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Family of protease enzymes
Like ADAMs, the name of the ADAMTS family refers to its disintegrin and metalloproteinase activity, and in the case of ADAMTS, the presence of a thrombospondin
ADAMTS
Metalloprotease enzyme
cases. Genomically, ADAMTS13 shares many properties with the 19 member ADAMTS family, all of which are characterised by a protease domain (the part that
ADAMTS13
Medical condition
Upshaw–Schulman syndrome. People with this syndrome generally have 5–10% of normal ADAMTS-13 activity. A 2024 study suggested that hereditary TTP is underdiagnosed
Thrombotic thrombocytopenic purpura
Thrombotic_thrombocytopenic_purpura
Abnormally low levels of platelets in the blood
the von Willebrand factor-cleaving protease ADAMTS-13. The plasmapheresis procedure also adds active ADAMTS-13 protease proteins to the patient, restoring
Thrombocytopenia
Protein-coding gene in humans
glioma. ADAMTS4 is the shortest known ADAMTS, lacking the C-terminal domain and is the only non-glycosylated ADAMTS. It also only has one thrombospondin
ADAMTS4
Class of enzymes
ADAMTS-4 endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme. This enzyme catalyses the following chemical reaction Glutamyl endopeptidase; bonds
ADAMTS-4_endopeptidase
Protein-coding gene in humans
and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This
ADAMTSL1
Group of enzymes
zinc dependent family, the ADAMTS family. More enzymes were discovered, ADAMTS5 and ADAMRS1. All of the enzymes in the ADAMTS family were exhibiting similar
Aggrecanase
Protein-coding gene in humans
with thrombospondin type 1 motif". Verma P, Dalal K (Dec 2011). "ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis". Journal of Cellular Biochemistry
ADAMTS5
Research area in which no drugs are currently approved
Pharmacokinetics and Pharmacodynamics of Single Ascending Doses of the Anti-ADAMTS-5 Nanobody®, M6495, in Healthy Male Subjects: A Phase I, Placebo-Controlled
Disease-modifying osteoarthritis drug
Disease-modifying_osteoarthritis_drug
Class of enzymes
ADAMTS13 endopeptidase (EC 3.4.24.87, ADAMTS VWF cleaving metalloprotease, ADAMTS-13, ADAMTS13, vWF-cleaving protease, VWF-CP, vWF-degrading protease
ADAMTS13_endopeptidase
Protein-coding gene in humans
at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4". Journal of Biological Chemistry. 276 (16): 13372–13378. doi:10
ADAMTS1
a disintegrin and metalloproteinase domain with throbospondin motifs (ADAMTS), and cysteine and serine proteases are involved in angiogenesis. This article
Proteases_in_angiogenesis
Protein-coding gene in humans
(2002). "Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3". J. Biol. Chem. 277 (8): 5756–66.
ADAMTS2
Protein-coding gene in humans
ADAMTS-like protein 4 is a protein that in humans is encoded by the ADAMTSL4 gene. This gene is a member of ADAMTS (a disintegrin and metalloproteinase
ADAMTSL4
Mammalian protein involved in blood clotting
1056/NEJMoa022831. PMID 12878741. Moake JL (January 2004). "von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. 41
Von_Willebrand_factor
Protein-coding gene in humans
"O-fucosylation of Thrombospondin Type 1 Repeats in ADAMTS-like-1/punctin-1 Regulates Secretion: Implications for the ADAMTS Superfamily". Journal of Biological Chemistry
ADAMTS7
Type of cartilage in humans
Yuan; Zhu, Peijun; Hao, Liang (8 July 2022). "The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis". Biomolecules. 12 (7): 959. doi:10.3390/biom12070959
Hyaline_cartilage
Protein-coding gene in humans
humans is encoded by the ADAMTS12 gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
ADAMTS12
Protein-coding gene in humans
JM, Jungers KA, et al. (2003). "Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1". J
ADAMTS9
Protein domain
historically. Therapeutic ADAM inhibitors might potentiate anti-cancer therapy. ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs) family
ADAM_(protein)
matrix metalloproteinase-1 EC 3.4.24.81: ADAM10 endopeptidase EC 3.4.24.82: ADAMTS-4 endopeptidase EC 3.4.24.83: anthrax lethal factor endopeptidase EC 3.4
List_of_EC_numbers_(EC_3)
Protein-coding gene in humans
humans is encoded by the ADAMTS8 gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
ADAMTS8
Protein-coding gene in humans
gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several
ADAMTS17
Protein-coding gene in humans
ADAMTS14 encodes a member of the ADAMTS protein family. Family members share several distinct protein modules, including a propeptide region, a metalloproteinase
ADAMTS14
2021 Sudanese short drama film
International Film Festival 2010–present Pumzi (2010) Blissi N'Diaye (2011) Adamt (2013) Stiff (2014) Logdgers (2016) Coat of Harms (2017) My Tyson (2018)
Al-Sit
Mutation at a location where intron splicing takes place
thrombocytopenic purpura). TTP is caused by deficiency of ADAMTS-13. A splice site mutation of ADAMTS-13 gene can therefore cause TTP. It is estimated that
Splice_site_mutation
Protein-coding gene
ADAMTS15 is a protein-coding gene that belongs to the ADAMTS family. The ADAMTS family, which stands for A Disintegrin-like and Metalloproteinase with
ADAMTS15
Michaelis, M.; Lindemann, S. (2018). "In vitro characterization of the ADAMTS-5 specific nanobody® M6495". Osteoarthritis and Cartilage. 26: S178. doi:10
Kinetic_exclusion_assay
Protein-coding gene in humans
belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are
ADAMTS10
2009 South African film
International Film Festival 2010–present Pumzi (2010) Blissi N'Diaye (2011) Adamt (2013) Stiff (2014) Logdgers (2016) Coat of Harms (2017) My Tyson (2018)
Pumzi
Protein that in humans is encoded by the ACAN gene
PMID 22297263. East CJ, Stanton H, Golub SB, Rogerson FM, Fosang AJ (Mar 2007). "ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in
Aggrecan
Complication of pregnancy associated with severe pre-eclampsia
"Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome". Haematologica
HELLP_syndrome
Protein-coding gene in the species Homo sapiens
"Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases". Development. 127 (24): 5475–85. doi:10.1242/dev.127
PAPLN
Synthetic material
antibodies, most commonly studied being 12F4.1H7, work to specifically suppress ADAMTS-5-induced aggrecan release. This in turn helps to slow down cartilage degradation
Artificial_cartilage
Medical condition
with each other and may amplify or reduce overall ADAMTS13 activity. The ADAMTS protease family contains enzymes that process collagen, cleave inter-cellular
Upshaw–Schulman_syndrome
Protein-coding gene in humans
2002). "Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3". The Journal of Biological Chemistry
ADAMTS3
Protein-coding gene in the species Homo sapiens
Quesada V, López-Otín C (April 2003). "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple
Gamma-glutamyltransferase_7
2017 British drama short film
International Film Festival 2010–present Pumzi (2010) Blissi N'Diaye (2011) Adamt (2013) Stiff (2014) Logdgers (2016) Coat of Harms (2017) My Tyson (2018)
1745_(film)
Protein-coding gene in the species Homo sapiens
PMID 16769693. Hills R, Mazzarella R, Fok K, et al. (2007). "Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic
Matrilin-3
Proteins from viper venom inhibiting platelets aggregation
the latter may arise from such a post-translational processing. ADAM and ADAMTS protein families, which include important protease enzymes. The secreted
Disintegrin
Protein in humans
humans is encoded by the ADAMTS6 gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein
ADAMTS6
Ethiopian singer and actress (born 1980)
Tilahun Zewege. She acted in films such as Laundry Boy, Selanchi (2009), Adamt (2013) and German film Der weiße Äthiopier (2015). Afterwards, Sayat began
Sayat_Demissie
Series of chemical reactions resulting in a cell response
periovulatory period in cattle: progesterone, prostaglandins, oxytocin and ADAMTS proteases". Animal Reproduction. 6 (1): 60–71. PMC 2853051. PMID 20390049
Biochemical_cascade
Life-threatening immune-related blood disease
PMID 20686117. S2CID 26844964. Moake, JL (2004). "von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Semin Hematol. 41 (1): 4–14
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
Chemical compound
MMP3/13 and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), thus attenuating cartilage degradation. The biosynthetic pathway of N-feruloylserotonin
N-Feruloylserotonin
Protein found in humans
is regulated through Notch 1 signaling, which is upregulated by the ECM. ADAMTS 1, 5, 7, 15, and 19 are zinc metalloenzymes responsible for degrading the
Zinc_transporter_ZIP8
Protein-coding gene in the species Homo sapiens
(Cyr61) Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS-4 (Aggrecanase 1) Activity". Arthritis & Rheumatology. 67 (6): 1557–1567
CYR61
Australian biomedical researcher
evaluating cartilage damage in arthritic disease. Her work showing that ADAMTS-5 is the major aggrecanase in mouse cartilage was published in the high-profile
Amanda_Fosang
Film festival held in Nigeria
Omoni Oboli Best Student Film Sodiq by Adeyemi Michael Best Short Film Adamt by Zalem Worldmariam (Ethiopia) Special Jury Mention Beleh by Eka Christa
Africa International Film Festival
Africa_International_Film_Festival
Protein found in humans
Miura R, Yamaguchi Y, Okada Y (Sep 2005). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican". Acta Neuropathologica. 110 (3): 239–46. doi:10
Brevican
ADAMTS
ADAMTS
ADAMTS
ADAMTS
Girl/Female
Hindu
Petal
Surname or Lastname
English
English : variant spelling of Bradbury.
Boy/Male
African, American, Arabic, Australian, British, Christian, English, Hebrew
Strength of God; The Memory of the Lord; The Lord has Remembered; God will Strengthen; Abbreviation of Ezekiel
Female
English
English form of French Hélène, probably HELEN means "torch." In mythology, this is the name of the most beautiful woman ever to exist whose abduction by Paris caused the Trojan war.
Boy/Male
Muslim
Name of a companion of the prophet
Girl/Female
Assamese, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit
Direction
Boy/Male
Hindu
Enjoying, Associate with the Goddess Lakshmi
Boy/Male
Hindu, Indian
Yoga
Girl/Female
Muslim/Islamic
Loftier more eminent
Boy/Male
Anglo, British, English
Name of a King
ADAMTS
ADAMTS
ADAMTS
ADAMTS
ADAMTS