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Search references for GSDMD. Phrases containing GSDMD
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Search references for GSDMD. Phrases containing GSDMD
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Protein found in humans
Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily
GSDMD
Type of programmed cell death
cytosolic gasdermin D (GSDMD). GSDMD can be cleaved to produce an N-terminal domain (GSDMD-N) and a C-terminal domain (GSDMD-C). GSDMD-N can oligomerize and
Pyroptosis
Cytosolic multiprotein complex that mediates the activation of Caspase 1
18 (IL-18), as well as the pore-forming molecule gasdermin D (GSDMD). The N-terminal GSDMD fragment resulting from this cleavage induces a pro-inflammatory
Inflammasome
American immunologist and researcher
activation, the protein gasdermin D (GSDMD) forms pores in the plasma membrane. Kagan and Broz independently found that GSDMD pores serve as membrane channels
Jonathan_C._Kagan
Chinese American biochemist
interleukin-1 family to cause their maturation, and cleave gasdermin D (GSDMD) to form pores on the cell surface that release the mature cytokines and
Hao_Wu_(biochemist)
Immune system messenger protein which induces inflammation
activates complex IIb, leading to apoptosis, or pyroptosis by cleaving GSDMD. The disabling of the IKK checkpoint can also indirectly activate complex
Tumor_necrosis_factor
Protein-coding gene in the species Homo sapiens
promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis". Cell Death Discovery. 9 (1) 26. doi:10.1038/s41420-023-01326-z
TNFRSF12A
Protein domain
A crucial downstream substrate for pyroptotic caspases is Gasdermin D (GSDMD) Inflammation is a protective attempt by an organism to restore a homeostatic
Caspase
Inflammatory cell death pathway
Yinghua; Cai, Tao; Wang, Fengchao; Shao, Feng (2015-10-29). "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death". Nature. 526
PANoptosis
Chemical compound
active pro-inflammatory cytokine forms and b) gasdermin D (also termed GSDMD) into its active form that triggers its parent cell's pyroptosis response
Itaconic_acid
Kenyan molecular biologist
This led to the discovery that caspase-mediated cleavage of the protein GSDMD creates a pore forming, plasma membrane disrupting amino-terminal fragment
Vishva_Dixit
Q96QA5 6685 GSDMB HGNC:23690; Q8TAX9 6686 GSDMC HGNC:7151; Q9BYG8 6687 GSDMD HGNC:25697; P57764 6688 GSDME HGNC:2810; O60443 6689 GSE1 HGNC:28979; Q14687
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
American geneticist
IQGAP1 mobilizes ESCRTs to protect the plasma membrane from pores formed by GSDMD, MLKL, M. tuberculosis, and SARS-CoV-2 ORF3a, and that ATG5 tunes the atg8ylation
Vojo_Deretic
GSDMD
GSDMD
GSDMD
GSDMD
Female
Slovene
Slovene form of Latin Cæcilia, CECILIJA means "blind."Â
Boy/Male
Muslim
Kind, Friend
Boy/Male
Hindu
Joy, Delight
Girl/Female
Indian, Punjabi, Sikh
Sweet Voice; True Saying
Female
English
Variant spelling of English Kaylin, CAYLIN means "girl."
Girl/Female
Hindu
Full of knowledge, Altar, A river in india
Girl/Female
Christian, French, German, Italian, Latin
Blooming; Flower; Form of Florence; Goddess of Flowers / Spring
Female
Russian
(Ðннушка) Diminutive form of Russian Anya, ANNUSHKA means "favor; grace."
Girl/Female
Arabic, Muslim
Wisdom; Advice
Surname or Lastname
English
English : variant spelling of Hetherington.
GSDMD
GSDMD
GSDMD
GSDMD
GSDMD