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Search references for EXOSITE. Phrases containing EXOSITE
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An exosite is a secondary binding site, remote from the active site, on an enzyme or other protein. This is similar to allosteric sites, but differs in
Exosite
Oligonucleotides which recognize the exosites of human thrombin
aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA, was generated
Anti-thrombin_aptamers
Exosite is an Internet of Things (IoT) software as a service company that develops software for companies that view and analyze data collected from sensors
Exosite_(company)
Anticoagulant medication taken by mouth
Bivalent DTIs (hirudin and analogs) bind both to the active site and exosite 1, while univalent DTIs bind only to the active site. The third class of
Direct_thrombin_inhibitor
Drug discovery
Ser-195. Thrombin also has two exosites (1 and 2). Thrombin is a little different from other serine proteases as exosite 1 is anion-binding and binds to
Discovery and development of direct thrombin inhibitors
Discovery_and_development_of_direct_thrombin_inhibitors
Drug prescribed for asthma patients
slower onset of action compared to salbutamol. Salmeterol binds to an exosite on the β2 adrenergic receptor, and this has been proposed to explain its
Long-acting beta-adrenoceptor agonist
Long-acting_beta-adrenoceptor_agonist
American actress
Miller, C.J., Lou, H.J., Turk, B.E. Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor. J. Biol. Chem. 2017
Eunice_Cho
Enzyme involved in blood coagulation in humans
WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG 1aix: HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR
Thrombin
Chemical compound in leeches
domain makes numerous electrostatic interactions with an anion-binding exosite of thrombin, while the last five residues are in a helical loop that forms
Hirudin
Pharmaceutical compound
Thrombin acts on two exosites to fibrinogen. Exosite 1 mediates the binding of thrombin to the Aα- and Bβ-chains, and exosite 2 causes an interaction
Batroxobin
Industrial machine software platform
IoT packages — Amazon Web Services (AWS), Ayla Networks, Cisco Jasper, Exosite, General Electric (GE), IBM, LogMeIn, Microsoft, PTC, SAP, and Zebra Technologies
Predix_(software)
Anticoagulant
factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin"
Heparin
Mammalian protein found in Homo sapiens
phospholipids for anticoagulation and to EPCR for cytoprotection. One particular exosite augments protein C's ability to inactivate Factor Va efficiently. Another
Protein_C
Mammalian protein found in Homo sapiens
modifications) on its surface region, that has been termed the "anion binding exosite." This site consists of an area of excess positive charge, which has been
Acrosin
Anticoagulant drug
specifically binding both to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Thrombin is a serine proteinase
Bivalirudin
Antiplatelet drug
"Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors". Journal of Medicinal Chemistry. 35 (24). American Chemical
Tirofiban
Physical interactions and constructions between multiple proteins
"Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors". Journal of Medicinal Chemistry. 35 (24). American Chemical
Protein–protein_interaction
Mammalian protein found in humans
in PAR1 is further aided by secondary interactions between thrombin's exosite and an acidic region of amino acid residues located C-terminal to Ser-42
Proteinase-activated receptor 1
Proteinase-activated_receptor_1
Mammalian protein found in humans
TISSUE FACTOR 1dva: Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor VIIA 1f7e: THE FIRST EGF-LIKE DOMAIN
Factor_VII
Oligonucleotide or peptide molecules that bind specific targets
aptamers. Anti-thrombin aptamers – Oligonucleotides which recognize the exosites of human thrombin Deoxyribozyme – DNA oligonucleotides that can perform
Aptamer
Protein family
2000). "Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor". EMBO J. 19 (21): 5650–60. doi:10.1093/emboj/19.21
Haemadin
Species of bacterium
protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates". PLOS Pathogens. 6 (11) e1001210. doi:10.1371/journal
Dichelobacter
Drug discovery
for LABAs. The first explained the long action in terms of a putative “exosite” or “exoceptor” distinct from the β2-adrenoreceptor that long aliphatic
Discovery and development of beta2 agonists
Discovery_and_development_of_beta2_agonists
sequences protrude from the globular structures of the proteases. Since this exosite was shown to be involved in the platelet aggregating activity of thrombin
Cerastocytin
Mammalian lipocalin-type protein
1997). "Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug". Proceedings of the National
Siderocalin
Technique for producing oligonucleotides that specifically bind to a target
reaction Anti-thrombin aptamers – Oligonucleotides which recognize the exosites of human thrombin Bacterial one-hybrid system – Method for identifying
Systematic evolution of ligands by exponential enrichment
Systematic_evolution_of_ligands_by_exponential_enrichment
Complex that catalyzes conversion of prothrombin to thrombin
discontinued. Coagulation cascade Hemostasis Krishnaswamy S (January 2005). "Exosite-driven substrate specificity and function in coagulation". J. Thromb. Haemost
Prothrombinase
Superfamily of proteins with similar structures and diverse functions
both of these coagulation proteases also contain binding sites (called exosites) for heparin. Heparin, therefore, also acts as a template for binding of
Serpin
Mammalian protein found in Homo sapiens
antithrombin reactivity with factor IXa by generating new interaction exosites". Biochemistry. 42 (27): 8143–8152. doi:10.1021/bi034363y. PMID 12846563
Antithrombin
Serine protease enzyme
Protein L4-100K from adenoviruses can also inhibit granzyme B by binding at exosites and specific binding pockets. L4-100K is an assembly protein that can transport
Granzyme_B
Protein family
propose that the surface of TMSs 2 and 5 rather serves as an "intramembrane exosite" mediating the recognition of substrate TMS. The rhomboid ortholog in D
Rhomboid_protease
Sub-discipline of biology
protease-substrate discovery. As protease exosites play roles in protein-protein recognition and interaction, biologists have used exosites as tools to screen for protease
Degradomics
Identifying the binding site of an antibody on its target antigen
spectrometry at nearly single amino acid residue resolution reveals novel exosites on ADAMTS13 critical for substrate recognition and mechanism of autoimmune
Epitope_mapping
Protein-coding gene in humans
Santamaria S, Minns AF (April 2023). "The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity". The Journal of Biological Chemistry
ADAMTS1
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Girl/Female
Muslim/Islamic
Blossoming flower
Boy/Male
German, Greek, Italian
Lion of Naples
Surname or Lastname
English
English : occupational name for a grinder of grain, i.e. a miller, Middle English, Old English grindere, an agent noun from Old English grindan ‘to grind’. Less often it may have referred to someone who ground blades to keep their sharpness or who ground pigments, spices, and medicinal herbs to powder.
Boy/Male
Indian, Punjabi, Sikh
Great Elixir
Boy/Male
Hindu, Indian, Telugu
Sweet
Female
African
immortal.
Girl/Female
Hindu, Indian
Daughter of Brija
Girl/Female
Gujarati, Hindu, Indian, Kannada, Sanskrit, Tamil
Musical Rhythm
Boy/Male
Muslim/Islamic
Helper
Boy/Male
Tamil
Chandramadhav | சஂதà¯à®°à®®à®¾à®¤à®¾à®µ
Sweet
EXOSITE
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EXOSITE