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GFRA1

GFRA1

Protein-coding gene in the species Homo sapiens

known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN)

GFRA1

Renal agenesis

Failure of the kidney(s) to develop during embryonic growth

from 33 stillborn fetuses were sequenced for mutations in RET, GDNF and GFRA1. Nineteen of the fetuses had BRA, ten had URA and 4 had congenital renal

Renal agenesis

Renal_agenesis

Enzyme-linked receptor

Class of enzymes

tyrphostins AG879 and AG1478 GDNF (glial cell-derived neurotrophic factor) GFRa1 GFRa1 " GDNF > neurturin > artemin GFRa2 GFRa2 " Neurturin > GDNF GFRa3 GFRa3

Enzyme-linked receptor

Enzyme-linked_receptor

Glial cell line-derived neurotrophic factor

Protein found in humans

Glial cell line-derived neurotrophic factor has been shown to interact with GFRA1 and GDNF family receptor alpha 1. The activity of GDNF, as well as other

Glial cell line-derived neurotrophic factor

Glial_cell_line-derived_neurotrophic_factor

Peritubular myoid cell

Smooth muscle cell found in testis

by the Sertoli cells during stages IX and I). Following this, GDNF binds GFRA1 on spermatogonial stem cells, and RET co-receptor (a transmembrane tyrosine

Peritubular myoid cell

Peritubular_myoid_cell

List of human protein-coding genes 3

HGNC:28159; Q3B7J2 6189 GFPT1 HGNC:4241; Q06210 6190 GFPT2 HGNC:4242; O94808 6191 GFRA1 HGNC:4243; P56159 6192 GFRA2 HGNC:4244; O00451 6193 GFRA3 HGNC:4245; O60609

List of human protein-coding genes 3

List_of_human_protein-coding_genes_3

Stem-cell niche

Specific location in the body containing stem cells

mouse SSCs in culture. However, the GDNF receptor c-RET and co-receptor GFRa1 are not solely expressed on the SSCs but also on Apaired and Aaligned, therefore

Stem-cell niche

Stem-cell_niche