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TRPC5

  • TRPC5
  • Protein-coding gene in the species Homo sapiens

    potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene. TrpC5 is subtype of

    TRPC5

    TRPC5

    TRPC5

  • Odontoblast
  • Type of cell that produces dentin in teeth

    of TRPC5 as cold transducer the odontoblast transduction theory has become a likely explanation of dentinal hypersensivity The contribution of TRPC5 channels

    Odontoblast

    Odontoblast

    Odontoblast

  • Transient receptor potential channel
  • Class of transport proteins

    Some TRP channels such as TRPA1 and TRPC5 are tightly associated with drug resistance during cancer treatment; TRPC5-mediated high Ca2+ influx activates

    Transient receptor potential channel

    Transient_receptor_potential_channel

  • TRPC
  • Family of transient receptor potential cation channels in animals

    one report that TRPC1 is also activated by stretching of the membrane and TRPC5 channels are activated by extracellular reduced thioredoxin. It has long

    TRPC

    TRPC

  • Neuronal calcium sensor-1
  • Neuronal calcium sensory protein

    subfamily, member 3) voltage-gated potassium channels Nitric oxide synthase TRPC5 channel Ric8a Frq modulates Ca2+ entry through a functional interaction

    Neuronal calcium sensor-1

    Neuronal calcium sensor-1

    Neuronal_calcium_sensor-1

  • Dehydroepiandrosterone sulfate
  • Chemical compound

    (outside of pregnancy). DHEA-S has also been found to inhibit the TRPV1 and TRPC5 transient receptor potential channels and to inhibit the P2X receptor. DHEA

    Dehydroepiandrosterone sulfate

    Dehydroepiandrosterone sulfate

    Dehydroepiandrosterone_sulfate

  • TRPC1
  • Protein and coding gene in humans

    mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. The highest density of TRPC1 protein is found in the lateral septum, an

    TRPC1

    TRPC1

    TRPC1

  • Dentin
  • Calcified tissue of the body; one of the four major components of teeth

    König C, Sinica V, Wyatt A, Winter Z, et al. (March 2021). "Odontoblast TRPC5 channels signal cold pain in teeth". Science Advances. 7 (13) eabf5567.

    Dentin

    Dentin

    Dentin

  • List of investigational borderline personality disorder drugs
  • modulator) BI-1358894 – transient receptor potential channel TRPC4 and TRPC5 inhibitor Lumateperone – atypical antipsychotic (non-selective monoamine

    List of investigational borderline personality disorder drugs

    List_of_investigational_borderline_personality_disorder_drugs

  • Susan Brain
  • Professor of Pharmacology at King's College London

    microvascular vasodilator. More recently her research found that the gene TRPC5 can help protect against pain in arthritis and that the gene TRPA1 is essential

    Susan Brain

    Susan_Brain

  • Alexander G. Obukhov
  • Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel". Journal of Biological Chemistry. 292 (3): 898–911. doi:10.1074/jbc

    Alexander G. Obukhov

    Alexander_G._Obukhov

  • SpyCatcher
  • Protein conjugation technology

    mammalian TRPC5 membrane channel protein which cannot be modified at the protein termini, without impacting on the channel properties of TRPC5. DogTag has

    SpyCatcher

    SpyCatcher

  • List of investigational antidepressants
  • List of pharmaceutical drugs under clinical development for treatment of depression

    channel agonist BI-1358894 – transient receptor potential cation TRPC4 and TRPC5 channel inhibitor BI-1569912 – NR2B subunit-containing ionotropic glutamate

    List of investigational antidepressants

    List_of_investigational_antidepressants

  • Calcium-binding protein 1
  • Protein found in humans

    interacts with CACNA1C via C-terminal C and IQ motifs. It interacts with TRPC5 and also interacts with MAP1LC3B via C-terminus and EF-hands 1 and 2 respectively

    Calcium-binding protein 1

    Calcium-binding protein 1

    Calcium-binding_protein_1

  • List of investigational anxiety disorder drugs
  • Investigational anxiety disorder drugs

    KAR-2618 (GFB-887; TRPC4/5 inhibitor) – transient receptor potential TRPC4 and TRPC5 cation channel inhibitor [13] SNTX-2643 (SENS-01) – atypical serotonin reuptake

    List of investigational anxiety disorder drugs

    List_of_investigational_anxiety_disorder_drugs

  • Myosin light-chain kinase
  • Class of kinase enzymes

    "Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells". The Journal of Physiology. 570 (Pt

    Myosin light-chain kinase

    Myosin light-chain kinase

    Myosin_light-chain_kinase

  • STMN3
  • Protein-coding gene in the species Homo sapiens

    regulation of microtubule dynamics. STMN3 has been shown to interact with TRPC5. GRCm38: Ensembl release 89: ENSMUSG00000027581 – Ensembl, May 2017 "Human

    STMN3

    STMN3

    STMN3

  • 2-Aminoethoxydiphenyl borate
  • Chemical compound

    Christian; Harteneck, Christian; Beech, David J. (2005-06-01). "Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular

    2-Aminoethoxydiphenyl borate

    2-Aminoethoxydiphenyl borate

    2-Aminoethoxydiphenyl_borate

  • TRPC4
  • Protein and coding gene in humans

    photosensitivity. TRPC4 has been shown to interact with ITPR1, TRPC1, and TRPC5. TRPC GRCh38: Ensembl release 89: ENSG00000133107 – Ensembl, May 2017 GRCm38:

    TRPC4

    TRPC4

    TRPC4

  • List of investigational post-traumatic stress disorder drugs
  • Investigational PTSD drugs

    [7] BI-1358894 – transient receptor potential cation channel TRPC4 and TRPC5 inhibitor [8] Cannabidiol (A-1002-N5S; CBD; Nantheia™) – cannabinoid, various

    List of investigational post-traumatic stress disorder drugs

    List_of_investigational_post-traumatic_stress_disorder_drugs

  • Cation channel superfamily
  • Family of ion channel proteins

    voltage sensor domain of voltage gated ion channels. TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7 TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8 TRPV1;

    Cation channel superfamily

    Cation channel superfamily

    Cation_channel_superfamily

  • MYLK
  • Gene of the immunoglobulin superfamily

    "Ca2+–calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells". J. Physiol. 570 (Pt 2): 219–35. doi:10

    MYLK

    MYLK

    MYLK

  • TRPC6
  • Protein and coding gene in humans

    2010). "Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels". Science Signaling. 3 (145) ra77. doi:10.1126/scisignal

    TRPC6

    TRPC6

    TRPC6

  • List of human protein-coding genes 8
  • Q13507 17473 TRPC4 HGNC:12336; Q9UBN4 17474 TRPC4AP HGNC:16181; Q8TEL6 17475 TRPC5 HGNC:12337; Q9UL62 17476 TRPC5OS HGNC:40593; A6NMA1 17477 TRPC6 HGNC:12338;

    List of human protein-coding genes 8

    List_of_human_protein-coding_genes_8

  • Ankyrin repeat
  • Protein domain

    TA-NFKBH; TEX14; TNKS; TNKS2; TNNI3K; TP53BP2; TRP7; TRPA1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7; TRPV1; TRPV2; TRPV3; TRPV4; TRPV5; TRPV6; UACA; USH1G; ZDHHC13;

    Ankyrin repeat

    Ankyrin repeat

    Ankyrin_repeat

  • STMN2
  • Protein-coding gene in the species Homo sapiens

    PMID 11882662. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology"

    STMN2

    STMN2

    STMN2

  • PDZ domain
  • Protein family

    SIPA1L3 SLC9A3R1 SLC9A3R2 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 SNX27 SPAL2 STXBP4 SYNJ2BP SYNPO2 SYNPO2L TAX1BP3 TIAM1 TIAM2 TJP1 TJP2 TJP3 TRPC4 TRPC5 USH1C WHRN

    PDZ domain

    PDZ domain

    PDZ_domain

  • MYLK3
  • Protein-coding gene in the species Homo sapiens

    "Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells". J. Physiol. 570 (Pt 2): 219–35. doi:10

    MYLK3

    MYLK3

    MYLK3

  • Index of biophysics articles
  • Index of articles on biophysics

    calcium channel TPCN1 TPCN2 TRPA (channel) TRPC TRPC1 TRPC2 TRPC3 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPML TRPN

    Index of biophysics articles

    Index_of_biophysics_articles

  • SESTD1
  • Protein-coding gene in the species Homo sapiens

    novel regulator of the transient receptor potential channels TRPC4 and TRPC5". J. Biol. Chem. 285 (16): 12426–34. doi:10.1074/jbc.M109.068304. PMC 2852980

    SESTD1

    SESTD1

    SESTD1

  • Trese Leinders-Zufall
  • Researcher

    Bufe; Arifovic; Weissgerber; Freichel; Zufall; Leinders-Zufall (2019). "Trpc5 deficieny causes hypoprolactinemia and altered function of oscillatory dopamine

    Trese Leinders-Zufall

    Trese Leinders-Zufall

    Trese_Leinders-Zufall

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Online names & meanings

  • Taizeen | تیزین
  • Boy/Male

    Muslim

    Taizeen | تیزین

    Encouragement

  • Emmitt
  • Surname or Lastname

    English

    Emmitt

    English : variant spelling of Emmett.

  • Meriem
  • Girl/Female

    Arabic, Australian, Muslim

    Meriem

    Mary

  • Iravati
  • Boy/Male

    Hindu, Indian, Punjabi, Sikh

    Iravati

    Ravi River in India

  • Hunter
  • Boy/Male

    American, Anglo, Australian, British, Chinese, English

    Hunter

    A Huntsman; Hunter

  • Chase
  • Surname or Lastname

    English

    Chase

    English : metonymic occupational name for a huntsman, or rather a nickname for an exceptionally skilled huntsman, from Middle English chase ‘hunt’ (Old French chasse, from chasser ‘to hunt’, Latin captare).Southern French : topographic name for someone who lived in or by a house, probably the occupier of the most distinguished house in the village, from a southern derivative of Latin casa ‘hut’, ‘cottage’, ‘cabin’.Thomas Chase came to MA from Chesham, Buckinghamshire, England, in the 1640s, and had many prominent descendants. Samuel Chase, born in Somerset Co., MD, in 1741, was one of the first members of the U.S. Supreme Court; Philander Chase, born in Cornish, NH, in 1741 was a prominent Episcopal clergyman, and his nephew Salmon Portland Chase (1808–73), also born in Cornish, was governor of OH, a U.S. senator, and secretary of the U.S. Treasury during the Civil War.

  • Voisttitoevetz
  • Boy/Male

    Native American

    Voisttitoevetz

    White cow.

  • ALTA
  • Female

    Spanish

    ALTA

    Spanish name derived from Latin alta, ALTA means "high."

  • YEJIDE
  • Female

    African

    YEJIDE

    image of her mother.

  • Rudradeva
  • Boy/Male

    Indian

    Rudradeva

    Lord Shiva

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TRPC5

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