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FOXC2

  • FOXC2
  • Protein-coding gene in the species Homo sapiens

    Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1

    FOXC2

    FOXC2

    FOXC2

  • Lymphedema–distichiasis syndrome
  • Medical condition

    Lymphedema–distichiasis syndrome is a medical condition associated with the FOXC2 gene. People with this hereditary condition have a double row of eyelashes

    Lymphedema–distichiasis syndrome

    Lymphedema–distichiasis syndrome

    Lymphedema–distichiasis_syndrome

  • FOXC2-AS1
  • Non-coding RNA in the species Homo sapiens

    FOXC2 antisense RNA 1 is a protein that in humans is encoded by the FOXC2-AS1 gene. "Human PubMed Reference:". National Center for Biotechnology Information

    FOXC2-AS1

    FOXC2-AS1

  • Pitt–Hopkins syndrome
  • Medical condition

    STHAG3 3.3 FOXC1 Axenfeld syndrome 3 Iridogoniodysgenesis, dominant type FOXC2 Lymphedema–distichiasis syndrome FOXE1 Bamforth–Lazarus syndrome FOXE3 Anterior

    Pitt–Hopkins syndrome

    Pitt–Hopkins syndrome

    Pitt–Hopkins_syndrome

  • Milroy's disease
  • Lymphedema commonly located in the legs

    been linked to a mutations in the 'forkhead' family transcription factor (FOXC2) gene located on the long arm of chromosome 16 (16q24.3). About 2000 cases

    Milroy's disease

    Milroy's disease

    Milroy's_disease

  • Forkhead box C1
  • Protein-coding gene in the species Homo sapiens

    regulation of embryonic and ocular development. FOXC1 and its close relative, FOXC2 are both critical components in the development of the heart and blood vessels

    Forkhead box C1

    Forkhead box C1

    Forkhead_box_C1

  • Meige disease
  • Medical condition

    been linked to a mutations in the ‘forkhead’ family transcription factor (FOXC2) gene located on the long arm of chromosome 16 (16q24.3). It is the most

    Meige disease

    Meige_disease

  • Varicose veins
  • Medical condition in which superficial veins become large and twisted

    Ed. Ng MY, Andrew T, Spector TD, Jeffery S (March 2005). "Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected

    Varicose veins

    Varicose veins

    Varicose_veins

  • Chromosome 16
  • Human chromosome

    member B FBRS: Probably fibrosin-1 long transcript protein FOXC2-AS1: encoding protein FOXC2 antisense RNA 1 GLG1: Golgi apparatus protein 1 HBAP1: Hemoglobin

    Chromosome 16

    Chromosome 16

    Chromosome_16

  • Schlemm's canal
  • Lymphatic-like vessel in the eye

    lymphatic endothelium, including the expression of PROX1, VEGFR3, CCL21, FOXC2, but lacked the expression of LYVE1 and PDPN. It develops via a unique mechanism

    Schlemm's canal

    Schlemm's canal

    Schlemm's_canal

  • Development, Growth & Differentiation
  • Academic journal

    Morikawa, M. Heglind, S. Enerback, T. Ezaki and J. Tamaoki 59 501-514 2017 Foxc2 influences alveolar epithelial cell differentiation during lung development

    Development, Growth & Differentiation

    Development,_Growth_&_Differentiation

  • Campomelic dysplasia
  • Medical condition

    STHAG3 3.3 FOXC1 Axenfeld syndrome 3 Iridogoniodysgenesis, dominant type FOXC2 Lymphedema–distichiasis syndrome FOXE1 Bamforth–Lazarus syndrome FOXE3 Anterior

    Campomelic dysplasia

    Campomelic dysplasia

    Campomelic_dysplasia

  • Tetralogy of Fallot
  • Type of congenital heart defect

    this gene have been associated with TOF, accounting for 2.4% of all cases. FOXC2 is another gene involved in embryonic development of the cardiac system

    Tetralogy of Fallot

    Tetralogy of Fallot

    Tetralogy_of_Fallot

  • List of human transcription factors
  • ENSG00000054598 Forkhead Known motif – High-throughput in vitro [244] WRWRTMAAYAW FOXC2 ENSG00000176692 Forkhead Known motif – High-throughput in vitro [245] WAHRTMAAYAWW

    List of human transcription factors

    List_of_human_transcription_factors

  • BSD domain
  • Protein family

    promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation". Science Signaling. 6 (257): ra2

    BSD domain

    BSD domain

    BSD_domain

  • Epithelial–mesenchymal transition
  • Biological process in animal connective tissue

    Twist, Goosecoid, TCF4 (also known as E2.2), homeobox protein SIX1 and FOXC2 (fork-head box protein C2) repress E-cadherin indirectly. SNAIL and ZEB

    Epithelial–mesenchymal transition

    Epithelial–mesenchymal_transition

  • FOX proteins
  • Family of transcription factors involved in anatomical development

    Hepatocyte nuclear factors.) FOXB1, FOXB2 FOXC1 (associated with glaucoma), FOXC2 (varicose veins) FOXD1, FOXD2, FOXD3 (vitiligo), FOXD4, FOXD4L1, FOXD4L3

    FOX proteins

    FOX proteins

    FOX_proteins

  • Developmental bioelectricity
  • Electric current produced in living cells

    Kanady, J. D; Munger, S. J; Witte, M. H; Simon, A. M (2015). "Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular

    Developmental bioelectricity

    Developmental bioelectricity

    Developmental_bioelectricity

  • Homeobox protein goosecoid
  • Protein-coding gene in the species Homo sapiens

    characteristics. GSC, along with other transcription factors like Twist, FOXC2, and Snail, induce epithelial to mesenchymal transitions by regulating the

    Homeobox protein goosecoid

    Homeobox protein goosecoid

    Homeobox_protein_goosecoid

  • Tricho-rhino-phalangeal syndrome Type 1
  • Medical condition

    STHAG3 3.3 FOXC1 Axenfeld syndrome 3 Iridogoniodysgenesis, dominant type FOXC2 Lymphedema–distichiasis syndrome FOXE1 Bamforth–Lazarus syndrome FOXE3 Anterior

    Tricho-rhino-phalangeal syndrome Type 1

    Tricho-rhino-phalangeal_syndrome_Type_1

  • List of genes mutated in cutaneous conditions
  • arachnodactyly Fibulin-4 Fibulin-4 Cutis laxa Fibulin-5 Fibulin-5 Cutis laxa FOXC2 Lymphedema–distichiasis syndrome Meige lymphedema GALNT3 Familial tumoral

    List of genes mutated in cutaneous conditions

    List_of_genes_mutated_in_cutaneous_conditions

  • GATA2 deficiency
  • Medical condition

    factor contributes to controlling the expression of two genes, PROX1 and FOXC2, which are required for the proper development of the lymphatic system,

    GATA2 deficiency

    GATA2_deficiency

  • SYAP1
  • Protein-coding gene in the species Homo sapiens

    promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation". Science Signaling. 6 (257): ra2

    SYAP1

    SYAP1

    SYAP1

  • Basal-like carcinoma
  • Breast cancer subtype

    pathways in BLBC leads to the expression of EMT-related transcription factors FOXC2, Twist, Slug, Snail, and LBX1, and then resulting in down-regulation of

    Basal-like carcinoma

    Basal-like carcinoma

    Basal-like_carcinoma

  • Tissue nanotransfection
  • necrotic and decays. Using a patented cocktail of plasmids (Etv2, Fli1, Foxc2, or EFF), these factors were delivered to the tissue above the surgery site

    Tissue nanotransfection

    Tissue_nanotransfection

  • List of OMIM disorder codes
  • with renal disease and diabetes mellitus; 153400; FOXC2 Lymphedema–distichiasis syndrome; 153400; FOXC2 Lymphoma, non-Hodgkin; 605027; PRF1 Lymphoma, non-Hodgkin

    List of OMIM disorder codes

    List_of_OMIM_disorder_codes

  • Cancer stem cell
  • Cancer cells with features of normal cells

    Hartwell K, Richardson AL, Weinberg RA (June 2007). "Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like

    Cancer stem cell

    Cancer stem cell

    Cancer_stem_cell

  • Margaret Buckingham
  • French-British biologist

    Tsutomu; Relaix, Frédéric; Buckingham, Margaret E. (December 2009). "Pax3:Foxc2 Reciprocal Repression in the Somite Modulates Muscular versus Vascular Cell

    Margaret Buckingham

    Margaret Buckingham

    Margaret_Buckingham

  • List of human protein-coding genes 3
  • Q99853 5791 FOXB2 HGNC:23315; Q5VYV0 5792 FOXC1 HGNC:3800; Q12948 5793 FOXC2 HGNC:3801; Q99958 5794 FOXD1 HGNC:3802; Q16676 5795 FOXD2 HGNC:3803; O60548

    List of human protein-coding genes 3

    List_of_human_protein-coding_genes_3

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Online names & meanings

  • Harlow
  • Boy/Male

    English

    Harlow

    Meadow of the hares.. Surname.

  • Suniya | سونییا
  • Girl/Female

    Muslim

    Suniya | سونییا

    Varnam

  • Daya
  • Girl/Female

    Gujarati, Hawaiian, Hebrew, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Oriya, Punjabi, Sanskrit, Sikh, Tamil, Telugu, Zimbabwe

    Daya

    Kindness; Mercy; Pity

  • Pullin
  • Surname or Lastname

    English (Bristol)

    Pullin

    English (Bristol) : variant spelling of Pullen.

  • Mulayka
  • Girl/Female

    Arabic, Muslim

    Mulayka

    Angel; Diminutive of Malaka

  • Magnor
  • Boy/Male

    Norse

    Magnor

    Fighter.

  • Dharamgun
  • Boy/Male

    Indian, Punjabi, Sikh

    Dharamgun

    Virtues of Righteousness

  • Avram
  • Boy/Male

    Australian, Chinese, Hebrew, Jewish

    Avram

    Original Name of the Father of the People; Father of Many; He who is High is Father; Father of a Multitude

  • Tahmid
  • Boy/Male

    Indian

    Tahmid

    Praise of almighty Allah, Thanks to the graceful and merciful Allah

  • Bharpur
  • Boy/Male

    Indian, Punjabi, Sikh

    Bharpur

    Perfect One; Satisfied

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FOXC2

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