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JAG2

JAG2

Protein-coding gene in the species Homo sapiens

Jagged-2 is a protein that in humans is encoded by the JAG2 gene. The Notch signaling pathway is an intercellular signaling mechanism that is essential

JAG2

Ovarian cancer

Cancer originating in or on the ovary

point mutation (402 C to G) adult granulosa cell ~100% JAG1 amplification 2% JAG2 amplification 3% KRAS amplification mucinous and low-grade serous 11% MAML1

Ovarian cancer

Ovarian_cancer

Limb–girdle muscular dystrophy

Muscular degenerative disorder primarily of the hip and shoulders

2021). "A form of muscular dystrophy associated with pathogenic variants in JAG2". American Journal of Human Genetics. 108 (5): 840–856. doi:10.1016/j.ajhg

Limb–girdle muscular dystrophy

Limb–girdle_muscular_dystrophy

Notch 2

Protein found in humans

syndrome. NOTCH2 has been shown to interact with: Delta-like 1 GSK3B, JAG1, and JAG2. GRCh38: Ensembl release 89: ENSG00000134250 – Ensembl, May 2017 GRCm38:

Notch 2

Notch_2

Basal cell

General cell type

precursor to gastric cancer. Furthermore, if the genes coding for Jag1 or Jag2 are mutated or deleted, this can cause a disruption of the critical Notch

Basal cell

Basal_cell

EGF-like domain

Protein domain named after the epidermal growth factor protein

FBN2; FBN3; GAS6; HABP2; HBEGF; HEG1; HGFAC; HMCN1; HSPG2; ITGB5; JAG1; JAG2; LDLR; LRP1; LRP10; LRP1B; LRP2; LRP4; LRP5; LRP6; LRP8; LTBP1; LTBP2; LTBP3;

EGF-like domain

EGF-like_domain

List of human protein-coding genes 4

HGNC:22984; Q9NQC1 7887 JADE3 HGNC:22982; Q92613 7888 JAG1 HGNC:6188; P78504 7889 JAG2 HGNC:6189; Q9Y219 7890 JAGN1 HGNC:26926; Q8N5M9 7891 JAK1 HGNC:6190; P23458

List of human protein-coding genes 4

List_of_human_protein-coding_genes_4