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Atypical antipsychotic medication
Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. It
Clozapine
Class of medications
antipsychotics, known as atypical antipsychotics, arrived with the introduction of clozapine in the early 1970s followed by others (e.g., risperidone, olanzapine,
Antipsychotic
Atypical antipsychotic medication
combination with an SSRI antidepressant. However, it is less potent than clozapine, amisulpride, olanzapine, risperidone, and paliperidone in alleviating
Quetiapine
Chemical compound
Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate Designer Receptors Exclusively Activated by Designer
Clozapine_N-oxide
Atypical antipsychotic medication
member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as
Loxapine
Mental disorder
suggests that clozapine may also be effective in treating schizoaffective disorder, particularly in those resistant to initial medication. Clozapine is an atypical
Schizoaffective_disorder
Chemical compound
DHA-clozapine (tentative trade name Clozaprexin) is an atypical antipsychotic drug candidate that was created and originally tested by chemists at Protarga
DHA-clozapine
Mental disorder with psychotic symptoms
antipsychotics, in which case clozapine is offered. Most antipsychotics improve schizophrenia symptoms, with clozapine the most effective overall; side
Schizophrenia
Class of pharmaceutical drugs
weeks to two of three different antipsychotics) in the remaining 20%. Clozapine is considered a first choice treatment for treatment resistant schizophrenia
Atypical_antipsychotic
Active metabolite of the drug clozapine
a major active metabolite of the atypical antipsychotic drug clozapine. Unlike clozapine, it possesses intrinsic activity at the D2/D3 receptors, and
Desmethylclozapine
Atypical antipsychotic medication
quit before the 6-week completion date. Treatment with olanzapine (like clozapine) may result in increased weight gain and increased glucose and cholesterol
Olanzapine
Medical condition
cases of bowel obstruction or constipation (such as those related to clozapine treatment) fecal vomiting has been identified as a cause of death. Fecal
Fecal_vomiting
Antipsychotic medication
second-generation antipsychotics with the exception of olanzapine and clozapine. A 2016 Cochrane review suggests that risperidone reduces the overall
Risperidone
further understanding of the use of clozapine. In 2022 he suggested a refined phenotype for genetic studies into clozapine-related agranulocytosis. His work
David_Taylor_(professor)
dibenzodiazepine, or substituted dibenzodiazepines, include the antipsychotic clozapine, the antihistamine clobenzepam, and the tricyclic antidepressant dibenzepin
Dibenzodiazepine
Anticonvulsant medication
publications and textbooks have expressed that lamotrigine could be added to clozapine as augmentation therapy against partial or non-responding patients with
Lamotrigine
Excessive production of saliva
Medications that can cause overproduction of saliva include: aripiprazole clozapine pilocarpine ketamine potassium chlorate risperidone pyridostigmine Substances
Hypersalivation
Neurological disorder featuring involuntary, repetitive body movements
possible (although this may temporarily worsen symptoms) or switching to clozapine. Other medications such as valbenazine, tetrabenazine, or botulinum toxin
Tardive_dyskinesia
Swiss multinational pharmaceutical corporation
the eighth largest by revenue in 2024. Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren; sold to GlaxoSmithKline in 2015 deal)
Novartis
Chemical compound
with similar pharmacology and effects to the structurally related drug clozapine. It has two enantiomers, but has only been studied as the racemic mix
Timelotem
Atypical antipsychotic and antiemetic medication
treatment option (although this is based on low-quality evidence) in clozapine-resistant cases of schizophrenia. Another recent study concluded that
Amisulpride
Informal term for a drug that binds to many different molecular targets or receptors
vestibular branches of the eighth cranial nerve and to the renal tubules. Clozapine and latrepirdine are examples of drugs used in the treatment of CNS disorders
Dirty_drug
Atypical antipsychotic
complications of the use of a number of different antipsychotics (most notably clozapine) which involves abnormalities in the composition of a person's blood (e
Sulpiride
Pharmaceutical compound
without producing catalepsy in rodents. Lu 38-012 partially substituted for clozapine in drug discrimination tests in rodents. It was developed by Lundbeck
Lu_38-012
Chemical compound
addition, alstonine, similarly to clozapine, indirectly inhibits the reuptake of glutamate in hippocampal slices. Unlike clozapine however, the effect of which
Alstonine
Chemical compound
Batelapine (developmental code name CGS-13429) is a structural analogue of clozapine which was investigated as a potential antipsychotic. List of investigational
Batelapine
Antidepressant
antipsychotic effects with a profile of activity described as similar to that of clozapine, and may be useful in the treatment of psychotic symptoms, such as in
Trimipramine
Drug which blocks dopamine receptors
depression, and tic disorders Clozapine binds D1 and D4 with the highest affinity but still binds D2 and D3. Clozapine is usually only prescribed when
Dopamine_antagonist
Compulsive performance of repetitive, mechanical tasks
the treatment of punding are atypical antipsychotics like quetiapine or clozapine. Amantadine has also been reported to be fairly effective, while memantine
Punding
Psychoactive drug, often called ecstasy
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
MDMA
episodes in the wake of psychotic medication withdrawal associated with Clozapine, rather than on medication resistance. A hypothetical condition related
Tardive_psychosis
Antihistamine medication
Zuclopenthixol Atypical antipsychotics: Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine
Cyproheptadine
Medication mainly used to treat gout
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Colchicine
Type of drug
use is limited due to its high toxicity and potential for addiction. Clozapine — used in treatment-resistant schizophrenia not responsive to at least
Drug_of_last_resort
Atypical antipsychotic medication
different from those of the other FDA-approved atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine, ziprasidone, and risperidone). It shows differential
Aripiprazole
Antidepressant medication
supported by the common practice of prescribing low-dose quetiapine and clozapine for PDP at doses too low to antagonize the D2 receptor, but sufficiently
Mirtazapine
Weight loss medication
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Phentermine
Non-opioid analgesic drug
rectifying potassium channel-specific: Barium Caramiphen Cloperastine Clozapine Dextromethorphan Ethosuximide Ifenprodil Tertiapin Tipepidine Activators
Suzetrigine
Class of drugs
VMAT2 inhibitor like valbenazine may help. The atypical antipsychotic clozapine has also been suggested as an alternative antipsychotic for patients experiencing
Typical_antipsychotic
Drug combination prescribed for weight loss; later withdrawn from market
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Fenfluramine/phentermine
Typical antipsychotic medication
Zuclopenthixol Atypical antipsychotics: Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine
Chlorpromazine
Dopamine agonist medication
Zuclopenthixol Atypical antipsychotics: Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine
Ropinirole
Antipsychotic drug
combination (citalopram/pipamperone) referred to as PipCit (code name PNB-01). Clozapine Melperone Pimozide Piritramide Risperidone Anvisa (2023-03-31). "RDC Nº
Pipamperone
Medical condition
and mirtazapine, and some antipsychotics. The atypical antipsychotic clozapine in particular is largely restricted to treatment-resistant cases and mandatory
Agranulocytosis
Type of medication
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Monoamine_oxidase_inhibitor
Muscle relaxant medication
Anisodamine Anisodine Atiprosin Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone) Benoxathian Beta blockers (e.g.
Cyclobenzaprine
Methods of managing schizophrenia
the negative symptoms and cognitive dysfunction. There is evidence of clozapine, amisulpride, olanzapine, and risperidone being the most effective medications
Management_of_schizophrenia
Interaction between schizophrenia and smoking
and non-smokers. It is recommended that the dosage for those smokers on clozapine be increased by 50%, and for those on olanzapine by 30%. The result of
Schizophrenia and tobacco smoking
Schizophrenia_and_tobacco_smoking
Antipsychotic medication
incidence of extrapyramidal side effects compared to the atypicals like clozapine and quetiapine, to which it is structurally related. Despite the relativity
Clotiapine
Drug side effect
fluphenazine, and pimozide. There is also a low incidence with thioridazine, clozapine, olanzapine, aripiprazole, and low doses of risperidone. Rabbit syndrome
Rabbit_syndrome
Serotonin receptor agonist
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
4-Hydroxytryptamine
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
List of miscellaneous 5-HT2A receptor agonists
List_of_miscellaneous_5-HT2A_receptor_agonists
Investigational antipsychotics
antagonist, and other actions – schizophrenia [257] Clozapine (clozapine ODT; clozapine once-daily; Clozapine QD; FazaClo HD; FazaClo LD; FazaClo ODT; Versacloz)
List of investigational antipsychotics
List_of_investigational_antipsychotics
Intentional act causing one's own death
supply have lower rates of homicide, rape, drug arrests, and other crimes. Clozapine may decrease the thoughts of suicide in some people with schizophrenia
Suicide
Experimental drug
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Bexicaserin
American forensic psychiatrist
reported a significantly lower rate of suicides in patients prescribed clozapine. Yale professor of psychiatry Michael Sernyak and others have critiqued
William_Reid_(psychiatrist)
Pharmaceutical compound
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
2,5-Dimethoxyamphetamine
Species of psychoactive cactus
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Peyote
Medication for overactive bladder
Anisodamine Anisodine Atiprosin Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone) Benoxathian Beta blockers (e.g.
Mirabegron
Blood pressure medication
Anisodamine Anisodine Atiprosin Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone) Benoxathian Beta blockers (e.g.
Carvedilol
Drug class
5-HT2A receptor antagonists include antipsychotics like chlorpromazine, clozapine, olanzapine, quetiapine, risperidone, spiperone (spiroperidol), and ziprasidone;
Serotonin 5-HT2A receptor antagonist
Serotonin_5-HT2A_receptor_antagonist
Medication for overactive bladder
AQ-RA 741 Atropine Atropine methonitrate Atypical antipsychotics (e.g., clozapine, fluperlapine, olanzapine (+fluoxetine), rilapine, quetiapine, tenilapine
Oxybutynin
Program that monitors medications with a high potential for serious adverse effects
high-risk drugs such as isotretinoin, which causes serious birth defects; clozapine, which can cause agranulocytosis; and thalidomide, which is used to treat
Risk Evaluation and Mitigation Strategies
Risk_Evaluation_and_Mitigation_Strategies
Chemical compound
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
5-MAPB
Typical antipsychotic medication
1993). "Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography". Brain
Haloperidol
Serotonergic psychedelic
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Deupsilocin
American scientist
the effectiveness of clozapine in treating suicide attempts in patients with schizophrenia, which led to FDA approval of clozapine for treating suicide
Herbert_Y._Meltzer
Protein-coding gene in the species Homo sapiens
Sonepiprazole Fananserin – mixed 5-HT2A / D4 antagonist Buspirone, an anxiolytic Clozapine - atypical antipsychotic with relative D4 and 5HT2A selectivity over D2
Dopamine_receptor_D4
Medication used to treat anxiety disorders
Zuclopenthixol Atypical antipsychotics: Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine
Buspirone
Parasympathetic nervous system inhibitors
that is also a metabolite of Loxapine, an antipsychotic Antipsychotics (clozapine, quetiapine) Atropine Benztropine Biperiden Chlorpheniramine Certain SSRIs
Anticholinergic
Family of transport proteins
rectifying potassium channel-specific: Barium Caramiphen Cloperastine Clozapine Dextromethorphan Ethosuximide Ifenprodil Tertiapin Tipepidine Activators
Voltage-gated_sodium_channel
Entactogen, stimulant, and psychedelic drug of the amphetamine family
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
3,4-Methylenedioxyamphetamine
Romantic delusional disorder
Tourette's syndrome), and atypical antipsychotics like risperidone and clozapine. Non-pharmacologic treatments that have shown some degree of efficacy
Erotomania
Drug used to reduce frequency of headaches
only partially effective and clozapine was ineffective. All three of these agents, pizotifen, cyproheptadine, and clozapine act as non-selective monoamine
Pizotifen
Protein family
buspirone and gepirone) Aripiprazole Asenapine Atipamezole Cirazoline Clozapine Efaroxan Fipamezole Idazoxan Lurasidone Melperone Mianserin Mirtazapine
Alpha-2_adrenergic_receptor
Psychedelic drug found in toads, mushrooms and plants
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Bufotenin
Abnormally low concentration of neutrophils (a type of white blood cell) in the blood
Propylthiouracil Levamisole Penicillamine Trimethoprim/sulfamethoxazole Clozapine Valproate Vaccination Venetoclax Severe bacterial infections, especially
Neutropenia
Barbiturate medication used to treat seizures and tremors
pharmacological agents include alprazolam, clonazepam, atenolol, sotalol, nadolol, clozapine, nimodipine, and botulinum toxin A. Many of these drugs were less effective
Primidone
Chlorpromazine, Citalopram, Clomipramine, Clonazepam, Clonidine, Clorazepate, Clozapine Daridorexant, Desvenlafaxine, Dextroamphetamine, Diazepam, Disulfiram
List of psychiatric medications
List_of_psychiatric_medications
Artificial biochemical receptors only responsive to predesigned drugs
receptors (GPCR) engineered to respond exclusively to synthetic ligands, like clozapine N-oxide (CNO), and not to endogenous ligands. Several types of these receptors
Receptor activated solely by a synthetic ligand
Receptor_activated_solely_by_a_synthetic_ligand
SSRI antidepressant
aripiprazole, clozapine, haloperidol, quetiapine, pimozide, ziprasidone, etc. CYP2D6 (weakly) which metabolizes aripiprazole, chlorpromazine, clozapine, codeine
Fluvoxamine
Chemical compound
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
1T-LSD
Antihypotensive medication
Anisodamine Anisodine Atiprosin Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone) Benoxathian Beta blockers (e.g.
Midodrine
Pharmaceutical drug
AQ-RA 741 Atropine Atropine methonitrate Atypical antipsychotics (e.g., clozapine, fluperlapine, olanzapine (+fluoxetine), rilapine, quetiapine, tenilapine
Dextromethorphan/quinidine
Delusion that others can hear one's thoughts
Keith; Cotes, Robert O.; Goldsmith, David R. (July 2020). "Integration of Clozapine-associated Harm Obsessions into Cognitive Behavioral Conceptualization
Thought_broadcasting
Pharmaceutical compound
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
(S)-DCPT
Asenapine • Blonanserin • Cariprazine • Carpipramine • Clocapramine • Clozapine • Gevotroline • Iloperidone • Lurasidone • Melperone • Molindone • Mosapramine •
List_of_dopaminergic_drugs
Antihypertensive medication
rectifying potassium channel-specific: Barium Caramiphen Cloperastine Clozapine Dextromethorphan Ethosuximide Ifenprodil Tertiapin Tipepidine Activators
Amlodipine/benazepril
Antipsychotic medication
get into the brain?--An in vitro approach comparing amisulpride with clozapine". Neuropsychopharmacology. 28 (11): 1916–22. doi:10.1038/sj.npp.1300244
Tiapride
Pharmaceutical compound
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
2C-iBu
Medical condition
polydipsia under control, including: Atypical antipsychotics, such as clozapine, olanzapine and risperidone Demeclocycline, a tetracycline antibiotic
Primary_polydipsia
Selective relaxant binding agent
AQ-RA 741 Atropine Atropine methonitrate Atypical antipsychotics (e.g., clozapine, fluperlapine, olanzapine (+fluoxetine), rilapine, quetiapine, tenilapine
Sugammadex
Chemical compound
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Zalsupindole
Antipsychotic drug
Melperone is reported to produce significantly less weight gain than clozapine and approximately as much weight gain as typical antipsychotics. It is
Melperone
Psychoactive drug taken by mouth
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
(R)-MDMA
Anticonvulsant medication
rectifying potassium channel-specific: Barium Caramiphen Cloperastine Clozapine Dextromethorphan Ethosuximide Ifenprodil Tertiapin Tipepidine Activators
Oxcarbazepine
Drug that blocks histamine or histamine agonists
sickness and vertigo) Clemastine Clomipramine (tricyclic antidepressant) Clozapine (atypical antipsychotic; trade name: Clozaril) Cyclizine Cyproheptadine
Antihistamine
Chemical compound
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
BOH-2C-B
Medication
Zuclopenthixol Atypical antipsychotics: Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine
Flibanserin
Class of chemical compounds
antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, elopiprazole, lurasidone, perospirone, quetiapine, tiospirone, umespirone
Substituted methoxyphenethylamine
Substituted_methoxyphenethylamine
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