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HIPK2

HIPK2

Protein-coding gene in the species Homo sapiens

protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically

HIPK2

Serine/threonine-specific protein kinase

Class of protein kinase enzymes

(2001). "Isolation and characterization of cDNAs for the protein kinase HIPK2". Biochim. Biophys. Acta. 1518 (1–2): 168–72. doi:10.1016/S0167-4781(00)00308-0

Serine/threonine-specific protein kinase

Serine/threonine-specific_protein_kinase

Transforming growth factor beta

Cytokine

DAXX is then phosphorylated by homeodomain-interacting protein kinase 2 (HIPK2), which then activates apoptosis signal-inducing kinase 1 (ASK1), which

Transforming growth factor beta

Transforming_growth_factor_beta

Site-directed mutagenesis

Technique in molecular biology

been used to uncover the phosphorylation of the protein CBP by the kinase HIPK2 Another comprehensive approach is site saturation mutagenesis where one

Site-directed mutagenesis

Site-directed_mutagenesis

Mammalian protein found in humans

EIF2AK2, ELL, EP300, ERCC6, GNL3, GPS2, GSK3B, HSP90AA1, HIF1A, HIPK1, HIPK2, HMGB1, HSPA9, Huntingtin, ING1, ING4, ING5, IκBα, KPNB1, LMO3, Mdm2, MDM4

P53

TP53INP1

Protein-coding gene in the species Homo sapiens

or "stress inducible protein". TP53INP1 has been shown to interact with HIPK2 and p53. GRCh38: Ensembl release 89: ENSG00000164938 – Ensembl, May 2017

TP53INP1

SENP1

Protein-coding gene in humans

Kim Y (2005). "Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease

SENP1

Autoradiograph

Radiograph made by recording radiation emitted by samples on photographic plates

of a recent study showing that CREB-binding protein is phosphorylated by HIPK2.) In plant physiology, autoradiography can be used to determine sugar accumulation

Autoradiograph

List of human protein-coding genes 4

O00291 7077 HIP1R HGNC:18415; O75146 7078 HIPK1 HGNC:19006; Q86Z02 7079 HIPK2 HGNC:14402; Q9H2X6 7080 HIPK3 HGNC:4915; Q9H422 7081 HIPK4 HGNC:19007; Q8NE63

List of human protein-coding genes 4

List_of_human_protein-coding_genes_4

DACH2

Protein-coding gene in humans

Y, Schmitz ML, Koseki H, Kitabayashi I (Sep 2006). "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel

DACH2

Death-associated protein 6

Protein found in humans

Some kind of positive feedback system was also discovered; JNK activates HIPK2, which stands for the translocation of nuclear Daxx to the cytoplasm. In

Death-associated protein 6

Death-associated_protein_6

GeneRIF

role in carcinogenesis of gall bladder cancer Degradation of endogenous HIPK2 depends on the presence of a functional p53 protein. p53 codon 72 alleles

GeneRIF

Circular RNA

Type of RNA found in cells

found 69 orthologous circRNAs. For example, both humans and mice encode the HIPK2 and HIPK3 genes, two paralogous kinases which produce a large amount of

Circular RNA

Circular_RNA

Mdm2

Protein-coding gene in humans

domain of Mdm2 may stimulate its ability to target p53 for degradation. HIPK2 is a protein that regulates Mdm2 in this way. The induction of the p14arf

Mdm2

Protein kinase domain

Protein domain

GRK7 ; GSG2 ; GSK3A ; GSK3B ; GUCY2C ; GUCY2D ; GUCY2F ; HCK ; HIPK1 ; HIPK2 ; HIPK3 ; HIPK4 ; HUNK ; ICK ; IGF1R ; IKBKB ; IKBKE ; ILK ; INSR ; INSRR ;

Protein kinase domain

Protein_kinase_domain

WDR68

Protein-coding gene in the species Homo sapiens

"The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions". EMBO J. 29 (22): 3750–61. doi:10.1038/emboj

WDR68

Mammalian protein found in Homo sapiens

signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK". Genes Dev. 18 (7): 816–29. doi:10.1101/gad.1170604. PMC 387421

NLK

Promiscuous gene expression

for activation of PGE of Aire-dependent TRAs. Worth mentioning is also Hipk2, which phosphorylates Aire and CBP however, its absence affects mostly PGE

Promiscuous gene expression

Promiscuous_gene_expression

S. Ganesh

Indian geneticist and molecular biologist

shock modulates the subcellular localization, stability, and activity of HIPK2". Biochemical and Biophysical Research Communications. 472 (4): 580–584

S. Ganesh

S._Ganesh

SKI protein

Protein-coding gene in the species Homo sapiens

(InterPro: IPR003380, IPR023216. SKI protein has been shown to interact with: HIPK2, MECP2, Mothers against decapentaplegic homolog 1 and Mothers against decapentaplegic

SKI protein