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CD2AP

  • CD2AP
  • Protein

    CD2-associated protein is a protein that in humans is encoded by the CD2AP gene. This gene encodes a scaffolding molecule that regulates the actin cytoskeleton

    CD2AP

    CD2AP

    CD2AP

  • Podocyte
  • Type of kidney cell

    infants are born with certain defects in these proteins, such as nephrin and CD2AP, their kidneys cannot function. People have variations in these proteins

    Podocyte

    Podocyte

    Podocyte

  • Nephrin
  • Mammalian protein found in Homo sapiens

    cardiovascular development. Nephrin has been shown to interact with: CASK, CD2AP, CDH3 and CTNND1, FYN, KIRREL, and NPHS2. Nephrin was first identified in

    Nephrin

    Nephrin

    Nephrin

  • Podocin
  • the latter of which interacts with the cytosolic tail of nephrin, with CD2AP serving as an adaptor. Podocin is localized on the membranes of podocyte

    Podocin

    Podocin

    Podocin

  • Alzheimer's disease among East Asians
  • multiple genes involved in amyloid-β production and clearance. BIN1 and CD2AP work together in facilitating the endocytosis of APP and BACE1 into endosomes

    Alzheimer's disease among East Asians

    Alzheimer's_disease_among_East_Asians

  • TRPC6
  • Protein and coding gene in humans

    interaction with podocyte-specific proteins such as nephrin, podocin and CD2AP allows this channel to be mechanosensitive, and hence TRPC6 channels can

    TRPC6

    TRPC6

    TRPC6

  • Dendrin
  • Protein

    plasticity and memory formation. Additionally, the protein binds to nephrin and CD2AP within the kidneys, where can help with intracellular signaling pathways

    Dendrin

    Dendrin

  • FCER1G
  • Protein-coding gene in the species Homo sapiens

    Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ (July 2012). "CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor

    FCER1G

    FCER1G

    FCER1G

  • CBL (gene)
  • Mammalian gene

    degradation. Cbl gene has been shown to interact with: Abl gene, ARHGEF7, C-Met, CD2AP, CSF1R. CRK, CRKL, EGFR, FRS2, FYN, Grb2, HCK, IGF1R, LCP2, NCK1, PDGFRA

    CBL (gene)

    CBL (gene)

    CBL_(gene)

  • Lorne Mendell
  • Professor of neuorbiology

    2016 publication that focused on the relationship between a protein called CD2AP and the plasticity of neurons. It is known that the growth of an axon of

    Lorne Mendell

    Lorne_Mendell

  • Blastic plasmacytoid dendritic cell neoplasm
  • Medical condition

    expressed on 80–100% of pDC but uncommon on AML, TCLL, or NKL blasts); 2) CD2AP and CLEC4C which are unique to pDC; and 3) myeloperoxidase, lysozyme, CD34

    Blastic plasmacytoid dendritic cell neoplasm

    Blastic plasmacytoid dendritic cell neoplasm

    Blastic_plasmacytoid_dendritic_cell_neoplasm

  • RAB4B
  • directly interact with STX4. Rab4B has also been shown to interact with: CD2AP RABEP1 RAB11FIP1 Rab-4B proteins have been found to be co-regulated with

    RAB4B

    RAB4B

    RAB4B

  • Tobias Huber
  • German nephrologist and internist (born 1971)

    of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest 116:1337-45. doi:10.1172/jci27400

    Tobias Huber

    Tobias_Huber

  • ABCA7
  • Protein-coding gene in the species Homo sapiens

    (May 2011). "Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease". Nature Genetics. 43 (5): 429–435

    ABCA7

    ABCA7

    ABCA7

  • 2011 in science
  • Amy (2011). "Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease". Nature Genetics. 43 (5): 429–435

    2011 in science

    2011 in science

    2011_in_science

  • RAB4A
  • Protein-coding gene in the species Homo sapiens

    humans is encoded by the RAB4A gene. RAB4A has been shown to interact with: CD2AP, KIF3B, RAB11FIP1, RABEP1, and STX4. GRCh38: Ensembl release 89: ENSG00000168118

    RAB4A

    RAB4A

    RAB4A

  • Gail Jarvik
  • American geneticist

    and etiology. Her highest cited paper is Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease at 1080

    Gail Jarvik

    Gail_Jarvik

  • Cingulin-like protein 1
  • Protein found in humans

    the Rho GEF GEF-H1, the Rac1 GEF Tiam1 Tiam1, and it forms a complex with CD2AP and SH3BP1. Association of paracingulin with the apical junctional complex

    Cingulin-like protein 1

    Cingulin-like protein 1

    Cingulin-like_protein_1

  • List of human protein-coding genes 2
  • HGNC:1637; P15813 2475 CD1E HGNC:1638; P15812 2476 CD2 HGNC:1639; P06729 2477 CD2AP HGNC:14258; Q9Y5K6 2478 CD2BP2 HGNC:1656; O95400 2479 CD3D HGNC:1673; P04234

    List of human protein-coding genes 2

    List_of_human_protein-coding_genes_2

  • PSTPIP1
  • Enzyme found in humans

    (2003). "The Wiskott–Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse"

    PSTPIP1

    PSTPIP1

    PSTPIP1

  • NPHS2
  • Protein-coding gene in the species Homo sapiens

    encoded by the NPHS2 gene. NPHS2 has been shown to interact with Nephrin and CD2AP. Focal segmental glomerulosclerosis GRCh38: Ensembl release 89: ENSG00000116218

    NPHS2

    NPHS2

    NPHS2

  • List of OMIM disorder codes
  • segmental, 2; 603965; TRPC6 Glomerulosclerosis, focal segmental, 3; 607832; CD2AP Glomerulosclerosis, focal segmental, 5; 613237; INF2 Glomuvenous malformations;

    List of OMIM disorder codes

    List_of_OMIM_disorder_codes

  • Alzheimer's disease in the Hispanic/Latino population
  • Hispanic/Latino population indicate that polymorphisms in the BIN1, ABAC7 and CD2AP genes are more significant in Caribbean Hispanics. For instance, one BIN1

    Alzheimer's disease in the Hispanic/Latino population

    Alzheimer's_disease_in_the_Hispanic/Latino_population

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