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Protein-coding gene in humans
non-small-cell lung cancer. BRAF-V600E mutation are present in 57% of Langerhans cell histiocytosis patients. The V600E mutation is a likely driver mutation
BRAF_(gene)
Genetic variant
V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. It is a driver mutation in a proportion
V600E
Chemical compound
binimetinib for the treatment of people with unresectable or metastatic BRAF V600E or V600K mutation-positive melanoma. Encorafenib is indicated in combination
Encorafenib
Anticancer medication
by the US Food and Drug Administration for the treatment of people with V600E mutated metastatic melanoma. It was approved for medical use in the European
Trametinib
Anti-cancer medication
metastatic melanoma with BRAF V600E mutation. Dabrafenib is indicated, in combination with trametinib, for BRAF V600E-positive unresectable or metastatic
Dabrafenib
Medical condition
typically show similar markers to reactive histiocytes, except when the BRAF V600E mutation is found. Classic signs, like foamy histiocytes, may not always
Erdheim–Chester_disease
Chemical compound
metastatic BRAF V600E or V600K mutation-positive melanoma. In October 2023, it was approved by the FDA for treatment of NSCLC with a BRAF V600E mutation in
Binimetinib
Skin cancer originating in melanocytes
search for the mutations. Melanoma with genetic mutations in the BRAF genes V600E or V600K (proteins involved in cell growth) are more responsive to therapy
Melanoma
Hematological malignancy
does not necessarily imply causation. A 2011 study identified somatic BRAF V600E mutations in all 47 HCL patients studied, and no such mutations in the 193
Hairy_cell_leukemia
Targeted cancer drug
pathway − if the B-Raf has the common V600E mutation. Vemurafenib only works in melanoma patients whose cancer has a V600E BRAF mutation (that is, at amino
Vemurafenib
Tumor made of enamel-producing cells (ameloblasts) in developing teeth
adjacent soft tissues is required. BRAF V600E gene and SMO gene mutations have been found in ameloblastomas. The V600E mutation is also seen in other malignant
Ameloblastoma
Medical condition
associated (P=0.0005) with BRAF V600E mutation. According to recent studies, papillary cancers carrying the common V600E mutation tend to have a more aggressive
Papillary_thyroid_cancer
Drug class
encorafenib for the treatment of patients with unresectable or metastatic BRAF V600E or V600K mutation-positive melanoma. Cobimetinib or XL518, approved by US
MEK_inhibitor
Class of organic compounds
et al. (September 2021). "Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy". Aging Cell. 20 (9) e13447
Cardiac_glycoside
Type of molecule that may be able to induce death of senescent cells
et al. (September 2021). "Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy". Aging Cell. 20 (9) e13447
Senolytic
Chemical compound
action. Kundu et al.[citation needed] further showed that inhibition of BRAF V600E activity by indole-3-carbinol resulted in downregulation of MITF-M by downstream
Indole-3-carbinol
Cancer treatment medicine
(January 2009). "CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations". Oncogene. 28 (1): 85–94. doi:10.1038/onc.2008.362. PMC 2898184
Sorafenib
Highly oxygenated polyketide
effecting the mitochondria. With its unique mechanism, effective also in BRAF V600E mutation cell lines, mensacarcin is a promising model for the development
Mensacarcin
Class of drugs used to treat malignant tumors
Everolimus (Afinitor) Vemurafenib Unresectable or metastatic melanoma with BRAF V600E mutation Blocks B-Raf kinase Dabrafenib Ibrutinib Mantle cell lymphoma,
Antineoplastic
Substance or process that is indicative of the presence of cancer in the body
(chronic myeloid leukemia), BRCA1 / BRCA2 (breast/ovarian cancer), BRAF V600E (melanoma/colorectal cancer), CA-125 (ovarian cancer), CA19.9 (pancreatic
Cancer_biomarker
Biochemical test for age
accelerated DNAm age in breast cancer. Colorectal cancer samples with a BRAF (V600E) mutation or promoter hypermethylation of the mismatch repair gene MLH1
Epigenetic_clock
Type of therapy
dabrafenib, LGX818) used to treat metastatic melanoma that harbors BRAF V600E mutation MEK inhibitors (trametinib, MEK162) are used in experiments, often
Targeted_therapy
Pharmaceutical compound
the proto-oncogene BRAF with activating mutations BRAF mutations (such as V600E), non-V600 BRAF mutations, and RAF fusions. It is being developed by MapKure
Brimarafenib
Mammalian protein found in Homo sapiens
contrast, growth factors such as IGF-1 and TGF-β (which is induced by the BRAF-V600E oncogene) suppress NIS gene expression, not letting NIS localize in the
Sodium/iodide_cotransporter
Italian hematologist, academic and researcher
cell leukemia (HCL). His discoveries of NPM1 mutations in AML and BRAF-V600E in HCL, identified new mechanisms of leukemogenesis and resulted into improvement
Brunangelo_Falini
Precision oncology research company
level, research demonstrating variable MAPK pathway activation in BRAF V600E–mutated melanoma despite identical genomic alterations and associated treatment
Astron_(research_center)
Indolent thyroid tumor
THADA gene fusions, and BRAF K601E mutations may be seen on occasion. BRAF V600E mutations and RET gene fusions that are commonly seen in classical type
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features
Noninvasive_follicular_thyroid_neoplasm_with_papillary-like_nuclear_features
Pharmaceuticals melanoma with BRAF V600E or V600K mutations Trametinib Novartis Pharmaceuticals melanoma with BRAF V600E or V600K mutations Dabrafenib Novartis
List of drugs granted breakthrough therapy designation
List_of_drugs_granted_breakthrough_therapy_designation
Medical condition
cells, similar to the monoclonal cells in Hairy cell leukemia, may have the V600E mutation in the BRAF gene. Patients with this lymphoma commonly have enlarged
Monoclonal B-cell lymphocytosis
Monoclonal_B-cell_lymphocytosis
American pathologist
Elenitoba-Johnson (30 June 2014). "High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis". Blood. 124 (10): 1655–1658. doi:10
Kojo Seys John Elenitoba-Johnson
Kojo_Seys_John_Elenitoba-Johnson
Mammalian protein found in Homo sapiens
single amino acid: Val 600 into Glu, and this aberrant gene product (BRAF-V600E) can be visualized by immunohistochemistry for clinical molecular diagnostics
C-Raf
Austrian oncologist
Birner, A. von Deimling, M. Preusser: Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases.
Matthias_Preusser
(uncommon/rare). Vemurafenib PO BRAF kinase inhibitor. BRAF kinase mutation V600E-positive Metastatic melanoma. Skin reactions, secondary malignancies (mostly
List_of_antineoplastic_agents
IgVH status miR-15a, miR-195, miR-221, miR-155, miR-23b Melanoma with BRAF V600E miR-193a, miR-338, miR-565 Lymphoma Diffuse Large B Cell Lymphoma has-miR-128
MicroRNA_sequencing
Chemical compound
"Pharmacokinetic Evaluation of [ 11 C]CEP-32496 in Nude Mice Bearing BRAF V600E Mutation-Induced Melanomas". Molecular Imaging. 17 1536012118795952. doi:10
Agerafenib
Chinese-American biologist and oncologist
activation of growth factor receptors, expression of K-Ras G12V and B-Raf V600E, and hypoxia induce the mitochondrial translocation of PGK1, which phosphorylates
Zhimin_Lu
Abnormal proliferation of Langerhans cells
McClain, Kenneth L.; Allen, Carl E. (10 December 2011). "1372 Frequent BRAF V600E Mutations Are Identified in CD207+ Cells in LCH Lesions, but BRAF Status
Langerhans_cell_histiocytosis
Human colon cancer cell line
oncogenic signaling pathways and their proliferative capacity. The BRAF V600E mutation in these cells constantly activates the MAP kinase signaling pathway
HT-29
Chemical compound
treatment of adults with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib. It is also indicated
Cobimetinib
Protein-coding gene in the species Homo sapiens
pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma". Oncogene. 33 (34): 4330–4339. doi:10.1038/onc.2013
Phosphoinositide-dependent kinase-1
Phosphoinositide-dependent_kinase-1
Spanish-American physician–scientist
people with a type of melanoma that contains a potent gene mutation, BRAF V600E, survived longer without the cancer progressing when they received a combination
Antoni_Ribas_(professor)
Medical condition
cases) Chromatin remodeling gene mutations (e.g., KMT2C, KMT2D) Rare BRAF V600E mutations (<5% of cases) Acinic cell carcinoma is believed to arise from
Acinic_cell_carcinoma
American scientist
Using Next-Generation Sequencing Identifies Concordant Occurrence of BRAF V600E Mutations. Chest. 2013, 143(6):1679-84. Dettmer M, Vogetseder A, Durso MB
Yuri_Nikiforov_(scientist)
Protein-coding gene in the species Homo sapiens
Tran SL, Gowrishankar K, Shaw HM, et al. (May 2013). "Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin
TBX3
Rare primary CNS tumor
occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation. J Neurooncol 128:293–302. https://doi.org/10.1007/s11060-016-2109-x
Diffuse leptomeningeal glioneuronal tumor
Diffuse_leptomeningeal_glioneuronal_tumor
American chemist
half of melanoma cells, the B-Raf protein contains a missense mutation (V600E mutation), which is responsible for cell transformation, invasion, and metastasis
Natalie_Ahn
Pharmaceutical compound
"Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in BrafV600E/PtenNULL Mice". The Journal of Investigative Dermatology. 142 (4): 1145–1157
4-Bromoresveratrol
Protein-coding gene in the species Homo sapiens
treatment in BRAF wild-type melanoma tumors comparing to ones with BRAF (V600E-vemurfenib resistant) mutation. Finally, in a 2013 study of castration-resistant
Embryonal fyn-associated substrate
Embryonal_fyn-associated_substrate
American physician-scientist
Ligon, Azra H.; Louis, David N.; Santagata, Sandro (2011-03-29). "BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic
Sandro_Santagata
British cancer biologist
Cartlidge, R. A.; Nelson, B.; Roberts, C. W.; McMahon, M. (May 2009). "BrafV600E cooperates with Pten loss to induce metastatic melanoma". Nature Genetics
Martin_McMahon_(biologist)
V600E
V600E
V600E
V600E
Boy/Male
Indian, Punjabi, Sikh
Embodiment of the Beginning-less
Female
Spanish
 Feminine form of Roman Latin Antonius, possibly ANTONIA means "invaluable." In use by the English, Italians and Spanish.
Girl/Female
Indian
A beautiful Raaga musical scale in hindustani indian music
Girl/Female
Hindu, Indian, Tamil
Jamuna River
Boy/Male
Hindu
The Moon
Boy/Male
Gujarati, Hindu, Indian, Kannada, Marathi, Sindhi, Telugu
Well Wisher
Boy/Male
Gaelic French Scottish
Crooked mouth.
Girl/Female
Indian, Tamil
Artistic
Girl/Female
Hindu, Indian
Garland of Gold
Boy/Male
Hindu, Indian, Tamil
Lord Shiva
V600E
V600E
V600E
V600E
V600E