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MMP14

  • MMP14
  • Protein-coding gene in the species Homo sapiens

    metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene. Matrix metalloproteinase-14 (MMP14), also known as MT1-MMP, is a zinc-dependent type I

    MMP14

    MMP14

    MMP14

  • Homeobox
  • DNA pattern affecting anatomy development

    respectively. HoxA3 induces endothelial cell (EC) migration by upregulating MMP14 and uPAR. Conversely, HoxD10 and HoxA5 have the opposite effect of suppressing

    Homeobox

    Homeobox

    Homeobox

  • Matrix metalloproteinase
  • Family of zinc-dependent metalloendopeptidases

    MMP-13 secreted Substrates include Col I, II, III, IV, IX, X, XIV, gelatin MMP14 MT1-MMP MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS

    Matrix metalloproteinase

    Matrix_metalloproteinase

  • Hemopexin family
  • Protein family

    metalloproteinases: MMP1, MMP2, MMP3, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP19, MMP20, MMP21, MMP24, MMP25, MMP27, MMP28, PRG4

    Hemopexin family

    Hemopexin_family

  • Peptidoglycan binding domain
  • Class of protein structural domains

    domain include: MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP19, MMP20, MMP21, MMP24, MMP25, MMP27, MMP28 PDB:

    Peptidoglycan binding domain

    Peptidoglycan binding domain

    Peptidoglycan_binding_domain

  • MMP2
  • Protein-coding gene in humans

    requires proteolytic processing. A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the

    MMP2

    MMP2

    MMP2

  • TIMP2
  • Protein-coding gene in the species Homo sapiens

    and dendritic spines plasticity. TIMP2 has been shown to interact with: MMP14 and MMP2. TIMP1, TIMP3, TIMP4 GRCh38: Ensembl release 89: ENSG00000035862

    TIMP2

    TIMP2

    TIMP2

  • PCSK6
  • Protein-coding gene in the species Homo sapiens

    induce smooth muscle cell migration in response to PDGFB by activating MMP14. When Pcsk6 was knocked out, the intimal hyperplasia response to in vivo

    PCSK6

    PCSK6

    PCSK6

  • Pediatric ependymoma
  • MEN1 mutations are occasionally found in pediatric ependymomas. MMP2 and MMP14 appear to also play a role in tumor growth and progression in intracranial

    Pediatric ependymoma

    Pediatric_ependymoma

  • Catenin beta-1
  • Mammalian protein found in humans

    (CCND1) Fibroblast growth factor 18 (FGF18) Matrix metalloproteinase-14 (MMP14) Myc proto-oncogene (MYC) Many of the genes activated by the β-catenin pathway

    Catenin beta-1

    Catenin beta-1

    Catenin_beta-1

  • List of human protein-coding genes 5
  • HGNC:7157; P24347 9657 MMP12 HGNC:7158; P39900 9658 MMP13 HGNC:7159; P45452 9659 MMP14 HGNC:7160; P50281 9660 MMP15 HGNC:7161; P51511 9661 MMP16 HGNC:7162; P51512

    List of human protein-coding genes 5

    List_of_human_protein-coding_genes_5

  • Winchester syndrome
  • Rare hereditary connective tissue disease

    ajhg.2012.07.022. PMC 3512002. PMID 22922033. Reference, Genetics Home. "MMP14 gene". Genetics Home Reference. Retrieved 2017-11-07. "Winchester Syndrome

    Winchester syndrome

    Winchester syndrome

    Winchester_syndrome

  • GalNAc-T activation pathway
  • Biological pathway implicated in tumorigenesis

    Calnexin is logically a promising targetable tumour antigen. In addition, MMP14 is another GalNAc-T substrate for which GALA induced glycosylation changes

    GalNAc-T activation pathway

    GalNAc-T_activation_pathway

  • Lumican
  • As lumican can directly bind to and inhibit matrix metalloproteinase-14 (MMP14), lumican may limit tumor progression by preventing extracellular matrix

    Lumican

    Lumican

    Lumican

  • MMP15
  • Protein-coding gene in the species Homo sapiens

    human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in

    MMP15

    MMP15

    MMP15

  • MMP16
  • Protein-coding gene in the species Homo sapiens

    "Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively"

    MMP16

    MMP16

    MMP16

  • NEDD9
  • Protein-coding gene in the species Homo sapiens

    Invasion is accompanied by proteolysis of the ECM through activation of MMP14, MMP2 and MMP9 metalloproteinases. NEDD9 is involved in chemokine-induced

    NEDD9

    NEDD9

    NEDD9

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Online names & meanings

  • Shipra | ஷிப்ரா
  • Girl/Female

    Tamil

    Shipra | ஷிப்ரா

    A river

  • Daphna
  • Girl/Female

    French, German, Greek, Hebrew

    Daphna

    Victory; Laurel

  • Shreemani
  • Girl/Female

    Hindu, Indian, Traditional

    Shreemani

    Beautiful; Rich

  • Mitin
  • Boy/Male

    Hindu

    Mitin

    Governor, Moment in time

  • Aashima
  • Girl/Female

    Indian

    Aashima

    Limitless, Protector, Defendant, Central

  • Binit
  • Boy/Male

    Hindu

    Binit

    Unassuming

  • Kaalaratri
  • Girl/Female

    Hindu

    Kaalaratri

    Goddess who is black like night

  • Annapurna
  • Girl/Female

    Indian

    Annapurna

    Goddess Parvati, Generous with food, Goddess of grains

  • Haricharan | ஹரிசரண
  • Boy/Male

    Tamil

    Haricharan | ஹரிசரண

    Feet of the Lord

  • Maiya
  • Girl/Female

    American, French, Gujarati, Hindu, Indian, Japanese, Latin, Telugu

    Maiya

    Mother

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MMP14

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