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Affecting GABA systems in the brain
is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). For example, a synapse is GABAergic if it
GABAergic
This is a list of hallucinogens, or psychoactive drugs that produce majorly altered states of consciousness. Psychdedelics, also known as serotonergic
List_of_hallucinogens
Main inhibitory neurotransmitter in the mammalian brain
intermediaries (G proteins) Neurons that produce GABA as their output are called GABAergic neurons. In adult vertebrates, GABA is usually considered as the major
GABA
Field of study
regulate nearby glutamate producing neurons. Both proteins are expressed by GABAergic neurons. Several studies have demonstrated that levels of both reelin
Epigenetics_of_schizophrenia
Nucleus in the basal ganglia of the brain
neurons (MSNs), which are the principal neurons of the striatum. They are GABAergic and, thus, are classified as inhibitory neurons. Medium spiny projection
Striatum
Structure in the basal ganglia of the brain
those of the globus pallidus, the neurons in pars reticulata are mainly GABAergic. The main input to the SNpr derives from the striatum. It comes by two
Substantia_nigra
Period of sleep in humans and other animals
include: The parafacial zone (GABAergic neurons), located within the medulla oblongata the nucleus accumbens core (GABAergic medium spiny neurons; specifically
Slow-wave_sleep
Projection neurons in the brain that synthesize and release dopamine
from other neurotransmitters systems, including glutaminergic inputs, GABAergic inputs, cholinergic inputs, and inputs from other monoaminergic nuclei
Dopaminergic_pathways
Part of the globus pallidus
midline of the brain. The GPe is predominantly composed of inhibitory GABAergic neurons that project axons to the subthalamic nucleus (in the diencephalon)
External_globus_pallidus
Group of neurons on the floor of the midbrain
RMTg) projects to the VTA with GABAergic afferents, functioning as a "master brake" for the VTA dopamine pathways. GABAergic inputs to the VTA also include
Ventral_tegmental_area
Protein found in humans
maintain elevated levels of neuronal excitation is through preventing GABAergic signaling activities. While glutamate is the brain's major excitatory
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Primary cell of the nervous system
Nedivi E (February 2006). "Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex". PLOS Biology. 4 (2) e29. doi:10
Neuron
Nucleus of the anterior hypothalamus
neurons in the VLPO that project to the ascending arousal system are GABAergic (neurons that produce GABA). In vitro studies in rats have shown that
Ventrolateral preoptic nucleus
Ventrolateral_preoptic_nucleus
Anxiolytic drug
needed] Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism
Fabomotizole
maturation of neural cells. Mello first investigations focused on the GABAergic system. During his time at the NIH, Mello found an inconsistency between
Fernando_Garcia_de_Mello
Impulse transmission between neurons
are located on the axon terminal of the presynaptic neuron, mainly at GABAergic and glutamatergic synapses. Neurotransmission is regulated by several
Neurotransmission
Brain structures in the forebrain
its cholinergic projection neurons, non-cholinergic neurons, especially GABAergic neurons, are more numerous, at least in rodents . Non-cholinergic neurons
Basal_forebrain
their production, and the GEs contribute significantly to building up the GABAergic cortical cell population. Another structure that the GEs contribute to
Ganglionic_eminence
Domesticated species of canid
"Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous
Dog
Neurons that are not motor or sensory
nucleoside analogs such as EdU. In 2008, a nomenclature for the features of GABAergic cortical interneurons was proposed, called Petilla terminology. Ia inhibitory
Interneuron
Chemical compound
Trional (Methylsulfonal) is a sedative-hypnotic and anesthetic drug with GABAergic actions[citation needed]. It has similar effects to Sulfonal, except it
Trional
Species of flowering plant
methysticum (kava), another anxiolytic GABAergic plant Valeriana officinalis (valerian), a sedative GABAergic plant "Scutellaria baicalensis". Germplasm
Scutellaria_baicalensis
Group of subcortical nuclei involved in the motor and reward systems
striatum. The striatum is composed mostly of medium spiny neurons. These GABAergic neurons project to the external (lateral) globus pallidus and internal
Basal_ganglia
Functional tissue of the brain
neurotransmitter such as excitatory dopaminergic neurons and inhibitory GABAergic neurons. Cortical interneurons only make up around a fifth of the neuronal
Brain_cell
Chemical compound
Tetronal is a sedative-hypnotic and anesthetic drug with GABAergic actions[citation needed]. It is not as effective as trional. Tetronal was introduced
Tetronal
Bilateral pathway in the brain
of this pathway release dopamine from axon terminals that synapse onto GABAergic medium spiny neurons (MSNs), also known as spiny projection neurons (SPNs)
Nigrostriatal_pathway
Type of GABAergic neuron in the striatum
as spiny projection neurons (SPNs), are a special type of inhibitory GABAergic neuron representing approximately 90% of neurons within the human striatum
Medium_spiny_neuron
Drug class
to increased extracellular concentrations of GABA and an increase in GABAergic neurotransmission. Tiagabine is a GRI that selectively inhibits the action
GABA_reuptake_inhibitor
Group of physical problems resulting from basal ganglia dysfunction
Connectivity diagram showing excitatory glutamatergic pathways as red, inhibitory GABAergic pathways as blue, and modulatory dopaminergic as magenta.
Basal_ganglia_disease
comprise the primary output of the basal ganglia, with its outgoing GABAergic neurons having an inhibitory function in the thalamus, the centromedian
Internal_globus_pallidus
Mammalian protein found in humans
presynaptic terminals of GABAergic (amygdala and cerebellum), glutamatergic (cortex, hippocampus and amygdala), dopaminergic, GABAergic interneurons, cholinergic
Cannabinoid_receptor_1
Chemical compound
Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku.
Afloqualone
Small lens-shaped nucleus in the brain
ganglia system. In humans there are also a small number (about 7.5%) of GABAergic interneurons that participate in the local circuitry; however, the dendritic
Subthalamic_nucleus
Science of drugs and medications and their effects
Serotonin receptor antagonist (5-HT3) Serotonin reuptake inhibitor (SRI) AA GABAergic GABA receptor agonist GABA receptor antagonist GABA reuptake inhibitor
Pharmacology
Chemical compound
the offspring of pregnant mice, which can be accompanied by decreased GABAergic transmission in the dentate gyrus. Poly I:C is a mismatched double-stranded
Polyinosinic:polycytidylic acid
Polyinosinic:polycytidylic_acid
Cerebellar neural cell
inhibitory GABAergic interneurons of the brain, found throughout different regions of the cortex and cerebellum. Basket cells are multipolar GABAergic interneurons
Basket_cell
Chemical compound
receptor antagonists like bicuculline and it has hence been labeled as GABAergic; however, it does not actually bind to GABA receptors, nor does it inhibit
Fengabine
Chemical compound
Cloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other
Cloroqualone
Chemical compound
Haxhiu MA, Martin RJ, Wilson CG (2006). "Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats". J Appl Physiol. 100 (1):
CGS-21680
Chemical compound
Side effects include dizziness and headaches. Mebutamate is one of many GABAergic drugs which act via allosteric agonism of the GABAA receptor at the β-subreceptor
Mebutamate
Region of the basal forebrain
The dopaminergic neurons of the mesolimbic pathway project onto the GABAergic medium spiny neurons of the nucleus accumbens and olfactory tubercle.
Nucleus_accumbens
GABA-releasing portion of the substantia nigra
of the neurons that project out of the pars reticulata are inhibitory GABAergic neurons (i.e., these neurons release GABA, which is an inhibitory neurotransmitter)
Pars_reticulata
Brain region having polygonal, fusiform, piriform neurons
layer of the dentate gyrus. The MRN was also found to be involved in GABAergic inhibitory control of serotonergic neurotransmission: GABA antagonist
Median_raphe_nucleus
Municipality in Navarre, Spain
et al. (July 2008). "Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex". Nat. Rev. Neurosci. 9 (7): 557–68
Petilla_de_Aragón
Pleasurable phenomenon elicited via direct stimulation of specific brain regions
relation to ICSS behavior: monoaminergic drugs, opioids, cholinergic drugs, GABAergic drugs, as well as a small number of drugs from other classes. These studies
Brain_stimulation_reward
GABAergic cortical interneurons. They are described as parvalbumin-containing and fast-spiking to distinguish them from other subtypes of GABAergic neurons
Chandelier_cell
One of the septal nuclei in the brain
in the generation of theta waves in the hippocampus. Specifically, the GABAergic cells of the medial septum that act as theta pacemakers target dentate
Medial_septal_nucleus
Interneuron cells in the retina of the eye
types of amacrine cells into subtypes. GABAergic, glycinergic, or neither: Amacrine cells can be either GABAergic, glycinergic or neither depending on what
Amacrine_cell
Medication
piperidine chemical class, one of many non-barbiturate, "barbiturate-like" GABAergic medications exhibiting general calming, relaxing, or "tranquilizing" properties
Glutethimide
Chemical compound
never marketed. It appears to exert its effects via acting through the GABAergic system. Benzodiazepine Borsini F, Volterra G, Cutrufo C, Furio M, Meli
Etazepine
Chemical compound
[citation needed] It exerts its pharmacological properties via enhancement of GABAergic inhibition. Fludiazepam has 4 times more binding affinity for benzodiazepine
Fludiazepam
Involuntary muscle contraction
tremor, but the mechanism behind this is unknown. Alcohol potentiates GABAergic transmission and might act at the level of the inferior olive. Tobacco
Tremor
Glutamatergic and GABAergic balance in the brain that affects seizure susceptibility
Glutamatergic and GABAergic balance in the brain that affects seizure susceptibility
Seizure_threshold
Drug that blocks histamine or histamine agonists
Serotonin receptor antagonist (5-HT3) Serotonin reuptake inhibitor (SRI) AA GABAergic GABA receptor agonist GABA receptor antagonist GABA reuptake inhibitor
Antihistamine
regulation, specifically for inducing slow-wave sleep. It is one of several GABAergic sleep-promoting nuclei in the brain, which also include the ventrolateral
Parafacial_zone
Chemical compound
Mebroqualone (MBQ) is a quinazolinone-class GABAergic and is an analogue of mecloqualone that has similar sedative and hypnotic properties to its parent
Mebroqualone
Amino acid and neurotransmitter
for the synthesis of the inhibitory gamma-aminobutyric acid (GABA) in GABAergic neurons. Its molecular formula is C 5H 9NO 4. Glutamic acid exists in
Glutamic_acid
Muscle relaxant medication
Carisoprodol is sometimes mixed with date rape drugs. As with other GABAergic drugs, combination with other drugs that depress the respiratory system
Carisoprodol
Chemical agents that inhibit Cholinesterase
Serotonin receptor antagonist (5-HT3) Serotonin reuptake inhibitor (SRI) AA GABAergic GABA receptor agonist GABA receptor antagonist GABA reuptake inhibitor
Cholinesterase_inhibitor
Type of inhibitory neuron in the human cerebral cortex
Rosehip neurons are inhibitory GABAergic neurons present in the first layer (the molecular layer) of the human cerebral cortex. They make up about 10–15%
Rosehip_neuron
Medication used for postpartum depression
acid (GABA) and is thought to exert antidepressant effects by enhancing GABAergic inhibition. The most common side effects include drowsiness, dizziness
Zuranolone
Chemical compound
radical to molecular oxygen (i.e., O2) and H 2O 2. A study conducted on the GABAergic neurons (i.e., nerve cells) in the neocortex of rat brains reported that
Α-Ketoglutaric_acid
Ionotropic receptor and ligand-gated ion channel
neurotransmitter in the central nervous system. Accurate regulation of GABAergic transmission through appropriate developmental processes, specificity
GABAA_receptor
Bi-directional nerve tract
subthalamic nucleus as part of the indirect pathway. The pallidal efferents are GABAergic, but also contain enkephalin. Its fibers interweave perpendicularly among
Subthalamic_fasciculus
Pathway in the hippocampus
for co-localization of both GABAergic (inhibitory) and glutamatergic neurotransmitters within mossy fiber terminals. GABAergic and glutamatergic co-localization
Mossy_fiber_(hippocampus)
Rare disorder involving deficiency in GABA degradation
uncoupling of the normal balance between glutamatergic excitatory activity and GABAergic inhibition, and may be responsible for the convulsive seizures that are
Succinic semialdehyde dehydrogenase deficiency
Succinic_semialdehyde_dehydrogenase_deficiency
Regulation of neurons by neurotransmitters
2007). "Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons". Cerebral Cortex. 17 (1): 163–174
Neuromodulation
Biochemical pathway that maintains glutamate supply in CNS
alternate mechanisms to cope with compromised glutamate–glutamine cycling. At GABAergic synapses, the cycle is called the GABA-glutamine cycle. Here the glutamine
Glutamate–glutamine_cycle
Electrical signal inhibiting a neuron from firing
Benzodiazepines (Valium) bind to the α and γ subunits of GABA receptors to improve GABAergic signaling. Alcohol also modulates ionotropic GABA receptors. Metabotropic
Inhibitory postsynaptic potential
Inhibitory_postsynaptic_potential
Raised body temperature caused by disease
receptor–expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling". Science Advances. 8 (51) eadd5463. Bibcode:2022SciA....8D5463N
Fever
Protein-coding gene in the species Homo sapiens
Accordingly, ATP depletion reduces the inhibitory transmission of the GABAergic system due to GABAA receptors rundown through β2. Since this rundown occasioned
GABRB2
Benzodiazepine anticonvulsant and anxiolytic
predominantly a positive allosteric modulator at the GABAA receptor to increase GABAergic transmission, particularly chloride conductance in neurons and with some
Clobazam
Class of compounds in the nervous system
"Regulation by Trace Amine-Associated Receptor 1 (TAAR1) of Dopaminergic-GABAergic Interaction in the Striatum: Effects of the Enhancer Drug (-)BPAP". Neurochem
Monoaminergic activity enhancer
Monoaminergic_activity_enhancer
Class of chemical compounds
inhibitors. Adenosinergic Adrenergic Cannabinoidergic Cholinergic Dopaminergic GABAergic Histaminergic Melatonergic Monoaminergic Opioidergic Serotonergic v t
Glycinergic
Protein-coding gene in the species Homo sapiens
subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment". Cell. 119 (2): 257–72.
NFASC
Obsolete sedative–hypnotic drug
human fetus, and it was not recommended during pregnancy. Like other GABAergic substances, prolonged use of methaqualone can lead to drug tolerance,
Methaqualone
Nociceptin receptor agonist
NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala". Frontiers in Integrative Neuroscience
MT-7716
Class of pharmacological agents
Serotonin receptor antagonist (5-HT3) Serotonin reuptake inhibitor (SRI) AA GABAergic GABA receptor agonist GABA receptor antagonist GABA reuptake inhibitor
Alpha_blocker
best known example. Adrenergic Cannabinoidergic Cholinergic Dopaminergic GABAergic Glycinergic Histaminergic Melatonergic Monoaminergic Opioidergic Serotonergic
Adenosinergic
Brain structure
onset and complexity tuned sustained responses. The nucleus is primarily GABAergic, and projects bilaterally to the inferior colliculus, and contralaterally
Lateral_lemniscus
Pharmaceutical drug
likely to be outweighed by the adverse effects associated with their [GABAergic agents'] use." In addition to being tested for antipsychotic-induced tardive
Progabide
Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous
Domestication_of_vertebrates
Calcium-binding protein with low molecular weight
N-terminal and C-terminal, respectively. Parvalbumin is present in some GABAergic interneurons in the nervous system, especially the reticular thalamus
Parvalbumin
Hungarian-American neuroscientist (born 1949)
and to behavior and sleep. He was the first to demonstrate the role of GABAergic interneurons in network oscillations. Buzsáki's recognition of the importance
György_Buzsáki
Pertaining to adrenaline or noradrenaline, or their receptors
transporter This includes antidepressants and drugs against ADHD. Dopaminergic GABAergic Nootropic Serotonergic Glutamatergic Racetam List of distinct cell types
Adrenergic
directly at the AIS, where they exert strong inhibitory influence through GABAergic transmission. The functional integrity of these connections is essential
Anaxonic_neuron
Species of plant
not fully understood beyond GABA modulation from Caleicine and other GABAergic compounds. The plant is known to potentiate dreams and hypnotic states
Calea_ternifolia
Medical condition
expression, which results in long-term changes in the function of the GABAergic neuronal system. During withdrawal from full or partial agonists, changes
Benzodiazepine_dependence
Chemical compound
Serotonin receptor antagonist (5-HT3) Serotonin reuptake inhibitor (SRI) AA GABAergic GABA receptor agonist GABA receptor antagonist GABA reuptake inhibitor
FAUC50
Structure within the basal ganglia of the brain
ganglia nuclei by the anterior commissure. The ventral pallidum contains GABAergic neurons, glutamatergic neurons, and cholinergic neurons that are well
Ventral_pallidum
American neuroscientist
corticotropin-releasing factor, nociceptin, and neuropeptide Y) signaling on GABAergic transmission in the central amygdala following excessive drinking and
Marisa_Roberto
State of decreased cerebral blood flow
circuit. The corticolimbothalamic circuit has a high concentration of GABAergic interneurons, which are neurons that predominantly work with the inhibitory
Hypofrontality
each participates in a different glomerulus. Glomeruli also contain the GABAergic (inhibitory) synapses of Golgi cells onto granule cells, and the glutamatergic
Glomerulus_(cerebellum)
Protein-coding gene in the species Homo sapiens
regulation of neurotransmitter secretion regulation of synaptic transmission, GABAergic positive regulation of insulin secretion involved in cellular response
BAIAP3
Class of medications used to alleviate anxiety
Russia in the early 2000s. Its mechanism of action is poorly defined, with GABAergic, NGF and BDNF release promoting, MT1 receptor agonism, MT3 receptor antagonism
Anxiolytic
Chemical compound
useful tool in studying the pharmacology of the GHB receptor in absence of GABAergic effects. Wu H, Zink N, Carter LP, Mehta AK, Hernandez RJ, Ticku MK, Lamb
4-Hydroxy-4-methylpentanoic acid
4-Hydroxy-4-methylpentanoic_acid
Earliest gonadal changes of puberty
stimulation of these hormones from the hypothalamus is suppressed through GABAergic-releasing inhibitory neurons in the central nervous system. Some input
Gonadarche
Type of neuron
cortex is no exception: like the hippocampus, it receives cholinergic and GABAergic input from the medial septal area, the central controller of theta. Grid
Grid_cell
Component of brain anatomy
through strata oriens and moleculare of subiculum and CA1. Cholinergic and GABAergic projections from MS-DBB to CA1 also pass through the fimbria. Fimbria
Hippocampus_anatomy
Group of neural structures responsible for motivation and desire
connect structures within the reward system are glutamatergic interneurons, GABAergic medium spiny neurons (MSNs), and dopaminergic projection neurons, although
Reward_system
GABAERGIC
GABAERGIC
GABAERGIC
GABAERGIC
Boy/Male
Tamil
Hari Krishna | ஹரிகரஷà¯à®£
Another name Lord Krishna
Boy/Male
Hindu, Indian
Sunray
Female
Finnish
 Pet form of Finnish Katariina, KATI means "pure." Compare with another form of Kati.
Girl/Female
Hindu, Indian
Whose Soul is for Religion
Boy/Male
Biblical
The world, rustiness.
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Telugu
The King; Lord Vishnu
Boy/Male
British, English
From the Brook by the Sea
Surname or Lastname
English, of Welsh origin
English, of Welsh origin : variant of Blevins.
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Tamil, Telugu
Light of the World
Girl/Female
Indian
GABAERGIC
GABAERGIC
GABAERGIC
GABAERGIC
GABAERGIC