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Protein-coding gene in the species Homo sapiens
Fanconi anemia group D2 protein (FANCD2) is a nuclear protein that in humans is encoded by the FANCD2 gene that plays a central role in the Fanconi anemia
FANCD2
Genetic disease causing anemia, birth defects, and cancers
E3 ubiquitin-ligase and monoubiquitinates FANCD2 and FANCI. Monoubiquitinated FANCD2, also known as FANCD2-L, then goes on to interact with a BRCA1/BRCA2
Fanconi_anemia
Protein-coding gene in the species Homo sapiens
(FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically heterogeneous
FANCE
Protein-coding gene in the species Homo sapiens
FANCD2/FANCI-associated nuclease 1 (KIAA1018) is an enzyme that in humans is encoded by the FAN1 gene. It is a structure dependent endonuclease. It is
FAN1
Gene known for its role in breast cancer
interact with BRE, BARD1, BCCIP, BRCA1, BRCC3, BUB1B, CREBBP, C11orf30, FANCD2, FANCG, FLNA, HMG20B, P53, PALB2, PCAF, PLK1, RAD51, RPA1, SHFM1 and SMAD3
BRCA2
Protein-coding gene in the species Homo sapiens
of FANCD2 to the mono-ubiquitinated isoform. In normal, non-mutant cells FANCD2 is mono-ubiquitinated in response to DNA damage. Activated FANCD2 protein
FANCL
Protein-coding gene in the species Homo sapiens
(FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and
FANCI
Protein-coding gene in the species Homo sapiens
ME (September 2009). "The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways". The Journal of Biological Chemistry. 284 (38):
PALB2
Cancer that originates in mammary glands
Thompson LH, Lamerdin JE, Brooks PJ (May 2009). "Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human
Breast_cancer
FECH 1:75,000-200,000 Fanconi anemia (FA) FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCP, FANCS, RAD51C
List_of_genetic_disorders
Protein-coding gene in the species Homo sapiens
name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene. The gene is encoded on Chromosome 3 (human) at p25.3 on the minus
FANCD2OS
Cancer affecting Tasmanian devils
chromosomes 1, 2 and 3. Some of the mutated or deleted genes in DFTD are RET, FANCD2, MAST3 and BTNL9-like gene. Classical DFTD likely originated in the Schwann
Devil_facial_tumour_disease
Protein-coding gene in the species Homo sapiens
(FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically heterogeneous
FANCB
Medical condition
the S phase, when there are errors in the cell DNA (2) to interact with FANCD2 that can activate the BRCA1/BRCA2 pathway of DNA repair. This explains why
Nijmegen_breakage_syndrome
Medical condition
pathway requires proteins produced by several other genes, including CHK2, FANCD2 and ATM. Harmful mutations in any of these genes disable the gene or the
BRCA_mutation
Protein-coding gene in the species Homo sapiens
JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8
RAD51L3
Model of DNA repair in biology
downstream targets FANCD2 and FANCI. ATM activates (phosphorylates) CHEK2 and FANCD2 CHEK2 phosphorylates BRCA1. Ubiquinated FANCD2 complexes with BRCA1
Double-strand break repair model
Double-strand_break_repair_model
Protein-coding gene in the species Homo sapiens
(FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the
FANCA
Gene known for its role in breast cancer
CHEK2 CLSPN COBRA1 CREBBP CSNK2B CSTF2 CDK2 DHX9 ELK4 EP300 ESR1 FANCA FANCD2 FHL2 H2AFX JUNB JunD LMO4 MAP3K3 MED17 MED21 MRE11A MSH2 MSH3 MSH6 Myc NBN
BRCA1
Protein-coding gene in the species Homo sapiens
FANCD2 protein to the mono-ubiquitinated isoform. In normal, non-mutant, cells FANCD2 is mono-ubiquinated in response to DNA damage. Activated FANCD2
FANCG
Biological cell regulation mechanisms
"Alcohol induces DNA damage and the Fanconi anemia D2 protein implicating FANCD2 in the DNA damage response pathways in brain". Alcoholism: Clinical and
Regulation_of_gene_expression
Chemical compound
Kaspers GJ, et al. (November 2019). "Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin"
Celastrol
Genus of amphibians
ME (September 2009). "The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways". The Journal of Biological Chemistry. 284 (38):
Xenopus
Phenomenon in genetics
"XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4". Molecular Cell. 54 (3): 460–471. doi:10.1016/j.molcel.2014
Crosslinking_of_DNA
Protein-coding gene in the species Homo sapiens
"XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4". Molecular Cell. 54 (3): 460–471. doi:10.1016/j.molcel.2014
ERCC4
Biological processes used in gene regulation
"Alcohol induces DNA damage and the Fanconi anemia D2 protein implicating FANCD2 in the DNA damage response pathways in brain". Alcoholism: Clinical and
Histone acetylation and deacetylation
Histone_acetylation_and_deacetylation
Developmental disorder involving the eye
syndrome (CJS) SALL4 AR Duane-radial ray syndrome, Okihiro syndrome FANCA, FANCD2, FANCE, FANCI, FANCL AR Fanconi anemia complementation groups A, D2, E,
Syndromic_microphthalmia
Protein-coding gene in the species Homo sapiens
essential for the activation of the FANCD2 protein to the mono-ubiquitinated isoform. In normal, non-mutant, cells FANCD2 is mono-ubiquinated in response
Fanconi anemia, complementation group C
Fanconi_anemia,_complementation_group_C
Canadian/British scientist
GL, Patel KJ, Passmore LA (2014). "The Genetic and Biochemical Basis of FANCD2 Monoubiquitination". Molecular Cell. 54 (5): 858–869. doi:10.1016/j.molcel
Lori_Passmore
Protein-coding gene in the species Homo sapiens
of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility". Scientific Reports. 7 (1):
Testis_expressed_15
Protein-coding gene in the species Homo sapiens
repair, cooperating with UHRF2 to promote the recruitment and activation of FANCD2 at interstrand cross-links. It also contributes to mitotic spindle organization
UHRF1
Protein
enzomenib, icovamenib, and ziftomenib. MEN1 has been shown to interact with: FANCD2, GFAP, JunD, NFKB1, MLL, RPA2, and VIM. GRCh38: Ensembl release 89: ENSG00000133895
MEN1
Protein-coding gene in the species Homo sapiens
JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Human Molecular Genetics. 13
RAD51C
Inherited genetic condition that predisposes a person to cancer
hypopigmentation. To date, the genes known to cause FA are: FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCO, FANCP and
Hereditary_cancer_syndrome
Group of proteins
(FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM) other: FANCD1, FANCD2, FANCI, FANCJ, FANCN, FANCP They are involved in DNA replication and damage
FANC_proteins
Medical condition
There are currently fifteen known FANC genes, with FANCA, FANCC, FANCG, and FANCD2 being the most common. For certain FA patients, androgen therapy works well
Congenital_hypoplastic_anemia
FAM180A Gene
accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. SLC25A29 Mitochondrial basic amino acids transporter Transports arginine
Family with sequence similarity 180A
Family_with_sequence_similarity_180A
Cell death resulting from a deficiency of or interaction between in two or more genes
defects beyond BRCA1/2 deficiencies. These include deficiencies in PALB2, FANCD2, RAD51, ATM, MRE11, p53, XRCC1 and LSD1. ARID1A, a chromatin modifier, is
Synthetic_lethality
Protein-coding gene in the species Homo sapiens
interact with: AURKB, BCL3, BRCA1, BRCA2, BRCC3, BRE, CSTF1, CSTF2, EWSR1, FANCD2, H2AFX, NPM1, P53, RAD51, TACC1, and UBE2D1. If a cancer cell's capacity
BARD1
Medical condition
emanate from either centromeres, telomeres or DNA crosslinks (as marked by FANCD2). Chromatin bridges can be viewed utilizing a laboratory technique known
Chromatin_bridge
Crossan, Gerry P.; Rosado, Ivan V.; Arends, Mark J.; Patel, Ketan J. (2011). "Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice".
Ketan_J._Patel
Protein-coding gene in the species Homo sapiens
been shown to interact with: Androgen receptor, BCL3, CREB1, ETV6, EDNRA FANCD2, HDAC7A, Mdm2, Myc, and PLA2G4A. PXR GRCh38: Ensembl release 89: ENSG00000172977
KAT5
HGNC:3582; O15360 5451 FANCB HGNC:3583; Q8NB91 5452 FANCC HGNC:3584; Q00597 5453 FANCD2 HGNC:3585; Q9BXW9 5454 FANCD2OS HGNC:28623; Q96PS1 5455 FANCE HGNC:3586;
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
Protein-coding gene in the species Homo sapiens
JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8
RAD51L1
Protein-coding gene in the species Homo sapiens
complex that is essential for the monoubiquitination of FANCD2 and this modified form of FANCD2 colocalizes with BRCA1, RAD51 and PCNA in foci that also
FANCF
Polish-born scientist
Cellular Biology 2000 Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair – Cell, 2007 Different telomere damage signaling
Agata_Smogorzewska
Mammalian protein found in Homo sapiens
shown to interact with: Abl gene, BRCA1, Bloom syndrome protein, DNA-PKcs, FANCD2, MRE11A, Nibrin, P53, RAD17, RAD51, RBBP8, RHEB, RRM2B, SMC1A TERF1, and
ATM_serine/threonine_kinase
Protein-coding gene in the species Homo sapiens
JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8
XRCC3
relationship with BARD1 Binding Direct physical interaction between two molecules FANCD2 has a "Binding" relationship with BRCA1 Protein Modification Changes the
EMBiology
Protein-coding gene in the species Homo sapiens
JP, Ashworth A, Jones NJ, Mathew CG (Jun 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Human Molecular Genetics. 13
XRCC2
Protein-coding gene in humans
"XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4". Molecular Cell. 54 (3): 460–71. doi:10.1016/j.molcel.2014
ERCC1
Protein-coding gene in the species Homo sapiens
DL, Hiom K, Patel KJ (July 2003). "BRCA1-independent ubiquitination of FANCD2". Mol. Cell. 12 (1): 247–54. doi:10.1016/s1097-2765(03)00281-8. PMID 12887909
UBE2D1
FANCD2
FANCD2
FANCD2
FANCD2
Girl/Female
Arabic, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Muslim, Sindhi, Telugu
Lightning; Bright
Girl/Female
Muslim/Islamic
Intelligent wise, learned
Female
Hebrew
(הָגָר) Hebrew name HAGAR means "flight." In the bible, this is the name of the mother of Ishmael.Â
Girl/Female
Muslim/Islamic
Leader pioneer
Boy/Male
Arabic, Muslim
Breeze of the Truth; Allah
Girl/Female
Welsh Hebrew
Bitter.
Surname or Lastname
English
English : from the expression ‘God speed (you)’; a wish for success for one setting out on an enterprise, presumably applied as a nickname for someone who habitually used this expression.
Girl/Female
Indian
The mixture of the smell of the petals of rose and sundal, Strong, Brave
Female
Hindi/Indian
(अà¤à¤¿à¤²à¤¾à¤·à¤¾) Hindi name ABHILASHA means "desire."
Girl/Female
Muslim
Sweet
FANCD2
FANCD2
FANCD2
FANCD2
FANCD2