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HERG

  • KCNH2
  • Mammalian protein found in humans

    Voltage-gated inwardly rectifying potassium channel KCNH2 also known as hERG (the human Ether-à-go-go-Related Gene) is a protein encoded by the gene KCNH2

    KCNH2

    KCNH2

    KCNH2

  • Cetirizine
  • Antihistamine medication

    not exhibit anticholinergic effects. It shows negligible inhibition of the hERG channel (IC50Tooltip half-maximal inhibitory concentration > 30 μM) and no

    Cetirizine

    Cetirizine

    Cetirizine

  • Ondansetron
  • Medication to prevent nausea and vomiting

    of 2-methylserotonin. Ondansetron shows human ether-à-go-go-related gene (hERG) inhibition, which is thought to underlie its QT prolongation. Onset of action

    Ondansetron

    Ondansetron

    Ondansetron

  • Methadone
  • Opioid analgesic and maintenance therapy

    other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with different potency. Dextromethadone

    Methadone

    Methadone

    Methadone

  • Ketamine
  • Dissociative anesthetic and anti-depressant

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Ketamine

    Ketamine

    Ketamine

  • Cocaine
  • Tropane alkaloid and stimulant drug

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Cocaine

    Cocaine

    Cocaine

  • Orphenadrine
  • Skeletal muscle relaxant

    dopamine reuptake inhibitor) Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker HERG potassium channel blocker George Rieveschl was a professor of chemistry at

    Orphenadrine

    Orphenadrine

    Orphenadrine

  • Gabapentin
  • Gamma-aminobutyric acid analog

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Gabapentin

    Gabapentin

    Gabapentin

  • Amitriptyline
  • Tricyclic antidepressant

    voltage-gated potassium channels Kv7.2/ Kv7.3, Kv7.1, Kv7.1/KCNE1, and hERG. Inhibition of serotonin and norepinephrine transporters by amitriptyline

    Amitriptyline

    Amitriptyline

    Amitriptyline

  • List of modafinil analogues and derivatives
  • JJC8-016 is blocking a specific protein (hERG) that can lead to heart problems (potent inhibition of the hERG antitarget and predicted cardiotoxicity)

    List of modafinil analogues and derivatives

    List of modafinil analogues and derivatives

    List_of_modafinil_analogues_and_derivatives

  • Cristina Nemerovschi
  • Romanian writer

    Rezervation" (Herg Benet, 2014) Cronicile fetei lup Series "Ceața" / "The fog" (Herg Benet, 2029) "Pervertirea" / "The Perverting" (Herg Benet, 2012, 2013

    Cristina Nemerovschi

    Cristina_Nemerovschi

  • Drug-induced QT prolongation
  • Changes to heartbeat caused by a drug

    reflected as QT prolongation. hERG trafficking inhibition A number of drugs that cause QT prolongation does not directly block hERG, but reduces the trafficking

    Drug-induced QT prolongation

    Drug-induced_QT_prolongation

  • Astemizole
  • Antihistamine drug

    fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade). Astemizole is a histamine H1-receptor antagonist. It has

    Astemizole

    Astemizole

    Astemizole

  • Barbiturate
  • Class of depressant drugs derived from barbituric acid

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Barbiturate

    Barbiturate

    Barbiturate

  • Chlorphenamine
  • Antihistamine used to treat allergies

    Suessbrich H, Waldegger S, Lang F, Busch AE (April 1996). "Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists

    Chlorphenamine

    Chlorphenamine

    Chlorphenamine

  • Lorazepam
  • Benzodiazepine medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Lorazepam

    Lorazepam

    Lorazepam

  • JJC8-088
  • Cocaine-like dopamine reuptake inhibitor derived from modafinil

    the sigma σ1 receptor (Ki = 41.6 nM). The drug has high affinity for the hERG antitarget (IC50Tooltip half-maximal inhibitory concentration = 130 nM) and

    JJC8-088

    JJC8-088

    JJC8-088

  • Pregabalin
  • Anticonvulsant medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Pregabalin

    Pregabalin

    Pregabalin

  • E-4031
  • Chemical compound

    experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type. E-4031 is a synthesized toxin that is a methanesulfonanilide class

    E-4031

    E-4031

    E-4031

  • Diphenhydramine
  • Antihistamine medication

    Suessbrich H, Waldegger S, Lang F, Busch AE (April 1996). "Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists

    Diphenhydramine

    Diphenhydramine

    Diphenhydramine

  • Propranolol
  • Beta blocker drug

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Propranolol

    Propranolol

    Propranolol

  • Escitalopram
  • SSRI antidepressant

    Kim IB, Choi JS, Sung KW, et al. (January 2014). "Escitalopram block of hERG potassium channels". Naunyn-Schmiedeberg's Archives of Pharmacology. 387

    Escitalopram

    Escitalopram

    Escitalopram

  • Kava
  • Species of plant

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Kava

    Kava

    Kava

  • Henipavirus
  • Genus of RNA viruses

    ViralZone: Henipavirus Henipavirus – Henipavirus Ecology Research Group (HERG) INFO Virus Pathogen Database and Analysis Resource (ViPR): Paramyxoviridae

    Henipavirus

    Henipavirus

    Henipavirus

  • Ibogaine
  • Psychoactive substance found in plants in the family Apocynaceae

    patients with underlying conditions. Cardiac risks likely occur through hERG channel blockade leading to QT prolongation and arrhythmias; the synthetic

    Ibogaine

    Ibogaine

    Ibogaine

  • Reichskommissariat Ostland
  • Territory of Nazi Germany from 1941 to 1945

    Chapter II: "Ostland", p. 253-259 and footnotes. Ostland – Verwaltungskarte. Herg. vom Reichskommissar f. d. Ostland, Abt. II Raum. Stand der Grenzen vom 1

    Reichskommissariat Ostland

    Reichskommissariat Ostland

    Reichskommissariat_Ostland

  • Whisky a Go Go
  • Nightclub in West Hollywood, California

    William D. Kaplan and William E. Trout. The human Ether-à-go-go-Related Gene (hERG) was so named because when Drosophila flies with mutations in the Ether-à-go-go

    Whisky a Go Go

    Whisky a Go Go

    Whisky_a_Go_Go

  • Minoxidil
  • Medication used to treat hair loss

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Minoxidil

    Minoxidil

    Minoxidil

  • Alcohol (drug)
  • Active ingredient in fermented drinks

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Alcohol (drug)

    Alcohol (drug)

    Alcohol_(drug)

  • Sildenafil
  • Drug for erectile dysfunction and hypertension

    Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is

    Sildenafil

    Sildenafil

    Sildenafil

  • CmERG1
  • Neurotoxin

    scorpion Centruroides margaritatus. It blocks human ether-a-go-go-Related gene (hERG) potassium channels, which are important for cardiac action potential repolarization

    CmERG1

    CmERG1

  • Cholesterol
  • Sterol biosynthesized by all animal cells

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Cholesterol

    Cholesterol

    Cholesterol

  • Chlorpromazine
  • Typical antipsychotic medication

    Prostatic hypertrophy Very rarely, elongation of the QT interval, due to hERG blockade, may occur, increasing the risk of potentially fatal arrhythmias

    Chlorpromazine

    Chlorpromazine

    Chlorpromazine

  • Domperidone
  • Peripheral D2 receptor antagonist

    interval and ventricular arrhythmias. The cause is thought to be blockade of hERG voltage-gated potassium channels. The risks are dose-dependent, and appear

    Domperidone

    Domperidone

    Domperidone

  • Topiramate
  • Medication used to treat epilepsy and migraine

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Topiramate

    Topiramate

    Topiramate

  • KcsA potassium channel
  • Prokaryotic potassium ion channel

    model for the channel dynamics of larger eukaryotic K+ channels, including hERG. The structure of KcsA is that of an inverted cone, with a central pore running

    KcsA potassium channel

    KcsA potassium channel

    KcsA_potassium_channel

  • Pethidine
  • Opioid analgesic

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Pethidine

    Pethidine

    Pethidine

  • Olanzapine
  • Atypical antipsychotic medication

    Roehr J, Rampe D (August 2002). "A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs". European Journal

    Olanzapine

    Olanzapine

    Olanzapine

  • Buprenorphine
  • Opioid used to treat pain and opioid use disorder

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Buprenorphine

    Buprenorphine

    Buprenorphine

  • Atomoxetine
  • Medication used to treat ADHD

    upon abrupt discontinuation. Atomoxetine has been found to directly inhibit hERG potassium currents with an IC50Tooltip half-maximal inhibitory concentration

    Atomoxetine

    Atomoxetine

    Atomoxetine

  • Amlodipine
  • Medication against high blood pressure

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Amlodipine

    Amlodipine

    Amlodipine

  • Lidocaine
  • Local anesthetic

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Lidocaine

    Lidocaine

    Lidocaine

  • Fentanyl
  • Opioid medication

    ISBN 978-1-119-71082-0. Tschirhart JN, Zhang S (October 2020). "Fentanyl-Induced Block of hERG Channels Is Exacerbated by Hypoxia, Hypokalemia, Alkalosis, and the Presence

    Fentanyl

    Fentanyl

    Fentanyl

  • Tabernanthalog
  • Pharmaceutical compound

    GABAA receptor. Tabernanthalog was found to be 100-fold less potent at the hERG antitarget compared to ibogaine, and hence is thought to have a much lower

    Tabernanthalog

    Tabernanthalog

    Tabernanthalog

  • Terfenadine
  • Chemical compound

    effects, also acts as a potassium channel blocker (Kv11.1 encoded by the gene hERG). Since its active metabolite is not a potassium channel blocker, no cardiotoxicity

    Terfenadine

    Terfenadine

    Terfenadine

  • Lamotrigine
  • Anticonvulsant medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Lamotrigine

    Lamotrigine

    Lamotrigine

  • Promethazine
  • Sedating antihistamine

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Promethazine

    Promethazine

    Promethazine

  • CJ-033466
  • Chemical compound

    with 30 times the potency of cisapride, and with lower affinity for the hERG channel. Imidazopyridine Mikami T, Ochi Y, Suzuki K, Saito T, Sugie Y, Sakakibara

    CJ-033466

    CJ-033466

    CJ-033466

  • Benzonatate
  • Oral cough medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Benzonatate

    Benzonatate

  • Oxa-noribogaine
  • Pharmaceutical compound

    synthetic benzofuran analogue of noribogaine. Although it still binds to hERG with similar avidity as noribogaine, it appears to be devoid of the proarrhythmic

    Oxa-noribogaine

    Oxa-noribogaine

    Oxa-noribogaine

  • Carbamazepine
  • Anticonvulsant medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Carbamazepine

    Carbamazepine

    Carbamazepine

  • Baclofen
  • Gabapentinoid and skeletal muscle relaxant

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Baclofen

    Baclofen

    Baclofen

  • Voltage-gated sodium channel
  • Family of transport proteins

    2 6.3 6.4 Kvα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP

    Voltage-gated sodium channel

    Voltage-gated_sodium_channel

  • Vanoxerine
  • Chemical compound

    inhibitor, serotonin transporter inhibitor, and as a blocker of the cardiac hERG repolarizing potassium channel (IKr). Vanoxerine has been researched for

    Vanoxerine

    Vanoxerine

    Vanoxerine

  • KCNH1-related disorders
  • Group of genetic disorders

    similarity between KCNH1 and KCNH2, which encodes Kv11.1, also known as hERG. hERG is essential for proper, rapid repolarization of cardiac action potentials

    KCNH1-related disorders

    KCNH1-related disorders

    KCNH1-related_disorders

  • Suzetrigine
  • Non-opioid analgesic drug

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Suzetrigine

    Suzetrigine

    Suzetrigine

  • Ketoconazole
  • Antifungal chemical compound

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Ketoconazole

    Ketoconazole

    Ketoconazole

  • Doxepin
  • Sedating antidepressant

    Gao Z, James AF, Leishman DJ, et al. (August 2007). "Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin". Biochemical Pharmacology

    Doxepin

    Doxepin

    Doxepin

  • Ranolazine
  • Drug used to treat angina

    Ranolazine also exhibits its effects on the delayed rectifier current (hERG/IKr potassium channels), it readily stimulates myogenesis, it reduces a pro-oxidant

    Ranolazine

    Ranolazine

    Ranolazine

  • Diallyl trisulfide
  • Chemical compound

    ability to change the opening of the human ether-à-go-go-related (hERG) channel. hERG is the pore-forming subunit of potassium channels that create delayed

    Diallyl trisulfide

    Diallyl_trisulfide

  • Loperamide
  • Medicine used to reduce diarrhea

    Loperamide, sold under the brand name Imodium, among others, is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea

    Loperamide

    Loperamide

    Loperamide

  • Tinuade Sanda
  • Nigerian Executive business leader

    (born 6 August 1979) is a Nigerian Executive business leader, founder of EmHERging a mentorship platform and former chief executive officer of EKo Electricity

    Tinuade Sanda

    Tinuade_Sanda

  • Remlifanserin
  • Pharmaceutical compound

    to the serotonin 5-HT2A and 5-HT2C receptors. It is expected to have less hERG inhibition and QT prolongation than pimavanserin. The drug blocks the head-twitch

    Remlifanserin

    Remlifanserin

    Remlifanserin

  • Cyproheptadine
  • Antihistamine medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Cyproheptadine

    Cyproheptadine

    Cyproheptadine

  • Valproate
  • Medication used for epilepsy, bipolar disorder and migraine

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Valproate

    Valproate

    Valproate

  • Curcumin
  • Principal curcuminoid of turmeric

    several proteins known to increase the risk of adverse effects, including hERG, cytochrome P450s, and glutathione S-transferase. Although curcumin has been

    Curcumin

    Curcumin

    Curcumin

  • Telmisartan/amlodipine/indapamide
  • Medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Telmisartan/amlodipine/indapamide

    Telmisartan/amlodipine/indapamide

  • CYP2D6
  • Human liver enzyme

    enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins". Chemico-Biological Interactions

    CYP2D6

    CYP2D6

    CYP2D6

  • Mosapride
  • Chemical compound

    agents, mosapride has little effect on potassium channels, no effect on hERG transfected cells, and no effect on cardiovascular function that could be

    Mosapride

    Mosapride

    Mosapride

  • Torsades de pointes
  • Type of abnormal heart rhythm

    directly linked to QT prolongation mediated predominantly by inhibition of the hERG channel and, in some cases, augmentation of the late sodium channel. The

    Torsades de pointes

    Torsades de pointes

    Torsades_de_pointes

  • Antitarget
  • Concept in pharmacology

    by chance. Among the best-known and most significant antitargets are the hERG channel and the 5-HT2B receptor, both of which cause long-term problems with

    Antitarget

    Antitarget

  • Tricyclic antidepressant
  • Class of medications

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Tricyclic antidepressant

    Tricyclic antidepressant

    Tricyclic_antidepressant

  • Haloperidol
  • Typical antipsychotic medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Haloperidol

    Haloperidol

    Haloperidol

  • Benzocaine
  • Local anaesthetic drug

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Benzocaine

    Benzocaine

    Benzocaine

  • Dazucorilant
  • Glucocorticoid receptor modulator

    "1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile". Bioorganic & Medicinal

    Dazucorilant

    Dazucorilant

    Dazucorilant

  • Mesobuthus eupeus
  • Species of scorpion

    rKv1.5, hKv3.1, rKv4.3, and hERG channels even at high concentrations. In contrast, BeKm-1 specifically inhibits hERG channels, which are potassium

    Mesobuthus eupeus

    Mesobuthus eupeus

    Mesobuthus_eupeus

  • BeKm-1 toxin
  • Scorpion toxin

    BeKm-1 acts by selectively inhibiting the human Ether-à-go-go-Related Gene (hERG) channels, which are voltage gated potassium ion channels. Be is the abbreviation

    BeKm-1 toxin

    BeKm-1_toxin

  • Diltiazem
  • Calcium channel blocker medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Diltiazem

    Diltiazem

    Diltiazem

  • Tetrodotoxin
  • Neurotoxin

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Tetrodotoxin

    Tetrodotoxin

    Tetrodotoxin

  • CNGB1
  • Protein-coding gene in the species Homo sapiens

    2 6.3 6.4 Kvα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP

    CNGB1

    CNGB1

    CNGB1

  • Levofloxacin
  • Antibiotic

    Levofloxacin and other fluoroquinolones show human ether-à-go-go-related gene (hERG) inhibition. This is thought to be responsible for their QT prolongation

    Levofloxacin

    Levofloxacin

    Levofloxacin

  • Phenibut
  • CNS depressant medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Phenibut

    Phenibut

    Phenibut

  • Hydroxychloroquine
  • Antimalarial medication

    Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains

    Hydroxychloroquine

    Hydroxychloroquine

    Hydroxychloroquine

  • Quinidine
  • Antiarrythmic medication

    also blocks certain voltage-gated potassium channels (e.g., Kv1.4, Kv4.2, hERG, among others), acts as an antimuscarinic and alpha-1 blocker, and is an

    Quinidine

    Quinidine

    Quinidine

  • Ibogalog
  • Class of chemical compounds

    receptor. In addition, the compounds have dramatically reduced potency at the hERG antitarget compared to ibogaine, which confers much less cardiotoxicity.

    Ibogalog

    Ibogalog

    Ibogalog

  • PNU-282,987
  • Chemical compound

    is not suitable for use in humans because of excessive inhibition of the hERG antitarget. PNU-282987 has been shown to initiate signaling that leads to

    PNU-282,987

    PNU-282,987

    PNU-282,987

  • Meclizine
  • Chemical compound

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Meclizine

    Meclizine

    Meclizine

  • Solifenacin
  • Chemical compound

    contraindication although solifenacin, like tolterodine and darifenacin, binds to hERG channels of the heart and may prolong the QT interval. This mechanism appears

    Solifenacin

    Solifenacin

    Solifenacin

  • Ether‐à‐go‐go potassium channel
  • Type of potassium channel

    such channel in the fruit fly Drosophila melanogaster. Examples include hERG, KCNH6, and KCNH7. Bauer, Christiane K.; Schwarz, Jürgen R. (March 2018)

    Ether‐à‐go‐go potassium channel

    Ether‐à‐go‐go_potassium_channel

  • Budipine
  • Pharmaceutical drug

    not precisely mimic the mechanism of an existing known treatment. It is an hERG blocker and can produce long QT syndrome as a side effect. Analogues include

    Budipine

    Budipine

    Budipine

  • Nifedipine
  • Calcium channel blocker medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Nifedipine

    Nifedipine

    Nifedipine

  • Nortriptyline
  • Antidepressant medication

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Nortriptyline

    Nortriptyline

    Nortriptyline

  • Prokinetic agent
  • Medication to promote gastrointestinal emptying

    poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K+] channels) contributes to its potential to cause

    Prokinetic agent

    Prokinetic_agent

  • Noribogaine
  • Principal psychoactive metabolite of the oneirogen ibogaine

    5-HT2A receptor. Noribogaine is a hERG inhibitor and appears at least as potent as ibogaine. The inhibition of the hERG potassium channel delays the repolarization

    Noribogaine

    Noribogaine

    Noribogaine

  • Pharmacology of ethanol
  • Pharmacodynamics and pharmacokinetics of ethanol

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Pharmacology of ethanol

    Pharmacology of ethanol

    Pharmacology_of_ethanol

  • APETx1
  • Peptide toxin from the venom of the aggregating anemone

    toxin acts as a gating modifier on the human ether-à-go-go-related gene (hERG) channel, a type of voltage-gated potassium channel, and as a blocker of

    APETx1

    APETx1

  • Potassium channel blocker
  • Several medications that disrupt movement of K+ ions

    rectifier outward potassium current (IKr) blocks potassium channels of the hERG-type Primarily inhibits outward voltage-gated Kv2.1 potassium channel currents

    Potassium channel blocker

    Potassium channel blocker

    Potassium_channel_blocker

  • Glipizide
  • Chemical compound

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Glipizide

    Glipizide

    Glipizide

  • JJC8-016
  • Abandoned drug

    ~2-fold lower affinity for the hERG. Newer related modafinil analogues and DRIs with further reduced affinity for the hERG were also subsequently developed

    JJC8-016

    JJC8-016

    JJC8-016

  • Chlorzoxazone
  • Muscle relaxant

    Quinidine ShK-186 Sotalol Tedisamil Terikalant Tetraethylammonium Vernakalant hERG (KCNH2, Kv11.1)-specific: Ajmaline Amiodarone AmmTX3 Astemizole Azaspiracid

    Chlorzoxazone

    Chlorzoxazone

    Chlorzoxazone

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  • Harrow
  • Surname or Lastname

    English and Scottish

    Harrow

    English and Scottish : habitational name from any of various places so named in England and Scotland, as for example Harrow in northwest London (Herges in Domesday Book), Harrow Head in Nether Wasdale, Cumbria, both named from Old English hearg, hærg ‘(pagan) temple’, and Harrow near Mey, Caithness.

    Harrow

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Online names & meanings

  • William
  • Boy/Male

    American, Anglo, Australian, British, Chinese, Christian, Danish, Dutch, English, Finnish, French, German, Indian, Irish, Jamaican, Modern, Portuguese, Shakespearean, Swedish, Swiss, Teutonic

    William

    Resolute Protector; Will-helmet; Will Desire; Valley; Unwavering Protector; Protect

  • Razi |
  • Boy/Male

    Muslim

    Razi |

    Thankful of anybody, Satisfied, Contended, Pleased

  • Tira
  • Girl/Female

    Danish, Hebrew, Hindu, Indian

    Tira

    Land; Auspicious Symbol

  • Ukashah
  • Boy/Male

    Arabic, Muslim

    Ukashah

    Spider Web; Cobweb

  • Polly
  • Girl/Female

    American, Australian, British, Christian, Danish, English, French, German, Hebrew, Irish, Latin

    Polly

    Bitterness; Rebelliousness; Form of Molly; From Mary; The Perfect One; Female Version of Paul; Little; Small

  • Sadha
  • Boy/Male

    Indian, Punjabi, Sikh

    Sadha

    Eternal

  • Swaminathan
  • Boy/Male

    Hindu, Indian, Sanskrit, Tamil

    Swaminathan

    Lord Murugan in the Temple of Swamimalai Near Kumbakonam

  • Ghadir
  • Girl/Female

    Arabic, Australian, Muslim

    Ghadir

    She was a Slave of Musa Al-hadi and Haroon Rashid

  • Kaalanjari
  • Girl/Female

    Hindu, Indian, Malayalam, Marathi

    Kaalanjari

    Parvati

  • ARAWN
  • Male

    Arthurian

    ARAWN

    , the eloquent.

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