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Chemical compound
Cyclopamine (11-deoxojervine) is a naturally occurring steroidal alkaloid. It is a teratogenic component of corn lily (Veratrum californicum), which when
Cyclopamine
Class of naturally occurring chemical compounds
consume but cannot detoxify the alkaloids. One example is the alkaloid cyclopamine, produced in the leaves of corn lily. During the 1950s, up to 25% of
Alkaloid
Extreme form of holoprosencephaly
process. One highly teratogenic alkaloid toxin that can cause cyclopia is cyclopamine or 2-deoxyjervine, found in the plant Veratrum californicum (also known
Cyclopia
Experimental drug
it is a semi-synthetic derivative of the alkaloid cyclopamine. The process begins with cyclopamine extracted from harvested Veratrum californicum which
Saridegib
Plant species in the bunchflower family
Washington, Oregon, N California It is a source of jervine, muldamine and cyclopamine, teratogens which can cause prolonged gestation associated with birth
Veratrum_californicum
Embryonic signaling pathway for proper cell differentiation
agents are cyclopamine-competitive. Itraconazole (Sporanox) has also been shown to target SMO through a mechanism distinct from cyclopamine and vismodegib
Hedgehog_signaling_pathway
Organic molecule weighing under 1000 daltons
adding to the media anti-shh antibodies, Hedgehog interacting protein, or cyclopamine, where the first two molecules are proteins and the last a small molecule
Small_molecule
Greek chemist and physician (born 1954)
synthesis of cyclopamine in Angewandte Chemie International Edition, which later reviews describe as the first synthesis of cyclopamine (via a semisynthetic
Athanassios_Giannis
Polycyclic organic compound having sterane as a core structure
are known in nature. For instance, ewes who graze on corn lily ingest cyclopamine (shown) and veratramine, two of a sub-family of steroids where the C-
Steroid
Prefix used in chemistry
Removal of atoms from rings: cyclopamine, an example of a complex C-nor-D-homosteroid, where the C-12 atom is removed from the normally 6-membered central
Nor-
Genus of plants
plant contains highly toxic, teratogenic alkaloids such as veratrine, cyclopamine, and jervine, it is believed to be the "hellebore" used by Hippocrates
Hellebore
Gene found in humans and other animals
flies to humans. It is the molecular target of the natural teratogen cyclopamine. It also is the target of vismodegib, the first hedgehog pathway inhibitor
Smoothened
Chemical compound
C27H39NO3 which is derived from the plant genus Veratrum. Similar to cyclopamine, which also occurs in the genus Veratrum, it is a teratogen implicated
Jervine
Genus of plants
potentially fatal cardiac arrhythmias if ingested. The teratogenic steroid Cyclopamine is also found in these plants and is known to induce holoprosencephaly
Veratrum
Canadian biologist (born 1958)
plant-derived compound, cyclopamine. Beachy noted the similarity to cyclopic Shh-/- mice and in a brilliant leap demonstrated that cyclopamine inhibits Hedgehog
Philip_A._Beachy
Species of plant
'Veratrum alkaloids', including O-acetyljervine, cevadine, cryptenamine, cyclopamine (11-deoxojervine), cycloposine, germitrine, germidine, jervine, muldamine
Veratrum_album
(cAMP) α-Cyclodextrin Cyclodextrin glycosyltransferase Cyclooxygenase Cyclopamine Cyclopiazonic acid Cysteine Cystine Cytidine Cytochalasin Cytochalasin
List_of_biomolecules
Chemical compound
cannot be treated with surgery or radiation. The substance acts as a cyclopamine-competitive antagonist of the smoothened receptor (SMO) which is part
Vismodegib
Israeli biotech company
precursors: Parthenolide, Puromycin, Rapamycin, Anisomycin, Thapsigargin, cyclopamine, Thiostrepton, Staurosporine, Mithramycin, Midostaurin, Wortmannin, K252a
Fermentek
Species of plant
Cyclopamine (11-deoxojervine) is one of the alkaloids isolated from the plant which interferes with the hedgehog signaling pathway (Hh). Cyclopamine is
Veratrum_nigrum
Class of chemical compounds
in the roots and rhizomes of these plants. They include veratridine, cyclopamine, and jervine. Because of their actions on the cardiovascular, neuromuscular
Steroidal_alkaloid
American organic chemist (born 1977)
(2025) (+)-Saxitoxin (2025) Dragocins A−C (2024) Dynobactin A (2024) (−)-Cyclopamine (2023) (+)-KB343 (2023) Portimine A and B (2023) Kibdelomycin (2022)
Phil_S._Baran
Cancer cells with features of normal cells
antagonise Wnt. Sonic hedgehog blockers are available, such as cyclopamine. A water-soluble cyclopamine may be more effective in cancer treatment. DMAPT, a water-soluble
Cancer_stem_cell
Inhibitor of Sonic hedgehog (Shh) signaling
synthetic agonists. SANT-2 efficiently displaces radiolabeled SAG-1.3 and cyclopamine bound to SMO, with inhibition constants (Kd) of 7.8 nM and 8.4 nM, respectively
SANT-2
Genus of theropod dinosaur
G.P. (2009). "Frame-shifts of digit identity in bird evolution and Cyclopamine-treated wings". Evolution & Development. 11 (2): 163–169. CiteSeerX 10
Limusaurus
Family of short non-coding RNA fragments
pathway. In further studies with mice, an inhibitor of the SHH pathway (cyclopamine drug) was sufficient to reduce proliferation of tumour cells that had
Mir-92 microRNA precursor family
Mir-92_microRNA_precursor_family
CYCLOPAMINE
CYCLOPAMINE
CYCLOPAMINE
CYCLOPAMINE
Boy/Male
Arabic, Indian, Muslim, Punjabi, Sikh
Noble One of God; One who has Good Judgement
Girl/Female
Tamil
Drishya | தà¯à®°à®¿à®·à¯à®¯
Sight
Girl/Female
Indian, Telugu
Good Intelligence; Star
Boy/Male
Hindu
Amuthan is derived from the word amurtham. this means the purity. it is the precious one
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Blue Lotus
Boy/Male
Indian
Cool
Boy/Male
Arabic, Indian, Muslim, Sanskrit
Spotless; Pure; Tree
Boy/Male
Latin
The Lord's.
Boy/Male
Arabic, Hindu, Indian, Marathi
King of the World; Moonlight
Girl/Female
French
Feminine of Bernard, meaning strong as a bear, or bear hard.
CYCLOPAMINE
CYCLOPAMINE
CYCLOPAMINE
CYCLOPAMINE
CYCLOPAMINE