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DIRAS3

DIRAS3

Mammalian protein found in Homo sapiens

GTP-binding protein Di-Ras3 (DIRAS3) also known as aplysia ras homology member I (ARHI) is a protein that in humans is encoded by the DIRAS3 gene. This gene is

DIRAS3

Genomic imprinting

Expression of genes depending on parentage

evidence, e.g., . DIRAS3 is a paternally expressed and maternally imprinted gene located on chromosome 1 in humans. Reduced DIRAS3 expression is linked

Genomic imprinting

Genomic_imprinting

DIRAS1

Mammalian protein found in Homo sapiens

homology with Ras and Rap. DIRAS1 differs from the more well-researched DIRAS3 in the length of its N-terminal extensions. While RIG is structurally similar

DIRAS1

Robert C. Bast Jr.

American physician-scientist

demonstrated that epithelial ovarian cancer is clonal in origin, they discovered DIRAS3 (ARHI), an imprinted tumor suppressor gene downregulated in many cancers

Robert C. Bast Jr.

Robert_C._Bast_Jr.

Chromosome 1

Human chromosome

DNA cross-link repair 1B DEPDC1 encoding protein DEP domain containing 1 DIRAS3 (1p31): DIRAS family, GTP-binding RAS-like 3 DISP3: encoding protein Dispatched

Chromosome 1

Chromosome_1

Ras GTPase

GTP-binding proteins functioning on cell-cycle regulation

there are many other members of this subfamily as well: DIRAS1; DIRAS2; DIRAS3; ERAS; GEM; MRAS; NKIRAS1; NKIRAS2; RALA; RALB; RAP1A; RAP1B; RAP2A; RAP2B;

Ras GTPase

Ras_GTPase

Ras superfamily

Protein superfamily of small GTPases

Overview Subfamily Function Members Ras cell proliferation DIRAS1; DIRAS2; DIRAS3; ERAS; GEM; HRAS; KRAS; MRAS; NKIRAS1; NKIRAS2; NRAS; RALA; RALB; RAP1A;

Ras superfamily

Ras_superfamily

List of human protein-coding genes 2

Q9H7Y0 4280 DIRAS1 HGNC:19127; O95057 4281 DIRAS2 HGNC:19323; Q96HU8 4282 DIRAS3 HGNC:687; O95661 4283 DIS3 HGNC:20604; Q9Y2L1 4284 DIS3L HGNC:28698; Q8TF46

List of human protein-coding genes 2

List_of_human_protein-coding_genes_2