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HUS1

  • HUS1
  • Protein-coding gene in the species Homo sapiens

    Checkpoint protein HUS1 is a protein that in humans is encoded by the HUS1 gene. The protein encoded by this gene is a component of an evolutionarily

    HUS1

    HUS1

    HUS1

  • Cell cycle checkpoint protein RAD1
  • Protein-coding gene in the species Homo sapiens

    germ cells and infertility. RAD1 homolog has been shown to interact with: HUS1, RAD17, and RAD9A, GRCh38: Ensembl release 89: ENSG00000113456 – Ensembl

    Cell cycle checkpoint protein RAD1

    Cell cycle checkpoint protein RAD1

    Cell_cycle_checkpoint_protein_RAD1

  • Microsporidia
  • Phylum of fungi

    derive from animals and bacteria, and some even from fungi. The Rad9-Rad1-Hus1 protein complex (also known as the 9-1-1 complex) in eukaryotes is recruited

    Microsporidia

    Microsporidia

    Microsporidia

  • RAD9A
  • Protein-coding gene in the species Homo sapiens

    It forms a checkpoint protein complex with Rad1 and Hus1. This is also known as the Rad9-Rad1-Hus1 or 9-1-1 complex. This complex is recruited by checkpoint

    RAD9A

    RAD9A

    RAD9A

  • G2-M DNA damage checkpoint
  • Cell cycle checkpoint in eukaryotic organisms

    abolishes checkpoint DNA repair, including rad1, rad9, hus1 and rad17. It has been hypothesized that rad9, hus1 and rad17 are similar to proteins involved in forming

    G2-M DNA damage checkpoint

    G2-M DNA damage checkpoint

    G2-M_DNA_damage_checkpoint

  • Ataxia telangiectasia and Rad3 related
  • Protein kinase that detects DNA damage and halts cell division

    that are needed for ATR activation. While RPA recruits ATRIP, the RAD9-RAD1-HUS1 (9-1-1) complex is loaded onto the DNA adjacent to the ssDNA; though ATRIP

    Ataxia telangiectasia and Rad3 related

    Ataxia telangiectasia and Rad3 related

    Ataxia_telangiectasia_and_Rad3_related

  • List of human protein-coding genes 4
  • HGNC:26909; P83105 7369 HTT HGNC:4851; P42858 7370 HUNK HGNC:13326; P57058 7371 HUS1 HGNC:5309; O60921 7372 HUS1B HGNC:16485; Q8NHY5 7373 HUWE1 HGNC:30892; Q7Z6Z7

    List of human protein-coding genes 4

    List_of_human_protein-coding_genes_4

  • RFC3
  • Protein-coding gene in the species Homo sapiens

    checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". The Journal of Biological Chemistry. 275 (38): 29767–71. doi:10

    RFC3

    RFC3

    RFC3

  • CpG site
  • Region of often-methylated DNA with a cytosine followed by a guanine

    RAD51B, XRCC3, RAD54B, BRCA1, SHFM1, GEN1, FANCE, FAAP20, SPRTN, SETMAR, HUS1, and PER1. About seventeen types of cancer are frequently deficient in one

    CpG site

    CpG site

    CpG_site

  • Werner syndrome helicase
  • Enzyme found in humans

    fragmentation. As shown by Pichierri et al., WRN interacts with the RAD9-RAD1-HUS1 (9.1.1) complex, one of the central factors of the replication checkpoint

    Werner syndrome helicase

    Werner syndrome helicase

    Werner_syndrome_helicase

  • DNA damage (naturally occurring)
  • Damage in DNA which occurs naturally

    DNA is damaged, it is hypothesized that RAD9 forms a complex with RAD1 and HUS1, and this complex is recruited to sites of DNA damage. It is in this way

    DNA damage (naturally occurring)

    DNA_damage_(naturally_occurring)

  • DNA clamp
  • Protein family

    eukaryotes, a homologous, heterotrimeric "9-1-1 clamp" made up of RAD9-RAD1-HUS1 (911) is responsible for DNA damage checkpoint control. This 9-1-1 clamp

    DNA clamp

    DNA clamp

    DNA_clamp

  • Proliferating cell nuclear antigen
  • Mammalian protein found in Homo sapiens

    Cohesion 2 Flap structure-specific endonuclease 1 GADD45A GADD45G HDAC1 HUS1 ING1 KCTD13 KIAA0101 Ku70 Ku80 MCL1 MSH3 MSH6 MUTYH P21 POLD2 POLD3 POLDIP2

    Proliferating cell nuclear antigen

    Proliferating cell nuclear antigen

    Proliferating_cell_nuclear_antigen

  • Eukaryotic DNA replication
  • DNA replication in eukaryotic organisms

    proteins are localized to a valid site of DNA replication stress. The RAD9-HUS1-Rad1 (9-1-1) heterotrimeric clamp and its clamp loader RFCRad17 are able

    Eukaryotic DNA replication

    Eukaryotic DNA replication

    Eukaryotic_DNA_replication

  • HDAC1
  • Protein-coding gene in the species Homo sapiens

    Death-associated protein 6, EED, EVI1, EZH2, FKBP3, GATA1, HMG20B, HSPA4, HUS1, Histone deacetylase 2, Homeobox protein TGIF1, Host cell factor C1, IFRD1

    HDAC1

    HDAC1

    HDAC1

  • List of fictional astronauts (exploration of inner Solar System)
  • last name given) NashaSlava1: Klara Vasily Yuraj (no last names given) JanHus1: Jakub Procházka Spaceman of Bohemia (2017), novel Spaceman (2024), film

    List of fictional astronauts (exploration of inner Solar System)

    List of fictional astronauts (exploration of inner Solar System)

    List_of_fictional_astronauts_(exploration_of_inner_Solar_System)

  • Regulation of transcription in cancer
  • Aspect of cancer

    RAD51B, XRCC3, RAD54B, BRCA1, SHFM1, GEN1, FANCE, FAAP20, SPRTN, SETMAR, HUS1, and PER1. About seventeen types of cancer are frequently deficient in one

    Regulation of transcription in cancer

    Regulation_of_transcription_in_cancer

  • RAD17
  • Protein-coding gene in the species Homo sapiens

    phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be

    RAD17

    RAD17

    RAD17

  • TOPBP1
  • Protein-coding gene in the species Homo sapiens

    TOPBP1 was found to associate with Rad9, which forms a complex with Rad1 and Hus1, hereby termed the 9-1-1 DNA repair clamp. TOPBP1 binds to Rad9 with its

    TOPBP1

    TOPBP1

    TOPBP1

  • CLSPN
  • Protein-coding gene in humans

    Syljuåsen RG, Lukas J, Bartek J (2006). "ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage". Cell Cycle

    CLSPN

    CLSPN

    CLSPN

  • Bcl-2-associated death promoter
  • Mammalian protein found in Homo sapiens

    Lieberman HB, Pledger WJ, Wang HG (November 2000). "PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19

    Bcl-2-associated death promoter

    Bcl-2-associated death promoter

    Bcl-2-associated_death_promoter

  • Bcl-2-like protein 1
  • Protein-coding gene in the species Homo sapiens

    Singh S, Lieberman HB, Pledger WJ, Wang HG (Nov 2000). "PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19

    Bcl-2-like protein 1

    Bcl-2-like protein 1

    Bcl-2-like_protein_1

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Online names & meanings

  • Farrer
  • Surname or Lastname

    English

    Farrer

    English : variant spelling of Farrar.German : variant of Forer or Fahrer.

  • Newcomb
  • Surname or Lastname

    English

    Newcomb

    English : nickname for a new arrival in a place, from Middle English newe-come(n) ‘recently come’, ‘just arrived’. The intrusive -b- is the result of the influence of place names ending in -combe (see Coombe).Americanized form of German Neukamm, possibly arising from a misinterpretation of its etymology as neu ‘new’ + Kamm ‘comb’ (see Neukam).According to family tradition, Capt. Andrew Newcomb was born in England in 1618 and died in Boston, MA, in 1686, leaving family who settled both in MA and in Kittery, ME. Among his descendants was the internationally renowned astronomer Simon Newcomb (1835–1909).

  • Sydney
  • Girl/Female

    American, Australian, British, Chinese, English, French, Hebrew, Jamaican

    Sydney

    Wide Meadow; Place Name; Saint Denis; Bright Fame

  • Bianca | பிஂகா
  • Girl/Female

    Tamil

    Bianca | பிஂகா

    White

  • Afif-ud-Din
  • Boy/Male

    Arabic, Muslim

    Afif-ud-Din

    Virtuous of the Religion

  • Esmay
  • Surname or Lastname

    English

    Esmay

    English : variant of Ismay, from a medieval female personal name of uncertain origin.

  • Tejas-Aditya
  • Boy/Male

    Indian

    Tejas-Aditya

    Rays of Sun

  • Rohil
  • Boy/Male

    Hindu, Indian, Marathi

    Rohil

    Risen; Ascended

  • Shadin
  • Boy/Male

    Arabic, Muslim

    Shadin

    Young; Fawn; Young Deer

  • Odele
  • Girl/Female

    German, Greek, Hebrew

    Odele

    Rich; Harmonious; Song; I will Praise the Lord

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HUS1

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HUS1