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Chemical compound
Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2). Dipthamide is named
Diphthamide
Exotoxin
domain blocks protein synthesis by transfer of ADP-ribose from NAD to a diphthamide residue of eukaryotic elongation factor 2 (eEF-2). A central translocation
Diphtheria_toxin
Class of enzymes
In enzymology, a diphthine—ammonia ligase (EC 6.3.1.14, diphthamide synthase, diphthamide synthetase) is an enzyme that catalyzes the chemical reaction
Diphthine—ammonia_ligase
Class of enzymes
enzymology, a NAD+-diphthamide ADP-ribosyltransferase (EC 2.4.2.36) is an enzyme that catalyzes the chemical reaction NAD+ + peptide diphthamide ⇌ {\displaystyle
NAD(+)—diphthamide ADP-ribosyltransferase
NAD(+)—diphthamide_ADP-ribosyltransferase
Novel drug development method
assumption that strains lacking the diphthamide synthetase gene should have high cofitness with strain lacking other diphthamide biosynthesis genes, they identified
Chemogenomics
Bacterial disease
ADP-ribosylation involves the transfer of an ADP-ribose from NAD+ to a diphthamide (a modified histidine) residue within the EF-2 protein. Since EF-2 is
Diphtheria
Chemical compound
importance beyond its canonical metabolic roles. Carnosinemia Beta-Alanine Diphthamide Imidazole propionate Pauly reaction "Histidine (HMDB0000177)". Human
Histidine
Protein-coding gene in the species Homo sapiens
including humans, contains a post translationally modified histidine diphthamide. It is the target of diphtheria toxin (from Corynebacterium diphtheriae)
EEF2
Human chromosome
containing 1 DHX8: encoding protein DEAH-box helicase 8 DPH1 encoding protein Diphthamide biosynthesis protein 1 DRC3 encoding protein Dynein regulatory complex
Chromosome_17
Chemical compound
Polyamine EIF5A EIF5A2 Diphthamide, another translation-related uncommon amino acid EEF2, eukaryotic elongation factor 2, utilizing diphthamide Park MH (2006)
Hypusine
Protein-coding gene in the species Homo sapiens
Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene. It encodes a protein that performs posttranslational modification
DPH1
Addition of a sulfate group to a compound
Citrullination Methylation Proline Hydroxylation Histidine Adenylylation Diphthamide formation Tryptophan C-mannosylation Crosslinks between two AAs Cysteine–Cysteine
Sulfation
Chemical changes in proteins following their translation from mRNA
peptide and leucine biosynthesis retinylidene Schiff base formation diphthamide formation (on a histidine found in eEF2) ethanolamine phosphoglycerol
Post-translational modification
Post-translational_modification
Addition of one or more ADP-ribose moieties to a protein
ADP-ribose acceptor sites such as serine, arginine, cysteine, lysine, diphthamide, phosphoserine, and asparagine have been identified in subsequent works
ADP-ribosylation
Protein-coding gene in the species Homo sapiens
by the DPH5 gene. This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found
DPH5
Topics referred to by the same term
NAD(P)(+)—protein-arginine ADP-ribosyltransferase, an enzyme NAD(+)—diphthamide ADP-ribosyltransferase, an enzyme Poly ADP ribose polymerase, an enzyme
ADP-ribosyltransferase
Class of enzymes
2PCI, 2PCK, 2PCM, and 2Z6R. Chen JY, Bodley JW (1988). "Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization
Diphthine_synthase
Protein family
near extreme C-terminus) Dph2 (PF01866) - diphthamide biosynthesis enzyme Dph2 (protein modification - diphthamide in translation elongation factor 2) (note
Radical_SAM_enzymes
4.2.35: flavonol-3-O-glycoside xylosyltransferase EC 2.4.2.36: NAD+—diphthamide ADP-ribosyltransferase EC 2.4.2.37: NAD+ —dinitrogen-reductase ADP-D-ribosyltransferase
List_of_EC_numbers_(EC_2)
DIPHTHAMIDE
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Boy/Male
Tamil
Poornendu | பூரà¯à®£à¯‡à®¨à¯à®¤à¯
Full Moon
Girl/Female
Australian, French, Hebrew
Tree
Boy/Male
Indian, Sanskrit
The Joyful; Delightful
Girl/Female
Indian, Sanskrit
Splitting; Breaking
Boy/Male
Christian & English(British/American/Australian)
People Triumph
Girl/Female
Bengali, Indian
Another Name of Goddess Durga
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Rajasthani, Sanskrit, Sindhi, Telugu
Golden
Surname or Lastname
English
English : variant of Garrett 1.German : from the Germanic personal name Gerwald, composed of the elements gÄr, gÄ“r ‘spear’, ‘lance’ + wald- ‘rule’.
Male
Celtic
, hereditary king.
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Tamil
Goddess Parvati
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