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Transcriptome instability is a genome-wide, pre-mRNA splicing-related characteristic of certain cancers. In general, pre-mRNA splicing is dysregulated
Transcriptome_instability
Process by which a gene can code for multiple proteins
individual cancers, a phenomenon referred to as transcriptome instability. Transcriptome instability has further been shown to correlate greatly with
Alternative_splicing
Protein-coding gene in the species Homo sapiens
It has also been found that DNMT3A-mutated cell lines exhibit transcriptome instability, in that they have much more erroneous RNA splicing as compared
DNA (cytosine-5)-methyltransferase 3A
DNA_(cytosine-5)-methyltransferase_3A
Single cell RNA sequencing method
that allows for the investigation of phenotypes at the level of the transcriptome, to elucidate gene functions in many cells, in a massively parallel
Perturb-seq
Species of bacteria
Single-cell transcriptomics using single-cell RNA-Seq gave the complete transcriptome of H. pylori which was published in 2010. This analysis of its transcription
Helicobacter_pylori
Concept in molecular biology
sequencing platforms to (i) formulate transcriptome dynamics on different time scales, (ii) measure the instability of cell states, and (iii) identify developmental
RNA_velocity
Oldest cultured human cell line (1951)
lineage. It did not resolve the haplotype but instead analyzed the transcriptome. The complete genome of HeLa cells was sequenced and published on 11
HeLa
Virus of the herpes family
Klichinsky M, et al. (August 2012). "An atlas of the Epstein–Barr virus transcriptome and epigenome reveals host-virus regulatory interactions". Cell Host
Epstein–Barr_virus
Chemical compound
PMID 8373778. Kalsotra, Auinash (2016-11-02). "Faculty of 1000 evaluation for Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation
Pseudouridine
Spore-forming organisms
Baldauf, Sandra L. (2024). "The Acrasis kona genome and developmental transcriptomes reveal deep origins of eukaryotic multicellular pathways". Nature Communications
Slime_mold
Type of genetic mutation
African cassava cultivar reveal novel pan-genome and allele-specific transcriptome features". GigaScience. 11 giac028. doi:10.1093/gigascience/giac028
Chromosomal_rearrangement
Long non-coding RNA transcribed from telomeres
transcripts have also been identified as part of the yeast telomeric transcriptome: a transcript complementary to the 5' subtelomeric sequence known as
Telomeric repeat–containing RNA
Telomeric_repeat–containing_RNA
Pathogens as a cause of cancer
discovered KSHV/HHV-8 in 1994, using a new technology called digital transcriptome subtraction. About 80% of Merkel cell carcinomas are caused by Merkel
Infectious_causes_of_cancer
Process by which structures originate and mature as a plant grows
PMID 28347942. Irie, Naoki; Kuratani, Shigeru (2011-03-22). "Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis"
Plant_development
DNA sequencing
contigs still need to be assembled. Transcriptomics is the study of the transcriptome, usually by characterizing the relative abundances of messenger RNA
Third-generation_sequencing
Deterioration of function with age
(December 2022). "Aging is associated with a systemic length-associated transcriptome imbalance". Nature Aging. 2 (12): 1191–1206. doi:10.1038/s43587-022-00317-6
Senescence
Cancer of the colon or rectum
Lee S, et al. (August 2017). "A pathology atlas of the human cancer transcriptome". Science. 357 (6352) eaan2507. Bibcode:2017Sci...357n2507U. doi:10
Colorectal_cancer
Project to catalogue genetic mutations responsible for cancer
TCGA was able to begin performing whole exome sequencing and whole transcriptome sequencing on all cases, and whole genome sequencing on 10% of the cases
The_Cancer_Genome_Atlas
Compact and highly condensed form of chromatin
Baas F, Riggins G, van Sluis P, et al. (February 2001). "The human transcriptome map: clustering of highly expressed genes in chromosomal domains". Science
Heterochromatin
Genus of bacteria
although it is often referred to as S. coelicolor for convenience. The transcriptome and translatome analyses of the strain A3(2) were published in 2016
Streptomyces
Academic discipline focused on effects of social factors on genome activity
into RNA in a particular population of cells is referred to as the transcriptome. Research has shown that the activity of gene profiles or gene programs
Sociogenomics
Sub-field of genomics
molecular-cytogenetic tumor data. Oncomine has compiled data from cancer transcriptome profiles. The integrative oncogenomics database IntOGen and the Gitools
Oncogenomics
Human transition from puberty to adult
; Zalsman G.; John J. Mann; Chechik G. (2014). "Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during
Adolescence
Human disease
carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes". Nature Genetics. 52 (8): 800–810. doi:10.1038/s41588-020-0673-7
Human papillomavirus infection
Human_papillomavirus_infection
Discipline combining epidemiology and pathology
Investigators can analyze genome, methylome, epigenome, metabolome, transcriptome, proteome, microbiome, immunity and interactome. A putative risk factor
Molecular pathological epidemiology
Molecular_pathological_epidemiology
Techniques used to study microbe gene expression
The Trinity software for RNA-seq, in comparison with other de novo transcriptome assemblers, was reported to recover more full-length transcripts over
Metatranscriptomics
Assisted reproductive technology procedure
1093/humupd/dmt014. PMID 23827986. Fragouli E, Lalioti MD, Wells D (2013). "The transcriptome of follicular cells: biological insights and clinical implications for
In_vitro_fertilisation
Viruses that can cause cancer
computer subtraction of human sequences from a tumor transcriptome, called digital transcriptome subtraction (DTS). DTS was used to isolate DNA fragments
Oncovirus
Ghanaian-British stem cell Scientist
(contrib.) Single cell data enables dissecting cell types present in bulk transcriptome data, 2024; (contrib.) Generation of two Alpha-I antitrypsin deficiency
James_Adjaye
Medical condition of dry eyes
occasional to severe and continuous. DED can lead to blurred vision, instability of the tear film, increased risk of damage to the ocular surface such
Dry_eye_syndrome
American academic
Zhu, Yi; et al. (2015). "The Achilles' heel of senescent cells: From transcriptome to senolytic drugs". Aging Cell. 14 (4): 644–658. doi:10.1111/acel.12344
Laura_Niedernhofer
Laboratory technique to multiply a DNA sample for study
primers (probes) to amplify DNA sequences from a sequenced genome or transcriptome. In silico PCR was proposed as an educational tool for molecular biology
Polymerase_chain_reaction
RNA produced by transcription
expand. cis-splicing Outron trans-splicing Transcription (biology) Transcriptome Strachan T, Read AP (January 2004). Human Molecular Genetics 3. Garland
Primary_transcript
Large actin extension of a developing neurite seeking its synaptic target
peripheral domains. Growth cones are molecularly specialized, with transcriptomes and proteomes that are distinct from those of their parent cell bodies
Growth_cone
Sections of the genome experiencing minimal changes across species
Sugano S (March 2011). "Ultraconserved cDNA segments in the human transcriptome exhibit resistance to folding and implicate function in translation
Ultraconserved_element
Protein-coding gene in the species Homo sapiens
genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage
FANCI
particular conditions. The transcriptome is distinct from the exome and the translatome. transcriptomics The study of the transcriptome of a particular genome
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
American biochemist
suppress certain functions in the codon-mediated gene regulation. “Transcriptome-Wide Comparison of Stress Granules and P Bodies Reveals that Translation
Roy_R._Parker
Small non-coding ribonucleic acid molecule
progressive mesangial loss and glomerular aneurysms. High throughput whole transcriptome profiling of the FoxD1-Dicer knockout mouse model revealed ectopic upregulation
MicroRNA
Phenomenon where corals expel algae tissue
PMID 25454780. Zhang, Yidan; Zhou, Zhi; Wang, Lingui; Huang, Bo (July 2018). "Transcriptome, expression, and activity analyses reveal a vital heat shock protein
Coral_bleaching
Protein-coding gene in humans
Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES
SCO2
Mammalian protein found in humans
an increase in lifespan associated with major changes in the liver transcriptome". PLOS ONE. 9 (1) e83988. Bibcode:2014PLoSO...983988F. doi:10.1371/journal
MTOR
Control of gene expression at the RNA level, between transcription and translation
binding proteins may regulate post transcriptionally large amount of the transcriptome, the targeting of a single gene is of interest to the scientific community
Post-transcriptional regulation
Post-transcriptional_regulation
DNA located outside the chromosomes of a cell
transcriptional output, ranking in the top 1% of genes in the entire transcriptome. In contrast to bacterial plasmids or mitochondrial DNA, ecDNA are chromatinized
Extrachromosomal_DNA
Annual award for research in human genetics
expression in autistic brain tissue in the first landmark large-scale transcriptome study of autistic brain. 2017 Sarah Medland Neuroimaging genetics, Child
Ruth_Stephens_Gani_Medal
Type of genomic structure
transcriptional output, ranking in the top 1% of genes in the entire transcriptome. In contrast to bacterial plasmids or mitochondrial DNA, ecDNA are chromatinized
Extrachromosomal_circular_DNA
Protein-coding gene in the species Homo sapiens
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES
UHRF1
Application of systems biology approaches to cancer research
include: The generation of comprehensive molecular datasets (genome, transcriptome, epigenomics, proteome, metabolome, etc.) The Cancer Genome Atlas data
Cancer_systems_biology
Online genome database
associate a particular cell's expression profile, molecular signature or transcriptome, which is essentially the cell's fingerprint, with the cell's phenotype
Cancer_Genome_Anatomy_Project
American biologist, author
evolution as a model, and genome chaos, an overarching phenomenon of genomic instability that results from stress and can rearrange the genome, characterized
Henry_Heng
Mammalian protein found in Homo sapiens
from mammalian sources have been difficult due to the low abundance and instability of the enzyme during purification procedures. Using information from
Asparagine_synthetase
Protein found in humans
Souza SJ, Simpson AJ (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy
Atrophin_1
Hypothesis that aging is caused by accumulated DNA damage
selected panel of genes in heart cells and, more recently, in the whole transcriptomes of immune cells, and human pancreas cells. The adult brain is composed
DNA_damage_theory_of_aging
Mammalian protein found in Homo sapiens
Souza SJ, Simpson AJ (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy
HERC2
and is currently being led by Marco Marra and Janessa Laskin. Genome instability has been identified as one of the underlying hallmarks of cancer. The
Personalized_onco-genomics
Protein-coding gene in the species Homo sapiens
Santoni FA, Antonarakis SE, Feki A (December 2014). "Data in brief: Transcriptome analysis of induced pluripotent stem cells from monozygotic twins discordant
SKIDA1
Structure in molecular biology
"G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome". FEBS Letters. 589 (14): 1653–68. Bibcode:2015FEBSL.589.1653S. doi:10
G-quadruplex
Chinese-American biochemist
Emili, Andrew; Xie, X. Sunney (2010). "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells". Science. 329 (5991):
Xiaoliang_Sunney_Xie
Overview of the events of 2020 in science
Narry; Chang, Hyeshik (14 May 2020). "The Architecture of SARS-CoV-2 Transcriptome". Cell. 181 (4): 914–921.e10. Bibcode:2020Cell..181..914K. doi:10.1016/j
April–June_2020_in_science
Inactivation of copies of X chromosome
Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, et al. (June 2015). "The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells". Cell.
X-inactivation
Computational and mathematical modeling of complex biological systems
e., genome-wide) insights and its focus on the metabolome, fluxome, transcriptome, and/or proteome. Top-down methods prioritize overall system states
Systems_biology
One of many possible double helical structures of DNA
and Bilateral Striatal Necrosis/Dystonia. Families with haploid ADAR transcriptome enabled mapping of Zα variants directly to disease, showing that genetic
Z-DNA
different proteins – in the mouse and human cortex and release the transcriptomes on a public database. A tech company reveals a new 127 quantum bit processor
2021_in_science
Behavioral pattern of microorganisms
Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: A Transcriptome Analysis". Journal of Bacteriology. 185 (7): 2066–2079. doi:10.1128/JB
Microbial_cooperation
Protein-coding gene in the species Homo sapiens
Grassi L, Moles A, D'Andrea D, Toschi N, et al. (September 2015). "The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions
LMTK3
Enzyme
Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES
KDM4A
RNA family
PMID 14691248. Ahn HW, Morin RD, Zhao H, et al. (Jul 2010). "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing"
MiR-138
Protein-coding gene in the species Homo sapiens
dominant-negative effect of truncating variants in the muscle context. Transcriptome analysis also revealed reduced expression of several muscle structural
CHAMP1
Protein-coding gene in the species Homo sapiens
Souza SJ, Simpson AJ (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy
Surfactant_protein_A2
Protein-coding gene in the species Homo sapiens
JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54
APPBP1
Protein-coding gene in the species Homo sapiens
de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy
PRDM2
Protein-coding gene in the species Homo sapiens
PMID 15073321. S2CID 6583298. Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES
LRDD
Protein-coding gene in the species Homo sapiens
M, Toyama S, Usami R, Ohtoko K, Kato S (August 2011). "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the
FAM208b
Family of viruses
PMID 26203654. Ying N, Wang Y, Song X, Qin B, Wu Y, Yang L, Fang W (May 2022). "Transcriptome analysis of Macrobrachium rosenbergii: Identification of precocious
Marnaviridae
TRANSCRIPTOME INSTABILITY
TRANSCRIPTOME INSTABILITY
TRANSCRIPTOME INSTABILITY
TRANSCRIPTOME INSTABILITY
Boy/Male
Indian
Valiant, Bold, A name of Lord Hanuman, Mighty, Brave, Lion, Tiger
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Unborn
Surname or Lastname
English
English : variant of Stone.
Girl/Female
British, Christian, English, Latin
Crowned with Laurels; Laurel
Girl/Female
Hindu
Knowledge /wisdom
Girl/Female
Hindu
Cute, Gem, Joyous song
Boy/Male
Sikh
Leader of all human beings, King of men, The king
Boy/Male
Dutch
Bird.
Boy/Male
Assamese, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Joyful Unending
Boy/Male
Australian, French, German, Italian, Polish
Rock; Glory; Rest; Battle; Cry
TRANSCRIPTOME INSTABILITY
TRANSCRIPTOME INSTABILITY
TRANSCRIPTOME INSTABILITY
TRANSCRIPTOME INSTABILITY
TRANSCRIPTOME INSTABILITY
pl.
of Instability
n.
Instability; unstableness.
n.
The quality of turning; instability; tergiversation.
a.
Uncertainty; instability.
a.
Done as from a copy; having the style or appearance of a transcription.
n.
The quality or condition of being fugitive; evanescence; volatility; fugacity; instability.
n.
Instability; inconstancy.
n.
The quality or condition of being unstable; want of stability, firmness, or steadiness; liability to give way or to fail; insecurity; precariousness; as, the instability of a building.
n.
The state or quality of being solid; density; consistency, -- opposed to fluidity; compactness; fullness of matter, -- opposed to openness or hollowness; strength; soundness, -- opposed to weakness or instability; the primary quality or affection of matter by which its particles exclude or resist all others; hardness; massiveness.
n.
Slipperiness; instability; as, the lubricity of fortune.
n.
Lack of determination of fixedness; inconstancy; fickleness; mutability; changeableness; as, instability of character, temper, custom, etc.
n.
The quality of being fickle; instability; inconsonancy.