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DNA structure
Gapmers are short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence. These linear pieces of genetic information
Gapmer
Disease in which fibrous connective tissue turns into bone
promising treatment is Antisense-mediated therapy using allele-selective LNA gapmers. Medical reports describing individuals affected by FOP date back to Dr
Fibrodysplasia ossificans progressiva
Fibrodysplasia_ossificans_progressiva
Pharmaceutical drug
Bepirovirsen (GSK3228836) is an antisense oligonucleotide gapmer developed to treat hepatitis B infection. Mak, Lung-Yi; Hui, Rex Wan-Hin; Fung, James;
Bepirovirsen
Antisense oligonucleotide
such as pain, swelling, itching, or bruising. Volanesorsen is an antisense gapmer oligonucleotide, a very short piece of synthetic RNA (a type of genetic
Volanesorsen
Pharmaceutical drug
from the middle section by spaces) are MOE-modified (i.e. inotersen is a gapmer). The most common side effects are injection site reactions (redness, swelling
Inotersen
Pharmaceutical compound
(codenamed IONIS-AGT-LRx), usually supplied as its sodium salt, is an antisense gapmer oligonucleotide designed to inhibit angiotensinogen as an alternative to
Evazarsen
on strain-promoted alkyne-azide cycloadditions: an MXD3 mRNA targeting gapmer (cEt and PS modified) linked to an anti-CD22 antibody targeting preB cells
Antibody–oligonucleotide conjugate
Antibody–oligonucleotide_conjugate
Drug used to treat genetic hypercholesterolemia
2’-O-methoxyethyl-modified ribose at the two ends, making mipomersen a gapmer. These modifications make the drug resistant to degradation by nucleases
Mipomersen
Muscular degenerative disease of the face, shoulder blades, and upper arms
Yokota T (2020-07-14). "Inhibition of DUX4 expression with antisense LNA gapmers as a therapy for facioscapulohumeral muscular dystrophy". Proceedings of
Facioscapulohumeral muscular dystrophy
Facioscapulohumeral_muscular_dystrophy
observed after local injection of phosphrothioate modified oligonucleotides. Gapmers often utilize nucleotides modified with phosphorothioate (PS) groups. Miravirsen
Phosphorothioate_nucleic_acid
Medication
oxygen and the 4' carbon atoms; this makes miravirsen a locked nucleic acid gapmer. Furthermore, miravirsen uses phosphorothioate linkages instead of the phosphate
Miravirsen
Group of genetic disorders
(2024-12-10). "Targeting heterozygous dominant negative variant of KCNA2 using Gapmer ASO for the treatment of drug-resistant epilepsy". Molecular Therapy. Nucleic
KCNA2-related_disorders
oligonucleotides (ASOs) known as gapmers can aid in decreasing the mutant RNA repeat transcripts. In the study, the gapmers tested contained specific modified
RNA-dominant_disease
Japanese biomedical scientist
Pieter Cullis. In 2020, they identified antisense oligonucleotides called gapmers that knock down the expression of a toxic gene called DUX4 in cell and
Toshifumi_Yokota
GAPMER
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Boy/Male
Hindu, Indian, Sanskrit
Servant of Lord Rama
Girl/Female
American, Australian
God's Promise
Boy/Male
Arabic, Muslim
Deep; Depth Like Sky; The Place Where Earth and Sky Meet; Silence
Male
English
Contracted form of Roman Latin Mauricius, MAURICE means "dark-skinned; Moor." Introduced to Britain by the Normans. Infrequently used by the French and English.
Boy/Male
English French
St. John.
Boy/Male
Tamil
Friend
Girl/Female
Hindu, Indian, Kannada, Marathi, Tamil, Telugu
Early Morning; From Sanskrit Word Prathyusham
Male
Spanish
Portuguese and Spanish form of Roman Latin Julius, JULIO means "descended from Jupiter (Jove)."
Male
French
Norman French form of Middle High German Haimirich, AIMERIC means "home-ruler."Â
Girl/Female
Indian, Telugu
Oneness; Non-duality
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