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Anticoagulant medication
Warfarin, sold under the brand name Coumadin among others, is used as an anticoagulant medication. It is commonly used to prevent deep vein thrombosis
Warfarin
Medical condition
(4-hydroxycoumarins, such as warfarin). Warfarin necrosis is a rare but severe complication of treatment with warfarin or related anticoagulants. The
Warfarin_necrosis
Class of drugs
heart–lung machines, and dialysis equipment. One of the first anticoagulants, warfarin, was initially approved as a rodenticide. Anticoagulants are closely related
Anticoagulant
Congenital disorder caused by maternal warfarin administration
Fetal warfarin syndrome is a disorder of the embryo which occurs in a child whose mother took the medication warfarin (brand name: Coumadin) during pregnancy
Fetal_warfarin_syndrome
Anticoagulant medication, sold as Pradaxa and other brands
over warfarin in preventing ischemic stroke; however, dabigatran was associated with a lower hazard for intracranial bleeding compared with warfarin, but
Dabigatran
Anticoagulant medication sold as Eliquis
through directly inhibiting factor Xa. It is used as an alternative to warfarin to prevent blood clots following hip or knee replacement and in those with
Apixaban
Medical condition
Warfarin resistance is a rare condition in which people have varying degrees of tolerance to the anticoagulant drug warfarin. In incomplete warfarin resistance
Warfarin_resistance
Fat-soluble vitamers
administration of ezetimibe to people who take warfarin (a vitamin K antagonist) would potentiate the warfarin effect. This has been confirmed in humans.
Vitamin_K
Anticoagulant drug
is unclear if use in pregnancy and breastfeeding is safe. Compared to warfarin it has fewer interactions with other medications. It works by blocking
Rivaroxaban
Liquid portion of whole blood
treatment for factor V deficiency. Reversal of warfarin effect: Patients who are anticoagulated with warfarin are deficient in the functional vitamin K dependent
Fresh_frozen_plasma
Chemical compound
occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments
Dicoumarol
Active ingredient in fermented drinks
of warfarin and can elevate the INR, and thus increase the risk of bleeding. The U.S. Food and Drug Administration (FDA) product insert on warfarin states
Alcohol_(drug)
superwarfarins because they are much more potent and long acting than warfarin. Brodifacoum Bromadiolone Difenacoum Flocoumafen Feinstein, D. L; Akpa
Superwarfarin
Blood test that evaluates clotting
determine the clotting tendency of blood, in conditions such as the measure of warfarin dosage, liver damage (cirrhosis), and vitamin K status. PT measures the
Prothrombin_time
Blockage of an artery in the lungs
surgery. Treatment is with anticoagulant medications such as heparin, warfarin, or one of the direct-acting oral anticoagulants (DOACs). These are recommended
Pulmonary_embolism
Change in the action or side effects of a drug caused
most commonly implicated conventional drugs in herb-drug interactions are warfarin, insulin, aspirin, digoxin, and ticlopidine, due to their narrow therapeutic
Drug_interaction
Tear of the inner lining of the vertebral artery
antiplatelet drugs such as aspirin or with anticoagulants such as heparin or warfarin. Vertebral artery dissection is less common than carotid artery dissection
Vertebral_artery_dissection
Estimation of stroke risk in some patients
oral anticoagulation therapy (OAC) with a vitamin K antagonist (VKA, e.g. warfarin with target INR of 2–3) or one of the direct oral anticoagulant drugs (DOACs
CHA2DS2–VASc_score
Phenomenon of medications attaching to blood proteins
the "fraction bound" of the anticoagulant warfarin is 97%. This means that out of the amount of warfarin in the blood, 97% is bound to plasma proteins
Plasma_protein_binding
Pharmaceutical drug
thrombocytopenia. Often these individuals require long-term anticoagulation. If warfarin is chosen as the long-term anticoagulant, this poses particular challenges
Argatroban
PMID 18728265. "Broom". WebMD. Chan, T. Y. (2001). "Interaction between warfarin and danshen (Salvia miltiorrhiza)". The Annals of Pharmacotherapy. 35 (4):
List of herbs with known adverse effects
List_of_herbs_with_known_adverse_effects
Anticoagulant
Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many
Acenocoumarol
Medical laboratory blood test
normalized ratio (INR) is also a warfarin study, with therapeutic ranges of 2–3 for standard warfarin and 3–4.5 for high-dose warfarin. In a veterinary study of
Clotting_time
Anticoagulant
replacement for warfarin that would overcome the problematic dietary, drug interaction, and monitoring issues associated with warfarin therapy. In 2006
Ximelagatran
Arterio-venous plexus at lateral wall of nose
Deficiency in clotting factors Immunodeficiency Anticoagulants such as warfarin and aspirin Thrombocytopenia Liver or kidney failure and vitamin C deficiency
Woodruff's_plexus
Medical condition
crystal embolism, atheroembolism, blue toe, purple toe syndrome, trash foot, warfarin blue toe syndrome Micrograph showing a cholesterol embolus in a medium
Cholesterol_embolism
Chemical used to kill rodents
than today's Sorexa D), back in the early 1970s, which contained 0.025% warfarin and 0.1% ergocalciferol. Today, Sorexa CD contains a 0.0025% difenacoum
Rodenticide
Enzyme protein
metabolized by CYP2C9, including drugs with a narrow therapeutic index such as warfarin and phenytoin, and other routinely prescribed drugs such as acenocoumarol
CYP2C9
Antiarrhythmic medication
that is severe muscle breakdown); warfarin (since the anticoagulation effects of warfarin depend on metabolism of warfarin by both cytochromes CYP2C9 and
Amiodarone
In enzymology, a vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) is an enzyme that catalyzes the chemical reaction 2-methyl-3-phytyl-1,4-naphthoquinone
Vitamin-K-epoxide reductase (warfarin-sensitive)
Vitamin-K-epoxide_reductase_(warfarin-sensitive)
Aromatic chemical compound
blood clotting. A related compound, the prescription drug anticoagulant warfarin, is used to inhibit formation of blood clots, deep vein thrombosis, and
Coumarin
Medication
if pure factor IX is not available. It may also be used for reversal of warfarin therapy. It is given by slow injection into a vein. Another product, activated
Prothrombin complex concentrate
Prothrombin_complex_concentrate
Chemical compound
1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred. Naisbitt
Phenindione
Chemical compound
4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned
Bromadiolone
Medical condition
deficiency can also be acquired due to vitamin K deficiency, treatment with warfarin, liver disease, kidney disease, chemotherapy, infection, surgery, birth
Protein_S_deficiency
Group of substances
most commonly used VKAs. In medicine, the most commonly used VKA is warfarin. Warfarin was initially used as a rodenticide, but made the transition to pharmaceutical
Vitamin_K_antagonist
Formation of a blood clot in a deep vein
treatment. Typical medications include rivaroxaban, apixaban, and warfarin. Beginning warfarin treatment requires an additional non-oral anticoagulant, often
Deep_vein_thrombosis
Plant leaves eaten as a vegetable
particularly notable. Accordingly, users of vitamin K antagonist medications like warfarin must limit their consumption of leaf vegetables. Leaf vegetables are plant
Leaf_vegetable
Species of flowering tree in the pea family
name for the tree, kumaru. Many anticoagulant prescription drugs, such as warfarin, are based on 4-hydroxycoumarin, a chemical derivative of coumarin initially
Dipteryx_odorata
Species of flowering plant
to seed. A. sinensis may increase the anticoagulant effects of the drug warfarin (as it contains coumarins), and consequently may increase the risk of bleeding
Angelica_sinensis
Australian-Swedish chemist and educator
in his work with molecular imprinting and concerning the anticoagulant warfarin. He has a number of editorial responsibilities, including editor-in-chief
Ian_A._Nicholls
American brand of rodent control products
as poison. In 1950, the Wisconsin Alumni Research Foundation patented warfarin, a new chemical compound which had been in development since the 1930s
D-CON
Blood thinning drugs
considered as an alternative to warfarin, particularly if a person is on several other medications that interact with warfarin, or if attending medical appointments
Direct_factor_Xa_inhibitors
Inflammatory disease involving a buildup of lesions in the walls of arteries
angioplasty. There is evidence that some anticoagulants, particularly warfarin, which inhibit clot formation by interfering with Vitamin K metabolism
Atherosclerosis
Drug discovery
warfarin in 1948. It wasn't until 1954 that it was approved for medicinal use in humans making warfarin the first oral anticoagulant drug. Warfarin treatment
Discovery and development of direct Xa inhibitors
Discovery_and_development_of_direct_Xa_inhibitors
Anticoagulant medication
and a direct factor Xa inhibitor. It is taken by mouth. Compared with warfarin, it has fewer drug interactions, and does not require regular assessment
Edoxaban
Medical diagnostic method
Ratio) levels in combination with anti-coagulation drugs, most commonly warfarin. The term "International Normalized Ratio" refers to the measurement used
INR_self-monitoring
Soviet secret police chief (1899–1953)
match the appearance or timeline of patients that experience severe warfarin or warfarin-related overdoses". Towards the end of his life, Stalin was "obsessive
Lavrentiy_Beria
Anticoagulant medication taken by mouth
members of the class are expected to replace heparin (and derivatives) and warfarin in various clinical scenarios. There are three types of DTIs, dependent
Direct_thrombin_inhibitor
Irregular beating of the atria of the heart
recommend an anti-clotting medication. Anti-clotting medications include warfarin and direct oral anticoagulants. While these medications reduce stroke risk
Atrial_fibrillation
American biochemist
American biochemist best known for his discovery of the anticoagulant warfarin. Link was born in LaPorte, Indiana to a Lutheran minister of German descent
Karl_Paul_Link
Species of flowering plant
spinach's high content of vitamin K, individuals taking the anticoagulant warfarin, which acts by inhibiting vitamin K, are instructed to minimize consumption
Spinach
Chemical compound
warfarin. This is shown by an increase in prothrombin time and/or international normalised ratio (INR) in patients taking roxithromycin and warfarin concurrently
Roxithromycin
Mammalian protein involved in blood clotting
thus Vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. Although it is not enzymatically active, it is structurally related
Protein_Z
anticoagulation therapy as measured by time in therapeutic INR range (TTR) (VKA e.g. warfarin). It has been suggested that it can aid in the medical decision making
SAMe-TT2R2_score
Reaction in organic chemistry
proline side group. A well-known Michael reaction is the synthesis of warfarin from 4-hydroxycoumarin and benzylideneacetone first reported by Link in
Michael_addition_reaction
Protein-coding gene in the species Homo sapiens
stereo-selectivity (contributing to warfarin resistance) and VKORC1 activity (such as warfarin metabolism). Warfarin is an anticoagulant that opposes the
VKORC1
vitamin K (due to poor nutrition or malabsorption) and in those taking warfarin or other medication that inhibits the action of vitamin K. A 1984 study
Des-gamma_carboxyprothrombin
Process of formation of blood clots
angioplasty. Of the anticoagulants, warfarin (and related coumarins) and heparin are the most commonly used. Warfarin affects the vitamin K-dependent clotting
Coagulation
Chemical compound
trial in 607 people, comparing it to the established vitamin K antagonist warfarin, found no difference in quality of anticoagulation or side effects between
Tecarfarin
Antacid medication
bleeding when using bismuth subsalicylate and anticoagulation therapy, like warfarin. Bismuth salts were in use in Europe by the late 1700s. The combination
Bismuth_subsalicylate
Condition involving impaired blood clotting ability
disease, can cause a reduction in clotting factors. Anticoagulants such as warfarin will also prevent clots from forming properly. Coagulopathy may also occur
Coagulopathy
Painful, necrotic skin lesions associated with chronic kidney disease
hyperparathyroidism, and hypervitaminosis D. In rare cases, certain medications such as warfarin can also result in calciphylaxis. The first skin changes in calciphylaxis
Calciphylaxis
Species of plant used as a spice
does interact with some medications, including the anticoagulant drug warfarin and the cardiovascular drug nifedipine. The characteristic fragrance and
Ginger
Accumulation of blood in the sheath of the rectus abdominis muscle
Multiplanar CT scan of a spontaneous rectus sheath hematoma because of warfarin treatment. Rectus sheath hematoma seen on axial CT – with active bleeding
Rectus_sheath_hematoma
Laboratory test
but not by heparin. The ECT is also unaffected by prior treatment with warfarin or the presence of phospholipid-dependent anticoagulants, such as lupus
Ecarin_clotting_time
Blood escaping from the circulatory system
bleeding, another common cause of bleeding is that related to the medication warfarin ("Coumadin" and others). This medication needs to be closely monitored
Bleeding
Group of anticoagulant drugs
4-hydroxycoumarin class is warfarin, in which the aromatic 3-position substituent is a simple phenyl group. So called "super-warfarins" or second-generation
4-Hydroxycoumarins
molecules which occur naturally dicoumarol and are made synthetically warfarin and function as anticoagulants. full content of NEJM article Archived 2009-02-27
Benzopyrone
Abnormally fast heart rhythm
selected patients benefit from blood thinners (anticoagulants) such as warfarin or novel anticoagulants. Atrial fibrillation affects about 25 per 1000
Supraventricular_tachycardia
Hemorrhagic fever caused by ebolaviruses
purpura, hereditary haemorrhagic telangiectasia, Kawasaki disease, and warfarin poisoning. An Ebola vaccine, rVSV-ZEBOV, was approved in the United States
Ebola
Vegetables of the family Brassicaceae
vegetables has potential risk from allergies, interference with drugs such as warfarin, and genotoxicity. People who can taste phenylthiocarbamide (PTC), which
Cruciferous_vegetables
Low platelet count due to heparin, associated with a risk of thrombosis
anticoagulant, warfarin, should not be used in HIT until the platelet count is at least 150 billion/L because a very high risk of warfarin necrosis exists
Heparin-induced thrombocytopenia
Heparin-induced_thrombocytopenia
Formation of blood clots inside the blood vessels
person, and the risk of complications from treatment.[citation needed] Warfarin and vitamin K antagonists are anticoagulants that can be taken orally to
Thrombosis
Antibiotic
potential to block the breakdown of warfarin and phenprocoumon. This can result in more action of drugs like warfarin, leading to more potential side effects
Levofloxacin
Drug
toe syndrome, and allergic rashes. A rare but severe adverse effect is warfarin necrosis of the skin and subcutaneous tissue during the first days of treatment
Phenprocoumon
Quantitative measurement of the relative safety of a drug
therapeutic levels and to minimize toxicity, include dimercaprol, theophylline, warfarin and lithium carbonate. Some antibiotics and antifungals require monitoring
Therapeutic_index
Mammalian protein found in Homo sapiens
vitamin K or antagonism by warfarin (or similar medication) leads to the production of an inactive factor X. In warfarin therapy, this is desirable to
Factor_X
Harmful, unintended response to medications
primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and
Adverse_drug_reaction
High tendency to bleed due to a blood clotting disorder
[citation needed] Acquired causes of coagulopathy include anticoagulation with warfarin, liver failure, vitamin K deficiency and disseminated intravascular coagulation
Bleeding_diathesis
Non-steroidal anti-inflammatory drug
this may cause seizures. It may also increase the plasma concentration of warfarin, methotrexate, sulfonylurea derivatives and lithium salts, so care should
Loxoprofen
Blood clot
reducing the risk of stroke, heart attack and pulmonary embolism. Heparin and warfarin are used to inhibit the formation and growth of existing thrombi, with
Thrombus
Neurological condition causing impairment in spatial perception and stability
other prescription drugs, such as proton-pump inhibitors or coumadin (warfarin) Dizziness may occur from an abnormality involving the brain (in particular
Dizziness
Immune disorder leading to increased risk of blood clots
clot (venous or arterial), anticoagulants such as warfarin are used to prevent future clots. If warfarin is used, the INR is kept between 2.0 and 3.0. Direct-acting
Antiphospholipid_syndrome
Chemical compound
chemical compound is an anti-coagulant with active half-life longer than warfarin and other synthetic 1,3-indandione anticoagulants. It is toxic to mammals
Diphenadione
Steroid medication
symptoms. Aspirin and other NSAIDs, as well as anticoagulants such as warfarin, add to the risk of gastrointestinal bleeding. Diuretics that excrete potassium
Triamcinolone
Patent-holding organization
early discoveries related to vitamin D, development of the blood thinner warfarin (named after WARF), the derivation of stem cells, and algorithms that speed
Wisconsin Alumni Research Foundation
Wisconsin_Alumni_Research_Foundation
Antibiotic derived from Penicillin
breast milk. Dicloxacillin has potential interactions with following drugs: Warfarin Methotrexate Tetracyclines Despite dicloxacillin being insensitive to beta-lactamases
Dicloxacillin
Class of enzymes
In enzymology, a vitamin-K-epoxide reductase (warfarin-insensitive) (EC 1.17.4.5) is an enzyme that catalyzes the chemical reaction 3-hydroxy-2-methyl-3-phytyl-2
Vitamin-K-epoxide reductase (warfarin-insensitive)
Vitamin-K-epoxide_reductase_(warfarin-insensitive)
Barbiturate
oxycodone Quinine Steroids, such as prednisone and cortisone Theophylline Warfarin Amobarbital has been known to decrease the effects of hormonal birth control
Amobarbital
Protease commonly found in natto
1006/bbrc.1993.2624. PMID 8280151. "Can You Take Nattokinase With Coumadin (Warfarin)?". PharmacistAnswers. Retrieved 2019-02-20. Sumi H, Hamada H, Tsushima
Nattokinase
Accumulation of calcium salts in bodily tissue, usually bone
bones". Harvard health Publishing. March 1, 2010. Paul Price, et al., "Warfarin-Induced Artery Calcification Is Accelerated by Growth and Vitamin D", Arteriosclerosis
Calcification
Antibiotic medication
unless liver impairment is present. It may decrease the effectiveness of warfarin, a commonly prescribed anticoagulant, in people with liver problems. Rifaximin
Rifaximin
Type of localized bleeding in tissues outside blood vessels
diverse etiologies such as adverse reactions from medications such as warfarin, straining, asphyxiation, platelet disorders and diseases such as cytomegalovirus);
Bruise
Species of tree
especially in terms of drug interactions. The dosing of anticoagulants, such as warfarin or antiplatelet medication, may be adversely affected by using ginkgo supplements
Ginkgo_biloba
Several genera of rodents
but soon after the program commenced the rodenticide and medical drug warfarin was introduced, which is much safer for people and more effective at killing
Rat
Combination drug
terfenadine, astemizole, indinavir, midazolam, calcium channel blockers, warfarin, cisapride and ciclosporin. Denyer SP, Hodges N, Gorman SP, eds. (2004)
Quinupristin/dalfopristin
reductase Vitamin-K-epoxide reductase (warfarin-sensitive) EC 1.17.4.4 Vitamin-K-epoxide reductase (warfarin-insensitive) EC 1.17.4.5 RRM1 RRM2 RRM2B
List_of_enzymes
Japanese voice actress
Project Eleanor Umamusume: Pretty Derby Rice Shower 2019 Arknights Exusiai / Warfarin Fire Emblem: Three Houses Ingrid Brandl Galatea Magia Record Ui Tamaki
Manaka_Iwami
Group of vitamins and bacterial metabolites
intake interferes with anticoagulant effects.[citation needed] Patients on warfarin (Coumadin) or being treated with other vitamin K antagonists are therefore
Vitamin_K2
WARFARIN
WARFARIN
WARFARIN
WARFARIN
Female
Egyptian
, Victorious Neith.
Girl/Female
Tamil
Invincible, Unconquerable, A winner
Biblical
exaltation of help
Boy/Male
Tamil
Lord Shiva, A name of Lord Rama
Girl/Female
Latin
who was the Mythological queen of Sparta and mother of Helen of Troy.
Girl/Female
Hindu, Indian
Saintly
Boy/Male
British, English
Fair; Handsome; Both a Diminutive of Albert
Boy/Male
Sikh
Beauty
Boy/Male
Muslim
The bestower
Boy/Male
Muslim
Light, Angel
WARFARIN
WARFARIN
WARFARIN
WARFARIN
WARFARIN