 164558 FEIS: isatin FNA: 200009571 FoC: 200009571 GBIF: 5374118 GRIN: 20462 iNaturalist: 77509
Isatis_tinctoria
Sulfur-containing aromatic compound
Viktor Meyer in 1882 as a contaminant in benzene. It was observed that isatin (an indole) forms a blue dye if it is mixed with sulfuric acid and crude
Thiophene
Chemical compound, food additive and dye
synthesis of indigo. He described his first synthesis of indigo in 1878 (from isatin) and a second synthesis in 1880 (from 2-nitrobenzaldehyde). (It was not
Indigo_dye
Chemical compound
synthesis, using anthranilic acid and ketones Pfitzinger reaction using an isatin with base and a carbonyl compound to yield substituted quinoline-4-carboxylic
Quinoline
Chemical compound
to develop with the study of the dye indigo. Indigo can be converted to isatin and then to oxindole. In 1866, Adolf von Baeyer reduced oxindole to indole
Indole
142–82–5 C8H4F3IO2 Togni reagent II C8H5F3N2OS riluzole 1744–22–5 C8H5NO2 isatin 91–56–5 C8H6BrN 5-bromoindole 10075–50–0 6-bromoindole 52415–29–9 C8H6ClN
Glossary_of_chemical_formulae
Method to determine protein concentration
Notably, Smith synthesized their own BCA via the Pfitzinger reaction of isatin and acetoin, substituting NaOH for KOH but otherwise following the synthetic
Bicinchoninic_acid_assay
Chemical compound
7-Dihydroisoindole Indole Indene Indoline Benzofuran Carbazole Carboline Isatin Methylindole Oxindole Pyrrole Skatole Benzene Isoindoline Isoindoline Speck
Isoindoline
Salol reaction Sandheimer Sandmeyer diphenylurea isatin synthesis Sandmeyer isonitrosoacetanilide isatin synthesis Sandmeyer reaction Sanger reagent Saponification
List_of_organic_reactions
Withdrawn antidepressant medication
remained unclear. Nomifensine was a progenitor to Gastrophenzine. See also: Isatin derivatives. The alkylation between N-methyl-2-nitrobenzylamine [56222-08-3]
Nomifensine
3.5.2.18: enamidase EC 3.5.2.19: streptothricin hydrolase EC 3.5.2.20: isatin hydrolase EC 3.5.3.1: arginase EC 3.5.3.2: guanidinoacetase EC 3.5.3.3:
List_of_EC_numbers_(EC_3)
Chemical compound
ordinary bond of this type is only 148 pm and for comparison the C-C bond in isatin is 154 pm long. On the other hand, no change is recorded in the aromatic
Tricyclobutabenzene
German chemist (1851–1930)
been named the Claisen rearrangement. Synthesis of isatin via a process known as the Claisen isatin synthesis, described for the first time in 1879. Designer
Rainer_Ludwig_Claisen
31741-76-1 C8H5NOS benzoyl isothiocyanate 532-55-8 C8H5NO2 isatin 91-56-5 C8H5NO2 phthalimide 85-41-6 C8H5NO3 isatoic anhydride 118-48-9 C8H5N3
List of compounds with carbon number 8
List_of_compounds_with_carbon_number_8
Index of chemical compounds with the same molecular formula
Indole-5,6-quinone, a chemical present in the browning reaction of fruits Isatin Phthalimide This set index page lists chemical structure articles associated
C8H5NO2
Protein found in humans
ANGSTROM CRYSTAL STRUCTURE OF CASPASE-3 (APOPAIN OR CPP32)IN COMPLEX WITH AN ISATIN SULFONAMIDE INHIBITOR. 1i3o: CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2
Caspase_3
Chemical compound
temperature within 12 hours. In the Pfitzinger reaction of 1-tetralone with isatin, a compound called tetrofan (3,4-dihydro-1,2-benzacridine-5-carboxylic acid)
1-Tetralone
Muscle enzyme involved in glycogen breakdown
interact with PRKAB2, WDYHV1, PYGL, PYGB, 5-aminoisatin, 5-nh2_caproyl-isatin, PHKG1, PPP1CA, PPP1R3A, DEGS1, SET, MAP3K3, INPP5K, PACSIN3, CLASP2, NIPSNAP2
Myophosphorylase
Chemical reaction
desired dioxindole (10). In the presence of oxygen, dioxindole converts to isatin through oxidation. The Martinet dioxindole synthesis is utilized in the
Martinet_dioxindole_synthesis
Reaction in organic chemistry
a dye of the so-called Ciba-Scarlet type, while condensation of 7 with isatin results in the thioindigo dye 9. W. K. Warburton (1957). "Arylthiazathiolium
Herz_reaction
Chemical reaction
B. Partale, W. (1927). "Diazo-methan undo-Nitroverbindungen, II.:N-Oxy-isatin auso-Nitro-benzoylchlorid". Chem. Ber. 60 (6): 1364–1370. doi:10.1002/cber
Wolff_rearrangement
Reactions in organic chemistry
doi:10.1002/prac.19301280101. Sumpter, Ward C. (1944). "The Chemistry of Isatin". Chem. Rev. 34 (3): 393–434. doi:10.1021/cr60109a003. Sumpter, Ward C.
Stollé_synthesis
Chemical compound
Bisoxatin (formula: C20H15NO4) is a laxative. It can be synthesized from isatin. Reddy, Srinivas Reddy Desi; Rane, Dnyandev Ragho; Velivela, Srinivas Rao;
Bisoxatin
Protein-coding gene in the species Homo sapiens
selective and further analogs (see 3d model) Chromone-3-phenylcarboxamides Isatins Phthalimides 8-Benzyloxycaffeines and CSC analogs (E
Monoamine_oxidase_B
Chemical compound
Naguib M (August 2008). "Design and Synthesis of a Novel Series of N-Alkyl Isatin Acylhydrazone Derivatives that Act as Selective Cannabinoid Receptor 2 Agonists
MDA-19
Chemical compound
Hetero-Diels-Alder Reaction of Danishefsky's Diene with α-Ketoesters and Isatins Catalyzed by a Chiral N , N′ -Dioxide/Magnesium(II) Complex". Chemistry
Danishefsky's_diene
Indian chemist
antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one". Pharmaceutica
Surendra_Nath_Pandeya
monoamine oxidase B inhibitory component of tribulin was later identified as isatin. This research included studies carried out at HM Prison Wormwood Scrubs
Merton_Sandler
American chemical engineer
for his paper "The Tolymercaptopropanones and their Condensation with Isatins" in 1947, which was published in the Journal of the American Chemical Society
Paul_K._Calaway
Chemical compound
Naguib M (August 2008). "Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists
BZO-CHMOXIZID
Protein-coding gene in the species Homo sapiens
allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins". Journal of Medicinal Chemistry. 52 (11): 3445–8. doi:10.1021/jm900286j
Muscarinic acetylcholine receptor M5
Muscarinic_acetylcholine_receptor_M5
Chemical compound
allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins". Journal of Medicinal Chemistry. 52 (11): 3445–3448. doi:10.1021/jm900286j
VU-0238429
Sriram D (October 2005). "Synthesis and evaluation of anti-HIV activity of isatin beta-thiosemicarbazone derivatives". Bioorganic & Medicinal Chemistry Letters
Discovery and development of non-nucleoside reverse-transcriptase inhibitors
Discovery_and_development_of_non-nucleoside_reverse-transcriptase_inhibitors
432 – indoramin MeSH D03.438.473.469 – iprindole MeSH D03.438.473.525 – isatin MeSH D03.438.473.600 – mazindol MeSH D03.438.473.615 – methisazone MeSH D03
List_of_MeSH_codes_(D03)
ISATIN
ISATIN
ISATIN
ISATIN
Girl/Female
Biblical American Latin
Watered by the dew.
Boy/Male
Arabic, Australian, Muslim, Pashtun
Made of Gold Metal
Boy/Male
Indian, Punjabi, Sikh
Queen of Flowers
Boy/Male
Tamil
Son, Inheritor
Surname or Lastname
English
English : unexplained. It is said to be from Old French dix marcs ‘ten marks’, perhaps denoting a valuation, but this is doubtful.
Girl/Female
Muslim
Happiness. Bliss. Felicity.
Boy/Male
Hindu, Indian, Sanskrit
The Lord of Rama
Girl/Female
Sikh
Diamond, Queen of gods
Boy/Male
Indian
Inhabitant
Girl/Female
Tamil
A woman with beautiful hair
ISATIN
ISATIN
ISATIN
ISATIN
ISATIN
n.
An orange-red crystalline substance, C8H5NO2, obtained by the oxidation of indigo blue. It is also produced from certain derivatives of benzoic acid, and is one important source of artificial indigo.
n.
A white crystalline substance obtained by the partial reduction of isatin.
a.
Alt. of Isatinic
n.
A white, crystalline, nitrogenous substance obtained by the reduction of isatin. It is a member of the indol series; -- hence its name.
n.
A dark yellow, crystalline substance, obtained by the action of ammonia on isatin.
n.
A complex nitrogenous radical, C8H4NO2, regarded as the essential residue of a series of compounds, related to isatin, which easily pass by reduction to indigo blue.
n.
One of a series of anhydrides resembling the lactams, but of an imido type; as, isatine is a lactim. Cf. Lactam.
a.
Pertaining to, or derived from, isatin; as, isatic acid, which is also called trioxindol.