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CDC37

CDC37

Protein-coding gene in humans

Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene. This protein is highly similar to Cdc 37, a cell division cycle control

CDC37

Tyrosine kinase inhibitor

Drug typically used in cancer treatment

Recently TKIs have been shown to deprive tyrosine kinases of access to the Cdc37-Hsp90 molecular chaperone system on which they depend for their cellular

Tyrosine kinase inhibitor

Tyrosine_kinase_inhibitor

Chaperone (protein)

Proteins assisting in protein folding

Hsp90. Hsp90 may also require co-chaperones-like immunophilins, Sti1, p50 (Cdc37), and Aha1, and also cooperates with the Hsp70 chaperone system. Hsp100

Chaperone (protein)

Chaperone_(protein)

Cyclin-dependent kinase 4

Human protein

replication. Cyclin-dependent kinase 4 has been shown to interact with: CDC37, CDKN1B, CDKN2B, CDKN2C, CEBPA, CCND1, CCND3, DBNL, MyoD, P16, PCNA, and

Cyclin-dependent kinase 4

Cyclin-dependent_kinase_4

Celastrol

Chemical compound

including the direct inhibition of IKKα and IKKβ kinases, inactivation of CDC37 and p23 (HSP90 chaperone proteins), suppression of proteasome function and

Celastrol

Cyclin-dependent kinase complex

phase KAP, Cks1, p27Kip1, and Spy-1 Cdk4 Cyclins D1, D2, D3 G1 phase HSP90-Cdc37 Cdk6 Cyclins D1, D2, D3 G1 phase p16INK4A, p19INK4D, and P18INK4C-cyclin

Cyclin-dependent kinase complex

Cyclin-dependent_kinase_complex

GHKL domain

Evolutionary conserved protein domain

Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)". Cell. 116 (1): 87–98. doi:10.1016/S0092-8674(03)01027-4. PMID 14718169

GHKL domain

GHKL_domain

PSKH2

and involves a number of membrane-associated proteins alongside the HSP90 Cdc37 molecular chaperone complex. PSKH2 exhibits significant sequence homology

PSKH2

HSP90AB1

Protein-coding gene in the species Homo sapiens

specificity and interaction with other HSPs. For example, the co-chaperone CDC37 (cell division cycle 37) stabilizes the cell cycle regulatory proteins CDK4

HSP90AB1

STK11

Protein-coding gene in the species Homo sapiens

is predominantly found in testes. STK11 has been shown to interact with: CDC37, FYN HSP90AA1 LYK5 SMARCA4 ESR1 Paola Marignani (living), scientist and

STK11

MAPK14

Protein-coding gene in the species Homo sapiens

addition to these phosphatases, other molecular components such as Hsp90-Cdc37 chaperone complex can also modulate p38 MAPK autophosphorylation activity

MAPK14

IKBKG

Protein-coding gene in humans

intraperitoneal injection. IKBKG has been shown to interact with: BCL10, CDC37, CHUK and IKK2, IRAK1, NCOA3, PPM1B, TANK, TNFAIP3, TRAF3IP2, and TRAF6

IKBKG

IKK2

Protein-coding gene in the species Homo sapiens

knee osteoarthritis. IKK-β (IKBKB) has been shown to interact with HDAC9, CDC37, CHUK CTNNB1, FANCA, IKBKG IRAK1, NFKBIA, MAP3K14, NFKB1, NFKBIB, NCOA3

IKK2

Co-chaperone

Protein

early onset of neurodegenerative diseases. Aha1 auxilin BAG1 CAIR-1/Bag-3 CDC37/p50 Chp1 Cysteine string protein (CSP) Cyp40 Djp1 DnaJ E3/E4-ubiquitin ligase

Co-chaperone

Cyclin-dependent kinase 3

Protein-coding gene in the species Homo sapiens

PMID 8846921. Lamphere L, Fiore F, Xu X, et al. (1997). "Interaction between Cdc37 and Cdk4 in human cells". Oncogene. 14 (16): 1999–2004. doi:10.1038/sj.onc

Cyclin-dependent kinase 3

Cyclin-dependent_kinase_3

Stress granule

Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

T-complex protein 1 subunit zeta CDC20 CDC20 Cell Division Cycle 20 CDC37 CDC37 Cell Division Cycle 37 CDC5L CDC5L Cell division cycle 5-like protein

Stress granule

Stress_granule

Stress-induced-phosphoprotein 1

Protein-coding gene in the species Homo sapiens

Briand PA, Donzé O, Picard D (September 2002). "The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically". Biological Chemistry. 383

Stress-induced-phosphoprotein 1

Stress-induced-phosphoprotein_1

CHUK

Protein-coding gene in humans

2002). "TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90". Mol. Cell. 9 (2): 401–10. doi:10.1016/S1097-2765(02)00450-1

CHUK

Heat shock protein 90kDa alpha (cytosolic), member A1

Protein-coding gene in the species Homo sapiens

(cytosolic), member A1 has been shown to interact with: AHSA1, AKT1, AR, C-Raf, CDC37, DAP3, EPRS, ERN1, ESR1 FKBP5, GNA12, GUCY1B3, HER2/neu, HSF1, Hop, NOS3

Heat shock protein 90kDa alpha (cytosolic), member A1

Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1

EIF2AK1

Protein-coding gene in the species Homo sapiens

Shao J, Grammatikakis N, Scroggins BT, et al. (2001). "Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated

EIF2AK1

LMTK3

Protein-coding gene in the species Homo sapiens

effective inhibitor of breast cancer growth in vivo. LMTK3 is an HSP90-CDC37 client protein which requires this interaction for folding and stability

LMTK3

Cyclin-dependent kinase 6

Protein found in humans

Brizuela L, Keezer S, Sardet C, et al. (April 1997). "Interaction between Cdc37 and Cdk4 in human cells". Oncogene. 14 (16): 1999–2004. doi:10.1038/sj.onc

Cyclin-dependent kinase 6

Cyclin-dependent_kinase_6

List of human protein-coding genes 2

HGNC:17839; Q8NHZ8 2579 CDC27 HGNC:1728; P30260 2580 CDC34 HGNC:1734; P49427 2581 CDC37 HGNC:1735; Q16543 2582 CDC37L1 HGNC:17179; Q7L3B6 2583 CDC40 HGNC:17350;

List of human protein-coding genes 2

List_of_human_protein-coding_genes_2

C19orf44

Mammalian protein found in Homo sapiens

the two-hybrid screening method. Interactions with Hsp90 co-chaperone (CDC37), and spermatid associated protein (SPERT) have been found. GRCh38: Ensembl

C19orf44