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INOSITOL TRISPHOSPHATE

  • Inositol trisphosphate
  • Chemical compound

    Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis

    Inositol trisphosphate

    Inositol_trisphosphate

  • Inositol trisphosphate receptor
  • Class of transport proteins

    Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3). InsP3R

    Inositol trisphosphate receptor

    Inositol trisphosphate receptor

    Inositol_trisphosphate_receptor

  • Inositol
  • Carbocyclic sugar

    biochemistry, medicine, and related sciences, inositol generally refers to myo-inositol (formerly meso-inositol), the most important stereoisomer of the chemical

    Inositol

    Inositol

    Inositol

  • Phosphatidylinositol (3,4,5)-trisphosphate
  • Chemical compound

    Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I phosphoinositide 3-kinases' (PI 3-kinases)

    Phosphatidylinositol (3,4,5)-trisphosphate

    Phosphatidylinositol (3,4,5)-trisphosphate

    Phosphatidylinositol_(3,4,5)-trisphosphate

  • Inositol phosphate
  • Class of chemical compounds

    inositol ring. inositol monophosphate (IP or IP1) inositol bisphosphate (IP2) inositol trisphosphate (IP3) inositol tetrakisphosphate (IP4) inositol pentakisphosphate

    Inositol phosphate

    Inositol phosphate

    Inositol_phosphate

  • Inositol-trisphosphate 3-kinase
  • Class of enzymes

    Inositol (1,4,5) trisphosphate 3-kinase (EC 2.7.1.127), abbreviated here as ITP3K, is an enzyme that facilitates a phospho-group transfer from adenosine

    Inositol-trisphosphate 3-kinase

    Inositol-trisphosphate 3-kinase

    Inositol-trisphosphate_3-kinase

  • Inositol-1,3,4-trisphosphate 5/6-kinase
  • inositol-1,3,4-trisphosphate 5/6-kinase (EC 2.7.1.159, Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase) is an enzyme with systematic name ATP:1D-myo-inositol

    Inositol-1,3,4-trisphosphate 5/6-kinase

    Inositol-1,3,4-trisphosphate_5/6-kinase

  • Ryanodine receptor
  • Class of intracellular transport proteins

    but they are shorter than the mammalian ones and may be closer to inositol trisphosphate (IP3) receptors. Ryanodine receptors mediate the release of calcium

    Ryanodine receptor

    Ryanodine receptor

    Ryanodine_receptor

  • Phosphatidylinositol
  • Signaling molecule

    Phosphatidylinositol or inositol phospholipid is a biomolecule. It was initially called "inosite" when it was discovered by Léon Maquenne and Johann Joseph

    Phosphatidylinositol

    Phosphatidylinositol

    Phosphatidylinositol

  • Inositol-polyphosphate 5-phosphatase
  • Class of enzymes

    The enzyme inositol-polyphosphate 5-phosphatase (EC 3.1.3.56), systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase, catalyses the following

    Inositol-polyphosphate 5-phosphatase

    Inositol-polyphosphate_5-phosphatase

  • Inositol polyphosphate kinase
  • Enzyme family

    various inositol phosphates. Members of the family include inositol-polyphosphate multikinases, inositol-hexakisphosphate kinases, inositol-trisphosphate 3-kinases

    Inositol polyphosphate kinase

    Inositol polyphosphate kinase

    Inositol_polyphosphate_kinase

  • Inositol-polyphosphate multikinase
  • Class of enzymes

    AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase

    Inositol-polyphosphate multikinase

    Inositol-polyphosphate_multikinase

  • ITPKB
  • Protein-coding gene in the species Homo sapiens

    Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene. The protein encoded by the ITPKB gene is one of 3 isoforms

    ITPKB

    ITPKB

    ITPKB

  • Inositol-phosphate phosphatase
  • Class of enzymes

    phosphatase, myo-inositol 1-phosphatase, inositol phosphatase, inositol monophosphate phosphatase, inositol-1(or 4)-monophosphatase, myo-inositol-1(or 4)-phosphate

    Inositol-phosphate phosphatase

    Inositol-phosphate phosphatase

    Inositol-phosphate_phosphatase

  • ITPR1
  • Protein-coding gene in the species Homo sapiens

    Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene. ITPR1 has been shown to interact with: AHCYL1, CA8

    ITPR1

    ITPR1

    ITPR1

  • ITPKA
  • Protein-coding gene in the species Homo sapiens

    Inositol-trisphosphate 3-kinase A is an enzyme that in humans is encoded by the ITPKA gene. ITPKA is one of three inositol-trisphosphate 3-kinase (ITP3K)

    ITPKA

    ITPKA

    ITPKA

  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
  • Phosphatase enzyme

    4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase

    Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

    Phosphatidylinositol-3,4,5-trisphosphate_5-phosphatase

  • ITPR2
  • Protein-coding gene in humans

    Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this

    ITPR2

    ITPR2

    ITPR2

  • Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
  • Class of enzymes

    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) catalyzes the chemical reaction 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O =

    Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

    Phosphatidylinositol-3,4,5-trisphosphate_3-phosphatase

  • Inositol-tetrakisphosphate 1-kinase
  • Enzyme

    inositol-trisphosphate 6-kinase, 1D-myo-inositol-trisphosphate 6-kinase, ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase, inositol-trisphosphate 5-kinase

    Inositol-tetrakisphosphate 1-kinase

    Inositol-tetrakisphosphate_1-kinase

  • Muscarinic acetylcholine receptor
  • Acetylcholine receptors named for their selective binding of muscarine

    class Gq, which use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signaling pathway. A receptor so

    Muscarinic acetylcholine receptor

    Muscarinic acetylcholine receptor

    Muscarinic_acetylcholine_receptor

  • Gq alpha subunit
  • Family of heterotrimeric G protein alpha subunits

    phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium

    Gq alpha subunit

    Gq_alpha_subunit

  • Myo-Inositol trispyrophosphate
  • Chemical compound

    cardiovascular disease and dementia Phytic acid Inositol Inositol phosphate Inositol trisphosphate myo-Inositol Biolo, A; Greferath, R; Siwik, DA; Qin, F;

    Myo-Inositol trispyrophosphate

    Myo-Inositol trispyrophosphate

    Myo-Inositol_trispyrophosphate

  • ITPR3
  • Protein-coding gene in the species Homo sapiens

    Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this

    ITPR3

    ITPR3

    ITPR3

  • Sweetness
  • Basic taste

    a G-protein gustducin and this sets off a signal which includes inositol trisphosphate (IP3), calcium release, and the opening of TRPM5 channels. This

    Sweetness

    Sweetness

    Sweetness

  • Mast cell
  • Cell found in connective tissue

    to catalyze phosphatidylinositol bisphosphate breakdown to yield inositol trisphosphate (IP3) and diacyglycerol (DAG). IP3 elevates calcium levels, and

    Mast cell

    Mast cell

    Mast_cell

  • Hydralazine
  • Anti-hypertension medication

    the arterial bed. The molecular mechanism involves inhibition of inositol trisphosphate-induced Ca2+ release from the sarcoplasmic reticulum in arterial

    Hydralazine

    Hydralazine

    Hydralazine

  • Ligand-gated ion channel
  • Type of ion channel transmembrane protein

    channel Voltage-dependent calcium channel Receptor (biochemistry) Inositol trisphosphate receptor Metabotropic receptor Ryanodine receptor "Gene Family:

    Ligand-gated ion channel

    Ligand-gated ion channel

    Ligand-gated_ion_channel

  • Nicotinamide adenine dinucleotide
  • Chemical compound which is reduced and oxidized

    calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate". J. Biol. Chem. 262 (20): 9561–8. doi:10.1016/S0021-9258(18)47970-7

    Nicotinamide adenine dinucleotide

    Nicotinamide adenine dinucleotide

    Nicotinamide_adenine_dinucleotide

  • Michael Berridge
  • British physiologist and biochemist

    for his work on cell signaling, in particular the discovery that inositol trisphosphate acts as a second messenger, linking events at the plasma membrane

    Michael Berridge

    Michael_Berridge

  • L-type calcium channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    L-type calcium channel

    L-type calcium channel

    L-type_calcium_channel

  • Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels
  • Group of membrane channel proteins

    The ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channel (RIR-CaC) family includes Ryanodine receptors and Inositol trisphosphate receptors. Members

    Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels

    Ryanodine-Inositol_1,4,5-triphosphate_receptor_calcium_channels

  • Phosphoinositide phospholipase C
  • Protein family

    messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG). The chemical reaction may be expressed as: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

    Phosphoinositide phospholipase C

    Phosphoinositide phospholipase C

    Phosphoinositide_phospholipase_C

  • Second messenger system
  • System of signaling molecules within a cell

    transduction. The enzyme phospholipase C produces diacylglycerol and inositol trisphosphate, which increases calcium ion permeability into the membrane. Active

    Second messenger system

    Second_messenger_system

  • Pacemaker current
  • Electric current in the heart

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Pacemaker current

    Pacemaker_current

  • Muscarinic acetylcholine receptor M1
  • Protein-coding gene in the species Homo sapiens

    class Gq that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so

    Muscarinic acetylcholine receptor M1

    Muscarinic acetylcholine receptor M1

    Muscarinic_acetylcholine_receptor_M1

  • Barbara E. Ehrlich
  • American biologist and academic (born 1952)

    Recent research investigates the function of polycystin-2, the inositol trisphosphate receptor, and the ryanodine receptor. Ehrlich was born in New London

    Barbara E. Ehrlich

    Barbara E. Ehrlich

    Barbara_E._Ehrlich

  • PLCD1
  • Protein-coding gene in the species Homo sapiens

    Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation

    PLCD1

    PLCD1

    PLCD1

  • 2-Aminoethoxydiphenyl borate
  • Chemical compound

    inhibition. Diver, J. M.; Sage, S. O.; Rosado, J. A. (2001-11-01). "The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+

    2-Aminoethoxydiphenyl borate

    2-Aminoethoxydiphenyl borate

    2-Aminoethoxydiphenyl_borate

  • Voltage-gated ion channel
  • Type of ion channel transmembrane protein

    voltage-gated ion channels, including: inwardly rectifying K+ channels, ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channels, transient receptor potential

    Voltage-gated ion channel

    Voltage-gated ion channel

    Voltage-gated_ion_channel

  • Magnesium transporter
  • Protein family

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Magnesium transporter

    Magnesium_transporter

  • Adrenaline
  • Hormone and medication

    Adrenaline also binds to α1 adrenergic receptors, causing an increase in inositol trisphosphate, inducing calcium ions to enter the cytoplasm. Calcium ions bind

    Adrenaline

    Adrenaline

    Adrenaline

  • Calreticulin
  • Soluble protein

    affinity, but high capacity, and can be released on a signal (see inositol trisphosphate). Calreticulin is located in storage compartments associated with

    Calreticulin

    Calreticulin

    Calreticulin

  • Vomeronasal receptor
  • Class of olfactory receptors

    expressing Gi2. Coupling of the receptors to this protein mediates inositol trisphosphate signaling. A number of human V1 receptor homologues have also been

    Vomeronasal receptor

    Vomeronasal receptor

    Vomeronasal_receptor

  • ITPK1
  • Protein-coding gene in the species Homo sapiens

    of Medicine. Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme"

    ITPK1

    ITPK1

    ITPK1

  • KiSS1-derived peptide receptor
  • Mammalian protein found in Homo sapiens

    of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell. Kisspeptins are neuropeptides

    KiSS1-derived peptide receptor

    KiSS1-derived peptide receptor

    KiSS1-derived_peptide_receptor

  • Caffeine
  • Central nervous system stimulant

    addition to its activity at adenosine receptors, caffeine is an inositol trisphosphate receptor 1 antagonist and a voltage-independent activator of the

    Caffeine

    Caffeine

    Caffeine

  • Skin sloughing
  • Shedding dead surface cells off the skin

    Phospholipase C triggers the release of intracellular calcium through inositol trisphosphate (IP3) and diacylglycerol (DAG). This increase of calcium then induces

    Skin sloughing

    Skin_sloughing

  • Babraham Institute
  • Life sciences research institution

    include the discovery of liposomes by Alec Bangham, the role of Inositol trisphosphate in the release of calcium from intracellular stores by Michael Berridge

    Babraham Institute

    Babraham Institute

    Babraham_Institute

  • Caffeine patch
  • Transdermal patch that releases caffeine into the body

    Apart from blocking adenosine receptors, caffeine also blocks the inositol trisphosphate receptor 1, the ionotropic glycine receptor, and activates ryanodine

    Caffeine patch

    Caffeine_patch

  • Head-twitch response
  • Head movement in rodents upon 5-HT2A receptor activation

    phosphatidylinositol-4,5-bisphosphate, leading to intracellular Ca2+ release by inositol trisphosphate and the activation of protein kinase C by diacylglycerol [18]. Gq-biased

    Head-twitch response

    Head-twitch response

    Head-twitch_response

  • Sperm chemotaxis
  • Guidance of sperm

    and protein kinase A as well as soluble guanylyl cyclase, cGMP, inositol trisphosphate receptor and store-operated Ca2+ channel was proposed. Chemotaxis

    Sperm chemotaxis

    Sperm_chemotaxis

  • Phosphatidylinositol-4,5-bisphosphate 3-kinase
  • 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate ⇌ {\displaystyle \rightleftharpoons } ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate Thus, the two substrates

    Phosphatidylinositol-4,5-bisphosphate 3-kinase

    Phosphatidylinositol-4,5-bisphosphate_3-kinase

  • HCN channel
  • Intermembrane proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    HCN channel

    HCN_channel

  • Alpha-1 adrenergic receptor
  • G protein-coupled receptor

    (PLC), which causes phosphatidylinositol to be transformed into inositol trisphosphate (IP3) and diacylglycerol (DAG). While DAG stays near the membrane

    Alpha-1 adrenergic receptor

    Alpha-1_adrenergic_receptor

  • Arachidonic acid
  • Fatty acid used metabolically in many organisms

    from phospholipids after phospholipase C (PLC) cleaves off the inositol trisphosphate group, yielding diacylglycerol (DAG), which subsequently is cleaved

    Arachidonic acid

    Arachidonic acid

    Arachidonic_acid

  • Adenophostin
  • Chemical compound

    Adenophostin A is a potent inositol trisphosphate (IP3) receptor agonist, but is much more potent than IP3. IP3R is a ligand-gated intracellular Ca2+ release

    Adenophostin

    Adenophostin

    Adenophostin

  • Phospholipase C
  • Class of enzymes

    phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), which serve as second messengers. Activators of each PLC

    Phospholipase C

    Phospholipase C

    Phospholipase_C

  • Aquaporin
  • Water channel protein in cell membranes

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Aquaporin

    Aquaporin

    Aquaporin

  • Voltage-gated sodium channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Voltage-gated sodium channel

    Voltage-gated_sodium_channel

  • Ryanodine receptor 1
  • Protein and coding gene in humans

    site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor". The Biochemical Journal. 354 (Pt 2): 413–22. doi:10

    Ryanodine receptor 1

    Ryanodine receptor 1

    Ryanodine_receptor_1

  • Epithelial sodium channel
  • Group of membrane proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Epithelial sodium channel

    Epithelial sodium channel

    Epithelial_sodium_channel

  • Adrenergic receptor
  • Class of G protein-coupled receptors

    phosphatidylinositol 4,5-bisphosphate (PIP2), which in turn causes an increase in inositol trisphosphate (IP3) and diacylglycerol (DAG). The former interacts with calcium

    Adrenergic receptor

    Adrenergic receptor

    Adrenergic_receptor

  • Gap junction
  • Cell-cell junction composed of innexins or connexins

    between cells through the transmission of small second messengers, such as inositol triphosphate (IP 3) and calcium (Ca2+ ), although different hemichannel

    Gap junction

    Gap junction

    Gap_junction

  • Spheroplast
  • Microbe with cell wall mostly removed

     234. ISBN 978-0-470-08766-4. Calvert, C.M.; Sanders, D. (1995). "Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar

    Spheroplast

    Spheroplast

  • Aquaporin-2
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Aquaporin-2

    Aquaporin-2

    Aquaporin-2

  • Diglyceride
  • Type of fat derived from glycerol and two fatty acids

    enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate diffuses into the cytosol, diacylglycerol remains

    Diglyceride

    Diglyceride

    Diglyceride

  • Nav1.8
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Nav1.8

    Nav1.8

    Nav1.8

  • Ankyrin-2
  • Protein-coding gene in the species Homo sapiens

    the inositol trisphosphate receptor, and a reduction of ankyrin-B in neonatal cardiomyocytes reduces the half-life of the inositol trisphosphate receptor

    Ankyrin-2

    Ankyrin-2

    Ankyrin-2

  • TRPV1
  • Human protein for regulating body temperature

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    TRPV1

    TRPV1

    TRPV1

  • TRPC4
  • Protein and coding gene in humans

    hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Lett. 487 (3): 377–83. Bibcode:2001FEBSL.487

    TRPC4

    TRPC4

    TRPC4

  • Calcium channel
  • Ion channel complex through which calcium ions pass

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Calcium channel

    Calcium_channel

  • Zymolyase
  • Enzyme mixture

    Schizosaccahromyces, Torulopsis Calvert, C.M.; Sanders, D. (1995). "Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar

    Zymolyase

    Zymolyase

  • Membrane channel
  • via a positive feedback loop. In addition, P2Y receptors activate inositol trisphosphate, which leads to a transient increase in intracellular calcium, and

    Membrane channel

    Membrane_channel

  • Porin (protein)
  • Group of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Porin (protein)

    Porin (protein)

    Porin_(protein)

  • Calcium-binding protein 1
  • Protein found in humans

    calmodulin (CaM) superfamily which modulates Ca2+-dependent activity of inositol trisphosphate receptors (InsP3RS). L-CaBP1 is also associated with the cytoskeleton

    Calcium-binding protein 1

    Calcium-binding protein 1

    Calcium-binding_protein_1

  • Aquaporin-5
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Aquaporin-5

    Aquaporin-5

    Aquaporin-5

  • ATP-sensitive potassium channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    ATP-sensitive potassium channel

    ATP-sensitive_potassium_channel

  • CCL5
  • Mammalian protein found in humans

    Schaller HC (November 2006). "RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor

    CCL5

    CCL5

    CCL5

  • Muscarinic acetylcholine receptor M3
  • Protein and coding gene in humans

    proteins of class Gq, which upregulate phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. The calcium function

    Muscarinic acetylcholine receptor M3

    Muscarinic acetylcholine receptor M3

    Muscarinic_acetylcholine_receptor_M3

  • SK channel
  • Protein subfamily of calcium-activated potassium channels

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    SK channel

    SK channel

    SK_channel

  • Membrane transport protein
  • Membrane protein involved in transportation

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Membrane transport protein

    Membrane_transport_protein

  • Bestrophin 1
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Bestrophin 1

    Bestrophin 1

    Bestrophin_1

  • Transporter Classification Database
  • Classification of membrane proteins including ion channels

    superfamily 1.A.2 Inward-rectifier K+ channel family 1.A.3 Ryanodine-inositol-1,4,5-trisphosphate receptor Ca2+ channel family 1.A.4 Transient receptor potential

    Transporter Classification Database

    Transporter_Classification_Database

  • List of Clarivate Citation laureates in Physiology or Medicine
  • "for research on cell signaling, particularly discovering that inositol trisphosphate acts as a second messenger, linking events at the plasma membrane

    List of Clarivate Citation laureates in Physiology or Medicine

    List_of_Clarivate_Citation_laureates_in_Physiology_or_Medicine

  • Cystic fibrosis transmembrane conductance regulator
  • Mammalian protein found in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Cystic fibrosis transmembrane conductance regulator

    Cystic fibrosis transmembrane conductance regulator

    Cystic_fibrosis_transmembrane_conductance_regulator

  • P-type calcium channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    P-type calcium channel

    P-type_calcium_channel

  • G protein
  • Type of proteins

    phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces calcium release from

    G protein

    G protein

    G_protein

  • Chloride channel
  • Class of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Chloride channel

    Chloride channel

    Chloride_channel

  • Profilin
  • Actin-binding protein

    membrane phospholipids (phosphatidylinositol (4,5)-bisphosphate and inositol trisphosphate). The function of this interaction is the sequestration of profilin

    Profilin

    Profilin

    Profilin

  • Two-pore channel
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    Two-pore channel

    Two-pore_channel

  • Fructose-bisphosphate aldolase
  • Protein family

    anion exchanger, phospholipase D (PLD2), glucose transporter GLUT4, inositol trisphosphate, V-ATPase and ARNO (a guanine nucleotide exchange factor of ARF6)

    Fructose-bisphosphate aldolase

    Fructose-bisphosphate aldolase

    Fructose-bisphosphate_aldolase

  • KCNK9
  • Protein-coding gene in the species Homo sapiens

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    KCNK9

    KCNK9

    KCNK9

  • TRPC6
  • Protein and coding gene in humans

    phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates TRPC6 channels, and IP3 binds to its receptor

    TRPC6

    TRPC6

    TRPC6

  • TRPA (ion channel)
  • Family of transport proteins

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    TRPA (ion channel)

    TRPA (ion channel)

    TRPA_(ion_channel)

  • Inositol-tetrakisphosphate 5-kinase
  • liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate

    Inositol-tetrakisphosphate 5-kinase

    Inositol-tetrakisphosphate_5-kinase

  • PLCG1
  • Protein found in humans

    The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate

    PLCG1

    PLCG1

    PLCG1

  • ASIC1
  • Protein found in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    ASIC1

    ASIC1

    ASIC1

  • D1–D2 dopamine receptor heteromer
  • Receptor heteromer

    phospholipase C activation, intracellular calcium release from inositol trisphosphate receptor-sensitive stores, CaMKII activation and BDNF production

    D1–D2 dopamine receptor heteromer

    D1–D2_dopamine_receptor_heteromer

  • GJB1
  • Protein-coding gene in humans

    protein: ion channels (TC 1A) Ca2+: Calcium channel Ligand-gated Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3 Voltage-gated L-type/Cavα

    GJB1

    GJB1

    GJB1

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  • Scyllite
  • n.

    A white crystalline substance of a sweetish taste, resembling inosite and metameric with dextrose. It is extracted from the kidney of the dogfish (of the genus Scylium), the shark, and the skate.

  • Inosinic
  • a.

    Pertaining to, or derived from, inosite; as, inosinic acid.

  • Phaseomannite
  • n.

    Same as Inosite.

  • Inosite
  • n.

    A white crystalline substance with a sweet taste, found in certain animal tissues and fluids, particularly in the muscles of the heart and lungs, also in some plants, as in unripe pease, beans, potato sprouts, etc. Called also phaseomannite.