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HES1

  • HES1
  • Protein-coding gene in the species Homo sapiens

    Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene

    HES1

    HES1

    HES1

  • Nirogacestat
  • Chemical compound

    spleen, BCL2L11 – a protein involved in Bcl-2-related apoptosis; decreased: HES1 – a transcription factor repressing NR3C1 glucocorticoid receptor upregulation)

    Nirogacestat

    Nirogacestat

    Nirogacestat

  • HES4
  • another gene called HES1. While both genes help suppress the development of other cell types, they do so in different ways. HES1 primarily keeps the cells

    HES4

    HES4

    HES4

  • Somite
  • Embryology concept

    Notch ligands, mutations of which cause various defects. Notch regulates HES1, which sets up the caudal half of the somite. Notch activation turns on LFNG

    Somite

    Somite

    Somite

  • TCF3
  • Protein-coding gene in the species Homo sapiens

    humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression. This gene encodes a

    TCF3

    TCF3

    TCF3

  • Thalamus
  • Structure within the brain

    neurotransmitter fates is controlled by the dynamic expression of Her6 the homolog of HES1. Expression of this hairy-like bHLH transcription factor, which represses

    Thalamus

    Thalamus

    Thalamus

  • HEY2
  • Protein-coding gene in the species Homo sapiens

    Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochemical

    HEY2

    HEY2

    HEY2

  • Basic helix–loop–helix
  • Protein structural motif

    BHLHB3; BHLHB4; BHLHB5; BHLHB8; CLOCK; EPAS1; FERD3L; FIGLA; HAND1; HAND2; HES1; HES2; HES3; HES4; HES5; HES6; HES7; HEY1; HEY2; HIF1A; ID1; ID2; ID3; ID4;

    Basic helix–loop–helix

    Basic helix–loop–helix

    Basic_helix–loop–helix

  • Nancy Papalopulu
  • Professor of Developmental Neuroscience

    microRNA miR-9 targets an important regulator of neuronal differentiation, HES1, allowing for precisely timed waves of neurogenesis. From January 2011 -

    Nancy Papalopulu

    Nancy Papalopulu

    Nancy_Papalopulu

  • Dalosirvat
  • Pharmaceutical compound

    are Wingless (Wnt), Sonic hedgehog (Shh), Hairy and enhancer of split 1 (Hes1), fibroblast growth factor 7 (FG7), and keratinocyte growth factor (KGF)

    Dalosirvat

    Dalosirvat

    Dalosirvat

  • List of human transcription factors
  • Inferred motif from similar protein – High-throughput in vitro [334] BBCACGTGY HES1 ENSG00000114315 bHLH Known motif – High-throughput in vitro [335] KDCRCGTGBB

    List of human transcription factors

    List_of_human_transcription_factors

  • FOXG1 syndrome
  • Medical condition

    length and branching of neurites, partly by positive regulatory mechanisms of HES1 and CREB1 gene expression. In the adult hippocampus, a reduction in FOXG1

    FOXG1 syndrome

    FOXG1 syndrome

    FOXG1_syndrome

  • List of intestinal epithelial differentiation genes
  • 18812176 GFI1 Required for proper allocation of secretory lineage 16230531 HES1 Hes1 Commitment to absorptive lineage 10615124 HNF1A HNF1-α Regulates terminal

    List of intestinal epithelial differentiation genes

    List_of_intestinal_epithelial_differentiation_genes

  • Oxysterol-binding protein
  • Protein family

    UniProt. Universal protein resource accession number P35843 for "Protein HES1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)"

    Oxysterol-binding protein

    Oxysterol-binding protein

    Oxysterol-binding_protein

  • Gillespie algorithm
  • Method for stochastic equation systems

    Burrage, Kevin; Leier, André; Tian, Tianhai (2006). "Oscillatory Regulation of hes1: Discrete Stochastic Delay Modelling and Simulation". PLOS Computational

    Gillespie algorithm

    Gillespie_algorithm

  • BHLHE41
  • Protein-coding gene in humans

    Quaggin SE (October 2004). "Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis". Gene Expression Patterns

    BHLHE41

    BHLHE41

    BHLHE41

  • Microlissencephaly
  • Microcephaly combined with lissencephaly

    safeguards neural progenitor maintenance involving transcriptional regulation of Hes1". Proceedings of the National Academy of Sciences. 114 (28): E5599–E5607

    Microlissencephaly

    Microlissencephaly

    Microlissencephaly

  • E-box
  • DNA response element in some eukaryotes

    DEC1 and DEC2 has a stronger effect on E-box than on EL-box. Furthermore, HES1, which can bind to a different consensus sequence (CACNAG, known as the N-box)

    E-box

    E-box

  • ASCL1
  • Protein-coding gene in humans

    Hairless (SuH) and Mastermind. This complex, by inducing the transcription of HES1, a transcriptional repressor, then represses the transcription of Asc and

    ASCL1

    ASCL1

    ASCL1

  • Notch signaling pathway
  • Series of molecular signals

    analysis and gain of function experiments revealed that Notch signaling targets Hes1 in the intestine and regulates a binary cell fate decision between adsorptive

    Notch signaling pathway

    Notch signaling pathway

    Notch_signaling_pathway

  • HES5
  • Protein-coding gene in the species Homo sapiens

    F, Kageyama R (August 2001). "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain". The

    HES5

    HES5

    HES5

  • Epigenetic regulation of neurogenesis
  • proliferation to differentiation by directly repressing stem cell genes like Hes1 and Tlx, as demonstrated in a 2019 study miRNAs can also act directly with

    Epigenetic regulation of neurogenesis

    Epigenetic regulation of neurogenesis

    Epigenetic_regulation_of_neurogenesis

  • GATD3
  • Protein-coding gene in the species Homo sapiens

    Rossier C, Lalioti MD, Antonarakis SE (Jun 1997). "Isolation of a human gene (HES1) with homology to an Escherichia coli and a zebrafish protein that maps to

    GATD3

    GATD3

    GATD3

  • Neurogenins
  • Protein family

    because Ngn3 is suppressed. It is important to mention that Ngn3 has three HES1 binding sites adjacent to the TATA box sequence that allow for the regulation

    Neurogenins

    Neurogenins

  • PAX3
  • Paired box gene 3

    et al. (February 2011). "Role of Pax3 acetylation in the regulation of Hes1 and Neurog2". primary. Molecular Biology of the Cell. 22 (4): 503–12. doi:10

    PAX3

    PAX3

    PAX3

  • Hes family bHLH transcription factor 2
  • Protein-coding gene in the species Homo sapiens

    HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription

    Hes family bHLH transcription factor 2

    Hes family bHLH transcription factor 2

    Hes_family_bHLH_transcription_factor_2

  • TOX
  • Protein-coding gene in the species Homo sapiens

    downstream activation of these Notch target genes. TOX was also found to bind Hes1, a Notch target gene, in embryonic kidney cells. Several ILC3 populations

    TOX

    TOX

    TOX

  • HES3
  • Protein-coding gene in the species Homo sapiens

    HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription

    HES3

    HES3

    HES3

  • Zona limitans intrathalamica
  • interplay between Shh from the ZLI and the bHLH factor Her6 (homolog to HES1) determines the neuronal identity within the thalamus: Her6 positive cells

    Zona limitans intrathalamica

    Zona limitans intrathalamica

    Zona_limitans_intrathalamica

  • HES6
  • Protein-coding gene in the species Homo sapiens

    Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. doi:10

    HES6

    HES6

    HES6

  • Basic helix-loop-helix ARNT-like protein 1
  • Human protein and coding gene

    regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6". Experimental & Molecular Medicine. 44 (11): 642–52. doi:10.3858/emm

    Basic helix-loop-helix ARNT-like protein 1

    Basic helix-loop-helix ARNT-like protein 1

    Basic_helix-loop-helix_ARNT-like_protein_1

  • FANCA
  • Protein-coding gene in the species Homo sapiens

    and FANCM. In complex with FANCF, FANCG and FANCL, FANCA interacts with HES1. This interaction has been proposed as essential for the stability and nuclear

    FANCA

    FANCA

    FANCA

  • GPO telephones
  • British General Post Office department for telephones and communication

    GPO tried again. The 300 series House Exchange System, now known as the HES1, was a combination of the Tele. 332L and the House Telephone System. From

    GPO telephones

    GPO_telephones

  • TLE2
  • Protein-coding gene in the species Homo sapiens

    encoded by the TLE2 gene. TLE2 has been shown to interact with TLE1 and HES1. GRCh38: Ensembl release 89: ENSG00000065717 – Ensembl, May 2017 GRCm38:

    TLE2

    TLE2

    TLE2

  • Bone morphogenetic protein 4
  • Human protein and coding gene

    subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids". Frontiers in Cellular Neuroscience. 8: 98. doi:10.3389/fncel

    Bone morphogenetic protein 4

    Bone morphogenetic protein 4

    Bone_morphogenetic_protein_4

  • Cord lining
  • show similarities to limbal stem cells in terms of expression of ABCG2, HES1 and BMI1 in addition to p63. When transplanted onto rabbit eyes with corneal

    Cord lining

    Cord_lining

  • List of human protein-coding genes 4
  • Q8IVU3 7023 HERPUD1 HGNC:13744; Q15011 7024 HERPUD2 HGNC:21915; Q9BSE4 7025 HES1 HGNC:5192; Q14469 7026 HES2 HGNC:16005; Q9Y543 7027 HES3 HGNC:26226; Q5TGS1

    List of human protein-coding genes 4

    List_of_human_protein-coding_genes_4

  • Hes3 signaling axis
  • Hes3, a transcription factor belonging to the Hes/Hey family of genes (see HES1). Hes3 has been used as a biomarker to identify putative endogenous stem

    Hes3 signaling axis

    Hes3_signaling_axis

  • Mir-185 microRNA precursor family
  • RNA family

    Soares MB, Mayanil CS (November 2010). "Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development". The Journal

    Mir-185 microRNA precursor family

    Mir-185_microRNA_precursor_family

  • Pediatric ependymoma
  • respectively. Over-expression of Notch ligands, receptors, and target genes (HES1, HEY2, and MYC), as well as down-regulation of Notch repressor (FBXW7) are

    Pediatric ependymoma

    Pediatric_ependymoma

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Online names & meanings

  • Jeanelle
  • Girl/Female

    American, Australian, British, English, French, Scottish

    Jeanelle

    Jehovah has been Gracious; Has Shown Favor; Variation of Jean; The Lord is Gracious

  • Vrusty
  • Girl/Female

    Hindu

    Vrusty

  • Brooke
  • Girl/Female

    American, Arabic, Australian, British, Christian, English, French, Indian, Jamaican

    Brooke

    A Small Fresh Water Stream; A Brook; A Stream; Breaking Forth; Dweller by the Brook; Lover

  • Muvesh | முவேஷ
  • Boy/Male

    Tamil

    Muvesh | முவேஷ

  • Suryali
  • Girl/Female

    Indian

    Suryali

    Goddess Laxmi

  • Isaam
  • Boy/Male

    Afghan, African, Arabic, Indian, Muslim, Swahili

    Isaam

    Safeguard; Guard

  • Tejender
  • Boy/Male

    Hindu, Indian, Punjabi, Sikh

    Tejender

    Source of Energy

  • ELIEZAR
  • Male

    Hebrew

    ELIEZAR

    Variant spelling of Hebrew Eliezer, ELIEZAR means "God has helped."

  • Viera
  • Girl/Female

    Australian, Czech, Jamaican

    Viera

    Latin True; Russian Faith

  • GÖZDE
  • Female

    Turkish

    GÖZDE

    Turkish name GÖZDE means "favorite."

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HES1

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