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Protein-coding gene in the species Homo sapiens
protein 2 (NPAS2) also known as member of PAS protein 4 (MOP4) is a transcription factor protein that in humans is encoded by the NPAS2 gene. NPAS2 is paralogous
NPAS2
American neuroscientist (born 1946)
transcription factors CLOCK and NPAS2 have overlapping roles in the SCN, revealing a new and unexpected role for NPAS2. His lab observed that CLOCK-deficient
Steven_M._Reppert
Human protein and coding gene
domain containing protein 2 (NPAS2, a CLOCK paralog) can substitute for CLOCK in these Clock-null mice. Mice with one NPAS2 allele showed shorter periods
CLOCK
Chemical element with atomic number 93 (Np)
solution. Three neptunium arsenide compounds have been prepared, NpAs, NpAs2, and Np3As4. The first two were first produced by heating arsenic and neptunium
Neptunium
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(III)_phosphide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(IV)_oxalate
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_tetrachloride
Human protein and coding gene
in Bmal1 was identified as having a link with bipolar disorder. Arntl, Npas2, and Per2 have also been associated with seasonal affective disorder in
Basic helix-loop-helix ARNT-like protein 1
Basic_helix-loop-helix_ARNT-like_protein_1
Group of chemical compounds
solution. Three neptunium arsenide compounds have been prepared, NpAs, NpAs2, and Np3As4. The first two were first created by heating arsenic and neptunium
Neptunium_compounds
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(V)_oxide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_trioxide
Protein structural motif
NEUROD2; NEUROD4; NEUROD6; NEUROG1; NEUROG2; NEUROG3; NHLH1; NHLH2; NPAS1; NPAS2; NPAS3; NPAS4; OAF1; OLIG1; OLIG2; OLIG3; PTF1A; SCL; SCXB; SIM1; SIM2;
Basic_helix–loop–helix
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_tetraiodide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_tetrabromide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(VII) oxide-hydroxide
Neptunium(VII)_oxide-hydroxide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_nitride
Inferred motif from similar protein – In vivo/Misc source [629] VVNGCACGTMBNS NPAS2 ENSG00000170485 bHLH Known motif – High-throughput in vitro [630] DMCACGTGY
List of human transcription factors
List_of_human_transcription_factors
Protein domain
chaperonins and other small molecules like dioxin, but PAS B domains in NPAS2, a homolog of the Drosophila clk gene, and the hypoxia inducible factor
PAS_domain
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunyl(V)_oxalate
Protein found in humans
has been shown to interact with: BAG1, CLOCK, CCND3, NCOA6, NCOR1, NCOR2, NPAS2, NRIP1, NR0B2, NR4A2, PML RXRA. Src, TADA3L, and ZBTB16. Knock-out mice
Retinoic_acid_receptor_alpha
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(IV)_phosphide
Class of chemical compounds
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunyl_carbonates
Compounds of neptunium and sulfur
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_sulfides
Protein-coding gene in the species Homo sapiens
LEF1, MAF, MAML1, MEF2C, MEF2D, MYBL2, Mdm2, MyoD, MEF2A, NCOA6, NFATC2, NPAS2, P53, PAX6, PCNA, POLI, PROX1, PTMA, PPARA, PPARG, RORA, RELA, SMAD1, SMAD2
EP300
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(IV)_oxide
DNA response element in some eukaryotes
rate of genetic expression), and transcription of circadian genes BMAL1/NPAS2 and BMAL1/CLOCK complexes. The binding specificity of different E-boxes
E-box
Disruption of the body's biological rhythms
function. Deletion or mutation of core clock genes (e.g. Bmal1, Clock, Npas2) was shown to have an adverse impact on cardiac function, including attenuating
Chronodisruption
Protein-coding gene in humans
gene copy. The protein product of the gene interacts with both CLOCK and NPAS2 to bind to E-box sequences in regulated promoters and activate their transcription
ARNTL2
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(III)_bromide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(III)_chloride
(2014) Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2. Biological Psychiatry 77:425-33 Sidor, M.M., Spencer, S., Dzirasa, K.,
Colleen_McClung
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(III)_fluoride
Q6NXP6 10696 NPAP1 HGNC:1190; Q9NZP6 10697 NPAS1 HGNC:7894; Q99742 10698 NPAS2 HGNC:7895; Q99743 10699 NPAS3 HGNC:19311; Q8IXF0 10700 NPAS4 HGNC:18983;
List of human protein-coding genes 5
List_of_human_protein-coding_genes_5
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(IV)_nitrate
concluded that FAA can be achieved without the Bmal1 gene. Cry1, Cry2, and NPAS2 (Clock gene paralog) knockout mice also show FAA activity, so none of these
Food-entrainable_oscillator
Protein-coding gene in the species Homo sapiens
form heterotetramer) VDR (optional) SHP (inhibitory) CLOCK MyoD NFKBIB NPAS2 POU2F1 TBP BCL3 BRD8 ITGB3BP NCOA2 NCOA3 NCOA6 PPARGC1A TADA3L IGFBP3 NRIP1
Retinoid_X_receptor_alpha
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_monocarbide
American chronobiologist (1934–2021)
genes included mutations and deletions to Per1, Per2, Cry1, Cry2, Bmal1, Npas2, CLOCK and CK1e. All of these mutants continued to respond and exhibit changes
Michael_Menaker
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(V)_fluoride
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(IV)_fluoride
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(VI)_fluoride
Protein and coding gene in humans
epsilon has been shown to interact with PER1, PER2, CRY1, CRY2, BMAL1, CLOCK, NPAS2, and AXIN1. PER1, PER2, and BMAL1 can be directly phosphorylated by CK1ɛ
Casein kinase 1 isoform epsilon
Casein_kinase_1_isoform_epsilon
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunyl_fluoride
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_diarsenide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunocene
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunyl_ammonium_nitrate
American neurologist and chronobiologist
β-amyloid and α-synuclein). These features were also observed when CLOCK and NPAS2 were deleted, which are circadian genes that work closely with BMAL1. Conversely
Erik_Musiek
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium(III)_iodide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_arsenide
Chemical compound
v t e Neptunium compounds Np(II) [K(2.2.2-crypt)][NpCp'3] Np(III) NpAs NpAs2 NpBr3 NpF3 NpCl3 NpI3 NpN NpP NpSi2 NpS Np2S3 Np(III,IV) Np3S5 Np(IV) NpCl4
Neptunium_silicide
NPAS2
NPAS2
NPAS2
NPAS2
Girl/Female
Hindu, Indian, Traditional
Goddess Durga
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Sindhi, Tamil, Telugu
The Moon
Boy/Male
Celtic
Choice.
Boy/Male
Hindu, Indian, Marathi, Tamil
Lord Murugan
Girl/Female
Indian
Reformer, Advisor
Girl/Female
Tamil
The earth
Boy/Male
Arabic, Muslim
Be Sympathetic
Boy/Male
Indian
The th month of the Muslim year
Girl/Female
Hindu, Indian
A Decree; Command
Girl/Female
Hindu
One who inspires
NPAS2
NPAS2
NPAS2
NPAS2
NPAS2