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Protein-coding gene in humans
Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene. Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis
PLD2
Class of enzymes
125 kDa. In mammals, six PLD isoenzymes (PLD1–PLD6) are expressed. PLD1 and PLD2 are the best characterized, responsible for classical phosphatidylcholine
Phospholipase_D
Sterol biosynthesized by all animal cells
phosphatidylinositol 4,5-bisphosphate (PIP2). PLD2 has a PIP2 binding domain. When PIP2 concentration in the membrane increases, PLD2 leaves the cholesterol-dependent
Cholesterol
Anesthesia resulting from effects on the lipid membrane
proteins. Phospholipase D2 (PLD2) is a palmitoylated protein that is activated by substrate presentation. Anesthetics cause PLD2 to move from GM1 lipids,
Membrane-mediated_anesthesia
Blister-like protrusion filled with serous fluid
Cell Line Is Positively Regulated by the Lipid Signalling Phospholipase D2 (PLD2)". Achievements in the Life Sciences. 10 (2): 125–135. doi:10.1016/j.als
Bleb_(medicine)
Phospholipase D2 (PLD2) binds PIP2 and localizes with lipid rafts. Increases in cholesterol overcome PIP2 binding and sequester PLD2 into GM1 lipid rafts
PIP2_domain
Activation of a protein by exposure to its substrate
phosphatidylinositol 4,5-bisphosphate (PIP2). PLD2 has a PIP2 binding domain. When PIP2 concentration in the membrane increases, PLD2 leaves the GM1 domains and associates
Substrate_presentation
Protein-coding gene in the species Homo sapiens
Ha SH, Kim DH, Kim IS, Kim JH, Lee MN, Lee HJ, et al. (December 2006). "PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals"
P70-S6_Kinase_1
Men's association football top division of Belarus
Club1 Seasons Debut Last Season Pld2 W D L Goals Points3 Best Result Dinamo Minsk 33 1992 — 939 560 202 177 1701–794 1882 1st (1992, 1992–93, 1993–94,
Belarusian_Premier_League
Protein-coding gene in the species Homo sapiens
D family, however, it has no known catalytic function similar to PLD1 or PLD2. PLD3 serves as a ssDNA 5' exonuclease in antigen presenting cells. PLD3
PLD3
Bulge in the plasma membrane of a cell
Cell Line Is Positively Regulated by the Lipid Signalling Phospholipase D2 (PLD2)". Achievements in the Life Sciences. 10 (2): 125–135. doi:10.1016/j.als
Bleb_(cell_biology)
Mammalian protein found in humans
5417.1161. PMID 10325225. Ha SH, Kim DH, Kim IS, et al. (December 2006). "PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals"
MTOR
Clinical Significance
PHLPP, PIP3-E, PLCD1, PLCD4, PLCG1, PLCG2, PLCH1, PLCH2, PLCL1, PLCL2, PLD1, PLD2, PLEK, PLEK2, PLEKHA1, PLEKHA2, PLEKHA3, PLEKHA4, PLEKHA5, PLEKHA6, PLEKHA7
Pleckstrin_homology_domain
Protein-coding gene in the species Homo sapiens
domains for activators, inhibitors, and catalysis, which it shares with PLD2. Domains for both activation and inhibition are referred to as the phox homology
Phospholipase_D1
Protein-coding gene in the species Homo sapiens
Hippocalcin takes part in the following processes: Activation of PLD1 and PLD2 expression Inhibition of apoptosis MAP kinase signalling Involved in long
Hippocalcin
Mammalian protein found in Homo sapiens
"GlycolysisGluconeogenesis_WP534". Aldolase A has been shown to interact with: PLD2, actin, GLUT4, phospholipase D2, light chain 8 of dynein, erythrocyte anion
Aldolase_A
Protein family
α-tubulin, light chain dynein, WASP, Band 3 anion exchanger, phospholipase D (PLD2), glucose transporter GLUT4, inositol trisphosphate, V-ATPase and ARNO (a
Fructose-bisphosphate aldolase
Fructose-bisphosphate_aldolase
Q63HM9 12296 PLCZ1 HGNC:19218; Q86YW0 12297 PLD1 HGNC:9067; Q13393 12298 PLD2 HGNC:9068; O14939 12299 PLD3 HGNC:17158; Q8IV08 12300 PLD4 HGNC:23792; Q96BZ4
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
Protein-coding gene in the species Homo sapiens
activate TREK-1 through the enzyme phospholipase D2 (PLD2). Prior to the addition of anesthetic, PLD2 associates with GM-1 lipid rafts. After anesthetic
KCNK2
Protein-coding gene in the species Homo sapiens
generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity". EMBO J. 19 (20): 5440–9. doi:10.1093/emboj/19.20.5440. PMC 314009
PIP5K1A
How drugs induce reversible suppression of consciousness
D2 (PLD2) is anesthetic sensitive and activates the potassium channel TREK-1 through a membrane mediated mechanism. The anesthetics displaced PLD2 from
Theories of general anaesthetic action
Theories_of_general_anaesthetic_action
Protein-coding gene in the species Homo sapiens
Ha SH, Kim DH, Kim IS, Kim JH, Lee MN, Lee HJ, et al. (December 2006). "PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals"
EIF4EBP1
Protein-coding gene in the species Homo sapiens
Amphiphysin has been shown to interact with DNM1, Phospholipase D1, CDK5R1, PLD2, CABIN1 and SH3GL2. Ap180 – ProteinPages displaying short descriptions with
Amphiphysin
Type of ion channel transmembrane protein
domain. The affinity of PA for TREK-1 is relatively weak but the enzyme PLD2 produces high local concentration of PA to activate the channel. nAChR: PA
Lipid-gated_ion_channels
Protein-coding gene in the species Homo sapiens
PRKCD has been shown to interact with: C1QBP, HER2/neu, INSR, MUC1, mTOR, PLD2, PTPN6, PTPRM, PDPK1, RASGRP3, SHC1 and STAT1. GRCh38: Ensembl release 89:
PRKCD
Protein-coding gene in the species Homo sapiens
inhibition of ARF1. ARF1 has been shown to interact with: CHRM3, COPB1, GGA3, and PLD2. GRCh38: Ensembl release 89: ENSG00000143761 – Ensembl, May 2017 GRCm38:
ARF1
Protein found in humans
type B, PDGFRB, PDGFRA, PTGS2, TRAF2, estrogen receptor alpha, caveolin 2, PLD2, Bruton's tyrosine kinase, and SCP2. All these interactions are through a
Caveolin_1
Protein found in humans
KHDRBS1, Linker of activated T cells, Lymphocyte cytosolic protein 2, PDGFRA, PLD2, RHOA, SOS1, TUB, TrkA, TrkB, VAV1, and Wiskott-Aldrich syndrome protein
PLCG1
Protein family
KIF16B (SNX23) NCF1; NCF1C; NCF4; NISCH PIK3C2A; PIK3C2B; PIK3C2G; PLD1; PLD2; PXK RPS6KC1 SGK3; SH3PXD2A; SNAG1; SNX9 Ponting CP (November 1996). "Novel
PX_domain
Protein-coding gene in the species Homo sapiens
KHDRBS1, Linker of activated T cells, Lymphocyte cytosolic protein 2, PDGFRA, PLD2, RHOA, SOS1, TUB, TrkA, TrkB, VAV1, and Wiskott-Aldrich syndrome protein
BAG3
Protein-coding gene in humans
Kim IS, Kim JH, Lee MN, Lee HJ, Kim JH, Jang SK, Suh PG, Ryu SH (2006). "PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals"
RPTOR
PLD2
PLD2
PLD2
PLD2
Girl/Female
Tamil
Sacred
Girl/Female
Biblical
A window, grief.
Boy/Male
Hindu
Fit, Clever, Capable
Girl/Female
Hindu
Girl/Female
Hindu
Victorious or Goddess of victory
Female
Polish
 Feminine form of Polish Stefan, STEFANIA means "crown." Compare with other forms of Stefania.
Boy/Male
Assamese, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu
One with Beautiful Eyes
Boy/Male
Indian, Punjabi, Sikh
Love for War
Boy/Male
Hindu, Indian, Malayalam, Marathi
Lord of Speech
Girl/Female
German, Hebrew, Latin
Wise Guardian; Ewe; Form of Regina; Queen
PLD2
PLD2
PLD2
PLD2
PLD2