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Mammalian protein found in Homo sapiens
Fanconi anemia, complementation group M, also known as FANCM is a human gene. It is an emerging target in cancer therapy, in particular cancers with specific
FANCM
Genetic disease causing anemia, birth defects, and cancers
FANCD1 (BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (BRIP1), FANCL, FANCM, FANCN (PALB2), FANCO (RAD51C), FANCP (SLX4), FANCQ (XPF), FANCS (BRCA1)
Fanconi_anemia
Cellular process
"MHF1 plays Fanconi anaemia complementation group M protein (FANCM)-dependent and FANCM-independent roles in DNA repair and homologous recombination in
Chromosomal_crossover
Class of enzymes that unpack genetic material
non-crossover (NCO) recombinant. In the yeast Schizosaccharomyces pombe the FANCM-family DNA helicase FmI1 directs NCO recombination formation during meiosis
Helicase
Model of DNA repair in biology
Landais I, de Graaf B, Hoatlin ME (Sep 2009). "The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways". Journal of Biological
Double-strand break repair model
Double-strand_break_repair_model
Telomerase-independent mechanism
Bythell-Douglas R, Dunn EA, Deans AJ (December 2019). "ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres". Nucleus
Alternative Lengthening of Telomeres
Alternative_Lengthening_of_Telomeres
Protein-coding gene in the species Homo sapiens
FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the
FANCI
Genetic disorder
07.001. PMC 6080766. PMID 30057030. Deans AJ, West SC (December 2009). "FANCM connects the genome instability disorders Bloom syndrome and Fanconi Anemia"
Bloom_syndrome
Class of enzymes
crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM". Proc. Natl. Acad. Sci. U.S.A. 112 (15): 4713–8. Bibcode:2015PNAS..112
RecQ_helicase
FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCP, FANCS, RAD51C, XPF 1:130,000 Fabry disease GLA (Xq22.1) P
List_of_genetic_disorders
Three-stranded nucleic acid structure
class capable of removing R-loops are branchpoint translocases such as FANCM, SMARCAL1 and ZRANB3 in humans or RecG in bacteria. Branchpoint translocases
R-loop
Group of proteins
by the interaction of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM and the accessory proteins (FAAP20, FAAP24, and FAAP100). These accessory
FANC_proteins
Mammalian protein found in humans
Bloom syndrome protein has been shown to interact with: ATM, CHAF1A, CHEK1, FANCM, FEN1, H2AFX, MCM6 MLH1 P53, RAD51L3, RAD51, RPA1, TOP3A, TP53BP1, WRN,
Bloom_syndrome_protein
Genus of amphibians
I, de Graaf B, Hoatlin ME (September 2009). "The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways". The Journal of Biological
Xenopus
Massive chromosomal rearrangement process linked to cancer
patients to cancer due to its effect on DNA repair pathways. Mutations in FANCM gene cause increased micronucleus formation and hence extreme chromothripsis
Chromothripsis
Protein-coding gene in the species Homo sapiens
III alpha, while OB2 binds to RMI2 within the Bloom Syndrome complex, and FANCM of the Fanconi Anaemia pathway. An insert within OB1 domain of RMI1 inserts
RMI1
Protein-coding gene in the species Homo sapiens
TOP3A and RECQ4A/B helicase antagonize formation of COs in parallel to FANCM helicase. Sequela-Arnaud et al. suggested that CO numbers are restricted
TOP3A
Mammalian protein found in humans
Cellular component extracellular region Fanconi anaemia nuclear complex FANCM-MHF complex extracellular space Biological process adenylate cyclase-inhibiting
Cortistatin_(neuropeptide)
Mammalian protein found in Homo sapiens
UniProt. Retrieved 2025-10-22. Ali AM, Singh TR, Meetei AR (July 2009). "FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA". Mutation Research. Fanconi
BRIP1
Inherited genetic condition that predisposes a person to cancer
FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCO, FANCP and BRCA2 (previously known as FANCD1). Inheritance
Hereditary_cancer_syndrome
Gene known for its role in breast cancer
Landais I, de Graaf B, Hoatlin ME (2009). "The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways". J. Biol. Chem. 284 (38):
BRCA2
Protein-coding gene in the species Homo sapiens
containing FANCL (as well as FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCM) is essential for the activation of FANCD2 to the mono-ubiquitinated isoform
FANCL
C, Froger N, Pradillo M, Santos JL, Chelysheva L, et al. (June 2012). "FANCM limits meiotic crossovers". Science. 336 (6088): 1588–90. Bibcode:2012Sci
Synthesis-dependent strand annealing
Synthesis-dependent_strand_annealing
Medical condition
demonstrated that the loss of the enzymes BLM (Bloom's Syndrome Helicase) or FANCM each result in a dramatic increase in the number of chromatin bridges. This
Chromatin_bridge
Protein-coding gene in the species Homo sapiens
I, de Graaf B, Hoatlin ME (September 2009). "The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways". The Journal of Biological
PALB2
O15287 5458 FANCI HGNC:25568; Q9NVI1 5459 FANCL HGNC:20748; Q9NW38 5460 FANCM HGNC:23168; Q8IYD8 5461 FANK1 HGNC:23527; Q8TC84 5462 FAP HGNC:3590; Q12884
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
British scientist
protein targets. Also, he has discovered that the Fanconi Anemia proteins FANCM and FAAP24 are required for checkpoint-kinase signalling (ATR) in response
Simon_Boulton
Medical condition
Companion Reviews and Search Terms FANCJ - Companion Reviews and Search Terms FANCM - Companion Reviews and Search Terms FANCN - Companion Reviews and Search
DNA repair-deficiency disorder
DNA_repair-deficiency_disorder
Protein-coding gene in the species Homo sapiens
I, de Graaf B, Hoatlin ME (September 2009). "The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways". The Journal of Biological
FANCD2
Protein-coding gene in the species Homo sapiens
— CHAMP1 deficiency creates synthetic lethality with inhibition of the FANCM translocase. Independently, the CHAMP1 complex is required for the survival
CHAMP1
Protein-coding gene in the species Homo sapiens
containing FANCG (as well as FANCA, FANCB, FANCC, FANCE, FANCF, FANCL and FANCM) is essential for the activation of the FANCD2 protein to the mono-ubiquitinated
FANCG
Protein-coding gene in the species Homo sapiens
complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCF, FANCG and FANCL, FANCA interacts with HES1. This
FANCA
FANCM
FANCM
FANCM
FANCM
Boy/Male
American, Bengali, British, Christian, English, French, German, Hebrew, Hindu, Indian, Malayalam
Gift of the Lord; A Legend Person
Girl/Female
Hindu, Indian, Kannada
Little One; Tiny Girl
Surname or Lastname
English and Scottish
English and Scottish : variant of Marr.
Girl/Female
Spanish
Weakness.
Male
Egyptian
, a high Egyptian functionary.
Girl/Female
British, English, Hindu, Indian
Owner; Powerful; Princess
Male
Polish
 Danish, German, Polish and Swedish form of Greek Klementos, KLEMENS means "gentle and merciful."
Boy/Male
Hindu, Indian, Traditional
A Wise Man; Poet
Girl/Female
Tamil
Roopavathi | ரூபாவதீ
Beautiful
Boy/Male
Hindu
Bright, Very bright, Happiness
FANCM
FANCM
FANCM
FANCM
FANCM