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RUNX2

  • RUNX2
  • Protein-coding gene in humans

    factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key

    RUNX2

    RUNX2

    RUNX2

  • Cleidocranial dysostosis
  • Birth defect of the collarbones, skull, and teeth

    inherited in an autosomal dominant manner. It is due to a defect in the RUNX2 gene which is involved in bone formation. Diagnosis is suspected based on

    Cleidocranial dysostosis

    Cleidocranial dysostosis

    Cleidocranial_dysostosis

  • Facial skeleton
  • Facial bones of a skull

    genes that control this craniofacial development. Of these genes, DCHS2, RUNX2, GLI3, PAX1 and PAX3 were found to determine nasal morphology, whereas EDAR

    Facial skeleton

    Facial skeleton

    Facial_skeleton

  • Sp7 transcription factor
  • Protein-coding gene in the species Homo sapiens

    among bone-forming vertebrate species It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into

    Sp7 transcription factor

    Sp7 transcription factor

    Sp7_transcription_factor

  • Core binding factor
  • Type of transcription factor

    Human: CBFB a DNA-binding CBFα chain (InterPro: IPR016554) Human: RUNX1, RUNX2, RUNX3 de Bruijn M, Speck N (2004). "Core-binding factors in hematopoiesis

    Core binding factor

    Core_binding_factor

  • Face
  • Front of a head

    et al. (19 May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications.

    Face

    Face

    Face

  • Ectodysplasin A receptor
  • Protein-coding gene in the species Homo sapiens

    Chacón-Duque (2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications.

    Ectodysplasin A receptor

    Ectodysplasin_A_receptor

  • Adenosine receptor
  • Class of four receptor proteins to the molecule adenosine

    route of differentiation to osteoblast, rather than chondrocyte via the Runx2 gene expression. Potential therapeutic application in aiding bone degenerative

    Adenosine receptor

    Adenosine receptor

    Adenosine_receptor

  • List of human transcription factors
  • RUNX1 ENSG00000159216 Runt Known motif – In vivo/Misc source [787] VACCACAV RUNX2 ENSG00000124813 Runt Known motif – High-throughput in vitro [788] HRACCRCADWAACCRCAV

    List of human transcription factors

    List_of_human_transcription_factors

  • Tooth eruption
  • Process in tooth development

    characterised by the identification of a heterozygous pathogenic variant in RUNX2 (CBFA1) and/or various clinical presentations and radiographs. There is

    Tooth eruption

    Tooth eruption

    Tooth_eruption

  • Chondroblast
  • Mesenchymal progenitor cell that forms a chondrocyte

    Chondroblast, formation. This factor is also expressed alongside Sox5 and Sox6. Runx2 is another important genetic component of Chondroblast formation. It has

    Chondroblast

    Chondroblast

    Chondroblast

  • Aglossia
  • Congenital tongue disorder

    then trigger the overexpression of the Runx2 gene in the lower jaw (mandibular arch). Overexpression of Runx2 was found to lead to malformations across

    Aglossia

    Aglossia

    Aglossia

  • Glucocerebroside
  • Family of lipids

    formation of new blood vessels (angiogenesis) by decreasing the activity of Runx2 transcription factor, which leads to less vascular endothelial growth factor

    Glucocerebroside

    Glucocerebroside

    Glucocerebroside

  • Sinodonty and Sundadonty
  • Patterns of dentitions in East Asia

    Andrés (19 May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications.

    Sinodonty and Sundadonty

    Sinodonty_and_Sundadonty

  • Tertomotide
  • Pharmaceutical compound

    Peptide GV1001 Enhances Bone Formation via Pin1-Mediated Augmentation of Runx2 and Osterix Stability". Biomolecules. 14 (7): 812. doi:10.3390/biom14070812

    Tertomotide

    Tertomotide

    Tertomotide

  • RUNX1
  • Protein-coding gene in humans

    purified RUNX2, the homolog of RUNX1. Purified transcription factors consisted of two subunits, a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding

    RUNX1

    RUNX1

    RUNX1

  • PRDM16
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    PRDM16

    PRDM16

    PRDM16

  • Protein c-Fos
  • Mammalian protein found in Homo sapiens

    with: BCL3, COBRA1, CSNK2A1, CSNK2A2, DDIT3, JUN NCOA1, NCOR2, RELA, RUNX1, RUNX2, SMAD3, and TBP. Leptomycin c-Jun Egr-1   Ion channel   G proteins & linked

    Protein c-Fos

    Protein c-Fos

    Protein_c-Fos

  • Hippo signaling pathway
  • Signaling pathway that controls organ size

    activated, YAP and TAZ can bind to several transcription factors including p73, Runx2 and several TEADs. YAP regulates the expression of Hoxa1 and Hoxc13 in mouse

    Hippo signaling pathway

    Hippo signaling pathway

    Hippo_signaling_pathway

  • LRP5
  • Protein-coding gene in the species Homo sapiens

    for KLF15 and SP1. In addition, 5' region of the LRP5 gene contains four RUNX2 binding sites. LRP5 has been shown in mice and humans to inhibit expression

    LRP5

    LRP5

    LRP5

  • Aortic stenosis
  • Narrowing of the exit of the heart's left ventricle

    pathways involving transcription factors such as msh homeobox 2 (Msx2) and Runx2/Cbfa1. The Wnt signaling pathway, activated by the low-density lipoprotein

    Aortic stenosis

    Aortic stenosis

    Aortic_stenosis

  • PEG3
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    PEG3

    PEG3

    PEG3

  • Androgen receptor
  • Mammalian protein found in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Androgen receptor

    Androgen receptor

    Androgen_receptor

  • Glucocorticoid receptor
  • Receptor to which cortisol and other glucocorticoids bind

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Glucocorticoid receptor

    Glucocorticoid receptor

    Glucocorticoid_receptor

  • Scandinavian hunter-gatherer
  • Archaeogenetic name for an ancestral genetic component

    Chacón-Duque (2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications.

    Scandinavian hunter-gatherer

    Scandinavian hunter-gatherer

    Scandinavian_hunter-gatherer

  • C7 protein
  • Engineered zinc finger protein

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    C7 protein

    C7_protein

  • List of genetic disorders
  • Chondrodysplasia, Grebe type GDF5 autosomal recessive Cleidocranial dysostosis RUNX2 1:7,800 Cockayne syndrome ERCC6, ERCC8 1:2,600-3,900 Coffin–Lowry syndrome

    List of genetic disorders

    List_of_genetic_disorders

  • Microsatellite
  • Repeating sequences of 2–13 base pairs of DNA

    action. For example, length changes in tandemly repeating regions in the Runx2 gene lead to differences in facial length in domesticated dogs (Canis familiaris)

    Microsatellite

    Microsatellite

  • Osteocalcin
  • Mammalian protein found in Homo sapiens

    S, et al. (April 2008). "Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells". Gene. 413

    Osteocalcin

    Osteocalcin

    Osteocalcin

  • Canavalia gladiata
  • Species of flowering plant

    Differentiation in MC3T3-E1 Osteoblast Cells by Activating the BMP2/SMAD/RUNX2 Pathway". Nutrients. 15 (20): 4372. doi:10.3390/nu15204372. ISSN 2072-6643

    Canavalia gladiata

    Canavalia gladiata

    Canavalia_gladiata

  • General transcription factor
  • Class of protein transcription factors

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    General transcription factor

    General transcription factor

    General_transcription_factor

  • DCHS2
  • Protein-coding gene in the species Homo sapiens

    V, et al. (May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications.

    DCHS2

    DCHS2

    DCHS2

  • Receptor (biochemistry)
  • Protein molecule receiving signals for a cell

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Receptor (biochemistry)

    Receptor (biochemistry)

    Receptor_(biochemistry)

  • List of OMIM disorder codes
  • TBX22 Cleft palate, isolated; 119540; UBB Cleidocranial dysplasia; 119600; RUNX2 C-like syndrome; 605039; CD96 Clopidogrel, impaired responsiveness to; 609535;

    List of OMIM disorder codes

    List_of_OMIM_disorder_codes

  • AP-1 transcription factor
  • Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)

    Wai PY, Mi Z, Gao C, Guo H, Marroquin C, Kuo PC (July 2006). "Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal

    AP-1 transcription factor

    AP-1 transcription factor

    AP-1_transcription_factor

  • Transcription factor Jun
  • Mammalian protein found in Homo sapiens

    MyoD NACA NELFB NFE2L1 NFE2L2 NCOR2 NCOA1 PIN1 RBM39 RELA RB1 RFWD2 RUNX1 RUNX2 SMAD3 STAT1 STAT3 TBP TGIF1 c-Jun N-terminal kinases GRCh38: Ensembl release

    Transcription factor Jun

    Transcription factor Jun

    Transcription_factor_Jun

  • Sex-determining region Y protein
  • Protein that initiates male sex determination in therian mammals

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Sex-determining region Y protein

    Sex-determining region Y protein

    Sex-determining_region_Y_protein

  • Myogenin
  • Mammalian protein found in Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Myogenin

    Myogenin

    Myogenin

  • ATF4
  • Mammalian protein found in Homo sapiens

    factor is also known to play role in osteoblast differentiation along with RUNX2 and osterix. Terminal osteoblast differentiation, represented by matrix

    ATF4

    ATF4

    ATF4

  • Transcription factor
  • Protein that regulates the rate of DNA transcription

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Transcription factor

    Transcription factor

    Transcription_factor

  • Rev-Erb
  • Type of protein

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Rev-Erb

    Rev-Erb

    Rev-Erb

  • NEUROD1
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    NEUROD1

    NEUROD1

    NEUROD1

  • SATB2
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    SATB2

    SATB2

    SATB2

  • XBP1
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    XBP1

    XBP1

    XBP1

  • SIM1
  • Genetic protein

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    SIM1

    SIM1

    SIM1

  • KLF4
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    KLF4

    KLF4

    KLF4

  • N-Myc
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    N-Myc

    N-Myc

    N-Myc

  • CAMP responsive element modulator
  • Protein found in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    CAMP responsive element modulator

    CAMP responsive element modulator

    CAMP_responsive_element_modulator

  • NFKB1
  • Protein-coding gene in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    NFKB1

    NFKB1

    NFKB1

  • RELA
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    RELA

    RELA

    RELA

  • MYF6
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    MYF6

    MYF6

    MYF6

  • E2F2
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    E2F2

    E2F2

    E2F2

  • Liver X receptor beta
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Liver X receptor beta

    Liver X receptor beta

    Liver_X_receptor_beta

  • Homeobox protein SIX1
  • Protein-coding gene in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Homeobox protein SIX1

    Homeobox protein SIX1

    Homeobox_protein_SIX1

  • LMX1A
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    LMX1A

    LMX1A

    LMX1A

  • CBFB
  • Protein-coding gene in humans

    of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically

    CBFB

    CBFB

    CBFB

  • MADS-box
  • Protein family

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    MADS-box

    MADS-box

  • HOPX
  • Protein-coding gene in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    HOPX

    HOPX

    HOPX

  • P53
  • Mammalian protein found in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    P53

    P53

    P53

  • NOBOX
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    NOBOX

    NOBOX

    NOBOX

  • SOX5
  • Protein-coding gene in Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    SOX5

    SOX5

    SOX5

  • Period (gene)
  • Gene located on the X chromosome of Drosophila melanogaster

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Period (gene)

    Period_(gene)

  • GABPA
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    GABPA

    GABPA

    GABPA

  • Runt domain
  • Evolutionary conserved protein domain

    proteins with a Runt domain include: RUNX1 – essential for hematopoiesis RUNX2 – critical for bone development RUNX3 – involved in neurogenesis and T-cell

    Runt domain

    Runt_domain

  • KLF17
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    KLF17

    KLF17

    KLF17

  • OTX1
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    OTX1

    OTX1

    OTX1

  • TBX2
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    TBX2

    TBX2

    TBX2

  • ATF7
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    ATF7

    ATF7

    ATF7

  • Osteochondroprogenitor cell
  • Bone or Cartilage forming cells

    Runx2 signalling pathways. TGF-β will act as a stimulator of chondrogenesis, and an inhibitor of osteoblastic differentiation, by blocking the Runx2 factor

    Osteochondroprogenitor cell

    Osteochondroprogenitor cell

    Osteochondroprogenitor_cell

  • Small heterodimer partner
  • Protein found in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Small heterodimer partner

    Small heterodimer partner

    Small_heterodimer_partner

  • Progesterone receptor
  • Cytoplasmic receptor protein found inside cells

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Progesterone receptor

    Progesterone receptor

    Progesterone_receptor

  • Sclerostin
  • Protein-coding gene in the species Homo sapiens

    PMC 403697. PMID 12975309. Sevetson B, Taylor S, Pan Y (April 2004). "Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)". The Journal

    Sclerostin

    Sclerostin

    Sclerostin

  • Peroxisome proliferator-activated receptor delta
  • Nuclear receptor protein found in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Peroxisome proliferator-activated receptor delta

    Peroxisome proliferator-activated receptor delta

    Peroxisome_proliferator-activated_receptor_delta

  • HOXC13
  • Protein-coding gene in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    HOXC13

    HOXC13

    HOXC13

  • Myc
  • Family of regulator genes

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Myc

    Myc

  • HOXA7
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    HOXA7

    HOXA7

    HOXA7

  • HOXB2
  • Protein-coding gene in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    HOXB2

    HOXB2

    HOXB2

  • Vitamin D receptor
  • Transcription factor activated by vitamin D

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Vitamin D receptor

    Vitamin D receptor

    Vitamin_D_receptor

  • HIVEP2
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    HIVEP2

    HIVEP2

    HIVEP2

  • EGR4
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    EGR4

    EGR4

    EGR4

  • Osteoblast
  • Cells that form bone tissue

    developing progenitor cells express the regulatory transcription factor Cbfa1/Runx2. A second required transcription factor is Sp7 transcription factor.

    Osteoblast

    Osteoblast

    Osteoblast

  • Oct-4
  • Mammalian protein found in Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Oct-4

    Oct-4

    Oct-4

  • CTCF
  • Transcription factor

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    CTCF

    CTCF

    CTCF

  • SOX9
  • Transcription factor gene of the SOX family

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    SOX9

    SOX9

    SOX9

  • NKX-homeodomain factor
  • Class of proteins

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    NKX-homeodomain factor

    NKX-homeodomain_factor

  • Bone sialoprotein
  • Protein-coding gene in the species Homo sapiens

    A, Waller SM, et al. (2003). "Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human

    Bone sialoprotein

    Bone sialoprotein

    Bone_sialoprotein

  • OSR1
  • Protein-coding gene in the species Homo sapiens

    mandible and developing eye. The expression of Osr1 is negatively regulated by Runx2 and Ikzf1. These genes are involved in osteoblast and lymphocyte differentiation

    OSR1

    OSR1

    OSR1

  • Aryl hydrocarbon receptor
  • Vertebrate receptor protein and transcription factor

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Aryl hydrocarbon receptor

    Aryl hydrocarbon receptor

    Aryl_hydrocarbon_receptor

  • Peroxisome proliferator-activated receptor gamma
  • Nuclear receptor protein found in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Peroxisome proliferator-activated receptor gamma

    Peroxisome proliferator-activated receptor gamma

    Peroxisome_proliferator-activated_receptor_gamma

  • Zinc finger
  • Small structural protein motif found mostly in transcriptional proteins

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Zinc finger

    Zinc finger

    Zinc_finger

  • Histone deacetylase
  • Class of enzymes important in regulating DNA transcription

    Mostly cytoplasm heart, liver, kidney, placenta α-Tubulin, HSP90, SHP, SMAD7 RUNX2 – HDAC10 1 Mostly cytoplasm liver, spleen, kidney – – – III sirtuins in

    Histone deacetylase

    Histone deacetylase

    Histone_deacetylase

  • GTF2F1
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    GTF2F1

    GTF2F1

    GTF2F1

  • GTF2H2
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    GTF2H2

    GTF2H2

    GTF2H2

  • CSDA (gene)
  • Protein-coding gene in humans

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    CSDA (gene)

    CSDA (gene)

    CSDA_(gene)

  • Basic helix–loop–helix
  • Protein structural motif

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    Basic helix–loop–helix

    Basic helix–loop–helix

    Basic_helix–loop–helix

  • IRX4
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    IRX4

    IRX4

    IRX4

  • ZNF34
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    ZNF34

    ZNF34

    ZNF34

  • ZBTB7B
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    ZBTB7B

    ZBTB7B

    ZBTB7B

  • HSF4
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    HSF4

    HSF4

    HSF4

  • PHF3
  • Protein-coding gene in the species Homo sapiens

    (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1

    PHF3

    PHF3

    PHF3

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Online names & meanings

  • Aaranie
  • Girl/Female

    Indian, Tamil

    Aaranie

    Goddess Amman

  • Shardambha
  • Girl/Female

    Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi

    Shardambha

    Goddess Saraswati

  • Emmett
  • Boy/Male

    Christian & English(British/American/Australian)

    Emmett

    Hard Working

  • Mubeena
  • Girl/Female

    Arabic

    Mubeena

    Evident; Clear

  • FOWKE
  • Male

    English

    FOWKE

    Variant form of English Fulke, FOWKE means "people, tribe."

  • Nadege
  • Girl/Female

    Australian, French, Russian

    Nadege

    Hope

  • Yathavan
  • Boy/Male

    Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Tamil, Telugu

    Yathavan

    Lord Vishnu

  • Kyle
  • Girl/Female

    American, Christian, Hebrew, Indian

    Kyle

    Narrow Split of Land

  • Leffingwell
  • Surname or Lastname

    English

    Leffingwell

    English : habitational name from a lost place in Essex (probably near Pebmarsh) recorded in Domesday Book as Liffildeuuella ‘spring or stream (Old English wella) of a woman named Lēofhild’.

  • Devnath
  • Boy/Male

    Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Mythological, Oriya, Telugu

    Devnath

    King of Gods

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