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Search references for HDAC4. Phrases containing HDAC4
See searches and references containing HDAC4!HDAC4
Protein found in humans
Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. Histones play a critical role in transcriptional
HDAC4
Tropane alkaloid and stimulant drug
vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5". Science Advances. 3 (11) e1701682. Bibcode:2017SciA....3E1682G
Cocaine
Class of enzymes important in regulating DNA transcription
nucleus and the cytoplasm, and is also membrane-associated. Class II HDACs (HDAC4, 5, 6, 7 9, and 10) are able to shuttle in and out of the nucleus, depending
Histone_deacetylase
Group of neural structures responsible for motivation and desire
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Reward_system
Medical condition
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Caffeine_dependence
Need for a drug, whose discontinuation results in withdrawal symptoms
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Substance_dependence
Class of reduction–oxidation proteins
(HDAC4), which allows HDAC4 to be imported from the cytosol, where the oxidized form resides, into the nucleus. Once in the nucleus, reduced HDAC4 downregulates
Thioredoxin
Cognitive process
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Motivational_salience
Disorder resulting in compulsive behaviors
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Addiction
Biological processes used in gene regulation
is thought to contribute to contractility. The Class IIA HDACs includes HDAC4, HDAC5, HDAC7 and HDAC9. HDACs 4 and 5 have been found to most closely resemble
Histone acetylation and deacetylation
Histone_acetylation_and_deacetylation
Chemical compound (CH3CH2CH2COOH)
Inhibited enzyme IC50 (nM) Entry note HDAC1 16,000 HDAC2 12,000 HDAC3 9,000 HDAC4 2,000,000 Lower bound HDAC5 2,000,000 Lower bound HDAC6 2,000,000 Lower
Butyric_acid
Continued use of cannabis despite clinically significant impairment
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Cannabis_use_disorder
Proposed compulsive sexual disorder
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Sexual_addiction
Compounds that inhibit histone deacetylases
-2, -3 and -8 are related to yeast RPD3 gene; Class IIA, which includes HDAC4, -5, -7 and -9; Class IIB -6, and -10 are related to yeast Hda1 gene; Class
Histone_deacetylase_inhibitor
Protein-coding gene in the species Homo sapiens
and proteolytic cleavage. MEF2C has been shown to interact with: EP300, HDAC4, HDAC7, HDAC9, MAPK7, SOX18 SP1, and TEAD1. SETD1A This gene is involved
MEF2C
Chinese biotechnology company
et al. (2013). "Eating disorder predisposition is associated with ESRRA and HDAC4 mutations". J Clin Invest. 123 (11): 4706–4713. doi:10.1172/jci71400. PMC 3809805
Complete_Genomics
Compulsion to engage in a non-substance related behavior
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Behavioral_addiction
Continual use of drugs despite negative consequences
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Substance_use_disorder
Medical condition
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Amphetamine_dependence
Protein-coding gene in the species Homo sapiens
therapy. BTG2 has been shown to interact with PRMT1, HOXB9, CNOT8 and HDAC1 HDAC4 and HDAC9. It has also been studied with Pax6 and Tbr2 when observing the
Protein_BTG2
Protein-coding gene in the species Homo sapiens
Saintignon J, Ferreira R, Pritchard LL, Mishal Z, et al. (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated
HDAC6
Protein-coding gene in the species Homo sapiens
Myocyte-specific enhancer factor 2A has been shown to interact with: ASCL1, EP300, HDAC4, HDAC9, Histone deacetylase 5, MAPK14, MEF2D, Mothers against decapentaplegic
Myocyte-specific enhancer factor 2A
Myocyte-specific_enhancer_factor_2A
Rare neurodegenerative disease
re-entry of post-mitotic (mature) neurons Synaptic/vesicular dysregulation HDAC4 dysregulation Histone hypermethylation and altered epigenetics Altered protein
Ataxia–telangiectasia
Protein-coding gene in the species Homo sapiens
NR, Vezmar M, Pelletier N, Crosato M, Heng HH, et al. (November 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional
HDAC9
Protein
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
FOSB
Transcription factor for converting Naive T cells to TFH
BCOR, BTLA, Ccr7, CD200, C-jun, CREBBP, CXCR5, EP300, EZH2, Gpr183, HDAC1, HDAC4, HDAC7A, HDAC5, ICOS, IRF8, IRF4, IL-6R, KM2TD, MET2B, NCOR2 NCOR2, SAP
BCL6
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
Treatment and management of addiction
Treatment_and_management_of_addiction
Type of RNA found in cells
effect on the myogenesis process. circLMO7 is involved in overexpression of HDAC4 and downregulates MEF2A expression by upregulating miR-378a-3p leading to
Circular_RNA
Protein-coding gene in the species Homo sapiens
has been shown to interact with: ADAM17, CIITA, DUSP1, DUSP3, ELK1, FHL2, HDAC4, MAP2K1, MAP3K1 MAPK14, MKNK1, MKNK2, Myc, NEK2, PEA15, PTPN7, Phosphatidylethanolamine
MAPK1
Protein-coding gene in humans
lysine residue (K69), by acetyltransferase (PCAF) and histone deacetylase 4 (HDAC4), respectively. In myocytes, MLP has the ability to oligomerize, forming
CSRP3
Substance-related disorder
vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5". Sci Adv. 3 (11) e1701682. Bibcode:2017SciA....3E1682G. doi:10
Gateway_drug_effect
Protein-coding gene in the species Homo sapiens
to interact with: BRAF, C-Raf, CD29, CDC25A, CDC25B, Cbl gene, EPB41L3, HDAC4 KCNK3, MAPK7, PTPN3, PRKCZ, RPS6KA1, TESK1, TNFAIP3, and WEE1. 14-3-3 proteins
YWHAB
Protein found in humans
receptor type 1, BCL6, BMI1, Calcitriol receptor, FHL2, GATA1, GATA2, HDAC1, HDAC4, HDAC5, HDAC6, Heparin-binding EGF-like growth factor, Nuclear receptor
Zinc finger and BTB domain-containing protein 16
Zinc_finger_and_BTB_domain-containing_protein_16
Protein-coding gene in the species Homo sapiens
of IFRD1 to bind selectively MEF2C, thus inhibiting its interaction with HDAC4. Therefore, IFRD1 appears to act as a positive cofactor of MyoD. More recently
IFRD1
platinum resistance from laboratory to clinic; such targets include AKT, MTOR, HDAC4, STAT1 and the Folate Receptors. Until September 2017 he was founding President
Hani_Gabra
Mammalian protein found in Homo sapiens
with MyoD at inducing the transcriptional activity of MEF2C (by displacing HDAC4 from MEF2C); moreover IFRD1 also represses the transcriptional activity
MyoD
Protein-coding gene in the species Homo sapiens
Miller–Dieker syndrome. YWHAE has been shown to interact with: C-Raf, CDC25B, HDAC4, kCNH2, IRS1 and IGF1R, MAP3K3, NDEL1, NGFRAP1, and TGF beta 1. 14-3-3 protein
YWHAE
Protein-coding gene in the species Homo sapiens
Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (Nov 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional
MEF2D
Human protein and coding gene
Zhang P, Sun Q, Zhao C, Ling S, Li Q, Chang YZ, et al. (March 2014). "HDAC4 protects cells from ER stress induced apoptosis through interaction with
DNA damage-inducible transcript 3
DNA_damage-inducible_transcript_3
Protein-coding gene in the species Homo sapiens
S2CID 4974360. Micheli L, D'Andrea G, Leonardi L, Tirone F (July 2017). "HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of
HDAC1
Protein-coding gene in the species Homo sapiens
patients. Dach1 promotes hepatic insulin resistance via Nuclear Exclusion of HDAC4. GRCh38: Ensembl release 89: ENSG00000276644 – Ensembl, May 2017 GRCm38:
DACH1
Heritable characteristics affecting learning
increased Nr4a2 and c-Fos expression HDAC3 interacts with NCoR[which?] and HDAC4 to perform its role in memory formation Research has shown that HDACs and
Epigenetics in learning and memory
Epigenetics_in_learning_and_memory
Enzyme found in humans
Saintignon J, Ferreira R, Pritchard LL, Mishal Z, et al. (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated
Histone_deacetylase_5
Protein-coding gene in humans
Ito A, Kane CD, et al. (2001). "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking". J. Biol. Chem
CAMK4
Protein-coding gene in the species Homo sapiens
Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood
EHMT2
Protein found in humans
co-repressor 2 has been shown to interact with: AR BCL6 C-Fos C-jun HDAC1 HDAC3 HDAC4 HDAC5 HDAC10 MeCP2 NR4A1 POU2F1 PPARD PGR PML RBPJ RELA RUNX1T1 RARA SIN3A
Nuclear receptor co-repressor 2
Nuclear_receptor_co-repressor_2
Protein-coding gene in humans
CBX5 (gene) has been shown to interact with: CBX1, CBX3, CHAF1A, DNMT3B, HDAC4, HDAC9, Histone deacetylase 5, Ku70, Lamin B receptor, MBD1, MIS12, SMARCA4
CBX5_(gene)
Field of study
class I, consisting of HDAC1, HDAC2, HDAC3, HDAC8, class II, consisting of HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10, class III, consisting of NAD+-dependent
Epigenetics of anxiety and stress–related disorders
Epigenetics_of_anxiety_and_stress–related_disorders
Human gene
BAG1, BAG2, BAG3, CatSperβ, CDC2, CHCHD3, DNAJC7, DNAJC8, DNAJC9, FOXP3, HDAC4, HOPX, HSP40, HSP90, HSP105, IRAK1BP1, METTL21A, NAA10, NEDD1, NOD2, PPP5C
HSPA1B
Chemical compound
Hammers H, et al. (February 2013). "Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment". Cancer
Tasquinimod
Protein found in humans
receptor, CHD1, Calcitriol receptor GPS2, Glucocorticoid receptor, HDAC3, HDAC4, HDAC7A, HDAC9, HEY2, Histone deacetylase 5, MAP3K7IP2, MECP2, Peroxisome
Nuclear receptor co-repressor 1
Nuclear_receptor_co-repressor_1
Human protein-coding gene
to interact with: Androgen receptor, Estrogen receptor alpha, HDAC3, and HDAC4. Testicular receptor GRCh38: Ensembl release 89: ENSG00000120798 – Ensembl
Testicular_receptor_2
Protein-coding gene in the species Homo sapiens
tuberous sclerosis. MAPK3 has been shown to interact with: DUSP3, DUSP6 GTF2I, HDAC4, MAP2K1, MAP2K2, PTPN7, RPS6KA2, and SPIB. GRCh38: Ensembl release 89: ENSG00000102882
MAPK3
HGNC:4852; Q13547 6963 HDAC2 HGNC:4853; Q92769 6964 HDAC3 HGNC:4854; O15379 6965 HDAC4 HGNC:14063; P56524 6966 HDAC5 HGNC:14068; Q9UQL6 6967 HDAC6 HGNC:14064;
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Protein-coding gene in humans
been shown to interact with: CBFA2T3, CCND1, GATA1, GATA2, GPS2, GTF2I, HDAC4, HDAC5, HDAC7A, HDAC9, MAP3K7IP2, MAPK11, NCOR1, NCOR2, PPARD, PPARG, PML
HDAC3
Precursor microRNA family
function as a tumour suppressor. One known target is histone deacetylase 4 (HDAC4), which is known to have a critical role in cancer development. Mir-22 also
Mir-22
HDAC4
HDAC4
HDAC4
HDAC4
Female
English
Latin form of Hebrew Qetsiyah, CASSIA means "cassia," a bark similar to cinnamon.Â
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Tamil, Telugu
Lord Krishna
Girl/Female
Tamil
Worship, Praise, Reverence
Girl/Female
Muslim
Light of contentment
Boy/Male
Muslim
The guided one
Boy/Male
Hindu, Indian, Kannada, Sanskrit, Telugu
Lord of the Gods
Girl/Female
Tamil
Shilathata Vinikshibda | ஷீலாததா விநீகà¯à®·à¯€à®ªà¯à®Ÿà®¾
At birth, Slammed by kamsa
Girl/Female
Arabic, Muslim
Devout Believer
Boy/Male
Tamil
Girl/Female
Hindu, Indian, Kannada, Sindhi
One with a Beautiful Smile
HDAC4
HDAC4
HDAC4
HDAC4
HDAC4