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Protein found in humans
Alpha-synuclein (aSyn) is a protein that in humans is encoded by the SNCA gene. It is a neuronal protein involved in the regulation of synaptic vesicle
Alpha-synuclein
Spherical inclusion commonly found in damaged neurons
atrophy. The defining proteinaceous component of Lewy bodies is alpha-synuclein (α-synuclein), which aggregates to form Lewy bodies within neuronal cell bodies
Lewy_body
Progressive neurodegenerative disease
related cell groups in the brainstem. Misfolded proteins, such as alpha-synuclein, aggregate to form clumps called Lewy bodies, if not cleared from cells
Parkinson's_disease
Protein family
electric ray. The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began
Synuclein
Neurodegenerative disorder
initial clinical manifestation of the disorder. A prion of the alpha-synuclein protein within affected neurons may cause MSA. About 55% of MSA cases
Multiple_system_atrophy
Drugs that inhibit α-synuclein
An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. α-Synuclein is a protein which is thought to be
Anti-α-synuclein_drug
Protein-coding gene in the species Homo sapiens
Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. Synuclein-gamma is a member of the synuclein family of proteins, which are believed
Gamma-synuclein
Medical condition
diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. The synucleinopathies
Synucleinopathy
Type of progressive dementia
synucleinopathy, meaning that it is characterized by abnormal deposits of alpha-synuclein protein in the brain. The synucleinopathies include Parkinson's disease
Dementia_with_Lewy_bodies
Pathogenic type of misfolded protein
were thought to be caused by PrP until 2015 when a prion form of alpha-synuclein was linked to multiple system atrophy (MSA). Misfolded proteins are also
Prion
Protein-coding gene in the species Homo sapiens
Beta-synuclein is a protein that in humans is encoded by the SNCB gene. The protein encoded by this gene is highly homologous to alpha-synuclein. These
Beta-synuclein
Experimental monoclonal antibody
PRX-002, RG-7935, RO-7046015) is an anti-α-synuclein drug acting as a monoclonal antibody against α-synuclein which is under development for the treatment
Prasinezumab
Form of dementia associated with Parkinson's disease
basis in neuroinflammation and alpha-synuclein aggregation involving the spreading of misfolded alpha-synuclein aggregates. After initiation of neuroinflammation
Parkinson's_disease_dementia
Models used in Parkinson's disease research
lungs and kidney, resulting high toxicity; as well, as death. Alpha-synuclein (α-synuclein) is an endogenous protein that is encoded by the SNCA gene and known
Animal models of Parkinson's disease
Animal_models_of_Parkinson's_disease
Chemical compound
Parkinson's disease that is designed to prevent misfolding of α-synuclein. Anti-α-synuclein drug List of investigational Parkinson's disease drugs Schwarz
Minzasolmin
Intelligence of machines
identify compounds that block the clumping, or aggregation, of alpha-synuclein (the protein that characterises Parkinson's disease). They were able to
Artificial_intelligence
Central nervous system disease
Parkinson's disease-associated mutant alpha-synucleins through axons of cultured neurons. Membrane damage by alpha-synuclein could be another Parkinson's disease
Neurodegenerative_disease
Investigational Parkinson's disease drugs
Alpha-synuclein aggregation inhibitor (ACI-5755; morphomer α-synuclein) – α-synuclein inhibitor [97] BEBT-758 – RNA interference and α-synuclein expression
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Medical condition
proteins such as alpha-synuclein. Alpha-synuclein is normally found in the presynaptic terminals of neurons. If alpha-synuclein is mis-folded and not cleared
Pathophysiology of Parkinson's disease
Pathophysiology_of_Parkinson's_disease
Cognitive disorder
Early onset dementia or young onset dementia refers to dementia with symptom onset prior to age 65 years. Early onset dementia is a general term that describes
Early_onset_dementia
Insoluble protein aggregate with a fibrillar morphology
atomic structures of amyloid fibrils formed by amyloid β peptides, α-synuclein, tau, and the FUS protein, associated with various neurodegenerative diseases
Amyloid
Pharmaceutical compound
of protein aggregation, particularly preventing the aggregation of α-synuclein which is implicated in the development of Parkinson's disease. Other proteins
Emrusolmin
Greek-American physician, scientist, (b 1960)
the Human Genome Project and the discovery of mutations in the alpha synuclein gene as the first genetic cause of Parkinson's disease while at the National
Mihael_Polymeropoulos
Classification of disease severity
One mechanism consists of an abnormal accumulation of the protein alpha-synuclein bound to ubiquitin in the damaged cells. This protein accumulation forms
Braak_staging
Chemical compound
modulate the aggregation of α-synuclein, both in vitro and in cellular models of neurodegenerative disease. Aggregation of α-synuclein is a major hallmark of
Fasudil
Pharmaceutical compound
developmental code name Lu AF82422) is a monoclonal antibody against α-synuclein which is under development for the treatment of multiple system atrophy
Amlenetug
Factors causing Parkinson's disease
proteins such as alpha-synuclein. Alpha-synuclein is normally found in the presynaptic terminals of neurons. If alpha-synuclein is mis-folded and not cleared
Causes_of_Parkinson's_disease
Umbrella term covering two types of dementia
neurites have been found to develop from the aggregation of misfolded alpha-synuclein, a protein thought to assist in neurotransmitter release and vesicle turnover;
Lewy_body_dementia
Process of introducing a phosphate group on to a protein
phosphorylated α-Synuclein to unphosphorylated α-Synuclein within a patient could be a marker of the disease progression. Antibodies that target α-Synuclein at phosphorylated
Protein_phosphorylation
Comune in Campania, Italy
by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein inclusions in other neurodegenerative disorders
Contursi_Terme
Structure in the basal ganglia of the brain
oxidative stress can be repaired by processes modulated by alpha-synuclein. Alpha synuclein is expressed in the substantia nigra, but its DNA repair function
Substantia_nigra
Italian neuroscientist
University of Cambridge. She is most noted for identifying the protein alpha-synuclein as the major component of Lewy bodies, the characteristic protein deposit
Maria_Grazia_Spillantini
Progressive neurodegenerative disease
Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein". Science. 349 (6248) 1255555. doi:10.1126/science.1255555. PMID 26250687
Alzheimer's_disease
Neurodegenerative disorder
Neuronal Alpha-Synuclein Disease (NSD) is a proposed new combined definition of Parkinson's disease and Dementia with Lewy bodies based on biology instead
Neuronal Alpha-Synuclein Disease
Neuronal_Alpha-Synuclein_Disease
Protein-coding gene in the species Homo sapiens
the substantia nigra pars compacta and the toxic aggregation of the α-synuclein protein into Lewy Bodies, all of which cause motor dysfunctions and dopamine
VPS35
Diseases caused by abnormal protein structure
"Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide". Journal of Alzheimer's Disease. 24 (Suppl
Proteinopathy
Virus of the herpes family
Epstein–Barr virus has been implicated in disorders related to alpha-synuclein aggregation (e.g., Parkinson's disease, dementia with Lewy bodies, and
Epstein–Barr_virus
(PARK1) in the brain protein, alpha-synuclein. Within days of the publication of the PARK1 findings, alpha-synuclein was discovered to be the major component
History of Parkinson's disease
History_of_Parkinson's_disease
Experimental monoclonal antibody
code names BIIB054, NI-202) is an anti-α-synuclein drug acting as a monoclonal antibody against α-synuclein which was under development for the treatment
Cinpanemab
; Low, Phillip A.; Soto, Claudio (5 February 2020). "Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy". Nature. 578
Protein misfolding cyclic amplification
Protein_misfolding_cyclic_amplification
US-based Parkinson's disease charity
can be detected by the presence of a biomarker protein, abnormal alpha-synuclein. The biomarker can be detected before the onset of symptoms. The organization
The_Michael_J._Fox_Foundation
Gastrointestinal dysfunction and Parkinson's disease
figure) and the presence of aggregated alpha-synuclein. Under physiological conditions, alpha-synuclein, a protein encoded by the SNCA gene, is found
Parkinson's disease and gut-brain axis
Parkinson's_disease_and_gut-brain_axis
Metabolic disease involving abnormal deposited amyloid proteins
precursor, wild type Aβ protein precursor, variant CNS CNS L L A H AαSyn α-Synuclein CNS L A ATau Tau CNS L A APrP Prion protein, wild type Prion protein variants
Amyloidosis
British physician and neuroscientist
Trust intermediate clinical fellowship to study the misfolding of alpha-synuclein in Parkinson's disease, and how this misfolding causes neurotoxicity.
Sonia_Gandhi_(scientist)
Protein without a fixed 3D structure
clear that IDPs are common among disease-related proteins, such as alpha-synuclein and tau. Proteins exist as an ensemble of similar structures with some
Intrinsically disordered proteins
Intrinsically_disordered_proteins
American medical researcher (1946–2022)
proteins in neurodegenerative diseases: tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease, and TDP-43 in Amyotrophic Lateral Sclerosis (ALS)
John_Q._Trojanowski
Medication used to treat Alzheimer's disease
specifically theorized to act by inhibiting cell-to-cell transmission of α-synuclein. Besides Parkinson's disease, memantine has been studied in the treatment
Memantine
Process of testing biological interventions on whole, living organisms
Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells". Journal of Biological Chemistry
In_vivo
Specialized technique for electron diffraction
from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56". doi:10.2210/pdb4znn/pdb. {{cite journal}}: Cite journal
Microcrystal electron diffraction
Microcrystal_electron_diffraction
Chemical compound
displace alpha-synuclein from neuronal membranes both in vitro, in isolated cells, and in a C. elegans Parkinson disease model. Since alpha synuclein accumulates
Squalamine
Chemical compound
including amyloid precursor proteins (APP) and amyloid beta, tau, alpha-synuclein (αSYN), huntingtin, and TDP-43. Buntanetap performs in a noncholinergic
Buntanetap
Danish healthcare company
tiered") Ordesekimab IL-15 Sanofi Gluten-free diet non-responsive Celiac disease II - Lu AF82422 Alpha-Synuclein Lundbeck Multiple system atrophy (MSA) II -
Genmab
Chemical compound
Cuminaldehyde has been investigated for inhibition of the fibrillation of alpha-synuclein, Cuminaldehyde can be prepared synthetically by the reduction of 4-isopropylbenzoyl
Cuminaldehyde
Three-dimensional arrangement of atoms in an amino acid-chain molecule
in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein". Biochemistry. 53 (46): 7170–7183. doi:10.1021/bi5009326. PMC 4245978
Protein_structure
Pharmaceutical compound
GBA1. Loss-of-function mutations in this gene are thought to promote α-synuclein accumulation and are among the leading genetic risk factors for Parkinson's
Pariceract
HIV entry inhibitor discovered in 1986
the synaptotoxic actions of oligomeric forms of amyloid beta and alpha-synuclein., as well as HIV gp120, via a PrPc dependent pathway. Synapse loss underlies
Peptide_T
American-Yemeni neuroscientist
several proteins linked to neurodegenerative diseases, including alpha-synuclein, Tau and several N-terminal fragments of the Huntingtin protein. In addition
Hilal_Lashuel
Protein-coding gene in the species Homo sapiens
Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease.Schaser AJ
SUB1
Mammalian protein found in Homo sapiens
its potent ability to block the aggregation of beta amyloid and alpha synuclein in vitro, and to block oligomer cytotoxicity in cells. Recent data show
Proprotein convertase subtilisin/kexin type 1 inhibitor
Proprotein_convertase_subtilisin/kexin_type_1_inhibitor
Particulate matter under 100 nm in diameter
Ultrafine Particulate Deposition, and Accumulation of Amyloid Β-42 and Α-Synuclein in Children and Young Adults". Toxicologic Pathology. 36 (2): 289–310
Ultrafine_particle
they are experimentally inducible by exposure of cells to abnormal α-synuclein seeds, suggesting that they are not characteristic only of tauopathies
Granulovacuolar_degeneration
Chemical compound
and inhibits GAPDH. Rasagiline has been found to bind reversibly to α-synuclein, a major protein involved in the pathophysiology of Parkinson's disease
Rasagiline
Therapy for the treatment of Parkinson's disease
(glial cell line-derived neurotrophic factor), the regulation of the α-synuclein and Parkin gene expression. Currently the main studies are using AAV2
Gene therapy in Parkinson's disease
Gene_therapy_in_Parkinson's_disease
Experimental NLRP3 inflammasome inhibitor for neurological conditions
of Parkinson's disease, including neurotoxin-based, genetic, and alpha-synuclein aggregate models. Treatment with MCC950 improved motor function, reduced
Selnoflast
Latin term meaning outside a natural biological environment
Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells". Journal of Biological Chemistry
In_vitro
Protein kinase found in humans
and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain". The Journal of Neuroscience. 32 (22): 7585–7593
LRRK2
Manganese poisoning
contain high levels of arsenic, manganese, selenium, and barium. Alpha synuclein Asphalt (disambiguation) Concrete Joss paper Parkinsonism Particulates
Manganism
Chemical compound
protein into mitochondrial matrix Anticoagulant function Modulates α-synuclein - malfunction of this process is thought to be a cause of Parkinson's
Cardiolipin
Award for breakthroughs in the life sciences
amyotrophic lateral sclerosis, and revealing that different forms of alpha-synuclein, in different cell types, underlie Parkinson's disease and Multiple System
Breakthrough Prize in Life Sciences
Breakthrough_Prize_in_Life_Sciences
Post-translational carbohydrate modification of proteins
aggregation of α-synuclein. As O-GlcNAc modification of α-synuclein has been found to inhibit its aggregation, elevating α-synuclein O-GlcNAc is being
O-GlcNAc
Subtype of Dopamine Receptor
pramipexole and rotigotine show neuroprotective effects, reduce alpha-synuclein aggregation, and improve motor and non-motor symptoms. Neuropsychiatric
Dopamine_receptor_D3
regions against brain diseases (19 Apr). Progress in screening: an α-synuclein SAA (assay) against Parkinson's disease (12 Apr), and exogenously administered
2023_in_science
Australian non-for-profit foundation
Parkinson's disease by NLRP3 inflammasome. The NLRP3 inflammasome reacts to synuclein containing protein clumps by increasing inflammatory signals which contributes
Shake it Up Australia Foundation
Shake_it_Up_Australia_Foundation
American neuroscientist and biochemist
by alpha-synuclein built-up, and that similar to the tau protein and Alzheimer's, healthy neurons may take up extracellular alpha-synuclein and become
Virginia_Man-Yee_Lee
Type of cytotoxic lymphocyte
disease, levels of Natural killer cells are elevated as they degrade alpha-synuclein aggregates, destroy senescent neurons, and attenuate the neuroinflammation
Natural_killer_cell
Cognitive decline
the brain. (A Lewy body is an inclusion body as an aggregate of alpha-synuclein a presynaptic protein in neurons). Parkinson's disease dementia, and dementia
Dementia
Class of enzymes
of PLD by the protein α-synuclein has been shown to lead to the specific loss of dopaminergic neurons in mammals. α-synuclein is the primary structural
Phospholipase_D
Dopamine-releasing portion of the substantia nigra
K; Paik, SR; Kim, J; Chung, KC (2003). "Parkin Cleaves Intracellular -Synuclein Inclusions via the Activation of Calpain". Journal of Biological Chemistry
Pars_compacta
Field of study
alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and fibrillar accumulation of Lewy bodies from misfolded alpha-synuclein.
Epigenetics of neurodegenerative diseases
Epigenetics_of_neurodegenerative_diseases
Chemical compound
and 3.2-fold respectively. Skp1 may increase the turnover rate of the α-synuclein protein, whose accumulation is associated with Parkinson's disease. Administration
9-Methyl-β-carboline
British medical researcher (born 1963)
PMC 2635561. PMID 17486044. Winslow, A. R.; Rubinsztein, D. C. (2010). "α-Synuclein impairs macroautophagy: implications for Parkinson's disease". The Journal
David_C._Rubinsztein
Computational models of intrinsically-disordered proteins
(December 2009). "Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements". Journal of
Conformational_ensembles
Amino acid substitutions that mimic a phosphorylated protein
Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein". Journal of Biological Chemistry. 283 (24): 16895–16905. doi:10.1074/jbc
Phosphomimetics
Chemical compound
peroxidation product that can structurally alter proteins and induce α-synuclein oligomers. Näsström, Thomas; Fagerqvist, Therese; Barbu, Mikael; et al
4-Oxo-2-nonenal
American chemist
investigates the structure and dynamics of proteins, including alpha-synuclein, which can aggregate to form amyloid fibrils, and collagen. The molecular
Jean_Baum
American scientist and academic
David A.; Walt, David R. (2024-01-16). "Toward the quantification of α-synuclein aggregates with digital seed amplification assays". Proceedings of the
David_R._Walt
Trademark name for a synthetic, organofluorine chemical compound
neuronal health. Notably, GenX exposure led to altered expression of α-synuclein, a protein closely linked to the development of Parkinson's disease. The
GenX
Family of heat shock proteins
neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha-synuclein species, pointing towards the possibility that increasing
Hsp70
Proteins or lipids chemically altered by sugar exposure
"Advanced glycation end products induce in vitro cross-linking of α-synuclein and accelerate the process of intracellular inclusion body formation"
Advanced glycation end-product
Advanced_glycation_end-product
Science fraudster
Alzheimer's and Parkinson's disease, particularly surrounding the alpha-synuclein protein. The dossier was sent to the HHS Office of Research Integrity
Eliezer_Masliah
Theory for what causes mental degenerative diseases
additionally posits that DOPAL oligomerizes with α-synuclein resulting in accumulation of oligomerized α-synuclein (i.e., synucleinopathy) and that this contributes
Catecholaldehyde_hypothesis
Fungal protein found in Saccharomyces cerevisiae S288c
is a heat-shock protein. It is known to reverse toxicity of mutant α-synuclein, TDP-43, FUS, and TAF15 in yeast cells. Conserved in prokaryotes (ClpB)
Hsp104
Artificial peptide attached to protein for marking purpose
Christopher M. (September 2010). "Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody" (PDF). Journal of Molecular Biology
Protein_tag
Swedish neuroscientist (born 1945)
as well as the use of rAAV vectors for overexpression of human alpha-synuclein for modeling Parkinson-like neuropathology in rodents and monkeys. In
Anders_Björklund
Human disease-causing mutation
Another potential consequence is abnormal levels of tau proteins and alpha-synuclein, which play a role in conditions like Alzheimer's, Lewy body dementia
HFE_H63D_gene_mutation
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
that yeast models of Parkinson's are more susceptible to toxicity from α-synuclein, the major protein component of Lewy bodies, under conditions of low proteasome
Proteasome
Group of brain diseases induced by prions
Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein". Science. 349 (6248) 1255555. doi:10.1126/science.1255555. PMID 26250687
Transmissible spongiform encephalopathy
Transmissible_spongiform_encephalopathy
British neurogeneticist
work described the discovery of a triplication mutation of the alpha-synuclein gene that causes a severe, early-onset form of Parkinson's disease. One
Andrew_Singleton
German anatomist
Braak, E.; Sandmann-Keil, D.; Rüb, U.; Gai WP, R.A.I (2001). "Alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain
Heiko_Braak
Protein-coding gene in the species Homo sapiens
ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript
RNF19A
SYNUCLEIN
SYNUCLEIN
SYNUCLEIN
SYNUCLEIN
Girl/Female
English
Based on the initials J. C. or an abbreviation of Jacinda.
Girl/Female
Muslim
Unique, Singular
Boy/Male
Muslim/Islamic
Honour hold in honour
Girl/Female
Indian
Aartis best wishes, Blessing
Surname or Lastname
English
English : variant of Bunting.German : from Middle High German bund, the noun from binden ‘to bind’, ‘to tie’; in what sense it became the basis for a name is unclear.
Boy/Male
Tamil
Dhruvesh | தà¯à®°à¯à®µà¯‡à®·
Atut Lakshya
Boy/Male
Gujarati, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Sanskrit, Telugu
Part of Earth; Attached to the Earth; Lord of the Earth
Boy/Male
English
Rhyming- a historical blacksmith with supernatural powers.
Boy/Male
Hindu, Indian
King
Girl/Female
Indian
Flaming, Bright
SYNUCLEIN
SYNUCLEIN
SYNUCLEIN
SYNUCLEIN
SYNUCLEIN