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Antifibrinolytic molecule
The drug aprotinin (AP, Trasylol, previously Bayer and now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI)
Aprotinin
Agent that prevents fibrinolysis
rich areas on the surface of fibrin.[citation needed] Another example, aprotinin, is a naturally occurring broad-spectrum protease inhibitor; some countries
Antifibrinolytic
German multinational pharmaceutical and biotechnology company
Advisory Panel on Trasylol (aprotinin)". Archived from the original on 2 April 2015. Wood, Shelly (29 September 2014). "Aprotinin Reintroduction Puts Lives
Bayer
Serine proteinase inhibitors which inhibit trypsin
weight A mixture of six different inhibitors Bovine pancreas and lung Aprotinin 6.5 kDa 2.5 times weight Also known as BPTI (basic pancreatic trypsin
Trypsin_inhibitor
factor activated, heparin insensitive test performed in the presence of aprotinin (fibrinolysis inhibitor, confirms hyperfibrinolysis by comparing the TEM
Hyperfibrinolysis
Medical diagnostic method
Clotting time measurements can be affected by drugs such as warfarin, aprotinin, and GpIIb/IIIa inhibitors, and physiologic disturbances such as hypothermia
Activated_clotting_time
Lysis buffer
mM PMSF (fresh from 1 M stock in i-propanol), 1 μg/mL each leupeptin, aprotinin, pepstatin, 1-5 mM EDTA, 0.5-1 mM EGTA, 5 mM aminocaproic acid) or commercial
Radioimmunoprecipitation assay buffer
Radioimmunoprecipitation_assay_buffer
InterPro Domain
molecular weight of 6 kDa. Examples of Kunitz-type protease inhibitors are aprotinin (bovine pancreatic trypsin inhibitor, BPTI), Alzheimer's amyloid precursor
Kunitz_domain
Process that prevents blood clots from growing
TEM profile in the absence or presence of the fibrinolysis inhibitor aprotinin. Clinically, the TEM is useful for near real-time measurement of activated
Fibrinolysis
Process of formation of blood clots
and lead to a de facto reduced bleeding rate. Before its withdrawal, aprotinin was used in some forms of major surgery to decrease bleeding risk and
Coagulation
Class of prescription drugs in India
OESTROGENIC & PROGESTATIONAL SUBSTANCES 32. ANTIBIOTICS 33. APRACLONIDINE 34. APROTININ 35. ORGANIC COMPOUND OF ARSENIC 36. ARTEETHER 37. ARTEMETHER 38. ARTESUNATE
Schedule_H
Synthetic compounds that act as serine protease inhibitors
protease inhibitors. These were developed in 2010 to replace the use of aprotinin during and after cardiac surgery, including surgeries with cardiopulmonary
CU-2010_and_CU-2020
carcinogenicity Antrafenine 1984 France Unspecific experimental toxicity Aprotinin (Trasylol) 2008 US Increased risk of death Ardeparin (Normiflo) 2001 US
List_of_withdrawn_drugs
Research institute of The Ottawa Hospital, Canada
within tumours in humans. Dean Fergusson and Paul Hebert discovered that aprotinin is associated with an increased risk of death compared to other drugs
Ottawa Hospital Research Institute
Ottawa_Hospital_Research_Institute
Pancreatic peptide released in shock
blocking its activity, for example using glucocorticoids, prostaglandins, aprotinin, captopril, imidazole or lidocaine.[citation needed] Myocardial+Depressant+Factor
Myocardial_depressant_factor
Potentially fatal complication of pregnancy
quick way to address this issue. Serine proteinase inhibitor FOY and Aprotinin have also been used to treat DIC in AFE. The successful use of heparin
Amniotic_fluid_embolism
Pharmaceutical compound
calcium salts. Formulations from different manufacturers may also contain aprotinin, fibronectin, plasminogen, and factor XIII. A formulation with human thrombin
Fibrin_glue
Inflammation of the tendon
(autologous blood, platelet-rich plasma, deproteinised haemodialysate, aprotinin, polysulphated glycosaminoglycan, skin derived fibroblasts etc.) for treating
Tendinopathy
Pharmaceutical drug classification
acid B02AA02 Tranexamic acid B02AA03 Aminomethylbenzoic acid B02AB01 Aprotinin B02AB02 Alfa1 antitrypsin B02AB04 Camostat B02AB05 Ulinastatin B02BA01
ATC_code_B02
Genetic engineering to produce pharmaceuticals
and Fraunhofer. ProdiGene – was developing several proteins, including aprotinin, trypsin and a veterinary TGE vaccine in corn. Was in process of launching
Pharming_(genetics)
Protein family
peptidase inhibitor I78 family includes Aspergillus elastase inhibitor. Aprotinin Bestatin Calpain inhibitor I and II Chymostatin E-64 Leupeptin
Protease_inhibitor_(biology)
Subgroup of serine proteases
hypermobile Ehlers-Danlos syndrome. Prekallikrein Kinin-kallikrein system Kinin Aprotinin List of cutaneous conditions Raspi G (September 1996). "Kallikrein and
Kallikrein
Scientific study of science
Hutton, Brian; Shapiro, Stan (2016). "Randomized controlled trials of aprotinin in cardiac surgery: Could clinical equipoise have stopped the bleeding
Metascience
Surgical treatment for eyes lacking functional lens capsules
fibrinogen (20 mg/0.5 ml), freeze-dried human thrombin (250 IU/0.5 ml), aprotinin solution (1,500 KIU in 0.5 ml), one ampoule of sterile water, four 21-gauge
Glued_intraocular_lens
Buffer to break cells in molecular biology
function because it mimics phosphate) 100 U/ml protease inhibitor, such as aprotinin SDS is ionic denaturing detergent. Hot SDS buffer is often used when the
Lysis_buffer
Viscoelastic method for hemostasis testing in whole blood
APTEM test is an EXTEM based assay in which fibrinolysis is inhibited by aprotinin in the reagent. A significant improvement of the clot in APTEM compared
Thromboelastometry
Medical intervention
acids Aminocaproic acid Tranexamic acid Aminomethylbenzoic acid serpins Aprotinin Alfa1 antitrypsin C1-inhibitor Camostat unsorted Ulinastatin #WHO-EM ‡Withdrawn
Hemostatic Powder Spray TC-325
Hemostatic_Powder_Spray_TC-325
Indian cardiovascular surgeon (1942–2024)
Bharat Dubey; Nita Saxena; Panangipalli Venugopal (2010). "Efficacy of Aprotinin, Epsilon Aminocaproic Acid, or Combination in Cyanotic Heart Disease"
Panangipalli_Venugopal
Open heart surgical procedure
opioid analgesic, to manage pain, cause sedation and induce serenity Aprotinin, or other antifibrinolytic, to prevent excessive bleeding Methylprednisolone
Arterial_switch_operation
9004-10-8 C267H404N72O78S6 insulin glargine 160337-95-1 C284H432N84O79S7 aprotinin 9087-70-1 C288H448N80O110S6 lepirudin 120993-53-5 C299H476N90O87S10 calciseptine
List of compounds with carbon numbers 50+
List_of_compounds_with_carbon_numbers_50+
Protein family
(ed.). "Inhibition of outer membrane proteases of the omptin family by aprotinin". Infection and Immunity. 83 (6): 2300–2311. doi:10.1128/IAI.00136-15
Omptin
(INN) aprocitentan (INN) Aprodine aprofene ru:Апрофен (INN) aprosulate sodium (INN) aprotinin (INN) aptazapine (INN) aptiganel (INN) aptocaine (INN)
List_of_drugs:_An–Ap
Turkish doctor (born 1945)
Canbaz S, Cıkırıkcıoglu M, Sunar H, Yuksel V, Duran E. The Importance of Aprotinin and Pentoxifylline in Preventing the Leucocyte Sequestration and Lung
Enver_Duran
Norwegian physiologist
Repeatable measurement of local and zonal GFR in the rat kidney with aprotinin (sm.m. O. Tenstad og H. E. Williamson), i Acta Physiologica Scandinavica
Knut_Aukland
Mammalian protein found in Homo sapiens
interact with: A2-Macroglobulin, β-amyloid precursor protein, APBB1, APOE, Aprotinin, C1S/C1q inhibitor, CALR, CD44, Chylomicron, Circumsporozoite protein
LRP1
Jockenhoevel S (November 2009). "Tranexamic acid--an alternative to aprotinin in fibrin-based cardiovascular tissue engineering". Tissue Engineering
Fibrin_scaffold
Mammalian protein found in humans
similarity to von Willebrand factor, fibronectin, actin, salivary proteins and aprotinin type protease inhibitors". The EMBO Journal. 9 (2): 385–93. doi:10.1002/j
Collagen,_type_VI,_alpha_3
Protein-coding gene in the species Homo sapiens
acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin". Pancreas. 19 (4): 325–334. doi:10.1097/00006676-199911000-00002. PMID 10547191
Kallistatin
Protein-coding gene in the species Homo sapiens
e PDB gallery 1eaw: CRYSTAL STRUCTURE OF THE MTSP1 (MATRIPTASE)-BPTI (APROTININ) COMPLEX 1eax: CRYSTAL STRUCTURE OF MTSP1 (MATRIPTASE) 2gv6: Crystal Structure
ST14
Protein-coding gene in the species Homo sapiens
human pancreatic proteinases by mucus proteinase inhibitor, eglin c and aprotinin". The Biochemical Journal. 313 (2): 555–60. doi:10.1042/bj3130555. PMC 1216943
SLPI
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(D12.776)
Protein-coding gene in the species Homo sapiens
for alpha-synuclein degradation. Various serine protease inhibitors (aprotinin, phenylmethyl sulfonyl fluoride, leupeptin, and 4-(2-aminoethyl)-benzenesulfonyl
KLK6
Neurotoxin from the Indian Red Scorpion
S2CID 25722401. Pandey, R; Deshpande, SB (August 2004). "Protective effects of aprotinin on respiratory and cardiac abnormalities induced by Mesobuthus tamulus
Tamulotoxin
GM virus environmental technique
et al. (June 2010). "Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression
Horizontal Environmental Genetic Alteration Agents
Horizontal_Environmental_Genetic_Alteration_Agents
APROTININ
APROTININ
APROTININ
APROTININ
Girl/Female
Afghan, African, Arabic, Hindu, Indian, Muslim, Parsi
Happy; Joyous; Bird
Boy/Male
Muslim
One who does much prostrations
Male
Arthurian
, ("horrid"); king Arthur's father.
Boy/Male
Indian, Punjabi, Sikh
Jewel of Victory
Boy/Male
Tamil
Chandavarman | சஂதாவரà¯à®®à®¨
An old king
Boy/Male
Tamil
Lord Murugan
Girl/Female
Hindu, Indian, Sanskrit
Koushthub the Gem Worn by Lord Vishnu
Girl/Female
Irish
Protective.
Girl/Female
Hindu
Joyous
Girl/Female
Muslim
APROTININ
APROTININ
APROTININ
APROTININ
APROTININ