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Class of very small bacterially produced peptide antibiotics
Microcins are very small bacteriocins, composed of relatively few amino acids. For this reason, they are distinct from their larger protein cousins. The
Microcin
Class of bacterially produced peptide antibiotics
include the bacteriocins from gram-positive bacteria, the colicins, the microcins, and the bacteriocins from Archaea. The bacteriocins from E. coli are
Bacteriocin
Class of chemical compounds
families, such as microcin E492, microcin B17 (LAP) and microcin J25 (Lasso peptide) are also considered microcins. Instead of being classified based
Ribosomally synthesized and post-translationally modified peptides
Ribosomally_synthesized_and_post-translationally_modified_peptides
Short chains of 2–50 amino acids
signaling molecules. Some microbes produce peptides as antibiotics, such as microcins and bacteriocins. Peptides frequently have post-translational modifications
Peptide
Rod-shaped, gram-negative bacterium
Salmonella and other coliform enteropathogens, through the production of microcin proteins the production of siderophores. Most E. coli strains do not cause
Escherichia_coli
Interlocked molecular structure resembling a dumbbell
including: cystine knot peptides, cyclotides or lasso-peptides such as microcin J25. The earliest reported synthesis of a rotaxane in 1967 relied on the
Rotaxane
Chemical compound
antimicrobial lasso peptides, which are targeting RNA polymerase (e.g. microcin J25, capistruin), or lipid II biosynthesis (e.g. siamycin-I). Lariocidin
Lariocidin
Chemical compound
"Structure of the mannose phosphotransferase system (man-PTS) complexed with microcin E492, a pore-forming bacteriocin". Cell Discovery. 7 (1): 20. doi:10
Mannose
Molecules connected due to their topology
systems including: cystine knots, cyclotides or lasso-peptides such as microcin J25 which are proteins, and a variety of peptides. Residual topology is
Mechanically interlocked molecular architectures
Mechanically_interlocked_molecular_architectures
Type of organic compound
Vancomycin, from the soil bacterium Amycolatopsis orientalis. Microcins, bacteriocins such as microcin V from Escherichia coli. Thiostrepton, from several strains
Secondary_metabolite
American biochemist
working with Christopher T. Walsh on the biosynthetic assembly of microcin E492m. Microcin E492m is an antibiotic peptide that can target Gram-negative bacteria
Elizabeth_Nolan
Protein family
modified microcin antibiotics, such as bottromycin. YcaO performs ATP dependent cyclodehydration to form the oxazole and thiazole moieties of the microcin. The
YcaO
1943 experiment into rate of mutations
of ferrichrome, albomycin and rifamycin. It also confers sensitivity to microcin J25 and colicin M and acts as a receptor for the phages T5 and phi80 as
Luria–Delbrück_experiment
Chemical compound
peptide (RiPP); it can be classified further as a thiazole/oxazole-modified microcin (TOMM) or a linear azole-containing peptide (LAP). The significance of
Plantazolicin
Canadian chemist (1971–2020)
Christopher T. Walsh. At the Harvard Medical School, Zamble worked on the microcin B17 synthetase. Zamble returned to Canada in 2001, where she was made a
Deborah_Zamble
Membrane proteins that adhere temporarily to membranes with which they are associated
Botulinum toxin B Heat-stable enterotoxin B δ-Endotoxins Bacteriocins, such as microcin) Lantibiotic peptides, such as nisin) Gramicidin S Microbial toxins are
Peripheral_membrane_protein
German sculptor
cyclotide kalata B1 Melittin, sculpture of melittin Nanos, sculpture of microcin J25 Steel Jellyfish, sculpture of green fluorescent protein Birth of an
Julian_Voss-Andreae
Classification of membrane proteins including ion channels
channel family 1.C.57 Clostridial cytotoxin family 1.C.58 The Microcin E492/C24 (Microcin E492) Family 1.C.74 Snake cytotoxin (SCT) family 1.C.97 Pleurotolysin
Transporter Classification Database
Transporter_Classification_Database
Bacterial metabolic pathway
"Structure of the mannose phosphotransferase system (man-PTS) complexed with microcin E492, a pore-forming bacteriocin". Cell Discovery. 7 (1): 20. doi:10
PEP_group_translocation
Gene family
(Pep3E) Family 3.A.1.117 The Drug Exporter-2 (DrugE2) Family 3.A.1.118 The Microcin J25 Exporter (McjD) Family 3.A.1.119 The Drug/Siderophore Exporter-3 (DrugE3)
ABC_transporter
Family of transport proteins
"Structure of the mannose phosphotransferase system (man-PTS) complexed with microcin E492, a pore-forming bacteriocin". Cell Discovery. 7 (1): 20. doi:10
PTS Mannose-Fructose-Sorbose Family
PTS_Mannose-Fructose-Sorbose_Family
Class of enzymes
OCLC 227210110. Collin F, Maxwell A (August 2019). "The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents". Journal
Topoisomerase
Chemical compound
Haygood, M.; Ravel, J. (2005). "Patellamide a and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum
Patellamide_A
Group of proteins
cytolytic virulence factor which is a member of the thiazole/oxadole-modified microcin (TOMM) family. This cytolysin is a post-translationally modified peptide
Streptolysin
German chemist
Modifications in the Ribosomal Biosynthesis of the Glycine-Rich Antibiotic Microcin B17". Angewandte Chemie International Edition in English. 32 (9). Wiley:
Günther_Jung
Chemical compound
in genome database using low-level homology of one of the proteins to microcin B17 synthetase. Cloning and expression of cluster in a heterologous host
Klebsazolicin
"Sequence Diversity in the Lasso Peptide Framework: Discovery of Functional Microcin J25 Variants with Multiple Amino Acid Substitutions". Journal of the American
Complex_lasso_proteins
Microbiologist and teacher, born 1953
P; Jebaratnam, D; Kolter, R (1994). "Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor". Proc Natl Acad
Roberto_Kolter
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Girl/Female
Muslim/Islamic
Understanding intelligent
Female
Yiddish
(קִיילֶע) Variant spelling of Yiddish Kayle, a form of Latin Cælia, probably KAYLA means "heaven." Compare with another form of Kayla.
Girl/Female
Hindu
Peaceful, Unique
Boy/Male
American, British, English
Wolf Spear
Girl/Female
Hindu, Indian
Hotness
Boy/Male
Indian, Sanskrit
Dividing
Boy/Male
Hindu, Indian, Marathi, Punjabi, Sikh
Bright; Shining; Pleasant
Girl/Female
Latin
Sister of Roma.
Male
French
French form of Roman Latin Pontius, PONS means "of the sea; seaman."
Boy/Male
Arabic, Muslim, Sindhi
A Place of Worship; Many of the Prominent People had this Name Including the Companions Ibn Khalid Al-juhanni and Ibn-hawzah RA
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