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Enzymes
Thiolases, also known as acetyl-coenzyme A acetyltransferases (ACAT), are enzymes which convert two units of acetyl-CoA to acetoacetyl CoA in the mevalonate
Thiolase
Protein-coding gene in the species Homo sapiens
Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT1 (Acetyl-Coenzyme A
ACAT1
Class of enzymes
acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA
Acetyl-CoA C-acetyltransferase
Acetyl-CoA_C-acetyltransferase
Index of enzymes associated with the same name
2-methylacetoacetyl-CoA thiolase may refer to: Acetyl-CoA C-acetyltransferase Acetyl-CoA C-acyltransferase This set index page lists enzyme articles associated
2-methylacetoacetyl-CoA thiolase
2-methylacetoacetyl-CoA_thiolase
Protein-coding gene in the species Homo sapiens
enzyme subunit beta, mitochondrial (TP-beta) also known as 3-ketoacyl-CoA thiolase, acetyl-CoA acyltransferase, or beta-ketothiolase is an enzyme that in
HADHB
Protein-coding gene in the species Homo sapiens
mitochondrial also known as hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit is a protein
HADHA
Organic compound
2NADH + FADH2 Condensation of pair of acetyl CoA molecules as catalyzed by thiolase. 2Ac−CoA → AcCH2C(O)−CoA + H−CoA In mammals, acetoacetate produced in the
Acetoacetic_acid
Medical condition
names 3-oxothiolase deficiency, Mitochondrial acetoacetyl-coenzyme A thiolase deficiency, Alpha-methyl-acetoacetyl-CoA thiolase deficiency Isoleucine
Beta-ketothiolase_deficiency
Condition in which damaged skeletal muscle breaks down rapidly
SCAD, MCAD, VLCAD, 3-hydroxyacyl-coenzyme A dehydrogenase deficiency), thiolase deficiency Mitochondrial myopathies: deficiency of succinate dehydrogenase
Rhabdomyolysis
Class of enzymes
In enzymology, a 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) is an enzyme that catalyzes the chemical reaction succinyl-CoA + acetyl-CoA ⇌ {\displaystyle \rightleftharpoons
3-oxoadipyl-CoA_thiolase
Drug for angina pectoris sold under many brand names
selectively inhibits the mitochondrial enzyme long-chain 3-ketoacyl-CoA thiolase, a key catalyst in the beta-oxidation of fatty acids. Inhibition of this
Trimetazidine
Energy-carrying molecule in living cells
because the liver lacks the enzyme β-ketoacyl-CoA transferase, also called thiolase. Acetoacetate in low concentrations is taken up by the liver and undergoes
Adenosine_triphosphate
Human chromosome
thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit HADHB: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme
Chromosome_2
Using body fats as fuel instead of carbohydrates
ketogenesis, two acetyl-CoA molecules condense to form acetoacetyl-CoA via thiolase. Acetoacetyl-CoA briefly combines with another acetyl-CoA via HMG-CoA synthase
Ketosis
Chemical compound
dehydrogenase, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and thiolase. The cycle produces a new fatty acid chain with two fewer carbons and acetyl-CoA
Acetyl-CoA
Chemical compound
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Leucine
Protein-coding gene in the species Homo sapiens
3-Ketoacyl-CoA thiolase, peroxisomal also known as acetyl-Coenzyme A acyltransferase 1 is an enzyme that in humans is encoded by the ACAA1 gene. Acetyl-Coenzyme
ACAA1
Chemical compound
cholesterol for neuronal cells. Mitochondrial acetoacetyl-CoA thiolase, also known as thiolase II, the enzyme responsible for catalyzing the synthesis of
Acetoacetyl-CoA
Process that produces butyric acid
One pathway for butyrate biosynthesis. Relevant enzymes: acetoacetyl-CoA thiolase, NAD- and NADP-dependent 3-hydroxybutyryl-CoA dehydrogenase, 3-hydroxybutyryl-CoA
Butyrate_fermentation
Group of coenzymes that metabolize fatty acids
oxidizes the alcohol group to a ketone. NADH is produced from NAD+. 4. Thiolase cleaves between the alpha carbon and ketone to release one molecule of
Acyl-CoA
Chemical compound (organic coenzyme)
interconverts to and from 3-oxohexanoyl-CoA by acetyl-CoA acetyltransferase (or thiolase). In terms of organic chemistry, the reaction is the reverse of a Claisen
Butyryl-CoA
Biological synthesis and degradation of lipids
enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase. The diagram to the left shows how fatty acids are converted into acetyl-CoA
Lipid_metabolism
Chemical compound (CH3CH2CH2COOH)
One pathway for butyrate biosynthesis. Relevant enzymes: acetoacetyl-CoA thiolase, NAD- and NADP-dependent 3-hydroxybutyryl-CoA dehydrogenase, 3-hydroxybutyryl-CoA
Butyric_acid
Chemical compound
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Β-Hydroxy β-methylbutyric acid
Β-Hydroxy_β-methylbutyric_acid
Pocket in the active site of an enzyme
Wierenga, Rik K. (December 1, 2002). "The Catalytic Cycle of Biosynthetic Thiolase: A Conformational Journey of an Acetyl Group through Four Binding Modes
Oxyanion_hole
thiolase, peroxisome sterol carrier protein thiolase, sterol carrier protein, oxopristanoyl-CoA thiolase, peroxisomal 3-oxoacyl coenzyme A thiolase,
Propionyl-CoA C2-trimethyltridecanoyltransferase
Propionyl-CoA_C2-trimethyltridecanoyltransferase
Process of fatty acid breakdown
Thiolysis occurs between C2 and C3 (alpha and beta carbons) of 3-ketoacyl CoA. Thiolase enzyme catalyzes the reaction when a new molecule of coenzyme A breaks
Beta_oxidation
Human chromosome
ACAT1: acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) ACRV1: encoding protein Acrosomal protein SP-10 AKIP1: A kinase interacting
Chromosome_11
Inner mitochondrial membrane protein
3-hydroxy acyl-coenzyme A dehydrogenase and long-chain 3-ketoacyl CoA thiolase. Fatty acid beta-oxidation (FAO) and oxidative phosphorylation (OXPHOS)
Mitochondrial trifunctional protein
Mitochondrial_trifunctional_protein
Class of enzymes
3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184 (1): 207–15. doi:10.1128/JB.184.1.207-215.2002. PMC 134768
Acetate_CoA-transferase
Protein-coding gene in the species Homo sapiens
acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 (acetyl-Coenzyme A
ACAT2
Series of interconnected biochemical reactions
Enzyme Reaction Description Acetoacetyl-CoA thiolase Acetyl-CoA (citric acid cycle) undergoes condensation with another acetyl-CoA molecule to form acetoacetyl-CoA
Mevalonate_pathway
Medical condition
dehydrogenase (LCHAD), long-chain enoyl-CoA hydratase, and long-chain thiolase activities. Trifunctional protein deficiency is characterized by decreased
Mitochondrial trifunctional protein deficiency
Mitochondrial_trifunctional_protein_deficiency
Class of enzymes
2010). "Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway". Proceedings of the National
Acetoacetyl-CoA_synthase
Chemical compound
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Β-Hydroxybutyric_acid
Investigational tinnitus drugs
Preductal; S-5016; Trimetazine; Vastarel; Vastinan) – long-chain 3-ketoacyl-CoA thiolase inhibitor and other actions [18] Antidepressants (e.g., sertraline, nortriptyline
List of investigational tinnitus drugs
List_of_investigational_tinnitus_drugs
Class of enzymes
C-acyltransferase. Other names in common use include peroxisomal thiolase 2, sterol carrier protein-, SCP, and PTE-2 (ambiguous). This enzyme participates
Propanoyl-CoA C-acyltransferase
Propanoyl-CoA_C-acyltransferase
Canadian cell biologist and academic
fully folded, and even oligomeric, protein complexes—including dimers like thiolase—challenging the prevailing dogma that proteins must unfold to cross organellar
Richard_A._Rachubinski
Chemical compound
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Β-Hydroxy_β-methylbutyryl-CoA
Class of enzymes
of the active site and dimerization interface that is highly similar to thiolase-fold containing enzymes. The dimerization interface contains both hydrophobic
Chalcone_synthase
mildronate 3-KAT inhibitors: trimetazidine 3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation. pFOX directly
Fatty acid oxidation inhibitors
Fatty_acid_oxidation_inhibitors
Set of biological processes
Dehydrogenation by 3-hydroxyacyl-CoA dehydrogenase, yielding 1 NADH + H+ Cleavage by thiolase, yielding 1 acetyl-CoA and a fatty acid that has now been shortened by
Fatty_acid_metabolism
Class of enzymes
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Enoyl-CoA_hydratase
Protein-coding gene in the species Homo sapiens
Kuroki Y (1997). "Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26". Genomics. 36 (1): 217–8. doi:10
T-complex_1
Chemical compound
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
HMG-CoA
Protein-coding gene in the species Homo sapiens
(AcAc-CoA). The product AcAc-CoA can then be converted by acetoacetyl-CoA thiolase into acetyl-CoA, which enters the citric acid cycle to generate energy
OXCT1
Class of enzymes
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Isovaleryl-CoA_dehydrogenase
Enzyme
mtFabH. The enzyme is a homodimer of mixed α-helices and β-sheets, or a thiolase fold. The catalytic triads of C122, H258, and N289 are shown in colour
Beta-ketoacyl-ACP synthase III
Beta-ketoacyl-ACP_synthase_III
Medical condition
deficiency, multiple carboxylase deficiency, mitochondrial acetoacetyl-CoA thiolase deficiency and malonic aciduria. 3-Methylcrotonyl-CoA carboxylase deficiency
3-Methylcrotonyl-CoA carboxylase deficiency
3-Methylcrotonyl-CoA_carboxylase_deficiency
Protein-coding gene in the species Homo sapiens
3-hydroxyacyl-CoA dehydrogenase hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit GRCh38: Ensembl
Hydroxyacyl-Coenzyme A dehydrogenase
Hydroxyacyl-Coenzyme_A_dehydrogenase
flavonol-3-O-triglucoside O-coumaroyltransferase EC 2.3.1.174: 3-oxoadipyl-CoA thiolase EC 2.3.1.175: deacetylcephalosporin-C acetyltransferase EC 2.3.1.176: propanoyl-CoA
List_of_EC_numbers_(EC_2)
metabolism of fatty acids. Middleton, B. (1973). "The oxoacyl-coenzyme A thiolases of animal tissues". Biochem. J. 132 (4): 717–730. doi:10.1042/bj1320717
3-Oxoacyl-CoA
epiphyseal disease Thies–Reis syndrome Thin ribs tubular bones dysmorphism Thiolase deficiency Thiopurine S methyltranferase deficiency Thomas–Jewett–Raines
List_of_diseases_(T)
Chemical compound
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Α-Ketoisocaproic_acid
Gene
3-Ketoacyl-CoA thiolase, mitochondrial also known as acetyl-Coenzyme A acyltransferase 2 is an enzyme that in humans is encoded by the ACAA2 gene. Acetyl-Coenzyme
ACAA2
Class of enzymes
Hashimoto T, Ui N (August 1981). "Properties of peroxisomal 3-ketoacyl-coA thiolase from rat liver". J. Biochem. 90 (2). Tokyo: 511–9. doi:10.1093/oxfordjournals
Acetyl-CoA C-myristoyltransferase
Acetyl-CoA_C-myristoyltransferase
Medical condition
enzymes in absence of D-BP such as palmitoyl-CoA oxidase, peroxisomal thiolase, and branched chain acyl-CoA oxidase. Möller G, van Grunsven EG, Wanders
D-bifunctional protein deficiency
D-bifunctional_protein_deficiency
L-3-hydroxy acyl-CoA dehydrogenase deficiency Medium-chain ketoacyl-CoA thiolase deficiency Dienoyl-CoA reductase deficiency Glutaric acidemia type II Carnitine
List of disorders included in newborn screening programs
List_of_disorders_included_in_newborn_screening_programs
Enzyme found in humans
Walton PA (April 1995). "Degradation of the cleaved leader peptide of thiolase by a peroxisomal proteinase". Proceedings of the National Academy of Sciences
Insulin-degrading_enzyme
Class of enzymes
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Methylcrotonyl-CoA carboxylase
Methylcrotonyl-CoA_carboxylase
Protein
C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while
SCP2
2-hydroxyglutaricaciduria 2-Hydroxyglutaricaciduria, rare (NIH) 2-Methylacetoacetyl CoA thiolase deficiency, rare (NIH) 2,8 dihydroxy-adenine urolithiasis 21 hydroxylase
List_of_diseases_(0–9)
Class of chemical compounds
Three acetyl-CoAs are converted into HMG-CoA by the cytosolic isoforms of thiolase and 3-hydroxy-3-methylglutaryl-CoA synthase. The HMG-CoA is then reduced
Juvenile_hormone
Class of enzymes
ribonucleate sulfurtransferase, transfer RNA sulfurtransferase, and transfer RNA thiolase. Abrell JW, Kaufman EE, Lipsett MN (1971). "The biosynthesis of 4-thiouridylate
TRNA_sulfurtransferase
Species of bacterium
acid-CoA ligase, three fatty acid dehydrogenases, a crotonase and three thiolases. Most of the degradation products of host proteins and lipids by the F
Flavobacterium_psychrophilum
Chemical compound
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Methylcrotonyl-CoA
Protein-coding gene in the species Homo sapiens
hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity, and 3-ketoacyl-CoA thiolase (MIM 604054). See also the L-bifunctional peroxisomal protein (EHHADH;
HSD17B4
Protein-coding gene in the species Homo sapiens
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
Methylglutaconyl-CoA hydratase
Methylglutaconyl-CoA_hydratase
Species of archaeon
adaptation, are isoprenoid side chains. Two specific enzymes, acetoacetyl-CoA thiolase and HMG-CoA synthase were discovered to participate in the melavonate pathway
Methanococcoides_burtonii
Chemical compound
reductase HMG-CoA synthase β-Hydroxybutyrate dehydrogenase Mevalonate pathway Thiolase Unknown enzyme β-Hydroxybutyrate Acetoacetyl-CoA Acetyl-CoA Acetoacetate
3-Methylglutaconyl-CoA
THIOLASE
THIOLASE
THIOLASE
THIOLASE
Surname or Lastname
English
English : variant of Reynard.
Boy/Male
Hindu, Indian
Prayer to God
Surname or Lastname
English (Devon)
English (Devon) : nickname from Middle English toute ‘buttocks’, ‘rump’, or a topographic name from the same word used in a transferred sense to denote a smooth, rounded hillock.
Girl/Female
Biblical
The stone of help.
Biblical
the hill of Mars
Boy/Male
British, English, Jamaican
A Steep Bank; From the Cliff
Boy/Male
Tamil
Logeshwaran | லோகேஷà¯à®µà®°à®£Â
Lord Shiva
Girl/Female
American, Australian, British, English
Pledge; Variant of Carlene and Charlene
Boy/Male
Australian, Indonesian
Enlightenment
Girl/Female
Hindu
Traveler
THIOLASE
THIOLASE
THIOLASE
THIOLASE
THIOLASE